16503-1-AP

antibody from Proteintech Group

Targeting: WDR48 KIAA1449, P80, SPG60

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Antibody Data

Product number

16503-1-AP

Provider

Proteintech Group

Product name

WDR48 antibody

Antibody type

Polyclonal

Description

WDR48 antibody (Cat. #16503-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

The USP1-WDR48 deubiquitinase complex functions as a molecular switch regulating tumor-associated macrophage activation and anti-tumor response.

Han D, Wang L, Jiang S, Su P, Chen B, Zhao W, Chen T, Zhang N, Wang X, Liang Y, Li Y, Li C, Chen X, Luo D, Yang Q
Cell death and differentiation 2026 Jan;33(1):92-110

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RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress.

Stanage TH, Li S, Segura-Bayona S, Idilli AI, Millar R, Hewitt G, Boulton SJ
Nature cell biology 2026 Feb;28(2):240-254

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Epigenetically elevated RAD51AP1 regulates the RAD51-UAF1 complex contributing to temozolomide resistance in EGFRvIII glioblastoma.

Chang Y, Yang J, Li Z, Zhu X, Jiang T, Wang Q, Yu M, Han B, Liu X
Chinese medical journal 2025 Apr 10;

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The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1.

Li N, Zhang E, Li Z, Lv S, Zhao X, Ke Q, Zou Q, Li W, Wang Y, Guo H, Song T, Sun L
The Journal of biological chemistry 2024 Mar;300(3):105707

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The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis.

Wang Z, Li T, Liu D, Li M, Liu S, Yu X, Li H, Song H, Zhao W, Liu Z, Chen X, Lu G, Chen ZJ, Huang T, Liu H
iScience 2024 Apr 19;27(4):109456

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The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.

Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E
Nature communications 2023 Oct 5;14(1):6173

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USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m(6)A Modification of YAP1 mRNA.

Ge X, Ye W, Zhu Y, Cui M, Zhou J, Xiao C, Jiang D, Tang P, Wang J, Wang Z, Ji C, Zhou X, Cao X, Liu W, Cai W
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Mar 1;43(9):1456-1474

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USP1-Associated Factor 1 Modulates Japanese Encephalitis Virus Replication by Governing Autophagy and Interferon-Stimulated Genes.

Xing J, Hu C, Che S, Lan Y, Huang L, Liu L, Yin Y, Li H, Liao M, Qi W
Microbiology spectrum 2023 Jun 15;11(3):e0318622

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USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1.

Han D, Wang L, Chen B, Zhao W, Liang Y, Li Y, Zhang H, Liu Y, Wang X, Chen T, Li C, Song X, Luo D, Li Z, Yang Q
Cell cycle (Georgetown, Tex.) 2021 Feb;20(3):320-331

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Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma.

Zhao Y, Xue C, Xie Z, Ouyang X, Li L
Cell proliferation 2020 Oct;53(10):e12908

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The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation.

Hodul M, Ganji R, Dahlberg CL, Raman M, Juo P
The Journal of biological chemistry 2020 Aug 14;295(33):11776-11788