SMG6

This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]

Description

SMG6 nonsense mediated mRNA decay factor

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

17:p13.3 (2059839 - 2303785)

Ensembl ID

ENSG00000070366  (ver. 99.38)

Orthologs

Mouse Smg6: ENSMUSG00000038290

UniProt

Q86US8

neXtProt

NX_Q86US8

Human splice variants
Mouse splice variants