FNab01597

antibody from FineTest Biotech

Targeting: CEP152 KIAA0912, MCPH9, SCKL5

Western blot

ELISA

Immunoprecipitation

Antibody data

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Validation data

Product number: FNab01597 - Provider product page
Provider: FineTest Biotech
Product name: CEP152 antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication(PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation(PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure(PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles(By similarity). Overexpression of CEP152 can drive amplification of centrioles(PubMed:20852615).
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: centrosomal protein 152kDa
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

CEP152 protein structure - FNab01597 shown in red.