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- References [7]
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- Western blot [2]
- Immunohistochemistry [1]
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- Product number
- 10997-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10997-2-AP, RRID:AB_2299887
- Product name
- POLG2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated POLG2 antibody (Cat. #10997-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Interference with mitochondrial metabolism could serve as a potential therapeutic strategy for advanced prostate cancer.
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication.
TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication.
The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit.
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
Wu C, Zhu H, Zhang Y, Ding L, Wang J
PloS one 2024;19(4):e0290753
PloS one 2024;19(4):e0290753
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
Tábara LC, Burr SP, Frison M, Chowdhury SR, Paupe V, Nie Y, Johnson M, Villar-Azpillaga J, Viegas F, Segawa M, Anand H, Petkevicius K, Chinnery PF, Prudent J
Cell 2024 Jul 11;187(14):3619-3637.e27
Cell 2024 Jul 11;187(14):3619-3637.e27
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S, Rodriguez-Enriquez R, Chevez JA, Lemersal I, Manor U, Shadel GS
Nature cell biology 2024 Feb;26(2):194-206
Nature cell biology 2024 Feb;26(2):194-206
Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication.
Wang X, Wang M, Cai M, Shao R, Xia G, Zhao W
Acta pharmaceutica Sinica. B 2023 Nov;13(11):4477-4501
Acta pharmaceutica Sinica. B 2023 Nov;13(11):4477-4501
TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication.
Inatomi T, Matsuda S, Ishiuchi T, Do Y, Nakayama M, Abe S, Kasho K, Wanrooij S, Nakada K, Ichiyanagi K, Sasaki H, Yasukawa T, Kang D
Biochimica et biophysica acta. Molecular cell research 2022 Jan;1869(1):119167
Biochimica et biophysica acta. Molecular cell research 2022 Jan;1869(1):119167
The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit.
Do Y, Matsuda S, Inatomi T, Nakada K, Yasukawa T, Kang D
Mitochondrion 2020 Jul;53:133-139
Mitochondrion 2020 Jul;53:133-139
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
Zhao X, Sun K, Lan Z, Song W, Cheng L, Chi W, Chen J, Huo Y, Xu L, Liu X, Deng H, Siegenthaler JA, Chen L
Scientific reports 2017 Apr 11;7:46344
Scientific reports 2017 Apr 11;7:46344
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 10997-2-AP( POLG2 Antibody) at dilution of 1:300
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 10997-2-AP( POLG2 Antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The POLG2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human POLG2. This antibody recognizes human,mouse,rat antigen. The POLG2 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
