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- Antibody Data
- Antigen structure
- References [13]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 14635-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14635-1-AP, RRID:AB_2082621
- Product name
- CNPY2, MSAP antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CNPY2, MSAP antibody (Cat. #14635-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Prognostic and immunological implications of paraptosis-related genes in lung adenocarcinoma: Comprehensive analysis and functional verification of hub gene.
Angiotensin-(1-9) prevents angiotensin II-induced endothelial apoptosis through CNPY2/PERK pathway.
MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling.
Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway.
Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.
Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.
Human adipose tissue- and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?
Liraglutide Increases VEGF Expression via CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury.
Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway.
Dexmedetomidine attenuates neuronal injury after spinal cord ischaemia-reperfusion injury by targeting the CNPY2-endoplasmic reticulum stress signalling.
CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.
Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol.
Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).
Zhuo Y, Song Y
Environmental toxicology 2024 Mar 6;
Environmental toxicology 2024 Mar 6;
Angiotensin-(1-9) prevents angiotensin II-induced endothelial apoptosis through CNPY2/PERK pathway.
Guo CL, Liu HM, Li B, Lu ZY
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):379-396
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):379-396
MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling.
Gu XJ, Li YJ, Wang F, Ye T
World journal of gastrointestinal oncology 2022 Nov 15;14(11):2170-2182
World journal of gastrointestinal oncology 2022 Nov 15;14(11):2170-2182
Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway.
Li J, Huang L, Xiong W, Qian Y, Song M
Biochemical and biophysical research communications 2022 May 7;603:35-40
Biochemical and biophysical research communications 2022 May 7;603:35-40
Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.
Zhao L, Li H, Gao Q, Xu J, Zhu Y, Zhai M, Zhang P, Shen N, Di Y, Wang J, Chen T, Huang M, Sun J, Liu C
Frontiers in pharmacology 2021;12:609693
Frontiers in pharmacology 2021;12:609693
Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.
Kakehashi A, Suzuki S, Shiota M, Raymo N, Gi M, Tachibana T, Stefanov V, Wanibuchi H
Cancers 2021 Jul 19;13(14)
Cancers 2021 Jul 19;13(14)
Human adipose tissue- and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?
Liu AM, Chen BL, Yu LT, Liu T, Shi LL, Yu PP, Qu YB, So KF, Zhou LB
Neural regeneration research 2020 Dec;15(12):2306-2317
Neural regeneration research 2020 Dec;15(12):2306-2317
Liraglutide Increases VEGF Expression via CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury.
Liu C, Liu Y, He J, Mu R, Di Y, Shen N, Liu X, Gao X, Wang J, Chen T, Fang T, Li H, Tian F
Frontiers in pharmacology 2019;10:789
Frontiers in pharmacology 2019;10:789
Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway.
Cui Y, Wang Y, Liu G
International journal of molecular medicine 2019 May;43(5):2015-2023
International journal of molecular medicine 2019 May;43(5):2015-2023
Dexmedetomidine attenuates neuronal injury after spinal cord ischaemia-reperfusion injury by targeting the CNPY2-endoplasmic reticulum stress signalling.
Zhao L, Zhai M, Yang X, Guo H, Cao Y, Wang D, Li P, Liu C
Journal of cellular and molecular medicine 2019 Dec;23(12):8173-8183
Journal of cellular and molecular medicine 2019 Dec;23(12):8173-8183
CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.
Hong F, Liu B, Wu BX, Morreall J, Roth B, Davies C, Sun S, Diehl JA, Li Z
Nature structural & molecular biology 2017 Oct;24(10):834-839
Nature structural & molecular biology 2017 Oct;24(10):834-839
Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol.
Do HT, Bruelle C, Tselykh T, Jalonen P, Korhonen L, Lindholm D
The Journal of biological chemistry 2013 Oct 11;288(41):29613-20
The Journal of biological chemistry 2013 Oct 11;288(41):29613-20
Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).
Do HT, Tselykh TV, Mäkelä J, Ho TH, Olkkonen VM, Bornhauser BC, Korhonen L, Zelcer N, Lindholm D
The Journal of biological chemistry 2012 Apr 13;287(16):12602-11
The Journal of biological chemistry 2012 Apr 13;287(16):12602-11
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 14635-1-AP(CNPY2,MSAP antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CNPY2,MSAP (IP:14635-1-AP, 3ug; Detection:14635-1-AP 1:500) with HepG2 cells lysate 600ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 14635-1-AP(CNPY2,MSAP antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CNPY2,MSAP antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CNPY2,MSAP. This antibody recognizes human,mouse,rat antigen. The CNPY2,MSAP antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
