Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11313-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11313-2-AP, RRID:AB_2223815
- Product name
- Alpha Actinin antibody
- Antibody type
- Polyclonal
- Description
- Alpha Actinin antibody (Cat. #11313-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CRISPR-Cas9-mediated deletion of carbonic anhydrase 2 in the ciliary body to treat glaucoma.
Improved Cell Adhesion on Self-Assembled Chiral Nematic Cellulose Nanocrystal Films.
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway.
N-arachidonoylphenolamine alleviates ischaemia/reperfusion-induced cardiomyocyte necroptosis by restoring proteasomal activity.
DPY30 Promotes Proliferation and Cell Cycle Progression of Colorectal Cancer Cells via Mediating H3K4 Trimethylation.
Ganoderma lucidum polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy.
SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells.
Modification of lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression.
MK-886 protects against cardiac ischaemia/reperfusion injury by activating proteasome-Keap1-NRF2 signalling.
Guanxinning injection ameliorates cardiac remodeling in HF mouse and 3D heart spheroid models via p38/FOS/MMP1-mediated inhibition of myocardial hypertrophy and fibrosis.
Activation of long-non-coding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 in troxerutin radioprotection.
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
Retinoic Acid Receptor Gamma (RARγ) Promotes Cartilage Destruction through Positive Feedback Activation of NF-κB Pathway in Human Osteoarthritis.
Identification and validation of an immune signature associated with EMT and metabolic reprogramming for predicting prognosis and drug response in bladder cancer.
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration.
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1.
MYPT1/PP1-Mediated EZH2 Dephosphorylation at S21 Promotes Epithelial-Mesenchymal Transition in Fibrosis through Control of Multiple Families of Genes.
Calponin 1 contributes to myofibroblast differentiation of human pleural mesothelial cells.
CaMKII and Kalirin, a Rac1-GEF, regulate Akt phosphorylation involved in contraction-induced glucose uptake in skeletal muscle cells.
A novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD.
Inhibitor of Differentiation-2 Protein Ameliorates DSS-Induced Ulcerative Colitis by Inhibiting NF-κB Activation in Neutrophils.
Adipocyte-specific deletion of Depdc5 exacerbates insulin resistance and adipose tissue inflammation in mice.
Disparate effects of MMP and TIMP modulation on coronary atherosclerosis and associated myocardial fibrosis.
Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice.
Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling.
Aging-dependent loss of GAP junction proteins Cx46 and Cx50 in the fiber cells of human and mouse lenses accounts for the diminished coupling conductance.
Dynamic spatiotemporal expression pattern of limbal stem cell putative biomarkers during mouse development.
miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury.
Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats.
Jiang J, Kong K, Fang X, Wang D, Zhang Y, Wang P, Yang Z, Zhang Y, Liu X, Aung T, Li F, Yu-Wai-Man P, Zhang X
Cell reports. Medicine 2024 May 21;5(5):101524
Cell reports. Medicine 2024 May 21;5(5):101524
Improved Cell Adhesion on Self-Assembled Chiral Nematic Cellulose Nanocrystal Films.
Wang X, Xu H, Ning F, Duan S, Hu Y, Ding X, Xu FJ
Macromolecular rapid communications 2024 Jun 24;:e2400339
Macromolecular rapid communications 2024 Jun 24;:e2400339
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway.
Lv C, Zhou L, Meng Y, Yuan H, Geng J
Cellular signalling 2024 Jan;113:110974
Cellular signalling 2024 Jan;113:110974
N-arachidonoylphenolamine alleviates ischaemia/reperfusion-induced cardiomyocyte necroptosis by restoring proteasomal activity.
Bai JQ, Li PB, Li CM, Li HH
European journal of pharmacology 2024 Jan 15;963:176235
European journal of pharmacology 2024 Jan 15;963:176235
DPY30 Promotes Proliferation and Cell Cycle Progression of Colorectal Cancer Cells via Mediating H3K4 Trimethylation.
Su WC, Mao XM, Li SY, Luo CY, Fan R, Jiang HF, Zhang LJ, Wang YT, Su GQ, Shen DY
International journal of medical sciences 2023;20(7):901-917
International journal of medical sciences 2023;20(7):901-917
Ganoderma lucidum polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy.
Zhen C, Wu X, Zhang J, Liu D, Li G, Yan Y, He X, Miao J, Song H, Yan Y, Zhang Y
Frontiers in pharmacology 2023;14:1127123
Frontiers in pharmacology 2023;14:1127123
SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells.
Wang Y, Wang JM, Xiao Y, Hu XB, Zheng SY, Fu JL, Zhang L, Gan YW, Liang XM, Li DW
Aging 2023 Sep 7;15(17):8812-8832
Aging 2023 Sep 7;15(17):8812-8832
Modification of lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression.
Zhang Z, Wang Y, Liang Z, Meng Z, Zhang X, Ma G, Chen Y, Zhang M, Su Y, Li Z, Liang Y, Niu H
iScience 2023 Nov 17;26(11):108142
iScience 2023 Nov 17;26(11):108142
MK-886 protects against cardiac ischaemia/reperfusion injury by activating proteasome-Keap1-NRF2 signalling.
Shi KN, Li PB, Su HX, Gao J, Li HH
Redox biology 2023 Jun;62:102706
Redox biology 2023 Jun;62:102706
Guanxinning injection ameliorates cardiac remodeling in HF mouse and 3D heart spheroid models via p38/FOS/MMP1-mediated inhibition of myocardial hypertrophy and fibrosis.
Fan S, Xiao G, Ni J, Zhao Y, Du H, Liang Y, Lv M, He S, Fan G, Zhu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114642
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114642
Activation of long-non-coding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 in troxerutin radioprotection.
Hu YJ, Song GY, Zhang F, Zhang N, Wang F, Wang JL, Wang X, Wang TY, Li YF, Yan YD, Dou WT, Cheng CY, Xu P
iScience 2023 Feb 17;26(2):105932
iScience 2023 Feb 17;26(2):105932
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
Cui L, Lu Y, Zheng J, Guo B, Zhao X
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335
Retinoic Acid Receptor Gamma (RARγ) Promotes Cartilage Destruction through Positive Feedback Activation of NF-κB Pathway in Human Osteoarthritis.
Yu YW, Li SY, Zhang LJ, Wang QL, Liu ZG, Chen QZ, Song HY, Shen DY, Yan J
Mediators of inflammation 2022;2022:1875736
Mediators of inflammation 2022;2022:1875736
Identification and validation of an immune signature associated with EMT and metabolic reprogramming for predicting prognosis and drug response in bladder cancer.
Zhang Z, Yu Y, Li P, Wang M, Jiao W, Liang Y, Niu H
Frontiers in immunology 2022;13:954616
Frontiers in immunology 2022;13:954616
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration.
Zou M, Ke Q, Nie Q, Qi R, Zhu X, Liu W, Hu X, Sun Q, Fu JL, Tang X, Liu Y, Li DW, Gong L
Cell death and differentiation 2022 Sep;29(9):1816-1833
Cell death and differentiation 2022 Sep;29(9):1816-1833
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
Zheng Z, Lei C, Liu H, Jiang M, Zhou Z, Zhao Y, Yu CY, Wei H
Advanced healthcare materials 2022 Oct;11(19):e2200990
Advanced healthcare materials 2022 Oct;11(19):e2200990
CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1.
Liang Z, Jiao W, Wang L, Chen Y, Li D, Zhang Z, Zhang Z, Liang Y, Niu H
Experimental cell research 2022 Oct 1;419(1):113279
Experimental cell research 2022 Oct 1;419(1):113279
MYPT1/PP1-Mediated EZH2 Dephosphorylation at S21 Promotes Epithelial-Mesenchymal Transition in Fibrosis through Control of Multiple Families of Genes.
Zhang L, Wang L, Hu XB, Hou M, Xiao Y, Xiang JW, Xie J, Chen ZG, Yang TH, Nie Q, Fu JL, Wang Y, Zheng SY, Liu YF, Gan YW, Gao Q, Bai YY, Wang JM, Qi RL, Zou M, Ke Q, Zhu XF, Gong L, Liu Y, Li DW
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(14):e2105539
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(14):e2105539
Calponin 1 contributes to myofibroblast differentiation of human pleural mesothelial cells.
Choo YY, Sakai T, Komatsu S, Ikebe R, Jeffers A, Singh KP, Idell S, Tucker TA, Ikebe M
American journal of physiology. Lung cellular and molecular physiology 2022 Mar 1;322(3):L348-L364
American journal of physiology. Lung cellular and molecular physiology 2022 Mar 1;322(3):L348-L364
CaMKII and Kalirin, a Rac1-GEF, regulate Akt phosphorylation involved in contraction-induced glucose uptake in skeletal muscle cells.
Liu S, Zhang J, Qi R, Deng B, Ni Y, Zhang C, Niu W
Biochemical and biophysical research communications 2022 Jun 25;610:170-175
Biochemical and biophysical research communications 2022 Jun 25;610:170-175
A novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD.
Shao Y, Yao Z, Zhou J, Yu M, Chen S, Yuan Y, Han L, Jiang L, Liu J
Nutrition & metabolism 2022 Dec 6;19(1):80
Nutrition & metabolism 2022 Dec 6;19(1):80
Inhibitor of Differentiation-2 Protein Ameliorates DSS-Induced Ulcerative Colitis by Inhibiting NF-κB Activation in Neutrophils.
Ren J, Yan D, Wang Y, Zhang J, Li M, Xiong W, Jing X, Li P, Zhao W, Xiong X, Wu M, Zhong G
Frontiers in immunology 2021;12:760999
Frontiers in immunology 2021;12:760999
Adipocyte-specific deletion of Depdc5 exacerbates insulin resistance and adipose tissue inflammation in mice.
Zhang J, Shi Y, Yang C, Sun B, Ma H, Huang R, Li Z, Wang M, Wang Q, Ma J, Xiong X
Biochemical and biophysical research communications 2021 Sep 10;569:118-124
Biochemical and biophysical research communications 2021 Sep 10;569:118-124
Disparate effects of MMP and TIMP modulation on coronary atherosclerosis and associated myocardial fibrosis.
Kremastiotis G, Handa I, Jackson C, George S, Johnson J
Scientific reports 2021 Nov 30;11(1):23081
Scientific reports 2021 Nov 30;11(1):23081
Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice.
Xin Y, Xu L, Zhang X, Yang C, Wang Q, Xiong X
Biochemical and biophysical research communications 2021 Mar 12;544:44-51
Biochemical and biophysical research communications 2021 Mar 12;544:44-51
Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling.
Jia P, Wu N, Yang H, Guo Y, Guo X, Sun Y
Translational research : the journal of laboratory and clinical medicine 2021 Jul;233:47-61
Translational research : the journal of laboratory and clinical medicine 2021 Jul;233:47-61
Aging-dependent loss of GAP junction proteins Cx46 and Cx50 in the fiber cells of human and mouse lenses accounts for the diminished coupling conductance.
Gong XD, Wang Y, Hu XB, Zheng SY, Fu JL, Nie Q, Wang L, Hou M, Xiang JW, Xiao Y, Gao Q, Bai YY, Liu YZ, Li DW
Aging 2021 Jul 4;13(13):17568-17591
Aging 2021 Jul 4;13(13):17568-17591
Dynamic spatiotemporal expression pattern of limbal stem cell putative biomarkers during mouse development.
Guo ZH, Zeng YM, Lin JS
Experimental eye research 2020 Mar;192:107915
Experimental eye research 2020 Mar;192:107915
miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury.
Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, Wang H, Xuan Q, Chen P, Xu J, Che L, Liu H, Zhong J, Sluijter JP, Li X, Rosenzweig A, Xiao J
Theranostics 2017;7(3):664-676
Theranostics 2017;7(3):664-676
Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats.
Yao W, Fan W, Huang C, Zhong H, Chen X, Zhang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2013 Mar;67(2):140-5
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2013 Mar;67(2):140-5
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The alpha Actinin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human alpha Actinin. This antibody recognizes human,mouse,rat antigen. The alpha Actinin antibody has been validated for the following applications: ELISA, WB analysis.