SCARF2

The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Description

Scavenger receptor class F member 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Cytosol

Predicted location

Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

22 (20424584 - 20437826)

Ensembl ID

ENSG00000244486  (ver. 103.38)

Orthologs

Mouse Scarf2: ENSMUSG00000012017

UniProt

Q96GP6

neXtProt

NX_Q96GP6

Human splice variants
Mouse splice variants

Protein structure