Antibody data

Product number
Ab113790 - Provider product page
Provider
Aladdin Scientific
Product name
Lyn Mouse mAb
Antibody type
Monoclonal
Description
Mouse anti Human Lyn Antibody, Monoclonal (1C8-H3-G6), could be used for WB and so on.Application:WB: 1/500-1/1000Protein FunctionDown regulates expression of stem cell growth factor receptor (KIT). Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation (By similarity). Acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
AA 8-238
Antibody clone number
1C8-H3-G6
Vial size
100_l,10_l,1ml,50_l
Concentration
1 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
LYN protein structure - Ab113790 shown in red.