KRT78

This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]

Description

Keratin 78

Tissue specificity

Tissue enriched (esophagus)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (52837804 - 52849092)

Ensembl ID

ENSG00000170423  (ver. 103.38)

Orthologs

Mouse Krt78: ENSMUSG00000050463

UniProt

Q8N1N4

neXtProt

NX_Q8N1N4

Human splice variants
Mouse splice variants

Protein structure