HPA023374

antibody from Atlas Antibodies

Targeting: PCM1 PTC4

Provider product page for HPA023374

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [23]
Comments [0]
Validations
Immunocytochemistry [1]

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Product number: HPA023374 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA023374, RRID:AB_1855073
Product name: Anti-PCM1
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human PCM1, Gene description: pericentriolar material 1, Alternative Gene Names: PTC4, Validated applications: IHC, ICC, Uniprot ID: Q15154, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.3 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

PCM1 protein structure - HPA023374 shown in red.

Submitted references A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease

Derks W, Rode J, Collin S, Rost F, Heinke P, Hariharan A, Pickel L, Simonova I, Lázár E, Graham E, Jashari R, Andrä M, Jeppsson A, Salehpour M, Alkass K, Druid H, Kyriakopoulos C, Taleb I, Shankar T, Selzman C, Sadek H, Jovinge S, Brusch L, Frisén J, Drakos S, Bergmann O
Circulation 2025;151(3):245-256

Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations

Sun C, Swoboda C, Morales F, Calvo C, Petrany M, Parameswaran S, VonHandorf A, Weirauch M, Lepper C, Millay D
Nature Communications 2024;15(1)

Global ischemia induces stemness and dedifferentiation in human adult cardiomyocytes after cardiac arrest

Jinton H, Sopasakis V, Sjölin L, Oldfors A, Jeppsson A, Oras J, Wernbom M, Vukusic K
Scientific Reports 2024;14(1)

Catecholamine treatment induces reversible heart injury and cardiomyocyte gene expression

Bode C, Preissl S, Hein L, Lother A
Intensive Care Medicine Experimental 2024;12(1)

Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development

Cui M, Bezprozvannaya S, Hao T, Elnwasany A, Szweda L, Liu N, Bassel-Duby R, Olson E
Developmental Cell 2023;58(24):2867-2880.e7

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Tan C, Chan P, Tan H, Tan S, Lee C, Wang J, Ye S, Werner H, Loh Y, Lee Y, Ackers-Johnson M, Foo R, Jiang J
Journal of Translational Medicine 2023;21(1)

Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution

Dos Santos M, Shah A, Zhang Y, Bezprozvannaya S, Chen K, Xu L, Lin W, McAnally J, Bassel-Duby R, Liu N, Olson E
Nature Communications 2023;14(1)

Sun C, Swoboda C, Petrany M, Parameswaran S, VonHandorf A, Weirauch M, Lepper C, Millay D
2023

HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes.

Boikova A, Bywater MJ, Quaife-Ryan GA, Straube J, Thompson L, Ascanelli C, Littlewood TD, Evan GI, Hudson JE, Wilson CH
Frontiers in cardiovascular medicine 2022;9:948281

RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development

Gan P, Wang Z, Morales M, Zhang Y, Bassel-Duby R, Liu N, Olson E
Developmental Cell 2022;57(8):959-973.e7

Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing

Cui M, Wang Z, Chen K, Shah A, Tan W, Duan L, Sanchez-Ortiz E, Li H, Xu L, Liu N, Bassel-Duby R, Olson E
Developmental Cell 2020;53(1):102-116.e8

Dietary protein restriction throughout intrauterine and postnatal life results in potentially beneficial myocardial tissue remodeling in the adult mouse heart

Hennig M, Ewering L, Pyschny S, Shimoyama S, Olecka M, Ewald D, Magarin M, Uebing A, Thierfelder L, Jux C, Drenckhahn J
Scientific Reports 2019;9(1)

A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes

So C, Seres K, Steyer A, Mönnich E, Clift D, Pejkovska A, Möbius W, Schuh M
Science 2019;364(6447)

Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of Bmp7 and Ctgf

Tan C, Wong J, Chan P, Tan H, Liao D, Chen W, Tan L, Ackers-Johnson M, Wakimoto H, Seidman J, Seidman C, Lunde I, Zhu F, Hu Q, Bian J, Wang J, Foo R, Jiang J
Circulation Research 2019;125(9):834-846

The Atrioventricular Junction: A Potential Niche Region for Progenitor Cells in the Adult Human Heart.

Vukusic K, Sandstedt M, Jonsson M, Jansson M, Oldfors A, Jeppsson A, Dellgren G, Lindahl A, Sandstedt J
Stem cells and development 2019 Aug 15;28(16):1078-1088

Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction

Zacchigna S, Martinelli V, Moimas S, Colliva A, Anzini M, Nordio A, Costa A, Rehman M, Vodret S, Pierro C, Colussi G, Zentilin L, Gutierrez M, Dirkx E, Long C, Sinagra G, Klatzmann D, Giacca M
Nature Communications 2018;9(1)

DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes

Nothjunge S, Nührenberg T, Grüning B, Doppler S, Preissl S, Schwaderer M, Rommel C, Krane M, Hein L, Gilsbach R
Nature Communications 2017;8(1)

Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

See K, Tan W, Lim E, Tiang Z, Lee L, Li P, Luu T, Ackers-Johnson M, Foo R
Nature Communications 2017;8(1)

A Method for the Acute and Rapid Degradation of Endogenous Proteins

Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, Schuh M
Cell 2017;171(7):1692-1706.e18

5'-Hydroxymethylcytosine Precedes Loss of CpG Methylation in Enhancers and Genes Undergoing Activation in Cardiomyocyte Maturation

Deng D, Kranzhöfer D, Gilsbach R, Grüning B, Backofen R, Nührenberg T, Hein L
PLOS ONE 2016;11(11):e0166575

BBS mutations modify phenotypic expression of CEP290-related ciliopathies

Zhang Y, Seo S, Bhattarai S, Bugge K, Searby C, Zhang Q, Drack A, Stone E, Sheffield V
Human Molecular Genetics 2014;23(1):40-51

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

Humbert M, Weihbrecht K, Searby C, Li Y, Pope R, Sheffield V, Seo S
Proceedings of the National Academy of Sciences 2012;109(48):19691-19696

Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover

Bergmann O, Zdunek S, Alkass K, Druid H, Bernard S, Frisén J
Experimental Cell Research 2011;317(2):188-194

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear membrane & centrosome.
Sample type: Human