FNab08667

antibody from FineTest Biotech
Targeting: THOC2 CXorf3, dJ506G2.1, MRX12, MRX35, THO2
Provider product page for FNab08667
Western blot
ELISA
Immunocytochemistry
Immunoprecipitation

Antibody data

Product number
FNab08667 - Provider product page
Provider
FineTest Biotech
Product name
THOC2 antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex(EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus(KSHV) intronless mRNAs and infectious virus production. THOC2(and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
THO complex 2
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
THOC2 protein structure - FNab08667 shown in red.