ARMC5

This gene encodes a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. The ARM repeat is a tandemly repeated sequence motif with approximately 40 amino acid long. This repeat is implicated in mediating protein-protein interactions. The encoded protein contains seven ARM repeats. Mutations in this gene are associated with primary bilateral macronodular adrenal hyperplasia, which is also known as ACTH-independent macronodular adrenal hyperplasia 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Description

Armadillo repeat containing 5

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Focal adhesion sites, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (31458080 - 31467166)

Ensembl ID

ENSG00000140691  (ver. 103.38)

Orthologs

Mouse Armc5: ENSMUSG00000042178

UniProt

Q96C12

neXtProt

NX_Q96C12

Human splice variants
Mouse splice variants

Protein structure