21537-1-AP

antibody from Proteintech Group

Targeting: RETREG1 FAM134B, FLJ20152, JK1

Provider product page for 21537-1-AP

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Immunohistochemistry

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Product number: 21537-1-AP - Provider product page
Provider: Proteintech Group
Product name: FAM134B antibody
Antibody type: Polyclonal
Description: KD/KO validated FAM134B antibody (Cat. #21537-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

RETREG1 protein structure - 21537-1-AP shown in red.

Submitted references Nanosized silicon nitride promotes vascularized osteogenesis through regulating the endothelial adherens junctions via the FRMD6/VE-cadherin pathway.

Wang R, Liu Z, Liu W, Zheng X, Zhao Y, Huang F, Wen S, Gan Y, Huang Z, Zhang Y, Lu Y, Rong M
Biomaterials 2026 Sep;332:124150

XIAP Stabilizes DDRGK1 to Promote ER-Phagy and Protects Against Noise-Induced Hearing Loss.

Yan L, Zhang Y, Du J, Zhu Y, Cao W, Wei Y, Wu H, Qiu S, Pan S, Chen L, Liang P, Chai R, Yang J, Fang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e11217

The multiple roles of Ggt1-Cre in the generation of transgenic mice.

Feng ZS, Luo J, Chen XC, Zhao PP, Qiu ST, Wu CY, Huang XR, Sun BC, Guo XJ, Ye ZN, Yang C, Liu HF, Tang JX
Cellular & molecular biology letters 2026 Jan 6;31(1):19

Membralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation.

Zhang J, Lu X, Li S, Wang T, Ahmad I, Zheng YH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(9):e19256

Autophagy cargo profiles in skeletal muscle during starvation and exercise.

Farhan M, Lyu S, Nguyen TP, Zhang D, Liang H, Zhou Y, An YA, Wang J, Yang H, Du G, Liu Y
Autophagy reports 2025;4(1):2593060

LAPTM4B as a key regulator in the copper-induced endoplasmic reticulum-lysosome interplay disorder in duck liver and the protective role of baicalin.

Shang H, Dai X, Chen J, Xing C, Gao X, Cao H, Hu G, Li H, Hu M, Yang F
Journal of animal science and biotechnology 2025 Sep 1;16(1):121

Cholesterol sensing by the SCAP-FAM134B complex regulates ER-phagy and STING innate immunity.

Li B, Zhou D, Wang X, Jiang X, Sang Y, Dai Y, Yao Y, Zhang Y, Chen C, Li S, Ni W, Zhou Q, Lin A, Hu X, Ge L, Wu Z, Xu P, Neculai D, Liu W, Sun Q
Nature cell biology 2025 Oct;27(10):1739-1756

Maresin1 ameliorates osseointegration in type 2 diabetes mellitus by promoting FAM134B-mediated ER-phagy in osteoblasts.

Gui H, Wang X, Wu A, Li B, Zhang B, Diao J, Chen J, Zhang X, Wu D, He Q, Xu X, Zhang D
Biochemical pharmacology 2025 Oct;240:117099

Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness.

Huang H, Shi W, Yan H, Fan L, Lu J, Long Z, Li X, Li J, Wang J, Liu L, Qian J
Autophagy 2025 Oct;21(10):2148-2167

ER-phagy Activation by AMFR Attenuates Cardiac Fibrosis Post-Myocardial Infarction via mTORC1 Pathway.

Wang Z, Niu K, Liu W, Wang X, Yang B, Li T, Chen Y, Jin Y, Chen Y, Lin Y, Jin X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e04552

Targeting FAM134B-DDX3X axis inhibiting AKT signaling in hepatocellular carcinoma.

Mo J, Su C, Liu Q, Li P, Xu L, Long X, Liang H, Zhang B, Chen J
Cell death & disease 2025 Nov 6;16(1):797

5-Aminoimidazole-4-carboxamide-1- β -d-ribofuranoside ameliorates lipotoxicity through enhanced reticulophagy in HepG2 cells.

Krishnan U A, Venkataraman AC, Ramachandran V
Biotechnology and applied biochemistry 2025 Nov 21;

AMFR-mediated ER-phagy regulation and therapeutic targeting in osteosarcoma: a multifunctional nanoplatform strategy.

Zhao Q, Lu X, Xu T, Gao Z, Peng L, Zhu B, Wang W, Liu Z, Yang G, Zhao H, Song Z, Lou Q, Li J, Ren Z, Yu Z, Jesus M F, Cui D
Journal of nanobiotechnology 2025 Nov 18;23(1):717

ADP ribosylation factor-like GTPase 6-interacting protein 5 (Arl6IP5) is an ER membrane-shaping protein that modulates ER-phagy.

Yamamoto Y, Sakisaka T
The Journal of biological chemistry 2025 May;301(5):108493

Mesenchymal stem cells enhance selective ER-phagy to promote α-synuclein clearance in Parkinson's disease.

Lee JE, Oh KW, Shin JY, Kim YJ, Lee SJ, Lee PH
Stem cells translational medicine 2025 May 31;14(6)

Reticulophagy promotes EMT-induced fibrosis in offspring's lung tissue after maternal exposure to carbon black nanoparticles during gestation by a m(5)C-dependent manner.

Du Z, Liu Q, Wang M, Gao Y, Li Q, Yang Y, Lu T, Bao L, Pang Y, Wang H, Niu Y, Zhang R
Journal of hazardous materials 2025 Mar 5;485:136873

Membralin Selects Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation.

Zheng YH, Zhang J, Lu X, Li S, Wang T, Ahmad I
Research square 2025 Jun 23;

Fufang zhenzhu tiaozhi capsule alleviates hypothalamic endoplasmic reticulum stress and leptin resistance through autophagy modulation in DIO rats.

Hua T, Wu Q, Huang Z, Cai J
Journal of ethnopharmacology 2025 Jul 24;351:120056

Therapy-induced senescent cancer cells contribute to cancer progression by promoting ribophorin 1-dependent PD-L1 upregulation.

Hwang HJ, Kang D, Shin J, Jung J, Ko S, Jung KH, Hong SS, Park JE, Oh MJ, An HJ, Yang WH, Ko YG, Cha JH, Lee JS
Nature communications 2025 Jan 3;16(1):353

GSTK1 and RETREG1/FAM134B-mediated reticulophagy attenuates tubular injury in diabetic nephropathy through endoplasmic reticulum stress and apoptosis.

Zhang S, Chen W, Wang W, Liu Y, Zhao C, Yang K, Dai W, Ou Y, Yin X, Long Y, Liu Y, Zhang L, Sun L, Liu F, Xiao L
Autophagy 2025 Dec;21(12):2826-2841

RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity.

Jin S, Yan M, Liu Y, Zhang S, Song H, Cao C, Li Y, Sun G, Ye L, Chen J, Han W, Li L, Chang Q
Autophagy 2025 Dec;21(12):2614-2632

Carvacrol alleviates endoplasmic reticulum stress and inflammation induced by lipopolysaccharide by enhancing endoplasmic reticulum autophagy in dairy mammary epithelial cells.

Yang Y, Li M, Wang J, Zhang H, Chang R, Zhao B, Aernouts B, Huang Q, Xu C
Journal of dairy science 2025 Dec;108(12):13919-13937

The impact of copper-induced oxidative damage on the endoplasmic reticulum quality control system in broiler kidneys.

Ma F, Wang M, Zhong G, Liao J, Huo Y, Wang Z, He S
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2025 Aug;38(4):1131-1143

CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression.

Mo J, Su C, Li P, Yang Z, Tao R, Liu Q, Yuan C, Xu L, Ge Q, Ning D, Liang H, Zhu H, Luo Y, Chen X, Chen J, Zhang B
Autophagy 2025 Apr;21(4):840-859

Hydrogen sulfide improves poststroke depression-induced inflammation in microglial cells by enhancing endoplasmic reticulum autophagy and inhibiting the cGAS-STING pathway.

Luo B, Xie Y, Kuang W, Wang Y, Chen G, Zhang Y, Yuan M
Neuroreport 2025 Apr 2;36(6):314-326

Methods for Monitoring ER-Phagy.

Di Monaco M, Peteri M, Liang JR
Methods in molecular biology (Clifton, N.J.) 2024;2845:109-126

Degradation of STIM1 through FAM134B-mediated ER-phagy is potentially involved in cell proliferation.

Kajiho H, Sakisaka T
The Journal of biological chemistry 2024 Sep;300(9):107674

RTN3L and CALCOCO1 function in parallel to maintain proteostasis in the endoplasmic reticulum.

Kumar K, Chidambaram R, Parashar S, Ferro-Novick S
Autophagy 2024 Sep;20(9):2067-2075

LW-213, a derivative of wogonin, triggers reticulophagy-mediated cell death in NSCLC via lysosomal damage combined with NPC1 inhibition.

Wang H, Jiang Y, Zhu M, Li H, Chen H, Wang H, Zhang S, Guo Q, Hui H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155958

AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity.

Zhang L, Wang H, Han C, Dong Q, Yan J, Guo W, Shan C, Zhao W, Chen P, Huang R, Wu Y, Chen Y, Qin Y, Chen M
Nature communications 2024 Nov 6;15(1):9578

Combinatorial selective ER-phagy remodels the ER during neurogenesis.

Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, Harper JW
Nature cell biology 2024 Mar;26(3):378-392

The p24-family and COPII subunit SEC24C facilitate the clearance of alpha1-antitrypsin Z from the endoplasmic reticulum to lysosomes.

Roberts BS, Mitra D, Abishek S, Beher R, Satpute-Krishnan P
Molecular biology of the cell 2024 Mar 1;35(3):ar45

Drp1 Aggravates Copper Nanoparticle-Induced ER-Phagy by Disturbing Mitochondria-Associated Membranes in Chicken Hepatocytes.

Li Q, Guo P, Wang S, Su L, Yu W, Guo J, Hu L, Zhang H, Pan J, Tang Z, Liao J
Journal of agricultural and food chemistry 2024 Jul 24;72(29):16506-16518

FAM134B deletion exacerbates apoptosis and epithelial-to-mesenchymal transition in rat lungs exposed to hyperoxia.

Guo H, Huang RR, Qu SS, Yao Y, Chen SH, Ding SL, Li YL
iScience 2024 Jul 19;27(7):110385

The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.

Jian F, Wang S, Tian R, Wang Y, Li C, Li Y, Wang S, Fang C, Ma C, Rong Y
Cell research 2024 Feb;34(2):151-168

Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus.

Xiang Q, Wouters C, Chang P, Lu YN, Liu M, Wang H, Yang J, Pekosz A, Zhang Y, Wang J
bioRxiv : the preprint server for biology 2024 Dec 5;

USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy.

Zhang M, Wang Z, Zhao Q, Yang Q, Bai J, Yang C, Zhang ZR, Liu Y
Autophagy 2024 Aug;20(8):1780-1797

Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development.

Lüningschrör P, Andreska T, Veh A, Wolf D, Giridhar NJ, Moradi M, Denzel A, Sendtner M
Developmental cell 2023 Sep 25;58(18):1733-1747.e6

Suberoylanilide hydroxamic acid upregulates reticulophagy receptor expression and promotes cell death in hepatocellular carcinoma cells.

Li JY, Tian T, Han B, Yang T, Guo YX, Wu JY, Chen YS, Yang Q, Xie RJ
World journal of gastroenterology 2023 Sep 14;29(34):5038-5053

A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models.

Kim DY, Shin JY, Lee JE, Kim HN, Chung SJ, Yoo HS, Kim SJ, Cho HJ, Lee EJ, Nam SJ, Kim SH, Jang J, Lee SE, Lee PH
Proceedings of the National Academy of Sciences of the United States of America 2023 Sep 12;120(37):e2221929120

Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress.

Pham TNM, Perumal N, Manicam C, Basoglu M, Eimer S, Fuhrmann DC, Pietrzik CU, Clement AM, Körschgen H, Schepers J, Behl C
Redox biology 2023 Nov;67:102943

Seneca Valley Virus Degrades STING via PERK and ATF6-Mediated Reticulophagy.

Bai L, Zhang R, Zheng H, Zhang Z, Zhang Z, Li Y
Viruses 2023 Nov 3;15(11)

Combinatorial selective ER-phagy remodels the ER during neurogenesis.

Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, Harper JW
bioRxiv : the preprint server for biology 2023 Nov 10;

Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy.

Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, González A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L, Hoffmann ME, Katona I, Koch N, Weis J, Kurth I, Gleeson JG, Reggiori F, Hummer G, Kessels MM, Qualmann B, Mari M, Dikić I, Hübner CA
Nature 2023 Jun;618(7964):402-410

Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.

González A, Covarrubias-Pinto A, Bhaskara RM, Glogger M, Kuncha SK, Xavier A, Seemann E, Misra M, Hoffmann ME, Bräuning B, Balakrishnan A, Qualmann B, Dötsch V, Schulman BA, Kessels MM, Hübner CA, Heilemann M, Hummer G, Dikić I
Nature 2023 Jun;618(7964):394-401

Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.

Deng H, Chen W, Zhang B, Zhang Y, Han L, Zhang Q, Yao S, Wang H, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113793

Molecular characterization of wild-type and HSAN2B-linked FAM134B.

Kanamori A, Hinaga S, Hirata Y, Amaya F, Oh-Hashi K
Molecular biology reports 2023 Jul;50(7):6005-6017

Sensitive imaging of Endoplasmic reticulum (ER) autophagy with an acidity-reporting ER-Tracker.

Shi Y, Zou X, Zheng X, Wu Y, Han J, Han S
Autophagy 2023 Jul;19(7):2015-2025

Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication.

Williams JM, Chen YJ, Cho WJ, Tai AW, Tsai B
The Journal of cell biology 2023 Jul 3;222(7)

V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation.

Sun Y, Wang X, Yang X, Wang L, Ding J, Wang CC, Zhang H, Wang X
Developmental cell 2023 Dec 4;58(23):2761-2775.e5

TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins.

Hayashi Y, Takatori S, Warsame WY, Tomita T, Fujisawa T, Ichijo H
The EMBO journal 2023 Dec 1;42(23):e114272

Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication.

Tan X, Cai K, Li J, Yuan Z, Chen R, Xiao H, Xu C, Hu B, Qin Y, Ding B
Cell reports 2023 Apr 25;42(4):112286

CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy.

Ishii S, Chino H, Ode KL, Kurikawa Y, Ueda HR, Matsuura A, Mizushima N, Itakura E
Molecular biology of the cell 2023 Apr 1;34(4):ar29

Sec23a inhibits the self-renewal of melanoma cancer stem cells via inactivation of ER-phagy.

Sun Z, Liu D, Zeng B, Zhao Q, Li X, Chen H, Wang J, Rosie Xing H
Cell communication and signaling : CCS 2022 Mar 2;20(1):22

Family with sequence similarity 134 member B-mediated reticulophagy ameliorates hepatocyte apoptosis induced by dithiothreitol.

Guo YX, Han B, Yang T, Chen YS, Yang Y, Li JY, Yang Q, Xie RJ
World journal of gastroenterology 2022 Jun 21;28(23):2569-2581

The unfolded protein response transducer IRE1α promotes reticulophagy in podocytes.

Navarro-Betancourt JR, Papillon J, Guillemette J, Chung CF, Iwawaki T, Cybulsky AV
Biochimica et biophysica acta. Molecular basis of disease 2022 Jun 1;1868(6):166391

STING1 is essential for an RNA-virus triggered autophagy.

Zhang R, Qin X, Yang Y, Zhu X, Zhao S, Zhang Z, Su Q, Zhao Z, Yin X, Meng X, Zhang Z, Li Y
Autophagy 2022 Apr;18(4):816-828

RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway.

Luo R, Liang H, Zhang W, Li G, Zhao K, Hua W, Song Y, Yang C
Acta biochimica et biophysica Sinica 2022 Apr 25;54(4):524-536

FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells.

Luo R, Li S, Li G, Lu S, Zhang W, Liu H, Lei J, Ma L, Ke W, Liao Z, Wang B, Song Y, Wang K, Zhang Y, Yang C
Oxidative medicine and cellular longevity 2021;2021:3843145

ATF4 links ER stress with reticulophagy in glioblastoma cells.

Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, Meyer N, Stolz A, Fulda S, Reggiori F, Kögel D, van Wijk S
Autophagy 2021 Sep;17(9):2432-2448

Endoplasmic reticulum tubules limit the size of misfolded protein condensates.

Parashar S, Chidambaram R, Chen S, Liem CR, Griffis E, Lambert GG, Shaner NC, Wortham M, Hay JC, Ferro-Novick S
eLife 2021 Sep 1;10

Sunitinib treatment promotes metastasis of drug-resistant renal cell carcinoma via TFE3 signaling pathway.

Li L, Zhao S, Liu Z, Zhang N, Pang S, Liu J, Liu C, Fan Y
Cell death & disease 2021 Feb 26;12(2):220

Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy.

Stefely JA, Zhang Y, Freiberger EC, Kwiecien NW, Thomas HE, Davis AM, Lowry ND, Vincent CE, Shishkova E, Clark NA, Medvedovic M, Coon JJ, Pagliarini DJ, Mercer CA
Autophagy 2020 Dec;16(12):2219-2237

CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy.

Nthiga TM, Kumar Shrestha B, Sjøttem E, Bruun JA, Bowitz Larsen K, Bhujabal Z, Lamark T, Johansen T
The EMBO journal 2020 Aug 3;39(15):e103649

Intrinsically Disordered Protein TEX264 Mediates ER-phagy.

Chino H, Hatta T, Natsume T, Mizushima N
Molecular cell 2019 Jun 6;74(5):909-921.e6

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.

An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW
Molecular cell 2019 Jun 6;74(5):891-908.e10

Excessive ER-phagy mediated by the autophagy receptor FAM134B results in ER stress, the unfolded protein response, and cell death in HeLa cells.

Liao Y, Duan B, Zhang Y, Zhang X, Xia B
The Journal of biological chemistry 2019 Dec 27;294(52):20009-20023

Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.

Cunningham CN, Williams JM, Knupp J, Arunagiri A, Arvan P, Tsai B
Molecular cell 2019 Aug 8;75(3):442-456.e4

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD.

Schultz ML, Krus KL, Kaushik S, Dang D, Chopra R, Qi L, Shakkottai VG, Cuervo AM, Lieberman AP
Nature communications 2018 Sep 10;9(1):3671

Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B.

Lennemann NJ, Coyne CB
Autophagy 2017 Feb;13(2):322-332

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