SH3KBP1

This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

Description

SH3 domain containing kinase binding protein 1

Tissue specificity

Low tissue specificity

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (19533977 - 19887600)

Ensembl ID

ENSG00000147010  (ver. 103.38)

Orthologs

Mouse Sh3kbp1: ENSMUSG00000040990

UniProt

Q96B97

neXtProt

NX_Q96B97

Human splice variants
Mouse splice variants

Protein structure