14731-1-AP

antibody from Proteintech Group

Targeting: TMEM98 DKFZP564K1964

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

14731-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#14731-1-AP, RRID:AB_11182589

Product name

TMEM98 antibody

Antibody type

Polyclonal

Description

KD/KO validated TMEM98 antibody (Cat. #14731-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium leading to nanophthalmos.

Rozumek GM, Brinkmeier ML, Guan B, Wang SQ, Tower C, Yang NT, Lim RS, Kong D, Soden D, Zhang Q, Han JY, Miller JM, Dong L, Hannum DF, Moroi SE, Richards JE, Hufnagel RB, Prasov L
JCI insight 2026 Mar 23;11(6)

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FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system.

Collins HY, Doan RA, Li J, Early JE, Madden ME, Simkins T, Lyons DA, Monk KR, Emery B
Nature communications 2025 Aug 21;16(1):7822

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Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium.

Rozumek GM, Brinkmeier ML, Guan B, Wang SQ, Tower C, Yang NT, Lim R, Dong L, Hannum DF, Moroi SE, Richards JE, Hufnagel RB, Prasov L
bioRxiv : the preprint server for biology 2025 Apr 25;

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FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNS.

Collins HY, Doan RA, Li J, Early JE, Madden ME, Simkins T, Lyons DA, Monk KR, Emery B
bioRxiv : the preprint server for biology 2024 Oct 17;

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Clinical features of patients with mutations in genes for nanophthalmos.

Li X, Xiao H, Su Y, Xiao X, Li S, Lin S, Fang L, Sun W, Wang P, Hejtmancik JF, Yu M, Chen L, Zhang Q, Liu X
The British journal of ophthalmology 2024 Nov 22;108(12):1679-1687

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Tumor-Suppressor Gene Transmembrane Protein 98 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer.

Wu SG, Xu JY, Lei J, Hu M, Zhou J
Frontiers in bioscience (Landmark edition) 2022 Jun 30;27(7):210

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TMEM98 is a negative regulator of FRAT mediated Wnt/ß-catenin signalling.

van der Wal T, Lambooij JP, van Amerongen R
PloS one 2020;15(1):e0227435

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The microRNA miR-29c-5p inhibits cell proliferation and migration by targeting TMEM98 in head and neck carcinoma.

Li J, Chen W, Luo L, Liao L, Deng X, Wang Y
Aging 2020 Nov 26;13(1):769-781

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The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.

Cross SH, Mckie L, Hurd TW, Riley S, Wills J, Barnard AR, Young F, MacLaren RE, Jackson IJ
PLoS genetics 2020 Apr;16(4):e1008583

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Variants in myelin regulatory factor (MYRF) cause autosomal dominant and syndromic nanophthalmos in humans and retinal degeneration in mice.

Garnai SJ, Brinkmeier ML, Emery B, Aleman TS, Pyle LC, Veleva-Rotse B, Sisk RA, Rozsa FW, Ozel AB, Li JZ, Moroi SE, Archer SM, Lin CM, Sheskey S, Wiinikka-Buesser L, Eadie J, Urquhart JE, Black GCM, Othman MI, Boehnke M, Sullivan SA, Skuta GL, Pawar HS, Katz AE, Huryn LA, Hufnagel RB, Genomic Ascertainment Cohort, Camper SA, Richards JE, Prasov L
PLoS genetics 2019 May;15(5):e1008130

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Missense Mutations in the Human Nanophthalmos Gene TMEM98 Cause Retinal Defects in the Mouse.

Cross SH, Mckie L, Keighren M, West K, Thaung C, Davey T, Soares DC, Sanchez-Pulido L, Jackson IJ
Investigative ophthalmology & visual science 2019 Jul 1;60(8):2875-2887