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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Immunohistochemistry [1]
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- Product number
- AF429 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal GFR alpha-2/GDNF R alpha-2 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human and mouse GFR alpha-2/GDNF R alpha-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human GFR alpha-3 is observed.
- Reactivity
- Human, Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement.
Neurturin Gene Therapy Protects Parasympathetic Function to Prevent Irradiation-Induced Murine Salivary Gland Hypofunction.
Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo.
Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
Parasympathetic stimulation improves epithelial organ regeneration.
Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats.
Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo.
Neurotrophin and GDNF family ligands promote survival and alter excitotoxic vulnerability of neurons derived from murine embryonic stem cells.
Expression and function of GDNF family ligands and receptors in the carotid body.
GDNF family receptors in the embryonic and postnatal rat heart and reduced cholinergic innervation in mice hearts lacking ret or GFRalpha2.
Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM
EMBO molecular medicine 2018 Mar;10(3)
EMBO molecular medicine 2018 Mar;10(3)
Neurturin Gene Therapy Protects Parasympathetic Function to Prevent Irradiation-Induced Murine Salivary Gland Hypofunction.
Ferreira JNA, Zheng C, Lombaert IMA, Goldsmith CM, Cotrim AP, Symonds JM, Patel VN, Hoffman MP
Molecular therapy. Methods & clinical development 2018 Jun 15;9:172-180
Molecular therapy. Methods & clinical development 2018 Jun 15;9:172-180
Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo.
Kim S, Moon GJ, Oh YS, Park J, Shin WH, Jeong JY, Choi KS, Jin BK, Kholodilov N, Burke RE, Kim HJ, Ha CM, Lee SG, Kim SR
Experimental & molecular medicine 2018 Feb 9;50(2):e440
Experimental & molecular medicine 2018 Feb 9;50(2):e440
Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
Trevaskis JL, Sacramento CB, Jouihan H, Ali S, Le Lay J, Oldham S, Bhagroo N, Boland BB, Cann J, Chang Y, O'Day T, Howard V, Reers C, Winzell MS, Smith DM, Feigh M, Barkholt P, Schreiter K, Austen M, Andag U, Thompson S, Jermutus L, Coghlan MP, Grimsby J, Dohrmann C, Rhodes CJ, Rondinone CM, Sharma A
Diabetes 2017 Jul;66(7):2007-2018
Diabetes 2017 Jul;66(7):2007-2018
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
Usoskin D, Furlan A, Islam S, Abdo H, Lönnerberg P, Lou D, Hjerling-Leffler J, Haeggström J, Kharchenko O, Kharchenko PV, Linnarsson S, Ernfors P
Nature neuroscience 2015 Jan;18(1):145-53
Nature neuroscience 2015 Jan;18(1):145-53
Parasympathetic stimulation improves epithelial organ regeneration.
Knox SM, Lombaert IM, Haddox CL, Abrams SR, Cotrim A, Wilson AJ, Hoffman MP
Nature communications 2013;4:1494
Nature communications 2013;4:1494
Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats.
Kobayashi T, Ahlenius H, Thored P, Kobayashi R, Kokaia Z, Lindvall O
Stroke 2006 Sep;37(9):2361-7
Stroke 2006 Sep;37(9):2361-7
Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo.
Malin SA, Molliver DC, Koerber HR, Cornuet P, Frye R, Albers KM, Davis BM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Aug 16;26(33):8588-99
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Aug 16;26(33):8588-99
Neurotrophin and GDNF family ligands promote survival and alter excitotoxic vulnerability of neurons derived from murine embryonic stem cells.
Lee CS, Tee LY, Dusenbery S, Takata T, Golden JP, Pierchala BA, Gottlieb DI, Johnson EM Jr, Choi DW, Snider BJ
Experimental neurology 2005 Jan;191(1):65-76
Experimental neurology 2005 Jan;191(1):65-76
Expression and function of GDNF family ligands and receptors in the carotid body.
Leitner ML, Wang LH, Osborne PA, Golden JP, Milbrandt J, Johnson EM Jr
Experimental neurology 2005 Feb;191 Suppl 1:S68-79
Experimental neurology 2005 Feb;191 Suppl 1:S68-79
GDNF family receptors in the embryonic and postnatal rat heart and reduced cholinergic innervation in mice hearts lacking ret or GFRalpha2.
Hiltunen JO, Laurikainen A, Airaksinen MS, Saarma M
Developmental dynamics : an official publication of the American Association of Anatomists 2000 Sep;219(1):28-39
Developmental dynamics : an official publication of the American Association of Anatomists 2000 Sep;219(1):28-39
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- GFRa-2/GDNF Ra-2 in Mouse Dorsal Root Ganglion. GFRa-2/GDNF Ra-2 in Mouse Dorsal Root Ganglion.
