29441-1-AP

antibody from Proteintech Group

Targeting: YTHDC1 KIAA1966, YT521, YT521-B

Provider product page for 29441-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [21]
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Product number: 29441-1-AP - Provider product page
Provider: Proteintech Group
Product name: YTHDC1 antibody
Antibody type: Polyclonal
Description: YTHDC1 antibody (Cat. #29441-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

YTHDC1 protein structure - 29441-1-AP shown in red.

Submitted references A machine learning-based epigenetic signature reveals YTHDC1 stabilizes POU5F1 to oppose tumor progression.

Fang C, Dai J, Weng Z, Zhang L, Xing Y, Liu D, Wu H, Li X, Liu Q, Su G
Journal of translational medicine 2026 Mar 20;24(1)

Silencing of Zc3h13 attenuates LPS-induced inflammatory response in macrophages via m6A-dependent stabilization of Spic mRNA.

Wang Y, Zhan C, Zhang Y, Li X, Mei L, Yang B, Shao M, Shao W
Journal of immunology (Baltimore, Md. : 1950) 2026 Mar 17;215(3)

m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.

Yin L, Zhang Y, Zhang B, Zhang J, Xiong M, Jiang N, Xiao J, Gao H, Xiong W, Wang X, Wang F, Yuan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e06600

Xist Repeat A coordinates an assembly of SR proteins to recruit SPEN and induce gene silencing.

Trotman JB, Porrello A, Schactler SA, DeLeon LE, Eberhard QE, Boyson SP, Zhang Z, Lee DM, Kirik SE, Sultana N, Nguyen SN, Beltejar MG, Shinn MK, Ong SE, Gonzalez-Perez MP, Shaffer SA, Dominguez D, Shechner DM, Calabrese JM
bioRxiv : the preprint server for biology 2025 May 26;

RNA m(6)A dynamics promote transcription and RNA stability of bivalent genes during iPSC-induced generation of human lung progenitors.

Dong S, Pang J, Wang Y, Han L, Zhou X, Huang F, Zhang S, Ma N, Huang H, Weng H
Cell reports 2025 Jun 24;44(6):115802

M6A-dependent RNA condensation underlies FUS autoregulation and can be harnessed for ALS therapy development.

Huang WP, Kumar V, Yap K, An H, John SJ, Hodgson RE, Avila AS, Day E, Ellis BCS, Chung TH, Lord J, Müller-McNicoll M, Makeyev EV, Shelkovnikova TA
Science advances 2025 Jul 25;11(30):eadx1357

Loss of YTHDC1 m(6)A reading function promotes invasiveness in urothelial carcinoma of the bladder.

Xu J, Koch J, Schmidt C, Nientiedt M, Neuberger M, Erben P, Michel MS, Rodríguez-Paredes M, Lyko F
Experimental & molecular medicine 2025 Feb;57(1):118-130

High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy.

Xing Z, Yang T, Li X, Xu H, Hong Y, Shao S, Li T, Ye L, Li Y, Jin X, Wei Y
Cell reports 2025 Apr 22;44(4):115545

KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m(6)A reader YTHDC1 protein degradation.

Yang Y, Zhang Y, Chen G, Sun B, Luo F, Gao Y, Feng H, Li Y
Journal of experimental & clinical cancer research : CR 2024 May 14;43(1):141

Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner.

Wu Y, Chen Y, Yan X, Dai X, Liao Y, Yuan J, Wang L, Liu D, Niu D, Sun L, Chen L, Zhang Y, Xiang L, Chen A, Li S, Xiang W, Ni Z, Chen M, He F, Yang M, Lian J
Autophagy 2024 Jul;20(7):1651-1672

Deciphering m6A dynamics at a single-base level during planarian anterior-posterior axis specification.

Chen L, Zhen H, Chen Z, Huang M, Mak DW, Jin W, Zou Y, Chen M, Zheng M, Xie Q, Zhou Z, Jin G
Computational and structural biotechnology journal 2023;21:4567-4579

The m6A reader YTHDC1-mediated lncRNA CTBP1-AS2 m6A modification accelerates cholangiocarcinoma progression.

Jin Z, Liu Y
Heliyon 2023 Sep;9(9):e19816

The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.

Yan B, Li X, Peng M, Zuo Y, Wang Y, Liu P, Ren W, Jin X
Experimental & molecular medicine 2023 Jun;55(6):1145-1158

Decoding m(6)A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance.

Cheng Y, Gao Z, Zhang T, Wang Y, Xie X, Han G, Li Y, Yin R, Chen Y, Wang P, Hu J, Zhang T, Guo C, Chai J, Wang J, Cui M, Gao K, Liu W, Yao S, Lu P, Cao Z, Zheng Y, Chang J, Liu Z, Song Q, Li W, Zhou F, Zhang H
Cell stem cell 2023 Jan 5;30(1):69-85.e7

METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy.

Pan Y, Chen H, Zhang X, Liu W, Ding Y, Huang D, Zhai J, Wei W, Wen J, Chen D, Zhou Y, Liang C, Wong N, Man K, Cheung AH, Wong CC, Yu J
Cell reports. Medicine 2023 Aug 15;4(8):101144

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554

Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019

RNA m(6)A Alterations Induced by Biomineralization Nanoparticles: A Proof-of-Concept Study of Epitranscriptomics for Nanotoxicity Evaluation.

Pan J, Wang J, Fang K, Hou W, Li B, Zhao J, Ma X
Nanoscale research letters 2022 Feb 5;17(1):23

YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway.

Li W, Ye K, Li X, Liu X, Peng M, Chen F, Xiong W, Wang Y, Zhu L
Journal of experimental & clinical cancer research : CR 2022 Aug 17;41(1):250

YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.

Zhu X, Yang H, Zhang M, Wu X, Jiang L, Liu X, Lv K
Cancer cell international 2021 Dec 4;21(1):645

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