19983-1-AP

antibody from Proteintech Group

Targeting: PRKDC DNA-PKC, DNA-PKcs, DNAPK, DNAPKc, DNPK1, HYRC, HYRC1, p350, p460, XRCC7

Provider product page for 19983-1-AP

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ELISA

Antibody data

Antibody Data
Antigen structure
References [30]
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Validations
Western blot [1]

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Product number: 19983-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19983-1-AP, RRID:AB_10642811
Product name: DNA-PKcs antibody
Antibody type: Polyclonal
Description: DNA-PKcs antibody (Cat. #19983-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PRKDC protein structure - 19983-1-AP shown in red.

Submitted references BMP9 potentiates immunotherapy in triple-negative breast cancer by suppressing Tregs infiltration via the PRKDC-CCL2 axis.

You Y, Wei L, Dai M, Zhao G, Fan K, Dang T, Sun H, Zhang L, Li Q, Sun M, Li X, He X, Yang S, Zeng T, Tang J, Zhang Y
Cancer letters 2026 Feb 28;639:218175

RHBDD1 induces cell cycle arrest in TP53-mutant NSCLC cells by promoting endoplasmic reticulum-associated degradation of p53 and DNA-PKcs.

Chen Y, Wang Y, Shen S, Zhang L, Liu J, Yan X, Peng H, Xu Z
European journal of medical research 2025 Sep 26;30(1):859

CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair.

Li Y, Cui L, Wang S, Zhao Q, Du F, Du S, Yu C, Xia M, Zhao S, Luan T, Liu Y, Cui B
Cell death & disease 2025 Nov 17;16(1):833

Guiqi Baizhu decoction enhances radiosensitivity in non-small cell lung cancer by inhibiting the HIF-1α/DNA-PKcs axis-mediated DNA repair.

Li Y, Yang G, Li Q, Zhang Y, Zhang S, Zhou T, Wang X, Liu F, Miao Z, Qi Y, Zhang L, Liu Y, Su H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156591

Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade.

Lin Y, Zhang J, Gao X, Wu Z, Yang L, Tian K, Lv X, Li J, Chen K, Zhang Y, Hu H, Zhu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156586

Combined Ribociclib and NU7026 administration enhances radio-sensitivity by inhibiting DNA repair in prostate cancer.

Sun J, Wang Y, Ma S, Zhang W, Yang L, Zhang B, Tang Q
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7075-7085

Moesin silencing enhances the radiosensitivity of glioblastoma by inhibiting DNA damage repair via CD44/AKT1 signaling pathway.

Ding X, Wang Y, Shao Z, Wen X, Wang B, Liu G, Xu C, Chai L, Qiu H, Zhang L
Discover oncology 2025 Jul 31;16(1):1451

Integrated proteogenomic characterization of ampullary adenocarcinoma.

Zhang Q, Xu X, Jiang D, Wang Y, Wang H, Zhu J, Tang S, Wang R, Zhao S, Li K, Feng J, Xiang H, Yao Z, Xu N, Fang R, Guo W, Liu Y, Hou Y, Ding C
Cell discovery 2025 Jan 7;11(1):2

L-arginine synergistic with 5-fluorouracil intervenes in DNA damage repair via the DNA-PKcs/ATM/ATR pathway in hepatocellular carcinoma cells.

Wang H, Xie H, Lin Y, Zhang Z, Zhang M, Zhao J, Zhao Q, Liu L
Acta biochimica et biophysica Sinica 2025 Aug 22;58(3):621-637

Dual role of p21 in regulating apoptosis and mitotic integrity in response to doxorubicin in colon cancer cells.

Kim H, Kim H, Jang E, Eom YW, Yoon G, Choi KS, Kim E
Cell death discovery 2025 Apr 2;11(1):133

A multifunctional targeted nano-delivery system with radiosensitization and immune activation in glioblastoma.

Wen X, Shao Z, Chen X, Liu H, Qiu H, Ding X, Qu D, Wang H, Wang AZ, Zhang L
Radiation oncology (London, England) 2024 Sep 12;19(1):119

Targeting PRKDC activates the efficacy of antitumor immunity while sensitizing to chemotherapy and targeted therapy in liver hepatocellular carcinoma.

Pan Y, Zhu Q, Hong T, Cheng J, Tang X
Aging 2024 May 22;16(10):9047-9071

CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway.

Lyu F, Huang S, Yan Z, He Q, Liu C, Cheng L, Cong Y, Chen K, Song Y, Xing Y
Cellular signalling 2024 Jul;119:111164

HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling.

Qiu H, Shao Z, Wen X, Qu D, Liu Z, Chen Z, Zhang X, Ding X, Zhang L
Journal of translational medicine 2024 Jul 29;22(1):688

CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.

Zhang T, Liu MQ, Xie GS, Wu DM, Luo PW, Liu T, Deng SH, Wang YY, He S, Zhou Y, Zhou J, Xu Y
Journal of Cancer 2023;14(8):1350-1361

Role of ionizing radiation activated NRF2 in lung cancer radioresistance.

Xu Q, Zhang P, Han X, Ren H, Yu W, Hao W, Luo B, Khan MI, Chen N
International journal of biological macromolecules 2023 Jun 30;241:124476

Antitumor efficacy of a recombinant EGFR-targeted fusion protein conjugate that induces telomere shortening and telomerase downregulation.

Tao HY, He SM, Zhao CY, Wang Y, Sheng WJ, Zhen YS
International journal of biological macromolecules 2023 Jan 31;226:1088-1099

PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma.

Zhao M, Li Y, Lu C, Ding F, Xu M, Ge X, Li M, Wang Z, Yin J, Zhang J, Wang X, Ge Z, Xiao H, Xiao Y, Liu H, Liu W, Cao Y, Wang Q, You Y, Wang X, Yang K, Shi Z, Qian X
Cancer research 2023 Apr 4;83(7):1094-1110

ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer.

Zhou C, Li S, Bin K, Qin G, Pan P, Ren D, Zhao Y, Xia W, Chen J, Liu J, Wu H, Zhou Y
Cancer letters 2022 Oct 28;547:215855

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.

Wang W, Li J, Tan J, Wang M, Yang J, Zhang ZM, Li C, Basnakian AG, Tang HW, Perrimon N, Zhou Q
Nature communications 2021 Jan 20;12(1):476

DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair.

Ma S, Rong Z, Liu C, Qin X, Zhang X, Chen Q
The Journal of cell biology 2021 Feb 1;220(2)

Long noncoding RNA lnc-RI regulates DNA damage repair and radiation sensitivity of CRC cells through NHEJ pathway.

Liu R, Zhang Q, Shen L, Chen S, He J, Wang D, Wang Q, Qi Z, Zhou M, Wang Z
Cell biology and toxicology 2020 Oct;36(5):493-507

HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response.

Guo Z, Wang S, Xie Y, Han Y, Hu S, Guan H, Xie D, Bai C, Liu X, Gu Y, Zhou PK, Ma T
Cell death & disease 2020 May 26;11(5):400

Targeting Ku86 enhances X-ray-induced radiotherapy sensitivity in serous ovarian cancer cells.

Ma Q, Kai J, Liu Y, Tong Y, Xie S, Zheng H, Wang Y, Guo L, Lu R
The international journal of biochemistry & cell biology 2020 Apr;121:105705

Stem cells from human exfoliated deciduous teeth ameliorate type II diabetic mellitus in Goto-Kakizaki rats.

Rao N, Wang X, Zhai Y, Li J, Xie J, Zhao Y, Ge L
Diabetology & metabolic syndrome 2019;11:22

Flavone protects HBE cells from DNA double-strand breaks caused by PM2.5.

Ren X, Tang Y, Sun J, Feng J, Chen L, Chen H, Zeng S, Chen C, Li X, Zhu H, Zeng Z
Human cell 2018 Apr;31(2):116-126

Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages.

Qi H, Jiang Z, Wang C, Yang Y, Li L, He H, Yu Z
Oncotarget 2017 Apr 25;8(17):29300-29317

Interaction of cellular proteins with BCL-xL targeted to cytoplasmic inclusion bodies in adenovirus infected cells.

Subramanian T, Vijayalingam S, Kuppuswamy M, Chinnadurai G
Virology 2015 Sep;483:21-31

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Dong H, Shi Q, Song X, Fu J, Hu L, Xu D, Su C, Xia X, Song E, Song Y
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6

IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV.

Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC
Science (New York, N.Y.) 2014 Jan 24;343(6169):428-32

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The DNA-PKcs antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human DNA-PKcs. This antibody recognizes human, mouse antigen. The DNA-PKcs antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 19983-1-AP.pdf

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