PDILT

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has has an N-terminal ER-signal sequence, two thioredoxin (TRX) domains with non-classical Ser-Lys-Gln-Ser and Ser-Lys-Lys-Cys motifs, respectively, two TRX-like domains, and a C-terminal ER-retention sequence. The protein lacks oxidoreductase activity in vitro and probably functions as a chaperone. This gene's expression appears to be limited to the testis. [provided by RefSeq, Dec 2016]

Description

Protein disulfide isomerase like, testis expressed

Tissue specificity

Tissue enriched (stomach)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

16 (20359175 - 20404737)

Ensembl ID

ENSG00000169340  (ver. 103.38)

Orthologs

Mouse Pdilt: ENSMUSG00000030968

UniProt

Q8N807

neXtProt

NX_Q8N807

Human splice variants
Mouse splice variants

Protein structure