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- Product number
- 15073-1-AP - Provider product page
- Provider
- Proteintech Group
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- Proteintech Cat#15073-1-AP, RRID:AB_2142033
- Product name
- METTL3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated METTL3 antibody (Cat. #15073-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, Mouse, Rat, Monkey and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Machine Learning and Experimental Validation of m6A RNA Methylation Related Signatures for Risk Prediction, Diagnostic Biomarkers, and Immune Subtypes in Chronic Kidney Disease.
Identification of m1A/m6A/m5C/m7G-related genes and clusters associated with neuropathic pain.
METTL3 mediates m(6)A methylation of ADAM17 to Downregulate ACE2-Ang-(1-7) axis and promote progression of hypertension.
METTL3 mitigates angiotensin II-induced renal hypertensive injury by regulating fatty acid oxidation.
Domain associated with zinc fingers-containing NF90-NF45 complex inhibits m(6)A modification of primary microRNA by suppressing METTL3/14 activity.
The mechanism by which methylase METTL3 affects intramuscular fat deposition.
CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression.
METTL3-based epitranscriptomic editing screening identifies functional m(6)A sites in cancers.
N(6)-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93.
YTHDF3-TRIM2-P53 axis promotes malignant progression in uveal melanoma (UVM).
MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids.
Polystyrene Nanoplastics induced placental toxicology by activating Keap1-mediated ferroptosis via METTL3-dependent m6A methylation.
Elevated m(6)A RNA modifications associate with immune dysregulation and cancer in people with HIV-1.
A machine learning-based epigenetic signature reveals YTHDC1 stabilizes POU5F1 to oppose tumor progression.
Integrative Multi-Analysis Identifies METTL3-Regulated FGF19 and H6PD as Candidate Targets in Diabetic Cognitive Impairment.
METTL3 stabilizes FASN mRNA by mediating m(6)A modification to promote malignant progression of diffuse large B-cell lymphoma.
The m(6)A modification mediates the imbalance of mitochondrial homeostasis and apoptosis induced by Benzo[b]fluoranthene in mouse spermatocytes: mitophagy versus mitochondrial damage.
N(6)-methyladenosine modification of MRP7 mRNA modulates its expression and paclitaxel sensitivity in lung cancer-derived A549 cells.
m(6)A modification in the 3'‑leader region of EBOV genome antagonizes ISG20 to facilitate viral replication.
Astrocytic Mettl14 depletion enhances cognitive function by attenuating astrogliosis via the DUSP1/MAPK pathway in APP/PS1 mice: targeting neuroinflammation in Alzheimer's disease.
Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival.
Xinfeng Capsule ameliorates RA joint injury by inhibiting cuproptosis via the METTL3/miR-221/222-3p/ATP7A Axis.
METTL3-mediated m6A modification of FDX1 confers resistance to cuproptosis and promotes hepatocellular carcinoma progression.
Sequence-dependent splicing dysregulation drives therapy resistance in pediatric AML.
Wilms' tumor 1-associating protein regulates the stress fiber reservoirs in endothelial cells via KLF2-IQGAP3.
Mettl3-Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS.
N6-methyladenosine (m(6)A) modification of TXNIP in 3'UTR instigates abdominal aorta aneurysm in mice.
m6A methylation-modified ETV1 drives multiple myeloma progression and M2 polarization of tumor-associated macrophage through transcriptional activation of RBMS1.
METTL14-dependent m(6)A modification restrains interferon signaling to prevent myocarditis and dilated Cardiomyopathy.
Cherry plum powder alleviates excessive proliferation and inflammation of keratinocytes in psoriasis by reducing N6 methyladenosine-modified S100A4.
Regulation of PSAT1 and PHGDH by m6A in endocrine-resistant breast cancer cells.
m6A Modification of ATOX1 Inhibits Acute Myeloid Leukemia Progression by Promoting Cuproptosis.
Manipulation therapy alleviates neuropathic pain via the SOCS1 m(6)A epigenetic loop.
METTL3-Mediated m6A Modification Enhances the Function of Adipose-Derived Stem Cells Under Hypoxic Conditions Thereby Improving Fat Graft Retention.
METTL3/miR-192-5p/SCD1 Axis Regulates Lipid Metabolism to Affect T Cell Differentiation in Asthma.
METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2.
Notch-Driven Cholangiocarcinogenesis Involves the Hippo Pathway Effector TAZ via METTL3-m6A-YTHDF1.
Atorvastatin Alleviates Sepsis-Induced Cardiomyopathy by Targeting the METTL3/IGF2BP1/CXCL2 Pathway.
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Deciphering single-cell landscape unravels cell-type-specific functional roles of RNA m(6)A modification in atherosclerosis.
EIF3B‑METTL3 complex promotes cell proliferation, invasion and EGFR/AKT signaling in cervical cancer.
Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet.
METTL3 Mediates Wnt/β-Catenin Pathway in Epithelial-Mesenchymal Transition of 16HBE Cells Induced by Beryllium Sulphate.
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
The m6A transferase METTL3 regulates high glucose-induced proliferation and apoptosis of human lens epithelial cells through the lncRNA TUG1/KHSRP/p38MAPK signaling axis.
Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism.
ADAP-METTL3 modulates the inflammatory responses of macrophages via m(6)A modification of Spry1.
Mechanisms of gypenosides in type 2 diabetes mellitus via regulation of m6A methylase METTL3/14 and demethylase FTO.
IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation.
METTL3-mediated modification of SIRT1 m6A methylation protects osteoblasts from TBHP-induced senescence and promotes osteoblast proliferation.
Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation.
PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m6A Methylation to Stabilize PARP1 mRNA.
SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m6A Modification.
Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.
Molecular mechanism of modified Yigong San formula against colorectal cancer via EZH2/METTL3/SOX4 pathway-mediated apoptosis.
METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.
METTL3/IGF2BP2 stabilizes IQGAP3 via m6A modification to drive HCC metastasis through TGF-β/Smad signaling and EMT.
METTL3 modulates bone Cancer pain via m(6)A-dependent JAK2/STAT3 activation in spinal astrocytes.
Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.
Effect of berberine on LPS-induced intestinal epithelial injury and m(6)A methylation in broilers.
Single-base m(6)A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4(+) T cells.
IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation.
The role of METTL3 in transposable elements regulation and 2C-like program induction in mouse embryonic stem cell.
Mechanism of the traditional Chinese medicine SMBJ alleviates diabetes mellitus-induced Leydig cell dysfunction in rats testes.
Global mapping of RNA N(6)-methyladenosine (m(6)A) in human subcutaneous and visceral adipose tissue reveals novel targets that correlate with clinical variables of obesity.
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
The Impact of METTL3 on MDM2 Promotes Podocytes Injury During Diabetic Kidney Disease.
STM2457 decreases m6A methylation to reduce cisplatin-induced ototoxicity via MAPK signaling.
METTL3 regulates ASMCs proliferation and M2 macrophage polarization via mediating the m6A methylation of TIMMDC1 in asthma.
β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor.
Heat stress enhances the expression of METTL3 to mediate N6-methyladenosine modification of SOS2 and NLRP3 inflammasome activation in boar Sertoli cells.
Betaine Alleviates Bisphosphonate-Related Osteonecrosis of the Jaw by Rescuing BMSCs Function in an m6A-METTL3-Dependent Manner.
Increased METTL3 Expression and m6A Methylation in Myoblasts of Facioscapulohumeral Muscular Dystrophy.
Metabolite-dependent m(6)A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration.
METTL3 inhibits primed-to-naïve transition of pluripotent stem cells through m(6)A-YTHDF2-pluripotency/Gstp1 mRNA degradation axis.
Phase transition of WTAP regulates m(6)A modification of interferon-stimulated genes.
METTL3-Driven m6A Modification of Cpt1a Gene in High Fat Diet Related Liver Cancer Tumor Macrophages Facilitates Type II Macrophage Differentiation.
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery.
METTL3 promotes osteogenesis by regulating N6-methyladenosine-dependent primary processing of hsa-miR-4526.
Subcellular level spatial transcriptomics with PHOTON.
Selective RNA sequestration in biomolecular condensates directs cell fate transitions.
SNORD9 promotes ovarian cancer tumorigenesis via METTL3/IGF2BP2-mediated NFYA m6A modification and is a potential target for antisense oligonucleotide therapy.
METTL3-Mediated m6A Methylation Stabilizes IFI27 to Drive Esophageal Squamous Cell Carcinoma Progression Through an IGF2BP2-Dependent Mechanism.
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway.
The m6A modification regulates the composition of myofiber types in chicken skeletal muscle.
Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML.
SRSF3 and hnRNP A1-mediated m6A-modified circCDK14 regulates intramuscular fat deposition by acting as miR-4492-z sponge.
Electroacupuncture regulates FTO/Nrf2/NLRP3 axis-mediated pyroptosis in cerebral ischemia-reperfusion injury.
Global analysis by LC-MS/MS of N6-methyladenosine and inosine in mRNA reveal complex incidence.
METTL3 mediates CPB1 expression by regulating transcription factor BACH2 to promote apoptosis and oxidative stress of lens epithelial cells.
Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment.
Targeting m(6)A demethylase FTO to heal diabetic wounds with ROS-scavenging nanocolloidal hydrogels.
The impact of YTHDF2-mediated NCOA4 methylation on myocardial ferroptosis.
METTL3-mediated N6-methyladenosine modification contributes to vascular calcification.
The IGF2BP2-circ-DAPK1 axis promotes high-glucose-induced ferroptosis of HUVECs by decreasing NQO1 expression.
Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence.
A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1.
Mitigation of Ferroptosis in Diabetic Kidney Disease Through Mesenchymal Stem Cell Intervention via the Smad2/3/METTL3/S1PR1 Axis.
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.
Reciprocal METTL3-PAX5 regulation in maintaining B-cell identity and promoting B-cell hyperreactivity in SLE.
O-GlcNAcylation with ubiquitination stabilizes METTL3 to promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer.
METTL3 facilitates osteoblast differentiation and bone regeneration via m6A-dependent maturation of pri-miR-324-5p.
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
A novel mechanism in driving non-small cell lung cancer progression: The METTL3/FOXA1/PTK2 cascade.
METTL3-mediated m (6)A modification facilitates Nectin-4-induced VNN1 upregulation and promotion of ESCC progression.
The m6A hypermethylation-induced PIR overexpression regulates H3K4me3 and promotes tumorigenesis of uveal melanoma.
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
METTL3 Inhibition Restores PD-L1 Expression and CD8+ T-cell Cytotoxic Function in Immunotherapy-Treated Gastric Cancer.
ALKBH5-mediated NPC2 mRNA m(6)A demethylation promotes resistance to oxaliplatin in colorectal cancer.
AlkB Homolog 5 Regulates Hexokinase 2-Mediated Glycolysis and Participates in the Progression of Endometriosis.
m(6)A alters ribosome dynamics to initiate mRNA degradation.
ALKBH5 regulates intrauterine adhesion progression through m6A dependent FABP4 mRNA stabilization and serum lipid metabolism.
N6-methyladenosine-modified circQKI inhibits prostate cancer docetaxel-sensitivity via miR-188-3p/Beclin-1 pathway.
METTL3 regulates Ambra1 expression in an m6A-YTHDF2-dependent manner to promote mantle cell lymphoma progression.
METTL3-Dependent YTHDF2 Mediates TSC1 Expression to Regulate Alveolar Epithelial Mesenchymal Transition and Promote Idiopathic Pulmonary Fibrosis.
Lipoxin A4 suppresses neutrophil extracellular traps formation through the FPR2-dependent regulation of METTL3 in ischemic stroke.
POU4F1 enhances lung cancer gemcitabine resistance by regulating METTL3-dependent TWF1 mRNA N6 adenosine methylation.
N6-methyladenosine-modified circRPS6KC1 regulated cellular senescence in prostate cancer via FOXM1/PCNA axis.
N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.
METTL3 stabilizes SERPINE2 via the m6A modification to drive the malignant progression of gastric signet ring cell carcinoma.
IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression.
YTH N(6)-methyladenosine RNA Binding Protein 1 Inhibits Smooth Muscle Cell Phenotypic Modulation and Neointimal Hyperplasia.
The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.
Single-base m(6)A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4(+) T cells.
ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization.
N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatocellular carcinoma.
N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.
Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis.
Organophosphate flame retardant triphenyl phosphate (TPhP) induced colonic fibrosis by bringing about epithelial-mesenchymal transition.
The mRNA Stability of PIEZO1, Regulated by Methyltransferase-Like 3 via N(6)-Methylation of Adenosine Modification in a YT521-B Homology Domain Family 2-Dependent Manner, Facilitates the Progression of Diabetic Retinopathy.
N(6)-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.
Mettl3-Mediated N6-Methyladenosine Modification Mitigates Ganglion Cell Loss and Retinal Dysfunction in Retinal Ischemia-Reperfusion Injury by Inhibiting FoxO1-Mediated Autophagy.
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
The YTHDC1 reader protein recognizes and regulates the lncRNA MEG3 following its METTL3-mediated m(6)A methylation: a novel mechanism early during radiation-induced liver injury.
Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation.
Hic-5 deficiency attenuates MAFLD by inhibiting neutrophils migration via the CXCL1-CXCR2 axis.
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
METTL3 promotes podocyte pyroptosis in diabetic nephropathy through N(6)-methyladenosine modification of TRIM29 mRNA.
Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC).
Novel role of FTO in regulation of gut-brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure.
SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication.
METTL3-mediated m(6)A modification regulates OSCC progression via the HNRNPA2B1/FOXQ1 axis.
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
IGF2BP3-STAT3-METTL3 axis promotes malignant progression in hepatocellular carcinoma (HCC).
USP25 deubiquitinates cytosolic METTL3 to impede glioma proliferation via an m6A-independent pathway.
Cistanche tubulosa improves peripheral neuropathy in MPTP-induced PD mice based on regulation of m6A methylation.
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Identification of the Pro-Tumorigenic Role of the ELK4-METTL3-CEMIP Axis in Colorectal Carcinoma: Promotion of Cancer Cell Stemness and Malignant Phenotypes.
Transcriptome-wide regulation of folate on neural mRNA m(6)A methylome via carbon metabolism in Drosophila and mammals.
METTL3 and METTL14 drive pancreatic adenocarcinoma progression via m6A-dependent alternative splicing in PANC-1 cells.
GPCPD1 is regulated by METTL3/IGF2BP3 dependent m(6)A modification to affect pig muscle fiber type conversion.
METTL3 promotes peritoneal metastasis of colorectal cancer through regulating m6A modification of NRXN3 mRNA.
hUC-MSC-derived extracellular vesicles protect lung tissue from cigarette smoke-induced injury by upregulating the METTL3-mediated m(6)A modification.
Melatonin via MTNR1B regulates METTL3 to protect ileum cell differentiation.
An epitranscriptomic program maintains skeletal stem cell quiescence via a METTL3-FEM1B-GLI1 axis.
Mechanistic study of METTL3 inducing ferroptosis to promote cervical cancer progression through mediating m6A modification of COTE-1.
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.
Spatial control of m(6)A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin.
IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression.
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms.
METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation.
METTL3 Promotes Cutaneous T-Cell Lymphoma Progression by Regulating ARHGEF12 Expression.
METTL3 Plays Regulatory Roles in Acute Pneumonia during Staphylococcus aureus Infection.
YTHDF3 drives tumor growth and metastasis by recruiting eIF4B to promote Notch2 translation in breast cancer.
AP001885.4 promotes the proliferation of esophageal squamous cell carcinoma cells by histone lactylation- and NF-κB (p65)-dependent transcription activation and METTL3-mediated mRNA stability of c-myc.
Evidence for the potential role of m6A modification in regulating autophagy in models of amyotrophic lateral sclerosis.
The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation.
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
m(6)A modification enhances the stability of CDC25A promotes tumorigenicity of esophagogastric junction adenocarcinoma via cell cycle.
METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients.
METTL3 Inhibition Suppresses Cell Growth and Survival in Colorectal Cancer via ASNS Downregulation.
Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolism.
N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.
Changes of m(6)A Regulatory Proteins and Nrf2 Signaling Molecules in Liver Tissue of Type 2 Diabetes Mellitus Rats.
Dexmedetomidine improves mitophagy and pyroptosis through the ALKBH5/FUNDC1 axis during epidural-related maternal fever.
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
LONP1 alleviates ageing-related renal fibrosis by maintaining mitochondrial homeostasis.
H3K36 methyltransferase SMYD2 affects cell proliferation and migration in Hirschsprung's disease by regulating METTL3.
METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
One-carbon metabolism supports S-adenosylmethionine and m6A methylation to control the osteogenesis of bone marrow stem cells and bone formation.
METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma.
Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2.
BUB1 potentiates gastric cancer proliferation and metastasis by activating TRAF6/NF-κB/FGF18 through m6A modification.
N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication.
PCAF-mediated acetylation of METTL3 impairs mRNA translation efficiency in response to oxidative stress.
Methyltransferase-Like 3-Mediated N6-Methyladenosine RNA Methylation Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Pyroptosis by Targeting PTEN.
Nuclear retention coupled with sequential polyadenylation dictates post-transcriptional m(6)A modification in the nucleus.
Coxsackievirus B3-Induced m(6)A Modification of RNA Enhances Viral Replication via Suppression of YTHDF-Mediated Stress Granule Formation.
Nr-CWS regulates METTL3-mediated m(6)A modification of CDS2 mRNA in vascular endothelial cells and has prognostic significance.
Single-cell sequencing reveals that specnuezhenide protects against osteoporosis via activation of METTL3 in LEPR(+) BMSCs.
ZNF740 facilitates the malignant progression of hepatocellular carcinoma via the METTL3/HIF‑1A signaling axis.
TGF-β Promotes Hepatocellular Carcinoma Metastasis Through Through m6A Modification of PCDHGA9.
N(6)-methyladenosine modification of SLC38A7 promotes cell migration, invasion, oxidative phosphorylation, and mitochondrial function in gastric cancer.
N6-methyladenosine RNA methylation modification regulates the transcription of viral-derived E (XSR) miRNAs to promote ALV-J replication.
Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy.
METTL3 -mediated m6A modification of circ_0000620 regulates cisplatin sensitivity and apoptosis in lung adenocarcinoma via the MiR-216b-5p/KRAS axis.
m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells.
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2.
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Distinct pathways utilized by METTL3 to regulate antiviral innate immune response.
Epitranscriptomic m(6)A modifications during reactivation of HIV-1 latency in CD4(+) T cells.
Negative Regulation of LINC01013 by METTL3 and YTHDF2 Enhances the Osteogenic Differentiation of Senescent Pre-Osteoblast Cells Induced by Hydrogen Peroxide.
20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3.
Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.
IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis.
Micropeptide AF127577.4-ORF hidden in a lncRNA diminishes glioblastoma cell proliferation via the modulation of ERK2/METTL3 interaction.
KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m(6)A reader YTHDC1 protein degradation.
Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis.
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Dynamics of N6-methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc.
Cell type-specific regulation of m(6) A modified RNAs in the aging Drosophila brain.
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN.
IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development.
N(6)-methyladenosine-modified VGLL1 promotes ovarian cancer metastasis through high-mobility group AT-hook 1/Wnt/β-catenin signaling.
Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.
METTL3-mediated pre-miR-665/DLX3 m(6)A methylation facilitates the committed differentiation of stem cells from apical papilla.
I-FABP protein/mRNA and IL-6 as biomarkers of intestinal barrier dysfunction in neonates with necrotizing enterocolitis and SPF BALB/c mouse models.
METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer.
Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation.
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions.
Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.
Influence of METTL3 knockdown on PDLSC osteogenesis in E. coli LPS-induced inflammation.
LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53-driven tumour progression through miR-5683/FGF2.
Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m(6)A Epitranscriptome via Bile Acid Metabolism.
SUMOylation modification of FTO facilitates oxidative damage response of arsenic by IGF2BP3 in an m6A-dependent manner.
Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway.
N6-Methyladenosine enhances the translation of ENO1 to promote the progression of bladder cancer by inhibiting PCNA ubiquitination.
Characterization of m6A Modifiers and RNA Modifications in Uterine Fibroids.
METTL3 and METTL14 regulate IL-6 expression via RNA m6A modification of zinc transporter SLC39A9 and DNA methylation of IL-6 in periodontal ligament cells.
m6A-modified RIPK4 facilitates proliferation and cisplatin resistance in epithelial ovarian cancer.
Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.
METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes.
Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis.
METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis.
Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma.
METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner.
FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.
Targeted m(6)A demethylation of ITGA6 mRNA by a multisite dCasRx-m(6)A editor inhibits bladder cancer development.
METTL3 promotes microglial inflammation via MEF2C in spinal cord injury.
RNA m(6) A Methylation Suppresses Insect Juvenile Hormone Degradation to Minimize Fitness Costs in Response to A Pathogenic Attack.
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
N(6)-methyladenosine modification of the mRNA for a key gene in purine nucleotide metabolism regulates virus proliferation in an insect vector.
Putrescine promotes MMP9-induced angiogenesis in skeletal muscle through hydrogen peroxide/METTL3 pathway.
SALL4 promotes cancer stem-like cell phenotype and radioresistance in oral squamous cell carcinomas via methyltransferase-like 3-mediated m6A modification.
METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4.
HNRNPH1 stabilizes FLOT2 mRNA in a non-canonical m6A-dependent manner to promote malignant progression in nasopharyngeal carcinoma.
m(6)A Modification of Profilin-1 in Vascular Smooth Muscle Cells Drives Phenotype Switching and Neointimal Hyperplasia via Activation of the p-ANXA2/STAT3 Pathway.
METTL3 governs thymocyte development and thymic involution by regulating ferroptosis.
Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication.
Biogenesis of circRBM33 mediated by N6-methyladenosine and its function in abdominal aortic aneurysm.
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
EZH2 promotes B-cell autoimmunity in primary Sjogren's syndrome via METTL3-mediated m6A modification.
N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1.
METTL3 mediates m6A modification of hsa_circ_0072380 to regulate the progression of gestational diabetes mellitus.
Androgens have therapeutic potential in T2 asthma by mediating METTL3 in bronchial epithelial cells.
METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis.
WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy.
High WTAP expression level as a promising biomarker for poor prognosis in colorectal cancer: a pilot study.
Methyltransferase METTL3 regulates neuropathic pain through m6A methylation modification of SOCS1.
Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.
N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer.
piR-27222 mediates PM(2.5)-induced lung cancer by resisting cell PANoptosis through the WTAP/m(6)A axis.
Epitranscriptomic m(5)C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection.
METTL3-mediated m(6)A modification of circGLIS3 promotes prostate cancer progression and represents a potential target for ARSI therapy.
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
METTL3-mediated upregulation of FAM135B promotes EMT of esophageal squamous cell carcinoma via regulating the Wnt/β-catenin pathway.
M6A-methylated circPOLR2B forms an R-loop and regulates the biological behavior of glioma stem cells through positive feedback loops.
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
Highly pathogenic PRRSV upregulates IL-13 production through nonstructural protein 9-mediated inhibition of N6-methyladenosine demethylase FTO.
RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
CHOP regulated by METTL14-m6A affects cell cycle arrest and regorafenib sensitivity in HCC cells.
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
METTL3 mediates SOX5 m6A methylation in bronchial epithelial cells to attenuate Th2 cell differentiation in T2 asthma.
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression.
Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation.
N6-methyladenosine participates in mouse hippocampus neurodegeneration via PD-1/PD-L1 pathway.
METTL3 promotes drug resistance to oxaliplatin in gastric cancer cells through DNA repair pathway.
Mettl3 synergistically regulates TGF-β/SMAD2/3 to promote proliferation and metastasis of gastric cancer.
Dissecting the effects of METTL3 on alternative splicing in prostate cancer.
METTL3-mediated m6A modification of has_circ_0007905 promotes age-related cataract progression through miR-6749-3p/EIF4EBP1.
Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.
m(6)A RNA methylation orchestrates transcriptional dormancy during paused pluripotency.
HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.
METTL3-stabilized super enhancers-lncRNA SUCLG2-AS1 mediates the formation of a long-range chromatin loop between enhancers and promoters of SOX2 in metastasis and radiosensitivity of nasopharyngeal carcinoma.
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.
Rna M(6) a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis.
PARP1 modulates METTL3 promoter chromatin accessibility and associated LPAR5 RNA m(6)A methylation to control cancer cell radiosensitivity.
Site-specific Atg13 methylation-mediated autophagy regulates epithelial inflammation in PM2.5-induced pulmonary fibrosis.
Dynamic N6-methyladenosine RNA methylation landscapes reveal epi-transcriptomic modulation induced by ammonia nitrogen exposure in the Pacific whiteleg shrimp Litopenaeus vannamei.
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane.
m(6)A governs length-dependent enrichment of mRNAs in stress granules.
YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner.
Enzymolysis-based RNA pull-down identifies YTHDC2 as an inhibitor of antiviral innate response.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Comprehensive Transcriptomic Profiling of m6A Modification in Age-Related Hearing Loss.
METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.
M2 macrophage exosomal LINC01001 promotes non-small cell lung cancer development by affecting METTL3 and glycolysis pathway.
DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer.
circRNA-miRNA-mRNA network analysis to explore the pathogenesis of abnormal spermatogenesis due to aberrant m6A methylation.
N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
RNA N6-methyladenosine reader IGF2BP3 interacts with MYCN and facilitates neuroblastoma cell proliferation.
Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification.
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.
MetBil as a novel molecular regulator in ischemia-induced cardiac fibrosis via METTL3-mediated m6A modification.
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.
METTL3 protects METTL14 from STUB1-mediated degradation to maintain m(6) A homeostasis.
YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.
Rewired m(6)A epitranscriptomic networks link mutant p53 to neoplastic transformation.
RNA binding protein YTHDF1 mediates bisphenol S-induced Leydig cell damage by regulating the mitochondrial pathway of BCL2 and the expression of CDK2-CyclinE1.
USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m(6)A Modification of YAP1 mRNA.
ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH.
Role of N6-adenosine-methyltransferase subunits METTL3 and METTL14 in the biological properties of periodontal ligament cells.
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
m(6)A epitranscriptomic regulation of tissue homeostasis during primate aging.
Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.
METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury.
Correlated with better prognosis, CSTA inhibits metastasis of nasopharyngeal carcinoma cells via suppressing AKT signaling through promoting METTL3 degradation.
METTL3 promotes proliferation of goat endometrial epithelial cells by regulating CTGF in an m6A-dependent manner†.
Comprehensive analysis of long non-coding RNA expression profiles of GC-1spg cells with m6A methylation knockdown.
High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m(6)A demethylation: a potential mechanism for diabetic cognitive dysfunction.
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
Targeting choroidal vasculopathy via up-regulation of tRNA-derived fragment tRF-22 expression for controlling progression of myopia.
Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.
Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization.
A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth.
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.
Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer.
FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.
The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.
METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.
Crosstalk between 5-methylcytosine and N(6)-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma.
Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway.
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Heterogeneous Nuclear Protein U Degraded the m(6)A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.
Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N(6)-Methyladenosine Modification of ATP13A3.
F-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner.
Novel RNA N6-methyladenosine regulator related signature for predicting clinical and immunological characteristics in breast cancer.
The m(6)A methyltransferase METTL3 affects cell proliferation and migration by regulating YAP expression in Hirschsprung disease.
RBM10 recruits METTL3 to induce N6-methyladenosine-MALAT1-dependent modification, inhibiting the invasion and migration of NSCLC.
m (6) A RNA methylation orchestrates transcriptional dormancy during developmental pausing.
Increased m6A-RNA methylation and demethylase FTO suppression is associated with silica-induced pulmonary inflammation and fibrosis.
Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.
Mettl3/Ythdf2 regulate macrophage inflammation and ROS generation by controlling Pyk2 mRNA stability.
Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging.
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
SON is an essential m(6)A target for hematopoietic stem cell fate.
METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis.
Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.
dTrmt10A impacts Hsp70 chaperone m(6)A levels and the stress response in the Drosophila brain.
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.
High Temperature-Induced m6A Epigenetic Changes Affect Early Porcine Embryonic Developmental Competence in Pigs.
m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.
A positive feedback circuit driven by m(6)A-modified circular RNA facilitates colorectal cancer liver metastasis.
Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma.
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
METTL14 is decreased and regulates m(6) A modification of α-synuclein in Parkinson's disease.
Maternal tamoxifen exposure leads to abnormal primordial follicle assembly.
WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata.
The roles of METTL3 on autophagy and proliferation of vascular smooth muscle cells are mediated by mTOR rather than by CDK1.
Characterization of m(6)A modifiers and RNA modifications in uterine fibroids.
A lncRNA from the FTO locus acts as a suppressor of the m(6)A writer complex and p53 tumor suppression signaling.
Reinvestigating the clinical relevance of the m(6)A writer METTL3 in urothelial carcinoma of the bladder.
METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.
Methyltransferase-like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation.
N6-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication.
YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1-RPN2-PI3K/AKT/mTOR Axis.
METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells.
FTO negatively regulates the cytotoxic activity of natural killer cells.
N(6)-Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication.
METTL3 enhances dentinogenesis differentiation of dental pulp stem cells via increasing GDF6 and STC1 mRNA stability.
N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.
3D-Printed β-Tricalcium Phosphate Scaffolds Promote Osteogenic Differentiation of Bone Marrow-Deprived Mesenchymal Stem Cells in an N6-methyladenosine-Dependent Manner.
M(6)A Modifier-Mediated Methylation Characterized by Diverse Prognosis, Tumor Microenvironment, and Immunotherapy Response in Hepatocellular Carcinoma.
RNA methylation-mediated LINC01559 suppresses colorectal cancer progression by regulating the miR-106b-5p/PTEN axis.
The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.
METTL3 Facilitates Tumor Progression by COL12A1/MAPK Signaling Pathway in Esophageal Squamous Cell Carcinoma.
Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis.
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
m(6)A mRNA Methylation Was Associated With Gene Expression and Lipid Metabolism in Liver of Broilers Under Lipopolysaccharide Stimulation.
METTL3/m(6)A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma.
Decreased RNA m(6)A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.
Integrative proteomics and m6A microarray analyses of the signatures induced by METTL3 reveals prognostically significant in gastric cancer by affecting cellular metabolism.
METTL3 antagonizes 5‑FU chemotherapy and confers drug resistance in colorectal carcinoma.
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.
CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
METTL3 suppresses anlotinib sensitivity by regulating m(6)A modification of FGFR3 in oral squamous cell carcinoma.
m(6)A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated CCND1 mRNA Stabilization.
Exploration of N6-Methyladenosine Profiles of mRNAs and the Function of METTL3 in Atherosclerosis.
Mettl3-dependent m(6)A modification attenuates the brain stress response in Drosophila.
FTO-dependent N(6)-Methyladenosine regulates the progression of endometriosis via the ATG5/PKM2 Axis.
The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
N(6)-Methyladenine Modification of Hepatitis Delta Virus Regulates Its Virion Assembly by Recruiting YTHDF1.
YTHDF3 modulates hematopoietic stem cells by recognizing RNA m(6)A modification on Ccnd1.
RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.
Metformin combats obesity by targeting FTO in an m(6)A-YTHDF2-dependent manner.
Adenosine N(6)-methylation upregulates the expression of human CYP2B6 by altering the chromatin status.
A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells.
Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.
Profiling RNA at chromatin targets in situ by antibody-targeted tagmentation.
N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.
Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.
METTL3 upregulates COPS5 expression in osteosarcoma in an m(6)A-related manner to promote osteosarcoma progression.
METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.
N6-methyladenosine modification contributes to arecoline-mediated oral submucosal fibrosis.
METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation.
Lactylation-driven METTL3-mediated RNA m(6)A modification promotes immunosuppression of tumor-infiltrating myeloid cells.
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.
lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus.
Detection of N6-methyladenosine in SARS-CoV-2 RNA by methylated RNA immunoprecipitation sequencing.
Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.
Long noncoding RNA lnc-H2AFV-1 promotes cell growth by regulating aberrant m6A RNA modification in head and neck squamous cell carcinoma.
DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.
METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation.
Mettl3-mediated m(6) A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects.
METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression.
Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA.
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.
Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.
Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma.
Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice.
N6-Methyladenosine Modification of CDH1 mRNA Promotes PM2.5-Induced Pulmonary Fibrosis via Mediating Epithelial Mesenchymal Transition.
RNA N(6)-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice.
m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.
Hepatitis B Virus X Protein Expression Is Tightly Regulated by N6-Methyladenosine Modification of Its mRNA.
METTL3-m(6)A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
TBK1-METTL3 axis facilitates antiviral immunity.
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.
N6-methyladenosine modification of the 5' epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein.
METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.
The m(6)A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis.
mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis.
METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10.
The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.
RNA-m6A modification of HDGF mediated by Mettl3 aggravates the progression of atherosclerosis by regulating macrophages polarization via energy metabolism reprogramming.
Stage-specific requirement for METTL3-dependent m(6)A modification during dental pulp stem cell differentiation.
Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression.
Role of N6-methyladenosine RNA modification in the imbalanced inflammatory homeostasis of arsenic-induced skin lesions.
Mettl3-mediated mRNA m(6)A modification controls postnatal liver development by modulating the transcription factor Hnf4a.
METTL14-dependent m(6)A modification controls iNKT cell development and function.
METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner.
PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Comprehensive analysis of RNA m6A methylation in pressure overload-induced cardiac hypertrophy.
m(6) A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels.
METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.
METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification.
m6A Modification-Mediated DUXAP8 Regulation of Malignant Phenotype and Chemotherapy Resistance of Hepatocellular Carcinoma Through miR-584-5p/MAPK1/ERK Pathway Axis.
Characterization of Long Non-coding RNAs Modified by m(6)A RNA Methylation in Skeletal Myogenesis.
Dynamic m(6)A mRNA Methylation Reveals the Role of METTL3/14-m(6)A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration.
Validated Impacts of N6-Methyladenosine Methylated mRNAs on Apoptosis and Angiogenesis in Myocardial Infarction Based on MeRIP-Seq Analysis.
Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.
Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis.
N6-methyladenosine regulates ATM expression and downstream signaling.
Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice.
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.
Binding of RNA m6A by IGF2BP3 triggers chemoresistance of HCT8 cells via upregulation of ABCB1.
Identification and Validation of m6A-Related lncRNA Signature as Potential Predictive Biomarkers in Breast Cancer.
Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.
N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway.
YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.
Vitamin B(12) Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.
Multiomics analysis identifies key genes and pathways related to N6-methyladenosine RNA modification in ovarian cancer.
CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.
METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
Systematic calibration of epitranscriptomic maps using a synthetic modification-free RNA library.
METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.
m(6)A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.
m(6)A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity.
Degradation of WTAP blocks antiviral responses by reducing the m(6) A levels of IRF3 and IFNAR1 mRNA.
Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis†.
Role of epigenetic m(6) A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.
Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.
METTL3 regulates skeletal muscle specific miRNAs at both transcriptional and post-transcriptional levels.
mTORC1 promotes cell growth via m(6)A-dependent mRNA degradation.
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity.
METTL3 regulates heterochromatin in mouse embryonic stem cells.
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.
RNA N(6)-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m(6)A-GLUT1-mTORC1 Axis and Is a Therapeutic Target.
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
mTORC1-chaperonin CCT signaling regulates m(6)A RNA methylation to suppress autophagy.
N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition.
N(6)-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles.
MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.
A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.
RNA m(6) A methylation regulates virus-host interaction and EBNA2 expression during Epstein-Barr virus infection.
YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.
Regulation of telomere homeostasis and genomic stability in cancer by N (6)-adenosine methylation (m(6)A).
The N(6)-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.
The m(6)A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.
N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.
Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs.
HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC.
Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts.
Local translation in nuclear condensate amyloid bodies.
Loss of m(6)A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury.
Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus.
YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.
Dynamic regulation of N(6),2'-O-dimethyladenosine (m(6)Am) in obesity.
Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice.
KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy.
Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication.
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
m(6)A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype.
Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m(6)A-GPR161 signalling axis.
Nonsegmented Negative-Sense RNA Viruses Utilize N(6)-Methyladenosine (m(6)A) as a Common Strategy To Evade Host Innate Immunity.
Autophagy of the m(6)A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.
A defined N6-methyladenosine (m(6)A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions.
Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke.
The M6A methyltransferase METTL3 promotes the development and progression of prostate carcinoma via mediating MYC methylation.
m(6)A RNA Methylation Regulators Contribute to Eutopic Endometrium and Myometrium Dysfunction in Adenomyosis.
m(6)A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.
m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation.
Knockdown of m6A methyltransferase METTL3 in gastric cancer cells results in suppression of cell proliferation.
N(6)-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling.
Validation strategies for antibodies targeting modified ribonucleotides.
METTL3 potentiates resistance to cisplatin through m(6) A modification of TFAP2C in seminoma.
Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
Context-dependent functional compensation between Ythdf m(6)A reader proteins.
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA.
Analysis of METTL3 and METTL14 in hepatocellular carcinoma.
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
Dynamic landscape and evolution of m6A methylation in human.
ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
Direct RNA sequencing enables m(6)A detection in endogenous transcript isoforms at base-specific resolution.
Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts.
Integrative network analysis identifies cell-specific trans regulators of m6A.
METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export.
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
NADP modulates RNA m(6)A methylation and adipogenesis via enhancing FTO activity.
Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism.
m(6)A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.
Interplay of m(6)A and H3K27 trimethylation restrains inflammation during bacterial infection.
Epitranscriptomic N(6)-Methyladenosine Modification Is Required for Direct Lineage Reprogramming into Neurons.
N(6)-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification.
Programmable RNA N(6)-methyladenosine editing by CRISPR-Cas9 conjugates.
Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.
Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.
Regulation of Co-transcriptional Pre-mRNA Splicing by m(6)A through the Low-Complexity Protein hnRNPG.
Resveratrol and Curcumin Improve Intestinal Mucosal Integrity and Decrease m(6)A RNA Methylation in the Intestine of Weaning Piglets.
Endoribonucleolytic Cleavage of m(6)A-Containing RNAs by RNase P/MRP Complex.
HIV-1 envelope proteins up-regulate N(6)-methyladenosine levels of cellular RNA independently of viral replication.
Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis.
m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells.
Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response.
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
m(6)A modification controls the innate immune response to infection by targeting type I interferons.
m(6)A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling.
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma.
METTL3 and ALKBH5 oppositely regulate m(6)A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N(6)-methyladenosine.
m(6)A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.
m(6)A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.
Mettl3-mediated mRNA m(6)A methylation promotes dendritic cell activation.
mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
The m(6)A-methylase complex recruits TREX and regulates mRNA export.
mRNA m(6)A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
A dynamic N(6)-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.
Mettl3-mediated m(6)A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m(6)A mRNA Methylation.
METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells.
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d.
Transient N-6-Methyladenosine Transcriptome Sequencing Reveals a Regulatory Role of m6A in Splicing Efficiency.
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
The Role of m(6)A/m-RNA Methylation in Stress Response Regulation.
The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.
Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.
Dynamic m6A modification regulates local translation of mRNA in axons.
N(6)-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
Region-specific RNA m(6)A methylation represents a new layer of control in the gene regulatory network in the mouse brain.
NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.
The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
m(6)A Facilitates eIF4F-Independent mRNA Translation.
m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.
N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.
RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.
AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N(6)-methyladenosine.
Thiol-linked alkylation of RNA to assess expression dynamics.
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
N6-methyladenosine-dependent regulation of messenger RNA stability.
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.
RNA-methylation-dependent RNA processing controls the speed of the circadian clock.
Chen J, Wang Z, Liao Y, Ding W
Journal of inflammation research 2026;19:553934
Journal of inflammation research 2026;19:553934
Identification of m1A/m6A/m5C/m7G-related genes and clusters associated with neuropathic pain.
Tan L, Gan X, Lu D, Liang Y, Fu W, Gan Z, Wang K, Tang H, Yang P
Frontiers in neurology 2026;17:1592545
Frontiers in neurology 2026;17:1592545
METTL3 mediates m(6)A methylation of ADAM17 to Downregulate ACE2-Ang-(1-7) axis and promote progression of hypertension.
Fei X, Li C, Bai J, Xu Y, Hu R, Wang X, Pan Y, Zhu X, Chen K, Chen A, Zhang L, Han Y
Journal of advanced research 2026 May;83:837-854
Journal of advanced research 2026 May;83:837-854
METTL3 mitigates angiotensin II-induced renal hypertensive injury by regulating fatty acid oxidation.
Fei XJ, Xie MY, Liu RR, Zhang Y, Yang LQ
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 May;1871(4):159743
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 May;1871(4):159743
Domain associated with zinc fingers-containing NF90-NF45 complex inhibits m(6)A modification of primary microRNA by suppressing METTL3/14 activity.
Higuchi T, Morioka S, Morisawa K, Matsukawa K, Ashida S, Suzuki T, Sakamoto S
FEBS open bio 2026 May;16(5):921-931
FEBS open bio 2026 May;16(5):921-931
The mechanism by which methylase METTL3 affects intramuscular fat deposition.
Yu B, Li K, Li X, Zhang J
Poultry science 2026 May;105(5):106670
Poultry science 2026 May;105(5):106670
CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression.
Sun Q, Chi R, Zhang X, Chen T, Xu X, Ma L, Tian X, Miao Y, Yu Y, Kang R, Kroemer G, Shi Y, Tang D, Wang J
Developmental cell 2026 May 13;61(5):1092-1110.e12
Developmental cell 2026 May 13;61(5):1092-1110.e12
METTL3-based epitranscriptomic editing screening identifies functional m(6)A sites in cancers.
Xu X, Wang Y, Zhu H, Lam M, Luo W, Teng M, Liu Y, Guo WY, Aastha A, Xu X, Chen S, Ci X, Wang S, Zeng Y, Zhu G, Kislinger T, Lupien M, Tsao MS, He HH
Nature cancer 2026 Mar;7(3):469-483
Nature cancer 2026 Mar;7(3):469-483
N(6)-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93.
Lee JH, Tingey M, Zhang Z, Buerger F, Hong J, Zhang G, Yang M, Du B, Jeong JH, John KA, Tamayo IM, Zhao QD, Hildebrandt F, Đurišić M, Stajić N, Spasojević B, Yang W, Xu K
Nature cell biology 2026 Mar;28(3):553-566
Nature cell biology 2026 Mar;28(3):553-566
YTHDF3-TRIM2-P53 axis promotes malignant progression in uveal melanoma (UVM).
Li H, Chen Y, Chen W, Li D, Hao R, Zhang W
Cellular signalling 2026 Mar;139:112316
Cellular signalling 2026 Mar;139:112316
MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids.
Uhl L, Aziba A, Löbbert S, Russell T, Krenz B, Montesinos F, Kannan T, Valanju OR, Schülein-Völk C, de Martines T, Bolz M, Fleischhauer D, Cossa G, Endres T, Solvie D, Gallant P, Rosenwald A, Maric HM, Papadopoulos D, Vos SM, Eilers M
Cell 2026 Mar 5;189(5):1371-1388.e29
Cell 2026 Mar 5;189(5):1371-1388.e29
Polystyrene Nanoplastics induced placental toxicology by activating Keap1-mediated ferroptosis via METTL3-dependent m6A methylation.
Chen Y, Liu Y, Zhang M, Li S, Yan Y, Yin C
Cell biology and toxicology 2026 Mar 3;42(1)
Cell biology and toxicology 2026 Mar 3;42(1)
Elevated m(6)A RNA modifications associate with immune dysregulation and cancer in people with HIV-1.
Mishra T, Tripathi S, Stapleton JT, Wu L
BMC cancer 2026 Mar 21;26(1)
BMC cancer 2026 Mar 21;26(1)
A machine learning-based epigenetic signature reveals YTHDC1 stabilizes POU5F1 to oppose tumor progression.
Fang C, Dai J, Weng Z, Zhang L, Xing Y, Liu D, Wu H, Li X, Liu Q, Su G
Journal of translational medicine 2026 Mar 20;24(1)
Journal of translational medicine 2026 Mar 20;24(1)
Integrative Multi-Analysis Identifies METTL3-Regulated FGF19 and H6PD as Candidate Targets in Diabetic Cognitive Impairment.
Fu J, Wang H, Yan J, Chen W, Wang R, Gao H, Li C
Biomolecules 2026 Mar 20;16(3)
Biomolecules 2026 Mar 20;16(3)
METTL3 stabilizes FASN mRNA by mediating m(6)A modification to promote malignant progression of diffuse large B-cell lymphoma.
Song X, Zhong Y, Yu N, Zou W, Li W, Lv Q, Luo Q, Zhong X
Cell & bioscience 2026 Mar 18;16(1)
Cell & bioscience 2026 Mar 18;16(1)
The m(6)A modification mediates the imbalance of mitochondrial homeostasis and apoptosis induced by Benzo[b]fluoranthene in mouse spermatocytes: mitophagy versus mitochondrial damage.
Shi CF, Han F, Jiang X, Sun L, Liu KL, Sun SQ, Li YQ, Wang JK, Ao L, Cao J, Chen Q, Liu JY
Journal of advanced research 2026 Mar 17;
Journal of advanced research 2026 Mar 17;
N(6)-methyladenosine modification of MRP7 mRNA modulates its expression and paclitaxel sensitivity in lung cancer-derived A549 cells.
Inamoto T, Nakano M, Fukami T, Nakajima M
Drug metabolism and pharmacokinetics 2026 Jun;68:101519
Drug metabolism and pharmacokinetics 2026 Jun;68:101519
m(6)A modification in the 3'‑leader region of EBOV genome antagonizes ISG20 to facilitate viral replication.
Zhao B, Cao Z, Zhang K, Xiao S, Shen X, Li F, Wu Y, Zhang B, Wang Q, Zhang H, Chuai X, Chiu S
International journal of biological macromolecules 2026 Jan;339(Pt 2):149804
International journal of biological macromolecules 2026 Jan;339(Pt 2):149804
Astrocytic Mettl14 depletion enhances cognitive function by attenuating astrogliosis via the DUSP1/MAPK pathway in APP/PS1 mice: targeting neuroinflammation in Alzheimer's disease.
Teng Y, Xu J, He S, Yi J, Li M, Tang Q, Chen X, Wei F, Liu Y, Jiang H, Xiang Y, Zhao JL, Yang J, Le W, Zheng M, Yang L
Molecular psychiatry 2026 Jan;31(1):318-331
Molecular psychiatry 2026 Jan;31(1):318-331
Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival.
Jiang X, Wang Y, Zhang X, Deng H, Fang L, Tafadzwa C, Yao J, Chen H, Ye A, Zhou K, Ling X, Xiao J
Clinical and translational medicine 2026 Jan;16(1):e70565
Clinical and translational medicine 2026 Jan;16(1):e70565
Xinfeng Capsule ameliorates RA joint injury by inhibiting cuproptosis via the METTL3/miR-221/222-3p/ATP7A Axis.
Wang H, Wang A, Liu J, Zhu NF, Cao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157644
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157644
METTL3-mediated m6A modification of FDX1 confers resistance to cuproptosis and promotes hepatocellular carcinoma progression.
Jiang Q, Peng C, Mao W, Yu Z, Feng Y, Li Y, Zhu J, Zhao J, Liao D, Sun T
Communications biology 2026 Jan 8;9(1):222
Communications biology 2026 Jan 8;9(1):222
Sequence-dependent splicing dysregulation drives therapy resistance in pediatric AML.
Huang Y, Xiao P, Qin L, Gao L, Zhao Y, Sui J, Hu W, Zhou L, Han N, Lv X, Chen K, Liu Y, Lin H, Shen S, Abdel-Wahab O, Hu S, Liu Z, Wang Q
Cell reports. Medicine 2026 Jan 20;7(1):102542
Cell reports. Medicine 2026 Jan 20;7(1):102542
Wilms' tumor 1-associating protein regulates the stress fiber reservoirs in endothelial cells via KLF2-IQGAP3.
Wu SY, Zhu YT, Cheng KR, Yan X, Wang NP, Zhang P, Wang YF
Cellular signalling 2026 Feb;138:112286
Cellular signalling 2026 Feb;138:112286
Mettl3-Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS.
Zhu F, Li H, Li X, Du C, Wang T, Zhou X, Xie X, Shao Y, Huang Y, Hu Y, Guo X, Zhu B, Yu S, Zhang X, Zhao B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e01242
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e01242
N6-methyladenosine (m(6)A) modification of TXNIP in 3'UTR instigates abdominal aorta aneurysm in mice.
Hantelys F, Yin W, Zou MH
iScience 2026 Feb 20;29(2):114630
iScience 2026 Feb 20;29(2):114630
m6A methylation-modified ETV1 drives multiple myeloma progression and M2 polarization of tumor-associated macrophage through transcriptional activation of RBMS1.
Liu Y, Geng Y, Zheng B, Zhang A, Yang K, Mao Y, Jiang L
Journal of translational medicine 2026 Feb 13;24(1)
Journal of translational medicine 2026 Feb 13;24(1)
METTL14-dependent m(6)A modification restrains interferon signaling to prevent myocarditis and dilated Cardiomyopathy.
Xi Y, Kuempel J, Choi S, DeSpain P, Zhang T, Zhu J, Osborn A, Rivera R, Zhong S, Wu X, Wang YX, Li Z, West AP, Li C, Tong CW, Zhang X, Peng X
bioRxiv : the preprint server for biology 2026 Apr 6;
bioRxiv : the preprint server for biology 2026 Apr 6;
Cherry plum powder alleviates excessive proliferation and inflammation of keratinocytes in psoriasis by reducing N6 methyladenosine-modified S100A4.
Wang H, Ding Y, Yu S, Wu W
Journal of molecular histology 2026 Apr 29;57(3)
Journal of molecular histology 2026 Apr 29;57(3)
Regulation of PSAT1 and PHGDH by m6A in endocrine-resistant breast cancer cells.
Piell KM, Vallarta A, Wilt AE, Avila-Valdes BL, Sumlut MH, Goli N, Petri BJ, He L, Zhang X, Clem BF, Klinge CM
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 15;:168266
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 15;:168266
m6A Modification of ATOX1 Inhibits Acute Myeloid Leukemia Progression by Promoting Cuproptosis.
Peng J, Fu X, Li S, Hu C, Zhao X, Peng J
Cancer research communications 2026 Apr 1;6(4):714-727
Cancer research communications 2026 Apr 1;6(4):714-727
Manipulation therapy alleviates neuropathic pain via the SOCS1 m(6)A epigenetic loop.
Wu L, Wang X, Yang P, Wang X, Zheng Y, Tang Y, Zheng H, Ning P, Tang H
The Korean journal of pain 2026 Apr 1;39(2):191-206
The Korean journal of pain 2026 Apr 1;39(2):191-206
METTL3-Mediated m6A Modification Enhances the Function of Adipose-Derived Stem Cells Under Hypoxic Conditions Thereby Improving Fat Graft Retention.
Guo Y, Hou M, Song J, Peng H, Liu S, Zhu J, Wang Q, Li J, Yi C, Li H
Stem cells international 2025;2025:5589397
Stem cells international 2025;2025:5589397
METTL3/miR-192-5p/SCD1 Axis Regulates Lipid Metabolism to Affect T Cell Differentiation in Asthma.
Chen Z, Yan D, Guo S, Song Y, Zhang X, Gu W, Dong H, Huang L
Mediators of inflammation 2025;2025:4955849
Mediators of inflammation 2025;2025:4955849
METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2.
Chen X, Ling Q, Xu J, Ye Y, Dong L
Open medicine (Warsaw, Poland) 2025;20(1):20251191
Open medicine (Warsaw, Poland) 2025;20(1):20251191
Notch-Driven Cholangiocarcinogenesis Involves the Hippo Pathway Effector TAZ via METTL3-m6A-YTHDF1.
Ma W, Zhang J, Chen W, Liu N, Wu T
Cellular and molecular gastroenterology and hepatology 2025;19(1):101417
Cellular and molecular gastroenterology and hepatology 2025;19(1):101417
Atorvastatin Alleviates Sepsis-Induced Cardiomyopathy by Targeting the METTL3/IGF2BP1/CXCL2 Pathway.
Zhang L, Yin Y, Zheng L, Wang Y, Zhao J, Mu F, Jin F, Gong R, Wang J
Journal of inflammation research 2025;18:14609-14628
Journal of inflammation research 2025;18:14609-14628
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Sun H, Qiao X, Peng X, Zhu H, Zhang L, Jiang L, Wang L, Xue C, Yang J, Yi W, Zhang B, Liu J, Duan W
Theranostics 2025;15(8):3532-3550
Theranostics 2025;15(8):3532-3550
Deciphering single-cell landscape unravels cell-type-specific functional roles of RNA m(6)A modification in atherosclerosis.
Ping X, Liang X, Xing W, Wang S, Gong F, Cheng Y, Duan S, Lv X, Li X, Zhang T, Chen C, Zhang Y, Yuan C, Liu S, Liu G, Sun B
Theranostics 2025;15(10):4785-4807
Theranostics 2025;15(10):4785-4807
EIF3B‑METTL3 complex promotes cell proliferation, invasion and EGFR/AKT signaling in cervical cancer.
Zhang C, Fan X, Yang J, Zhu P
Oncology reports 2025 Sep;54(3)
Oncology reports 2025 Sep;54(3)
Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet.
Liu D, Zhao Y, Dai J, Li R, Yuan J, Shen K, He Z, Gu S
Toxicology 2025 Sep;516:154172
Toxicology 2025 Sep;516:154172
METTL3 Mediates Wnt/β-Catenin Pathway in Epithelial-Mesenchymal Transition of 16HBE Cells Induced by Beryllium Sulphate.
Yan C, Li G, Huang L, Zhang Z
Journal of applied toxicology : JAT 2025 Sep;45(9):1787-1797
Journal of applied toxicology : JAT 2025 Sep;45(9):1787-1797
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
He Y, Pan X, Liu Z, Zuo P, Sheng Z, Hao C, Tao Z, Chen Z, Song J, Ma G, Ling S
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
The m6A transferase METTL3 regulates high glucose-induced proliferation and apoptosis of human lens epithelial cells through the lncRNA TUG1/KHSRP/p38MAPK signaling axis.
Li Y, Yao Z, Gao X, Niu Y, Gao Z, Jiang S
Experimental eye research 2025 Sep;258:110492
Experimental eye research 2025 Sep;258:110492
Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism.
Tang R, Zhang Z, Liu X, Liao Y, Chen Y, Xiao M, Li Y, Zhou C, Tan Z, Zhang C, Chen C, Rong Z, Liu Y, Li P, Du Q, He Q, Lei Y, Wu Z, Lu S, Xu J, Wang W, Shi S, Yu X
Gastroenterology 2025 Sep;169(4):615-631.e32
Gastroenterology 2025 Sep;169(4):615-631.e32
ADAP-METTL3 modulates the inflammatory responses of macrophages via m(6)A modification of Spry1.
Dong A, Zhang P, Yang F, Wang Y, Liu H
Cell death & disease 2025 Oct 7;16(1):708
Cell death & disease 2025 Oct 7;16(1):708
Mechanisms of gypenosides in type 2 diabetes mellitus via regulation of m6A methylase METTL3/14 and demethylase FTO.
Li J, Zhang S, Tian R, Tai H, Zhang Y, Hu M, Gong G, Sun J, Wu N
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2025 Oct 28;50(10):1735-1754
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2025 Oct 28;50(10):1735-1754
IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation.
Sharma G, Gutierrez M, Jones AE, Kapoor S, Jaiswal AK, Neeb ZT, Rios A, Dorairaj P, Thaxton ML, Lin TL, Tran TM, Kabbani LES, Ritter AJ, Scherer GM, Sorrentino JP, Stiles L, Hoeve JT, Damoiseaux RD, Garg NK, Divakaruni AS, Sanford JR, Rao DS
Cell reports 2025 Oct 28;44(10):116330
Cell reports 2025 Oct 28;44(10):116330
METTL3-mediated modification of SIRT1 m6A methylation protects osteoblasts from TBHP-induced senescence and promotes osteoblast proliferation.
Chen Y, Wang Y, Xiao H, Teng F, Yang A, Liu J, Liu Z, Sheng X, Zhang C, Zhang S, Geng B, Xia Y
Chemico-biological interactions 2025 Oct 22;420:111672
Chemico-biological interactions 2025 Oct 22;420:111672
Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation.
Zhou Z, Zhu S, Hong Y, Jin G, Ma R, Lin F, Zhang Y, Lee HY, Liu N
Cell 2025 Oct 16;188(21):5878-5894.e18
Cell 2025 Oct 16;188(21):5878-5894.e18
PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m6A Methylation to Stabilize PARP1 mRNA.
Qi Z, He L, Xu Z, Luo X, Ji L, Lin C, Giuliano AE, Cui X, Deng Z, Wu J, Lin SL, Cui Y
Cancer research 2025 Oct 15;85(20):3949-3965
Cancer research 2025 Oct 15;85(20):3949-3965
SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m6A Modification.
Zuo X, Xu J, Yang D, Yang C, Liu X, Chen N, Wang H, Luo X, Luo Q, Wang Y, Wei Q, Yang Y, Zhao H, Xu J, Wang W, Liu T, Yi P
Cancer research 2025 Oct 15;85(20):3894-3909
Cancer research 2025 Oct 15;85(20):3894-3909
Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.
Wang N, Dai J, Li R, Li W, Liu D, Liu X, Mei Z, Lu H, He Z, Gu S
Ecotoxicology and environmental safety 2025 Oct 15;305:119228
Ecotoxicology and environmental safety 2025 Oct 15;305:119228
Molecular mechanism of modified Yigong San formula against colorectal cancer via EZH2/METTL3/SOX4 pathway-mediated apoptosis.
Wang J, Zhang XW, Tang BW, Li Z, Song N
World journal of gastrointestinal oncology 2025 Oct 15;17(10):108410
World journal of gastrointestinal oncology 2025 Oct 15;17(10):108410
METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.
Tang Y, Li Z, Zhao X, Niu X, Ning S, Liu L, Liu Z, Zhang J, Zhao Q, Han L
Reproduction (Cambridge, England) 2025 Oct 1;170(4)
Reproduction (Cambridge, England) 2025 Oct 1;170(4)
METTL3/IGF2BP2 stabilizes IQGAP3 via m6A modification to drive HCC metastasis through TGF-β/Smad signaling and EMT.
Pan D, Zhang H, Zhou J, He S, Yuan G
Pathology, research and practice 2025 Nov;275:156228
Pathology, research and practice 2025 Nov;275:156228
METTL3 modulates bone Cancer pain via m(6)A-dependent JAK2/STAT3 activation in spinal astrocytes.
Liu M, Yang L, Yan Z, Huang Y
Cellular signalling 2025 Nov;135:112046
Cellular signalling 2025 Nov;135:112046
Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.
Wang J, Deng J, Sun B, Qiao G, Yang J, Gao Z, Zhang Q, Dong M, Qu P, Wang Z
Cellular signalling 2025 Nov;135:112024
Cellular signalling 2025 Nov;135:112024
Effect of berberine on LPS-induced intestinal epithelial injury and m(6)A methylation in broilers.
Yuan L, Li W, Li G, Jin W, Wang B, Li S, Wang H
Poultry science 2025 Nov;104(11):105677
Poultry science 2025 Nov;104(11):105677
Single-base m(6)A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4(+) T cells.
Huang S, Zhao Y, Phillips S, Warrick JE, Kearse MG, He C, Wu L
Journal of virology 2025 Nov 25;99(11):e0153625
Journal of virology 2025 Nov 25;99(11):e0153625
IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation.
Xiong X, Wang X, Wang Z, Chen F, Shi Y, Chen X, Gong W, Jia X, Xu J
Cell reports 2025 Nov 25;44(11):116511
Cell reports 2025 Nov 25;44(11):116511
The role of METTL3 in transposable elements regulation and 2C-like program induction in mouse embryonic stem cell.
Chen X, Chen B, Zhao Y, Wen Z, Hao J, Jin L, Li D, Quan X, Wu K, Deng M, Bao X, Wang J, Chen J
Cell regeneration (London, England) 2025 Nov 20;14(1):47
Cell regeneration (London, England) 2025 Nov 20;14(1):47
Mechanism of the traditional Chinese medicine SMBJ alleviates diabetes mellitus-induced Leydig cell dysfunction in rats testes.
Zhang W, Liu Y, Tong L, Jin Y, Gao C, Cui Y, Jin B, Sun D
Scientific reports 2025 Nov 12;15(1):39656
Scientific reports 2025 Nov 12;15(1):39656
Global mapping of RNA N(6)-methyladenosine (m(6)A) in human subcutaneous and visceral adipose tissue reveals novel targets that correlate with clinical variables of obesity.
Rønningen T, Zeng Y, Dahl MB, Wang J, Visnovska T, Tannæs TM, la Cour Poulsen L, Cayir A, Svensson SIA, Svanevik M, Hertel JK, Hjelmesæth J, Kristinsson JA, Mala T, Blüher M, He HH, Valderhaug TG, Böttcher Y
Biomarker research 2025 Nov 12;13(1):146
Biomarker research 2025 Nov 12;13(1):146
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
Zhu ZM, Huo FC, Shi C, Li MT, Zhou Y, Zhang LS, Pei DS
International journal of biological macromolecules 2025 May;309(Pt 2):142880
International journal of biological macromolecules 2025 May;309(Pt 2):142880
The Impact of METTL3 on MDM2 Promotes Podocytes Injury During Diabetic Kidney Disease.
Wu H, Yu Z, Yang Y, Han Z, Pan Q, Chen Y, Yu H, Shen S, Xu L
Journal of cellular and molecular medicine 2025 May;29(10):e70627
Journal of cellular and molecular medicine 2025 May;29(10):e70627
STM2457 decreases m6A methylation to reduce cisplatin-induced ototoxicity via MAPK signaling.
Liao J, Wu X, Zeng Q, Huo Q, Nie G
Biochemical pharmacology 2025 May;235:116820
Biochemical pharmacology 2025 May;235:116820
METTL3 regulates ASMCs proliferation and M2 macrophage polarization via mediating the m6A methylation of TIMMDC1 in asthma.
Zhang S, Wen X, Liu L
Immunobiology 2025 May;230(3):152912
Immunobiology 2025 May;230(3):152912
β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor.
Kim JS, Cho S, Jeong MY, Rivera-Piza A, Kim Y, Wu C, Yoon YE, Lee I, Choi JW, Lee HL, Shin SW, Shin J, Gil H, Lee MG, Keum N, Kim JA, Lee D, Jung YH, Chung S, Shin MJ, Hong S, Chi SG, Lee SJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156599
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156599
Heat stress enhances the expression of METTL3 to mediate N6-methyladenosine modification of SOS2 and NLRP3 inflammasome activation in boar Sertoli cells.
Zhang X, Tang Y, Wang J, Yang M, Jiang J, Xue H, Wang Y, Zhang J, Wang X
Journal of hazardous materials 2025 May 5;488:137432
Journal of hazardous materials 2025 May 5;488:137432
Betaine Alleviates Bisphosphonate-Related Osteonecrosis of the Jaw by Rescuing BMSCs Function in an m6A-METTL3-Dependent Manner.
Jin Y, Song J, Diao Z, Han X, Fan Z
International journal of molecular sciences 2025 May 29;26(11)
International journal of molecular sciences 2025 May 29;26(11)
Increased METTL3 Expression and m6A Methylation in Myoblasts of Facioscapulohumeral Muscular Dystrophy.
Settas N, Bittel AJ, Chen YW
International journal of molecular sciences 2025 May 28;26(11)
International journal of molecular sciences 2025 May 28;26(11)
Metabolite-dependent m(6)A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration.
Li Z, Guo Z, Yang Z, Yang B, Hu Y, Xie X, Zong Z, Chen Z, Zhang K, Zhao P, Li G, Yang X, Bian L
Cell reports 2025 May 27;44(5):115611
Cell reports 2025 May 27;44(5):115611
METTL3 inhibits primed-to-naïve transition of pluripotent stem cells through m(6)A-YTHDF2-pluripotency/Gstp1 mRNA degradation axis.
Li S, Hao J, Hong G, Dong H, Liu H, Jin L, Zhang Z, Wu H, Hu M, Huang R, Luo G, He J, Chen J, Wu K
Cell regeneration (London, England) 2025 May 27;14(1):19
Cell regeneration (London, England) 2025 May 27;14(1):19
Phase transition of WTAP regulates m(6)A modification of interferon-stimulated genes.
Cai S, Zhou J, Luo X, Zhang C, Jin S, Ren J, Cui J
eLife 2025 May 27;13
eLife 2025 May 27;13
METTL3-Driven m6A Modification of Cpt1a Gene in High Fat Diet Related Liver Cancer Tumor Macrophages Facilitates Type II Macrophage Differentiation.
Zhu L, Li X, Wang W
Frontiers in bioscience (Landmark edition) 2025 May 26;30(5):36971
Frontiers in bioscience (Landmark edition) 2025 May 26;30(5):36971
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery.
Du J, Wu J, Song Q, Li S, Hong Y, Anwar A, Fu Q, Liu J
Journal of molecular histology 2025 May 20;56(3):161
Journal of molecular histology 2025 May 20;56(3):161
METTL3 promotes osteogenesis by regulating N6-methyladenosine-dependent primary processing of hsa-miR-4526.
Song Y, Gao H, Pan Y, Gu Y, Sun W, Liu J
Stem cells (Dayton, Ohio) 2025 May 15;43(5)
Stem cells (Dayton, Ohio) 2025 May 15;43(5)
Subcellular level spatial transcriptomics with PHOTON.
Rajachandran S, Xu Q, Cao Q, Zhang X, Chen F, Mangiameli SM, Chen H
Nature communications 2025 May 14;16(1):4457
Nature communications 2025 May 14;16(1):4457
Selective RNA sequestration in biomolecular condensates directs cell fate transitions.
Pessina P, Nevo M, Shi J, Kodali S, Casas E, Cui Y, Richards AL, Park EJ, Chen X, Levin-Ferreyra F, Stevenson E, Krogan NJ, Swaney DL, Ying Q, Chen Q, Brumbaugh J, Di Stefano B
bioRxiv : the preprint server for biology 2025 May 10;
bioRxiv : the preprint server for biology 2025 May 10;
SNORD9 promotes ovarian cancer tumorigenesis via METTL3/IGF2BP2-mediated NFYA m6A modification and is a potential target for antisense oligonucleotide therapy.
Chen S, Wen JT, Zhang S, Wang JL, Yuan J, Bao HJ, Chen X, Zhao Y
Life sciences 2025 May 1;368:123527
Life sciences 2025 May 1;368:123527
METTL3-Mediated m6A Methylation Stabilizes IFI27 to Drive Esophageal Squamous Cell Carcinoma Progression Through an IGF2BP2-Dependent Mechanism.
Zhang X, Bai Y, Shang L, Wang Y, Yao W, Wu S
Journal of biochemical and molecular toxicology 2025 Mar;39(3):e70167
Journal of biochemical and molecular toxicology 2025 Mar;39(3):e70167
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
Xu J, Ren Y, Lu J, Qin F, Yang D, Tang C, Yang Y, Xu J, Liu T, Yi P
Clinical and translational medicine 2025 Mar;15(3):e70249
Clinical and translational medicine 2025 Mar;15(3):e70249
Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway.
Wang J, He Y, Zhu X, Zhu J, Deng Z, Zhang H, Chen Y, Zhang G, Shi T, Chen W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2409419
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2409419
The m6A modification regulates the composition of myofiber types in chicken skeletal muscle.
Shan Y, Liu Y, Zhang M, Pang L, Ji G, Ju X, Tu Y, Shu J
Poultry science 2025 Mar;104(3):104811
Poultry science 2025 Mar;104(3):104811
Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML.
Zhong Y, Zhang R, Lu L, Tan H, You Y, Mao Y, Yuan Y
Cell communication and signaling : CCS 2025 Mar 8;23(1):126
Cell communication and signaling : CCS 2025 Mar 8;23(1):126
SRSF3 and hnRNP A1-mediated m6A-modified circCDK14 regulates intramuscular fat deposition by acting as miR-4492-z sponge.
Qin C, Xu F, Yue B, Zhong J, Chai Z, Wang H
Cellular & molecular biology letters 2025 Mar 4;30(1):26
Cellular & molecular biology letters 2025 Mar 4;30(1):26
Electroacupuncture regulates FTO/Nrf2/NLRP3 axis-mediated pyroptosis in cerebral ischemia-reperfusion injury.
Li C, Ji H, Mao W, Zhang L, Tong T, Wang J, Cai L, Wang H, Sun T, Yi H, Li S, Tu Y, Zhang J, Wang H, Wu H, Han W, Wang Y
Neuroreport 2025 Mar 19;36(5):257-266
Neuroreport 2025 Mar 19;36(5):257-266
Global analysis by LC-MS/MS of N6-methyladenosine and inosine in mRNA reveal complex incidence.
Stejskal S, Rájecká V, Covelo-Molares H, Sinigaglia K, Brožinová K, Kašiarová L, Dohnálková M, Reyes-Gutierrez PE, Cahová H, Keegan LP, O'Connell MA, Vaňáčová Š
RNA (New York, N.Y.) 2025 Mar 18;31(4):514-528
RNA (New York, N.Y.) 2025 Mar 18;31(4):514-528
METTL3 mediates CPB1 expression by regulating transcription factor BACH2 to promote apoptosis and oxidative stress of lens epithelial cells.
Sheng Z, Pan Y, Shao L, Bao Y
Journal of bioenergetics and biomembranes 2025 Jun;57(2-3):161-171
Journal of bioenergetics and biomembranes 2025 Jun;57(2-3):161-171
Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment.
Li T, Zhao J, Yuan J, Ding R, Yang G, Cao J, Zhao X, Liu J, Liu Y, Xu P, Deng J, Miao X, Cheng X
Materials today. Bio 2025 Jun;32:101648
Materials today. Bio 2025 Jun;32:101648
Targeting m(6)A demethylase FTO to heal diabetic wounds with ROS-scavenging nanocolloidal hydrogels.
Zheng X, Deng S, Li Y, Luo Z, Gan Z, Zheng Z, Xu R, Xiao S, Cai Y, Meng J, Li L, Li C, Xue X, Dai W, Qin S, Wang M, Zeng K, Xiao Z, Xia L
Biomaterials 2025 Jun;317:123065
Biomaterials 2025 Jun;317:123065
The impact of YTHDF2-mediated NCOA4 methylation on myocardial ferroptosis.
Shao X, Sun M, Wang R, Leng M, Diao H, Li X, Wang D, Wu K, Wang L, Lv W, Rong X, Zhang Y
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1453-1466
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1453-1466
METTL3-mediated N6-methyladenosine modification contributes to vascular calcification.
Li L, Chai Q, Guo C, Wei J, Qin Y, Liu H, Lu Z
Journal of molecular and cellular cardiology 2025 Jun;203:22-34
Journal of molecular and cellular cardiology 2025 Jun;203:22-34
The IGF2BP2-circ-DAPK1 axis promotes high-glucose-induced ferroptosis of HUVECs by decreasing NQO1 expression.
Qiu C, Zheng X, Zhou X, Wang B, Chen T, Xu Y, Yu X, Lu W, Wu Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167797
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167797
Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence.
Luo T, Chen Z, Zhang F, Liu H, Huang F, Zhang X, Feng J, Ding S, Liu L, Guan W, Zeng A, Hao H
Viruses 2025 Jun 9;17(6)
Viruses 2025 Jun 9;17(6)
A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1.
Xu W, Yi J, Wei X, Wang M, Zhao M, Zhao M, Wang X, Shen Y, Wang Z, Jin S
Journal of translational medicine 2025 Jun 4;23(1):629
Journal of translational medicine 2025 Jun 4;23(1):629
Mitigation of Ferroptosis in Diabetic Kidney Disease Through Mesenchymal Stem Cell Intervention via the Smad2/3/METTL3/S1PR1 Axis.
Huang LL, Hou YY, Yang J, Liao XN, Ma JS, Wang WC, Quan YX, Jiang HY, Bai YH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70714
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70714
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.
Zhu C, Li R, You X, Xu J, Wang J, Dong D, Chen X, Wang K
NPJ precision oncology 2025 Jun 17;9(1):193
NPJ precision oncology 2025 Jun 17;9(1):193
Reciprocal METTL3-PAX5 regulation in maintaining B-cell identity and promoting B-cell hyperreactivity in SLE.
Yang Y, Zhang Y, Xie S, Liu K, Liu M, Li Y, Luo H, Zuo X, Zhang H, Guo M
Molecular medicine (Cambridge, Mass.) 2025 Jun 12;31(1):236
Molecular medicine (Cambridge, Mass.) 2025 Jun 12;31(1):236
O-GlcNAcylation with ubiquitination stabilizes METTL3 to promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer.
Wang Q, Wei D, Li C, Yang X, Su K, Wang T, Zou R, Wang L, Cun D, Tang B, Wu T
Molecular medicine (Cambridge, Mass.) 2025 Jun 10;31(1):228
Molecular medicine (Cambridge, Mass.) 2025 Jun 10;31(1):228
METTL3 facilitates osteoblast differentiation and bone regeneration via m6A-dependent maturation of pri-miR-324-5p.
Xiao J, Xu Z, Deng Z, Xie J, Qiu Y
Cellular immunology 2025 Jul;413:104974
Cellular immunology 2025 Jul;413:104974
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
Wang H, Peng H, Zhang Z, Abulimiti Y, Hu J, Zhou Y, Ji P, Li D
Clinical and translational medicine 2025 Jul;15(7):e70392
Clinical and translational medicine 2025 Jul;15(7):e70392
A novel mechanism in driving non-small cell lung cancer progression: The METTL3/FOXA1/PTK2 cascade.
Zhang X, Chen Y, Wang L, Lin Q, Li T, He C
Mutation research 2025 Jul-Dec;831:111911
Mutation research 2025 Jul-Dec;831:111911
METTL3-mediated m (6)A modification facilitates Nectin-4-induced VNN1 upregulation and promotion of ESCC progression.
Long Y, Yang H, Zhang R, Zhao Q, Yang M, Song G, Liu K
Acta biochimica et biophysica Sinica 2025 Jul 30;58(2):353-368
Acta biochimica et biophysica Sinica 2025 Jul 30;58(2):353-368
The m6A hypermethylation-induced PIR overexpression regulates H3K4me3 and promotes tumorigenesis of uveal melanoma.
Tian H, Chen Y, Dong X, Fan X, Jia R
Cancer letters 2025 Jul 28;623:217729
Cancer letters 2025 Jul 28;623:217729
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
Grande RC, Lin CC, Cammer M, Emesom ED, Khurram MA, Boutell C, Denes LT, Lionnet T, Wilson AC, Mohr I
Cell reports 2025 Jul 22;44(7):115826
Cell reports 2025 Jul 22;44(7):115826
METTL3 Inhibition Restores PD-L1 Expression and CD8+ T-cell Cytotoxic Function in Immunotherapy-Treated Gastric Cancer.
Fang M, Li Y, Wang P, Wang Y, Wang X, Wa X, Zhang Y, He Z, Li J, Li L, Su Y, Zhou H, He J, Liu Y
Cancer immunology research 2025 Jul 2;13(7):1037-1052
Cancer immunology research 2025 Jul 2;13(7):1037-1052
ALKBH5-mediated NPC2 mRNA m(6)A demethylation promotes resistance to oxaliplatin in colorectal cancer.
Wan P, Ren Y, Li HT
Functional & integrative genomics 2025 Jul 19;25(1):158
Functional & integrative genomics 2025 Jul 19;25(1):158
AlkB Homolog 5 Regulates Hexokinase 2-Mediated Glycolysis and Participates in the Progression of Endometriosis.
Liu JJ, Fang YQ, Xiong WQ, Liu HW, Li JY, Wang XP, Wang HJ, Zhang L, Liu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70813
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70813
m(6)A alters ribosome dynamics to initiate mRNA degradation.
Murakami S, Olarerin-George AO, Liu JF, Zaccara S, Hawley B, Jaffrey SR
Cell 2025 Jul 10;188(14):3728-3743.e20
Cell 2025 Jul 10;188(14):3728-3743.e20
ALKBH5 regulates intrauterine adhesion progression through m6A dependent FABP4 mRNA stabilization and serum lipid metabolism.
Yang X, Feng Q
Communications biology 2025 Jul 1;8(1):973
Communications biology 2025 Jul 1;8(1):973
N6-methyladenosine-modified circQKI inhibits prostate cancer docetaxel-sensitivity via miR-188-3p/Beclin-1 pathway.
Zhao T, Li K, Zhang Y, Dong Y, Li Y, Pang M, Wei Y, Yao B, Zhu Q
Life sciences 2025 Jul 1;372:123646
Life sciences 2025 Jul 1;372:123646
METTL3 regulates Ambra1 expression in an m6A-YTHDF2-dependent manner to promote mantle cell lymphoma progression.
Li S, Jiang Z, Wei W, Deng S, Duan T
Journal of translational medicine 2025 Jul 1;23(1):703
Journal of translational medicine 2025 Jul 1;23(1):703
METTL3-Dependent YTHDF2 Mediates TSC1 Expression to Regulate Alveolar Epithelial Mesenchymal Transition and Promote Idiopathic Pulmonary Fibrosis.
Liu M, Sheng Y, Li M, Pan T, Jiang W, Zhang Y, Pan X, Huang C, Li J, Wang Y
Journal of cellular physiology 2025 Jan;240(1):e31473
Journal of cellular physiology 2025 Jan;240(1):e31473
Lipoxin A4 suppresses neutrophil extracellular traps formation through the FPR2-dependent regulation of METTL3 in ischemic stroke.
Wei N, Lu T, Gu J, Cai H
Brain research bulletin 2025 Jan;220:111178
Brain research bulletin 2025 Jan;220:111178
POU4F1 enhances lung cancer gemcitabine resistance by regulating METTL3-dependent TWF1 mRNA N6 adenosine methylation.
Tang J, Liu Z, Xie G, Wang C, Jiang Y
3 Biotech 2025 Jan;15(1):7
3 Biotech 2025 Jan;15(1):7
N6-methyladenosine-modified circRPS6KC1 regulated cellular senescence in prostate cancer via FOXM1/PCNA axis.
Shu X, Yi J, Li J, Ying Y, Tang Y, Chen Z, Wang J, Zhang F, Lu D, Wu Y, Sun J, Lin S, Qi Z, Chen D, Wang X, Chen H, Xie L, Ma X, Luo J
Cellular signalling 2025 Jan;125:111510
Cellular signalling 2025 Jan;125:111510
N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.
Rui Y, Zhang H, Yu K, Qiao S, Gao C, Wang X, Yang W, Asadikaram G, Li Z, Zhang K, Peng J, Li J, He J, Wang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2408488
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2408488
METTL3 stabilizes SERPINE2 via the m6A modification to drive the malignant progression of gastric signet ring cell carcinoma.
Yan T, Wang Q, Liu Y
Translational cancer research 2025 Jan 31;14(1):78-92
Translational cancer research 2025 Jan 31;14(1):78-92
IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression.
Tian Q, Dan G, Wang X, Zhu J, Chen C, Tang D, Wang Z, Chen D, Lei S, Yang C, Wang H, Guo B, Jin B, Chen T, Tang L
Cell death discovery 2025 Jan 25;11(1):22
Cell death discovery 2025 Jan 25;11(1):22
YTH N(6)-methyladenosine RNA Binding Protein 1 Inhibits Smooth Muscle Cell Phenotypic Modulation and Neointimal Hyperplasia.
Tian K, Cai D, Yang S, Zhao W, Mei X, Chen SY
Cells 2025 Jan 22;14(3)
Cells 2025 Jan 22;14(3)
The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.
Lan T, Gao F, Cai Y, Lv Y, Zhu J, Liu H, Xie S, Wan H, He H, Xie K, Liu C, Wu H
Nature communications 2025 Jan 2;16(1):333
Nature communications 2025 Jan 2;16(1):333
Single-base m(6)A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4(+) T cells.
Huang S, Zhao Y, Phillips S, Wilms B, He C, Wu L
bioRxiv : the preprint server for biology 2025 Jan 2;
bioRxiv : the preprint server for biology 2025 Jan 2;
ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization.
Guan Z, Wang X, Xu C, Lu R
Heliyon 2025 Jan 15;11(1):e41495
Heliyon 2025 Jan 15;11(1):e41495
N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatocellular carcinoma.
Fang R, Jia Z, Xin Y, Zhao K, Qin W, Lu H, Zhou Y, Yang Y, Fang H
Cell death discovery 2025 Jan 10;11(1):3
Cell death discovery 2025 Jan 10;11(1):3
N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.
Feng S, Zhang Q, Liu Q, Huang C, Zhang H, Wang F, Zhu Y, Jian Q, Chen X, Jiang Q, Yan B
Diabetes 2025 Jan 1;74(1):82-95
Diabetes 2025 Jan 1;74(1):82-95
Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis.
Zheng W, Fu Z, Tan X, Liang X, Cao L
Biochemical genetics 2025 Feb;63(1):433-464
Biochemical genetics 2025 Feb;63(1):433-464
Organophosphate flame retardant triphenyl phosphate (TPhP) induced colonic fibrosis by bringing about epithelial-mesenchymal transition.
Peng C, Wang M, Zheng C, Zhang X, Chen Y, Wang L
Ecotoxicology and environmental safety 2025 Feb;291:117913
Ecotoxicology and environmental safety 2025 Feb;291:117913
The mRNA Stability of PIEZO1, Regulated by Methyltransferase-Like 3 via N(6)-Methylation of Adenosine Modification in a YT521-B Homology Domain Family 2-Dependent Manner, Facilitates the Progression of Diabetic Retinopathy.
Han N, Yu N, Yu L
The American journal of pathology 2025 Feb;195(2):265-280
The American journal of pathology 2025 Feb;195(2):265-280
N(6)-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
Zhang Y, Shen G, Zhang D, Meng T, Lv Z, Chen L, Li J, Li K
Clinical and translational medicine 2025 Feb;15(2):e70228
Clinical and translational medicine 2025 Feb;15(2):e70228
SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.
Xin W, Zhou J, Peng Y, Gong S, Liao W, Wang Y, Huang X, Mao Y, Yao M, Qin S, Xiong J, Li Y, Lan Q, Huang Y, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233
Mettl3-Mediated N6-Methyladenosine Modification Mitigates Ganglion Cell Loss and Retinal Dysfunction in Retinal Ischemia-Reperfusion Injury by Inhibiting FoxO1-Mediated Autophagy.
Zhu F, Feng J, Pan Y, Ouyang L, He T, Xing Y
Investigative ophthalmology & visual science 2025 Feb 3;66(2):58
Investigative ophthalmology & visual science 2025 Feb 3;66(2):58
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
Ding K, Zhang Z, Han Z, Shi L, Li X, Liu Y, Li Z, Zhao C, Cui Y, Zhou L, Xu B, Zhou W, Zhao Y, Wang Z, Huang H, Xie L, Chen XW, Chen Z
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
The YTHDC1 reader protein recognizes and regulates the lncRNA MEG3 following its METTL3-mediated m(6)A methylation: a novel mechanism early during radiation-induced liver injury.
Song GY, Yu QH, Xing XK, Fan XM, Xu SG, Zhang WB, Wu YY, Zhang N, Chao TZ, Wang F, Ding CS, Guo CY, Ma L, Sun CY, Duan SY, Xu P
Cell death & disease 2025 Feb 24;16(1):127
Cell death & disease 2025 Feb 24;16(1):127
Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation.
Quarto G, Li Greci A, Bizet M, Penning A, Primac I, Murisier F, Garcia-Martinez L, Borges RL, Gao Q, Cingaram PKR, Calonne E, Hassabi B, Hubert C, Herpoel A, Putmans P, Mies F, Martin J, Van der Linden L, Dube G, Kumar P, Soin R, Kumar A, Misra A, Lan J, Paque M, Gupta YK, Blomme A, Close P, Estève PO, Caine EA, Riching KM, Gueydan C, Daniels DL, Pradhan S, Shiekhattar R, David Y, Morey L, Jeschke J, Deplus R, Collignon E, Fuks F
Cell 2025 Feb 20;188(4):998-1018.e26
Cell 2025 Feb 20;188(4):998-1018.e26
Hic-5 deficiency attenuates MAFLD by inhibiting neutrophils migration via the CXCL1-CXCR2 axis.
Ren B, Li H, Liu S, Huang Z, Bai J, Jiang Z, Xu T, Gu B, Yu W, Sun L, Tan P, Fu W
Journal of gastroenterology 2025 Dec;60(12):1535-1553
Journal of gastroenterology 2025 Dec;60(12):1535-1553
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Chen T, Wang J, Xu Y, Zhu Y, Jin Y, Fan Q
Renal failure 2025 Dec;47(1):2521455
Renal failure 2025 Dec;47(1):2521455
METTL3 promotes podocyte pyroptosis in diabetic nephropathy through N(6)-methyladenosine modification of TRIM29 mRNA.
Xu X, Huang X, Zhang C, Mi X, Zhang C, Hua F, Zhang L
Renal failure 2025 Dec;47(1):2497492
Renal failure 2025 Dec;47(1):2497492
Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC).
Shaikh S, Zhao X, Wagner RT, Pan X, Hlady RA, Wang L, Ho TH, Robertson KD
Epigenetics 2025 Dec;20(1):2456418
Epigenetics 2025 Dec;20(1):2456418
Novel role of FTO in regulation of gut-brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure.
Chen R, Chai X, Zhang Y, Zhou T, Xia Y, Jiang X, Lv B, Zhang J, Zhou L, Tian X, Wang R, Mao L, Zhao F, Zhang H, Hu J, Qiu J, Zou Z, Chen C
Gut microbes 2025 Dec;17(1):2438471
Gut microbes 2025 Dec;17(1):2438471
SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication.
Zhou S, Hui X, Wang W, Zhao C, Jin M, Qin Y, Chen M
Emerging microbes & infections 2025 Dec;14(1):2447620
Emerging microbes & infections 2025 Dec;14(1):2447620
METTL3-mediated m(6)A modification regulates OSCC progression via the HNRNPA2B1/FOXQ1 axis.
Wang X, Li Y
Scientific reports 2025 Dec 9;16(1):2362
Scientific reports 2025 Dec 9;16(1):2362
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Zhou P, Huang Y, Wang Z, Chen D, Long B, Qin P, Li Y, Yang C, Li Q
Molecular biomedicine 2025 Dec 29;6(1):150
Molecular biomedicine 2025 Dec 29;6(1):150
IGF2BP3-STAT3-METTL3 axis promotes malignant progression in hepatocellular carcinoma (HCC).
Xu Y, Cao Y, Yang J, Yu X, Yang L, Xie Y, Zhao J, Zhang Y
Human genomics 2025 Dec 25;20(1):21
Human genomics 2025 Dec 25;20(1):21
USP25 deubiquitinates cytosolic METTL3 to impede glioma proliferation via an m6A-independent pathway.
Zhang B, Han W, Gao X, Li W, Yu J, Zhao W, He J, Qiu X, Lu Z, Zhou L, Hu Y, Xie Y, Geng Y, Lu H, Zhao W, Liao X, Chen S, Liu X, Chen S, Tan G, Zhang Y, Wang Z
iScience 2025 Dec 19;28(12):113918
iScience 2025 Dec 19;28(12):113918
Cistanche tubulosa improves peripheral neuropathy in MPTP-induced PD mice based on regulation of m6A methylation.
Li Y, Jia W, Hu J, Zhang B, Qi X, Yang J, Yang X
Animal models and experimental medicine 2025 Aug;8(8):1441-1455
Animal models and experimental medicine 2025 Aug;8(8):1441-1455
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Liu X, Cui Y, Gong J, Yu X, Cui Y, Xuan Y
Oncogene 2025 Aug;44(29):2474-2489
Oncogene 2025 Aug;44(29):2474-2489
Identification of the Pro-Tumorigenic Role of the ELK4-METTL3-CEMIP Axis in Colorectal Carcinoma: Promotion of Cancer Cell Stemness and Malignant Phenotypes.
Zhang L, Yang F, Zhang X, Dong D, Fang X, Meng L, Chang T
Journal of gastroenterology and hepatology 2025 Aug;40(8):1963-1975
Journal of gastroenterology and hepatology 2025 Aug;40(8):1963-1975
Transcriptome-wide regulation of folate on neural mRNA m(6)A methylome via carbon metabolism in Drosophila and mammals.
Liu A, Huo Z, Xu Z, Liu S, Jiao Y, Li R, Lu Y, Yang M, Huang J, Huang C, Wang X
Communications biology 2025 Aug 4;8(1):1151
Communications biology 2025 Aug 4;8(1):1151
METTL3 and METTL14 drive pancreatic adenocarcinoma progression via m6A-dependent alternative splicing in PANC-1 cells.
Tang B, Wang L, Wei D, Wang T, Zou R, Su K, Wu T, Cun D, Wang Q
Discover oncology 2025 Aug 21;16(1):1590
Discover oncology 2025 Aug 21;16(1):1590
GPCPD1 is regulated by METTL3/IGF2BP3 dependent m(6)A modification to affect pig muscle fiber type conversion.
Yang Y, Tan B, Xiao L, Huang H, Xu W, Su J, Zhao Y, Hong L, Cai G, Li Z, Dai L, Gu T
Gene 2025 Aug 20;962:149578
Gene 2025 Aug 20;962:149578
METTL3 promotes peritoneal metastasis of colorectal cancer through regulating m6A modification of NRXN3 mRNA.
Lan TH, Li W, Wang X, Geng YJ, Pang B, Kang LF, Li DY, Pang LY, Zhang XX, Zhang CQ, Wang GQ, Li ZX, Zhou CM, Jiang X, Zhao ZR
iScience 2025 Aug 15;28(8):113165
iScience 2025 Aug 15;28(8):113165
hUC-MSC-derived extracellular vesicles protect lung tissue from cigarette smoke-induced injury by upregulating the METTL3-mediated m(6)A modification.
Wen J, Xu J, Li Y, Ma L, Wang J, Huang S, Yi X
American journal of physiology. Cell physiology 2025 Aug 1;329(2):C426-C439
American journal of physiology. Cell physiology 2025 Aug 1;329(2):C426-C439
Melatonin via MTNR1B regulates METTL3 to protect ileum cell differentiation.
Li Y, Sun Y, Chen Y, Dong Y
Inflammation 2025 Apr;48(2):935-949
Inflammation 2025 Apr;48(2):935-949
An epitranscriptomic program maintains skeletal stem cell quiescence via a METTL3-FEM1B-GLI1 axis.
Wang J, Liu W, Zhang T, Cui M, Gao K, Lu P, Yao S, Cao Z, Zheng Y, Tian W, Li Y, Yin R, Hu J, Han G, Liang J, Zhou F, Chai J, Zhang H
The EMBO journal 2025 Apr;44(8):2263-2278
The EMBO journal 2025 Apr;44(8):2263-2278
Mechanistic study of METTL3 inducing ferroptosis to promote cervical cancer progression through mediating m6A modification of COTE-1.
Min L, Huo F, Zhu Z, Din L, Zhang L, Xu Y, Xing X, Zhang P, Wang Q
Cellular signalling 2025 Apr;128:111649
Cellular signalling 2025 Apr;128:111649
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.
He X, Li Y, Li J, Li Y, Chen S, Yan X, Xie Z, Du J, Chen G, Song J, Mei Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413121
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413121
Spatial control of m(6)A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin.
Huang X, Zhang J, Cun Y, Ye M, Ren Z, Guo W, Ma X, Liu J, Luo W, Sun X, Shao J, Wu Z, Zhu X, Wang J
Molecular cell 2025 Apr 3;85(7):1349-1365.e10
Molecular cell 2025 Apr 3;85(7):1349-1365.e10
IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression.
Luo X, Xie L, Ma X, Chen N, Xu J, Jiang X, Liu X, Yang Y, Liu T, Yi P, Xu J
Communications biology 2025 Apr 29;8(1):680
Communications biology 2025 Apr 29;8(1):680
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms.
Xia Q, Zhong R, Zheng J, Zhou X, Zhao X, Wang S, Wang B, Wu Q, Xie C, Kong B, Zhang Q, Huang T
Cell reports 2025 Apr 22;44(4):115484
Cell reports 2025 Apr 22;44(4):115484
METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation.
Tong Y, Chen Z, Wu J, Huang Q, He Y, Shang H, Xia D, Peng E, Wang Z, Liang X, Tang K
Journal for immunotherapy of cancer 2025 Apr 15;13(4)
Journal for immunotherapy of cancer 2025 Apr 15;13(4)
METTL3 Promotes Cutaneous T-Cell Lymphoma Progression by Regulating ARHGEF12 Expression.
Gan L, Kong Y, Shi H, Zhang C, Tian C, Chen H
International journal of molecular sciences 2025 Apr 11;26(8)
International journal of molecular sciences 2025 Apr 11;26(8)
METTL3 Plays Regulatory Roles in Acute Pneumonia during Staphylococcus aureus Infection.
Wu M, Nie Q, Zhang Y, Qin J, Ye L, Zhao R, Dai M, Wu M
ACS infectious diseases 2025 Apr 11;11(4):905-916
ACS infectious diseases 2025 Apr 11;11(4):905-916
YTHDF3 drives tumor growth and metastasis by recruiting eIF4B to promote Notch2 translation in breast cancer.
Chen H, Lin L, Qiao Z, Pei Y, Gao Y, Lou K, Yang L, Li C, He Y, Bai J, Zhang G
Cancer letters 2025 Apr 1;614:217534
Cancer letters 2025 Apr 1;614:217534
AP001885.4 promotes the proliferation of esophageal squamous cell carcinoma cells by histone lactylation- and NF-κB (p65)-dependent transcription activation and METTL3-mediated mRNA stability of c-myc.
Fu C, Jiang W, Wang C, Song SJ, Tao H, Zhang XG, Li WT, Jin X, Yu BB, Hao JJ, Sun WJ, Bai J, Shi ZZ
Animal cells and systems 2024;28(1):536-550
Animal cells and systems 2024;28(1):536-550
Evidence for the potential role of m6A modification in regulating autophagy in models of amyotrophic lateral sclerosis.
An D, Han J, Fang P, Bu Y, Ji G, Liu M, Deng J, Song X
CytoJournal 2024;21:33
CytoJournal 2024;21:33
The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation.
Li Y, Ma B, Wang Z, Chen Y, Dong Y
International journal of biological sciences 2024;20(7):2491-2506
International journal of biological sciences 2024;20(7):2491-2506
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
Hu Y, Li Y, Xiong H, Zhang Y, Wang F, Zhuo W, Zeng Z, Zhao Y, Wang H, Hu P, Han S, Huang Y, Lv G, Zhao G
International journal of biological sciences 2024;20(11):4341-4363
International journal of biological sciences 2024;20(11):4341-4363
m(6)A modification enhances the stability of CDC25A promotes tumorigenicity of esophagogastric junction adenocarcinoma via cell cycle.
Pan Y, Feng H, Zhou J, Zhang W, Liu Y, Zheng J, Wang J, Gao S, Li Y
International journal of biological sciences 2024;20(11):4209-4221
International journal of biological sciences 2024;20(11):4209-4221
METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients.
Tan Q, Yang L, Yuan S, Zheng D, Lin Y, Chen K, He Y, Chen S, Hao J, Dai J, He S, Mao F, Leng X, Jiang H, Yang J
Open medicine (Warsaw, Poland) 2024;19(1):20240899
Open medicine (Warsaw, Poland) 2024;19(1):20240899
METTL3 Inhibition Suppresses Cell Growth and Survival in Colorectal Cancer via ASNS Downregulation.
Yu Y, Hai Y, Zhou H, Bao W, Hu X, Gao Y, Wu J
Journal of Cancer 2024;15(15):4853-4865
Journal of Cancer 2024;15(15):4853-4865
Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolism.
Zhao Y, Han S, Zeng Z, Zheng H, Li Y, Wang F, Huang Y, Zhao Y, Zhuo W, Lv G, Wang H, Zhao G, Zhao E, Hu Y, Hu P, Zhao G
Theranostics 2024;14(18):7088-7110
Theranostics 2024;14(18):7088-7110
N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.
Jiang S, Gao L, Li J, Zhang F, Zhang Y, Liu J
Frontiers in cell and developmental biology 2024;12:1383232
Frontiers in cell and developmental biology 2024;12:1383232
Changes of m(6)A Regulatory Proteins and Nrf2 Signaling Molecules in Liver Tissue of Type 2 Diabetes Mellitus Rats.
Wang N, Yang J, Liu X, Liu G, He Z, Gu S
Cell biochemistry and biophysics 2024 Sep;82(3):2217-2226
Cell biochemistry and biophysics 2024 Sep;82(3):2217-2226
Dexmedetomidine improves mitophagy and pyroptosis through the ALKBH5/FUNDC1 axis during epidural-related maternal fever.
Xiao F, Yao H, Qian J, Huang J, Xia G
Advances in medical sciences 2024 Sep;69(2):272-280
Advances in medical sciences 2024 Sep;69(2):272-280
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
Cai Y, Zhou J, Xu A, Huang J, Zhang H, Xie G, Zhong K, Wu Y, Ye P, Wang H, Niu H
The Journal of biological chemistry 2024 Sep;300(9):107598
The Journal of biological chemistry 2024 Sep;300(9):107598
LONP1 alleviates ageing-related renal fibrosis by maintaining mitochondrial homeostasis.
Zhang C, Shen S, Xu L, Li M, Tian B, Yao L, Zhu X
Journal of cellular and molecular medicine 2024 Sep;28(17):e70090
Journal of cellular and molecular medicine 2024 Sep;28(17):e70090
H3K36 methyltransferase SMYD2 affects cell proliferation and migration in Hirschsprung's disease by regulating METTL3.
Hou X, Yang Y, Wang C, Huang Z, Zhang M, Yang J, Li N, Yang H, Yang L, Wu K
Journal of cellular physiology 2024 Sep;239(9):e31402
Journal of cellular physiology 2024 Sep;239(9):e31402
METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
Wang P, Zhou W, Chen F, Zhang X, Zhang Q, Chen Y, Zhang N
Experimental gerontology 2024 Sep;194:112496
Experimental gerontology 2024 Sep;194:112496
One-carbon metabolism supports S-adenosylmethionine and m6A methylation to control the osteogenesis of bone marrow stem cells and bone formation.
Zhang W, Bai Y, Hao L, Zhao Y, Zhang L, Ding W, Qi Y, Xu Q
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 Sep 2;39(9):1356-1370
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 Sep 2;39(9):1356-1370
METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma.
Wang J, Xiu M, Wang J, Gao Y, Li Y
Journal of hematology & oncology 2024 Sep 2;17(1):78
Journal of hematology & oncology 2024 Sep 2;17(1):78
Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2.
Zhu M, Huang F, Sun H, Liu K, Chen Z, Yu B, Hao H, Liu H, Ding S, Zhang X, Liu L, Zhang K, Ren J, Liu Y, Liu H, Shan C, Guan W
Signal transduction and targeted therapy 2024 Sep 18;9(1):243
Signal transduction and targeted therapy 2024 Sep 18;9(1):243
BUB1 potentiates gastric cancer proliferation and metastasis by activating TRAF6/NF-κB/FGF18 through m6A modification.
Wang K, Shen K, Wang J, Yang K, Zhu J, Chen Y, Liu X, He Y, Zhu X, Zhan Q, Shi T, Li R
Life sciences 2024 Sep 15;353:122916
Life sciences 2024 Sep 15;353:122916
N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication.
Zhao H, Gao Z, Sun J, Qiao H, Zhao Y, Cui Y, Zhao B, Wang W, Chiu S, Chuai X
Viruses 2024 Sep 11;16(9)
Viruses 2024 Sep 11;16(9)
PCAF-mediated acetylation of METTL3 impairs mRNA translation efficiency in response to oxidative stress.
Liu C, Yu M, Wang M, Yang S, Fu Y, Zhang L, Zhu C, Zhang H
Science China. Life sciences 2024 Oct;67(10):2157-2168
Science China. Life sciences 2024 Oct;67(10):2157-2168
Methyltransferase-Like 3-Mediated N6-Methyladenosine RNA Methylation Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Pyroptosis by Targeting PTEN.
Jiang Y, Liu H, Shi R, Hao Y, Zhang J, Xin W, Li Y, Ma C, Zheng X, Zhang L, Zhao X, Zhu D
Journal of the American Heart Association 2024 Oct;13(19):e034470
Journal of the American Heart Association 2024 Oct;13(19):e034470
Nuclear retention coupled with sequential polyadenylation dictates post-transcriptional m(6)A modification in the nucleus.
Tang P, Yang J, Chen Z, Du C, Yang Y, Zhao H, Huang L, Li G, Liu F, Dong B, Shan T, Bao X, Zhou Y
Molecular cell 2024 Oct 3;84(19):3758-3774.e10
Molecular cell 2024 Oct 3;84(19):3758-3774.e10
Coxsackievirus B3-Induced m(6)A Modification of RNA Enhances Viral Replication via Suppression of YTHDF-Mediated Stress Granule Formation.
Zhao G, Zhang HM, Chen YT, Shi K, Aghakeshmiri S, Yip F, Luo H, McManus B, Yang D
Microorganisms 2024 Oct 26;12(11)
Microorganisms 2024 Oct 26;12(11)
Nr-CWS regulates METTL3-mediated m(6)A modification of CDS2 mRNA in vascular endothelial cells and has prognostic significance.
Zhang J, Chen F, Wei W, Ning Q, Zhu D, Fan J, Wang H, Wang J, Zhang A, Jin P, Li Q
Communications biology 2024 Oct 18;7(1):1348
Communications biology 2024 Oct 18;7(1):1348
Single-cell sequencing reveals that specnuezhenide protects against osteoporosis via activation of METTL3 in LEPR(+) BMSCs.
Wei J, Dong R, Ma Y, Wang J, Tian S, Tu X, Mu Z, Liu YQ
European journal of pharmacology 2024 Oct 15;981:176908
European journal of pharmacology 2024 Oct 15;981:176908
ZNF740 facilitates the malignant progression of hepatocellular carcinoma via the METTL3/HIF‑1A signaling axis.
Zhang H, Han B, Tian S, Gong Y, Liu L
International journal of oncology 2024 Nov;65(5)
International journal of oncology 2024 Nov;65(5)
TGF-β Promotes Hepatocellular Carcinoma Metastasis Through Through m6A Modification of PCDHGA9.
Wang H, Guan W, Zhang X, Wu Y, Ou Y, Zhang Y, Zeng Z, Yao H
Cancer biotherapy & radiopharmaceuticals 2024 Nov;39(9):644-653
Cancer biotherapy & radiopharmaceuticals 2024 Nov;39(9):644-653
N(6)-methyladenosine modification of SLC38A7 promotes cell migration, invasion, oxidative phosphorylation, and mitochondrial function in gastric cancer.
Hua Y, Hua WJ, Feng CC, Zhu QW
The Journal of biological chemistry 2024 Nov;300(11):107843
The Journal of biological chemistry 2024 Nov;300(11):107843
N6-methyladenosine RNA methylation modification regulates the transcription of viral-derived E (XSR) miRNAs to promote ALV-J replication.
Cao Y, Ren Q, Chang S, Cui W, Zhao P, Wang Y
Veterinary microbiology 2024 Nov;298:110218
Veterinary microbiology 2024 Nov;298:110218
Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy.
Wu K, Li S, Hong G, Dong H, Tang T, Liu H, Jin L, Lin S, Ji J, Hu M, Chen S, Wu H, Luo G, Wu H, Kong X, Chen J, He J, Wu H
Clinical and translational medicine 2024 Nov;14(11):e70089
Clinical and translational medicine 2024 Nov;14(11):e70089
METTL3 -mediated m6A modification of circ_0000620 regulates cisplatin sensitivity and apoptosis in lung adenocarcinoma via the MiR-216b-5p/KRAS axis.
Li X, Wang Y, Cheng J, Qiu L, Wang R, Zhang Y, Wang H
Cellular signalling 2024 Nov;123:111349
Cellular signalling 2024 Nov;123:111349
m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells.
Zhou Q, Liu X, Lu H, Li N, Meng J, Huang J, Zhang Z, Liu J, Fan W, Li W, Li X, Liu X, Zuo H, Yang P, Hou S
Journal of neuroinflammation 2024 Nov 6;21(1):289
Journal of neuroinflammation 2024 Nov 6;21(1):289
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2.
Lv D, Dixit D, Cruz AF, Kim LJY, Duan L, Xu X, Wu Q, Zhong C, Lu C, Gersey ZC, Gimple RC, Xie Q, Yang K, Liu X, Fang X, Wu X, Kidwell RL, Wang X, Bao S, He HH, Locasale JW, Agnihotri S, Rich JN
Cell metabolism 2024 Nov 5;36(11):2419-2436.e8
Cell metabolism 2024 Nov 5;36(11):2419-2436.e8
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Zhu X, Wang J, Zhang H, Yue H, Zhu J, Li J, Wang K, Shen K, Yang K, Leng X, Xi Q, Shi T
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Distinct pathways utilized by METTL3 to regulate antiviral innate immune response.
Hao H, Zhang F, Chen Z, Tan Z, Zhang H, Feng X, Zhang X, Deng T, Zhan G, Luo T, Zhang K, Ding S, Liu H, Zheng Z, Wang Y, Huang F, Guan W
iScience 2024 Nov 15;27(11):111071
iScience 2024 Nov 15;27(11):111071
Epitranscriptomic m(6)A modifications during reactivation of HIV-1 latency in CD4(+) T cells.
Mishra T, Phillips S, Zhao Y, Wilms B, He C, Wu L
mBio 2024 Nov 13;15(11):e0221424
mBio 2024 Nov 13;15(11):e0221424
Negative Regulation of LINC01013 by METTL3 and YTHDF2 Enhances the Osteogenic Differentiation of Senescent Pre-Osteoblast Cells Induced by Hydrogen Peroxide.
Song J, Wang Y, Zhu Z, Wang W, Yang H, Shan Z
Advanced biology 2024 May;8(5):e2300642
Advanced biology 2024 May;8(5):e2300642
20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3.
Cheng S, Chen L, Ying J, Wang Y, Jiang W, Zhang Q, Zhang H, Wang J, Wang C, Wu H, Ye J, Zhang L
Journal of ginseng research 2024 May;48(3):298-309
Journal of ginseng research 2024 May;48(3):298-309
Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.
Zhang X, Li Z, Peng Q, Liu C, Wu Y, Wen Y, Zheng R, Xu C, Tian J, Zheng X, Yan Q, Wang J, Ma J
The Journal of biological chemistry 2024 May;300(5):107226
The Journal of biological chemistry 2024 May;300(5):107226
IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis.
Nan Y, Chen M, Wu W, Huang R, Sun W, Lu Q, Gu Z, Mao X, Xu H, Wang Y
Cell death discovery 2024 May 3;10(1):215
Cell death discovery 2024 May 3;10(1):215
Micropeptide AF127577.4-ORF hidden in a lncRNA diminishes glioblastoma cell proliferation via the modulation of ERK2/METTL3 interaction.
Du B, Zhang Z, Jia L, Zhang H, Zhang S, Wang H, Cheng Z
Scientific reports 2024 May 27;14(1):12090
Scientific reports 2024 May 27;14(1):12090
KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m(6)A reader YTHDC1 protein degradation.
Yang Y, Zhang Y, Chen G, Sun B, Luo F, Gao Y, Feng H, Li Y
Journal of experimental & clinical cancer research : CR 2024 May 14;43(1):141
Journal of experimental & clinical cancer research : CR 2024 May 14;43(1):141
Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis.
Ji W, Huo Y, Zhang Y, Qian X, Ren Y, Hu C, Zhang J
International immunopharmacology 2024 May 10;132:111968
International immunopharmacology 2024 May 10;132:111968
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Ou X, Tan Y, Xie J, Yuan J, Deng X, Shao R, Song C, Cao X, Xie X, He R, Li Y, Tang H
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
Dynamics of N6-methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc.
Liu L, Sun H, Zhang Y, Liu C, Zhuang Y, Liu M, Ai X, Long D, Huang B, Li C, Zhou Y, Dong S, Feng C
JOR spine 2024 Mar;7(1):e1316
JOR spine 2024 Mar;7(1):e1316
Cell type-specific regulation of m(6) A modified RNAs in the aging Drosophila brain.
Perlegos AE, Byrns CN, Bonini NM
Aging cell 2024 Mar;23(3):e14076
Aging cell 2024 Mar;23(3):e14076
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
Yuan D, Li H, Dai W, Zhou X, Zhou W, He L
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022
METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN.
Chen S, Duan X, He Y, Chen W
Bioscience reports 2024 Mar 29;44(3)
Bioscience reports 2024 Mar 29;44(3)
IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development.
Lv L, Wei Q, Zhang J, Dong Y, Shan Z, Chang N, Zhao Y, Bian P, Yi Q
Cellular & molecular biology letters 2024 Mar 19;29(1):39
Cellular & molecular biology letters 2024 Mar 19;29(1):39
N(6)-methyladenosine-modified VGLL1 promotes ovarian cancer metastasis through high-mobility group AT-hook 1/Wnt/β-catenin signaling.
Li H, Cai L, Pan Q, Jiang X, Zhao J, Xiang T, Tang Y, Wang Q, He J, Weng D, Zhang Y, Liu Z, Xia J
iScience 2024 Mar 15;27(3):109245
iScience 2024 Mar 15;27(3):109245
Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.
Liu X, Wang N, Gu S, He Z
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289
METTL3-mediated pre-miR-665/DLX3 m(6)A methylation facilitates the committed differentiation of stem cells from apical papilla.
Gu T, Guo R, Fang Y, Xiao Y, Chen L, Li N, Ge XK, Shi Y, Wu J, Yan M, Yu J, Li Z
Experimental & molecular medicine 2024 Jun;56(6):1426-1438
Experimental & molecular medicine 2024 Jun;56(6):1426-1438
I-FABP protein/mRNA and IL-6 as biomarkers of intestinal barrier dysfunction in neonates with necrotizing enterocolitis and SPF BALB/c mouse models.
Chen J, Yan Z, Lin Z, Fan Y, Bao X, Chen X, Zheng A
The Journal of international medical research 2024 Jun;52(6):3000605241254788
The Journal of international medical research 2024 Jun;52(6):3000605241254788
METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer.
Yuan XN, Shao YC, Guan XQ, Liu Q, Chu MF, Yang ZL, Li H, Zhao S, Tian YH, Zhang JW, Wei L
Biochimica et biophysica acta. Molecular cell research 2024 Jun;1871(5):119716
Biochimica et biophysica acta. Molecular cell research 2024 Jun;1871(5):119716
Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
Hu W, Wang M, Sun G, Zhang L, Lu H
Cellular signalling 2024 Jun;118:111139
Cellular signalling 2024 Jun;118:111139
m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation.
Klein P, Petrić Howe M, Harley J, Crook H, Esteban Serna S, Roumeliotis TI, Choudhary JS, Chakrabarti AM, Luisier R, Patani R, Ramos A
Nature communications 2024 Jun 6;15(1):4819
Nature communications 2024 Jun 6;15(1):4819
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions.
Xian G, Huang R, Xu M, Zhao H, Xu X, Chen Y, Ren H, Xu D, Zeng Q
Experimental & molecular medicine 2024 Jul;56(7):1560-1573
Experimental & molecular medicine 2024 Jul;56(7):1560-1573
Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.
Yang F, Wang P, Dong X, Dai W, Chen W, Yuan G, Bai D, Xu H
Oral diseases 2024 Jul;30(5):3308-3320
Oral diseases 2024 Jul;30(5):3308-3320
Influence of METTL3 knockdown on PDLSC osteogenesis in E. coli LPS-induced inflammation.
Chen H, Peng L, Wang Z, He Y, Zhang X
Oral diseases 2024 Jul;30(5):3225-3238
Oral diseases 2024 Jul;30(5):3225-3238
LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53-driven tumour progression through miR-5683/FGF2.
Liu N, Jiang X, Zhang G, Long S, Li J, Jiang M, Jia G, Sun R, Zhang L, Zhang Y
Clinical and translational medicine 2024 Jul;14(7):e1777
Clinical and translational medicine 2024 Jul;14(7):e1777
Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m(6)A Epitranscriptome via Bile Acid Metabolism.
Yang M, Zheng X, Fan J, Cheng W, Yan TM, Lai Y, Zhang N, Lu Y, Qi J, Huo Z, Xu Z, Huang J, Jiao Y, Liu B, Pang R, Zhong X, Huang S, Luo GZ, Lee G, Jobin C, Eren AM, Chang EB, Wei H, Pan T, Wang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2307981
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2307981
SUMOylation modification of FTO facilitates oxidative damage response of arsenic by IGF2BP3 in an m6A-dependent manner.
Zhang H, Chen Q, Han H, Guo C, Jiang X, Xia Y, Zhang Y, Zhou L, Zhang J, Tian X, Mao L, Qiu J, Zou Z, Chen C
Journal of hazardous materials 2024 Jul 5;472:134440
Journal of hazardous materials 2024 Jul 5;472:134440
Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway.
Zou D, Yang Y, Ji F, Lv R, Wu H, Hou G, Xu T, Zhou H, Hu C
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16638-16650
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16638-16650
N6-Methyladenosine enhances the translation of ENO1 to promote the progression of bladder cancer by inhibiting PCNA ubiquitination.
Shen C, Liu J, Xie F, Yu Y, Ma X, Hu D, Liu C, Wang Y
Cancer letters 2024 Jul 28;595:217002
Cancer letters 2024 Jul 28;595:217002
Characterization of m6A Modifiers and RNA Modifications in Uterine Fibroids.
George JW, Cancino RA, Griffin Miller JL, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
Endocrinology 2024 Jul 1;165(8)
Endocrinology 2024 Jul 1;165(8)
METTL3 and METTL14 regulate IL-6 expression via RNA m6A modification of zinc transporter SLC39A9 and DNA methylation of IL-6 in periodontal ligament cells.
Huang J, Wang Y, Zhou Y
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119605
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119605
m6A-modified RIPK4 facilitates proliferation and cisplatin resistance in epithelial ovarian cancer.
Yin X, Zhao S, Zhang M, Xing J, Zhou J, Gao W, Chen L, Zhang Y, Lin L, Lu M, Li W, Shang J, Zhu X
Gynecologic oncology 2024 Jan;180:99-110
Gynecologic oncology 2024 Jan;180:99-110
Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.
Zhao S, Dong Y, Li Y, Wang Z, Chen Y, Dong Y
International journal of molecular sciences 2024 Jan 5;25(2)
International journal of molecular sciences 2024 Jan 5;25(2)
METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes.
Hu J, Duan H, Zou J, Ding W, Wei Z, Peng Q, Li Z, Duan R, Sun J, Zhu J
Aging 2024 Jan 4;16(1):299-321
Aging 2024 Jan 4;16(1):299-321
Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis.
Fang X, Ao X, Xiao D, Wang Y, Jia Y, Wang P, Li M, Wang J
Cellular & molecular biology letters 2024 Jan 3;29(1):3
Cellular & molecular biology letters 2024 Jan 3;29(1):3
METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis.
Zhang Y, Kong Y, Zhang W, He J, Zhang Z, Cai Y, Zhao Y, Xu Q
Clinical epigenetics 2024 Jan 24;16(1):18
Clinical epigenetics 2024 Jan 24;16(1):18
Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma.
Dai W, Tian R, Yu L, Bian S, Chen Y, Yin B, Luan Y, Chen S, Fan Z, Yan R, Pan X, Hou Y, Li R, Chen J, Shu M
Nature communications 2024 Jan 2;15(1):131
Nature communications 2024 Jan 2;15(1):131
METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner.
Cao F, Chen G, Xu Y, Wang X, Tang X, Zhang W, Song X, Yang X, Zeng W, Xie J
Cell death & disease 2024 Jan 13;15(1):43
Cell death & disease 2024 Jan 13;15(1):43
FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.
Chen K, Wang Y, Dai X, Luo J, Hu S, Zhou Z, Shi J, Pan X, Cao T, Xia J, Li Y, Wang Z, Ma J
Cell death & disease 2024 Jan 12;15(1):37
Cell death & disease 2024 Jan 12;15(1):37
Targeted m(6)A demethylation of ITGA6 mRNA by a multisite dCasRx-m(6)A editor inhibits bladder cancer development.
Ying X, Huang Y, Liu B, Hu W, Ji D, Chen C, Zhang H, Liang Y, Lv Y, Ji W
Journal of advanced research 2024 Feb;56:57-68
Journal of advanced research 2024 Feb;56:57-68
METTL3 promotes microglial inflammation via MEF2C in spinal cord injury.
Wang D, Qian W, Wu D, Wu Y, Lu K, Zou G
Cell and tissue research 2024 Feb;395(2):189-197
Cell and tissue research 2024 Feb;395(2):189-197
RNA m(6) A Methylation Suppresses Insect Juvenile Hormone Degradation to Minimize Fitness Costs in Response to A Pathogenic Attack.
Guo Z, Bai Y, Zhang X, Guo L, Zhu L, Sun D, Sun K, Xu X, Yang X, Xie W, Wang S, Wu Q, Crickmore N, Zhou X, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2307650
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2307650
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, Wang Y, Wang X, Wang S, Zhao Q, Zeng W, Huang J, Ma H, Xie J
The Journal of clinical investigation 2024 Feb 6;134(6)
The Journal of clinical investigation 2024 Feb 6;134(6)
N(6)-methyladenosine modification of the mRNA for a key gene in purine nucleotide metabolism regulates virus proliferation in an insect vector.
Zhu M, Wu N, Zhong J, Chen C, Liu W, Ren Y, Wang X, Jin H
Cell reports 2024 Feb 27;43(2):113821
Cell reports 2024 Feb 27;43(2):113821
Putrescine promotes MMP9-induced angiogenesis in skeletal muscle through hydrogen peroxide/METTL3 pathway.
Hu C, Ji F, Lv R, Zhou H, Hou G, Xu T
Free radical biology & medicine 2024 Feb 20;212:433-447
Free radical biology & medicine 2024 Feb 20;212:433-447
SALL4 promotes cancer stem-like cell phenotype and radioresistance in oral squamous cell carcinomas via methyltransferase-like 3-mediated m6A modification.
Huang J, Li H, Yang Z, Liu R, Li Y, Hu Y, Zhao S, Gao X, Yang X, Wei J
Cell death & disease 2024 Feb 14;15(2):139
Cell death & disease 2024 Feb 14;15(2):139
METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4.
Shen C, Jiang Y, Lin J, Guo Q, Fang D
Journal of molecular histology 2024 Dec;55(6):1163-1175
Journal of molecular histology 2024 Dec;55(6):1163-1175
HNRNPH1 stabilizes FLOT2 mRNA in a non-canonical m6A-dependent manner to promote malignant progression in nasopharyngeal carcinoma.
Li Q, Liu J, Zeng C, Qin D, Zhang Z, Lv Q, Li J, Huang W
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2279-2295
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2279-2295
m(6)A Modification of Profilin-1 in Vascular Smooth Muscle Cells Drives Phenotype Switching and Neointimal Hyperplasia via Activation of the p-ANXA2/STAT3 Pathway.
Gao XF, Chen AQ, Tang HY, Kong XQ, Zhang H, Wang ZM, Lu W, Wang LG, Wang F, Zhou WY, Gu Y, Zuo GF, Ge Z, Zhang JJ, Chen SL
Arteriosclerosis, thrombosis, and vascular biology 2024 Dec;44(12):2543-2559
Arteriosclerosis, thrombosis, and vascular biology 2024 Dec;44(12):2543-2559
METTL3 governs thymocyte development and thymic involution by regulating ferroptosis.
Jing H, Song J, Sun J, Su S, Hu J, Zhang H, Bi Y, Wu B
Nature aging 2024 Dec;4(12):1813-1827
Nature aging 2024 Dec;4(12):1813-1827
Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication.
Liu B, Tian X, Li L, Zhang R, Wu J, Jiang N, Yuan M, Chen D, Su A, Xu S, Wu Z
EMBO reports 2024 Dec;25(12):5599-5619
EMBO reports 2024 Dec;25(12):5599-5619
Biogenesis of circRBM33 mediated by N6-methyladenosine and its function in abdominal aortic aneurysm.
Xu Y, Weng X, Qiu J, Wang S
Epigenetics 2024 Dec;19(1):2392401
Epigenetics 2024 Dec;19(1):2392401
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
Li F, Wang F, Wang L, Wang J, Wei S, Meng J, Li Y, Feng L, Jiang P
Epigenetics 2024 Dec;19(1):2326868
Epigenetics 2024 Dec;19(1):2326868
EZH2 promotes B-cell autoimmunity in primary Sjogren's syndrome via METTL3-mediated m6A modification.
Yang Y, Li M, Ding L, Zhang Y, Liu K, Liu M, Li Y, Luo H, Zuo X, Zhang H, Guo M
Journal of autoimmunity 2024 Dec;149:103341
Journal of autoimmunity 2024 Dec;149:103341
N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1.
Xu L, Chen S, Fan Q, Zhu Y, Mei H, Wang J, Yu H, Chen Y, Liu F
BMC biology 2024 Dec 31;22(1):302
BMC biology 2024 Dec 31;22(1):302
METTL3 mediates m6A modification of hsa_circ_0072380 to regulate the progression of gestational diabetes mellitus.
Zhang S, Cai S, Ye L, Shen L, Zhu C, Huang J, Wang Z, Chen H
Gene 2024 Dec 30;931:148894
Gene 2024 Dec 30;931:148894
Androgens have therapeutic potential in T2 asthma by mediating METTL3 in bronchial epithelial cells.
Chen Z, Shang Y, Duan W, Zhu L, Ji X, Gong S, Xiang X
International immunopharmacology 2024 Dec 25;143(Pt 1):113322
International immunopharmacology 2024 Dec 25;143(Pt 1):113322
METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Yang J, Jiang T, Lu X, Li X, Zhou X, Guo X, Ma C, Xie X, Li D, Yu S, An J, Zhao B, Li H
International immunopharmacology 2024 Dec 25;143(Pt 1):113308
International immunopharmacology 2024 Dec 25;143(Pt 1):113308
Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis.
Li F, Tao H, Wei Y, Meng R, Li Y, Nie L, Zhang Y, Chang J
Frontiers in bioscience (Landmark edition) 2024 Dec 18;29(12):421
Frontiers in bioscience (Landmark edition) 2024 Dec 18;29(12):421
WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy.
Fu K, Jing C, Shi J, Mao S, Lu R, Yang M, Chen Y, Qian B, Wang Y, Li L
Biochemical and biophysical research communications 2024 Dec 17;738:150524
Biochemical and biophysical research communications 2024 Dec 17;738:150524
High WTAP expression level as a promising biomarker for poor prognosis in colorectal cancer: a pilot study.
Relucenti M, Tito C, Mercantini P, Pilozzi E, Barbaranelli C, Cristiano L, Savarese D, Bastianelli D, Fazi F, Petrozza V, Li X, Chen R, Miglietta S, Familiari G
European journal of histochemistry : EJH 2024 Dec 16;68(4)
European journal of histochemistry : EJH 2024 Dec 16;68(4)
Methyltransferase METTL3 regulates neuropathic pain through m6A methylation modification of SOCS1.
Wu L, Ning P, Liang Y, Wang T, Chen L, Lu D, Tang H
Neuropharmacology 2024 Dec 15;261:110176
Neuropharmacology 2024 Dec 15;261:110176
Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.
Xu XF, Chen J, Long LH, Zhang AM, Yang JW, Li YJ, Chen L, Zhong XL, Xu Y, Cao WY
Journal of affective disorders 2024 Dec 1;366:262-272
Journal of affective disorders 2024 Dec 1;366:262-272
N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer.
Ding P, Wu H, Wu J, Li T, He J, Ju Y, Liu Y, Li F, Deng H, Gu R, Zhang L, Guo H, Tian Y, Yang P, Meng N, Li X, Guo Z, Meng L, Zhao Q
Oncogene 2024 Aug;43(34):2548-2563
Oncogene 2024 Aug;43(34):2548-2563
piR-27222 mediates PM(2.5)-induced lung cancer by resisting cell PANoptosis through the WTAP/m(6)A axis.
Ma W, Xu L, Wang Y, Chen S, Li D, Huo X, Li R, Zhu X, Chen N, Jin Y, Luo J, Li C, Zhao K, Zheng Y, Han W, Yu D
Environment international 2024 Aug;190:108928
Environment international 2024 Aug;190:108928
Epitranscriptomic m(5)C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection.
Wang H, Feng J, Fu Z, Xu T, Liu J, Yang S, Li Y, Deng J, Zhang Y, Guo M, Wang X, Zhang Z, Huang Z, Lan K, Zhou L, Chen Y
Science advances 2024 Aug 9;10(32):eadn9519
Science advances 2024 Aug 9;10(32):eadn9519
METTL3-mediated m(6)A modification of circGLIS3 promotes prostate cancer progression and represents a potential target for ARSI therapy.
Cheng X, Yang H, Chen Y, Zeng Z, Liu Y, Zhou X, Zhang C, Xie A, Wang G
Cellular & molecular biology letters 2024 Aug 14;29(1):109
Cellular & molecular biology letters 2024 Aug 14;29(1):109
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Ni S, Huang X, Li X, Shi C, Fan M, Zhao L, Rong Z, Zhang H
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
METTL3-mediated upregulation of FAM135B promotes EMT of esophageal squamous cell carcinoma via regulating the Wnt/β-catenin pathway.
Zhang TT, Yi W, Dong DZ, Ren ZY, Zhang Y, Du F
American journal of physiology. Cell physiology 2024 Aug 1;327(2):C329-C340
American journal of physiology. Cell physiology 2024 Aug 1;327(2):C329-C340
M6A-methylated circPOLR2B forms an R-loop and regulates the biological behavior of glioma stem cells through positive feedback loops.
Lin H, Cui Z, E T, Xu H, Wang D, Wang P, Ruan X, Liu L, Xue Y
Cell death & disease 2024 Aug 1;15(8):554
Cell death & disease 2024 Aug 1;15(8):554
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
Yang Y, Ren J, Zhang J, Shi H, Wang J, Yan Y
Redox biology 2024 Apr;70:103067
Redox biology 2024 Apr;70:103067
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573
Cancer gene therapy 2024 Apr;31(4):562-573
Highly pathogenic PRRSV upregulates IL-13 production through nonstructural protein 9-mediated inhibition of N6-methyladenosine demethylase FTO.
Gong X, Liang Y, Wang J, Pang Y, Wang F, Chen X, Zhang Q, Song C, Wang Y, Zhang C, Fang X, Chen X
The Journal of biological chemistry 2024 Apr;300(4):107199
The Journal of biological chemistry 2024 Apr;300(4):107199
RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
Sun Y, Chen D, Sun S, Ren M, Zhou L, Chen C, Zhao J, Wei H, Zhao Q, Qi Y, Zhang J, Zhang G, Liu H, Yang Q, Liu Q, Wang Y, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122
CHOP regulated by METTL14-m6A affects cell cycle arrest and regorafenib sensitivity in HCC cells.
Pan Y, You B, Zhao X, Zhang S, Li W
BMC cancer 2024 Apr 25;24(1):525
BMC cancer 2024 Apr 25;24(1):525
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
Cao L, Han R, Zhao Y, Qin X, Li Q, Xiong H, Kong Y, Liu Z, Li Z, Dong F, Li T, Zhao X, Lei L, Zhao Q, Liu D, Wang B, Wu X
Cell reports 2024 Apr 23;43(4):114032
Cell reports 2024 Apr 23;43(4):114032
METTL3 mediates SOX5 m6A methylation in bronchial epithelial cells to attenuate Th2 cell differentiation in T2 asthma.
Chen Z, Shang Y, Zhang X, Duan W, Li J, Zhu L, Ma L, Xiang X, Jia J, Ji X, Gong S
Heliyon 2024 Apr 15;10(7):e28884
Heliyon 2024 Apr 15;10(7):e28884
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression.
Qiao Y, Su M, Zhao H, Liu H, Wang C, Dai X, Liu L, Liu G, Sun H, Sun M, Wang J, Li Z, Fan J, Zhang Q, Li C, Situ F, Xue J, Jia Z, Zhang C, Zhang S, Shan C
Journal of experimental & clinical cancer research : CR 2024 Apr 10;43(1):108
Journal of experimental & clinical cancer research : CR 2024 Apr 10;43(1):108
Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
Guan S, Chen X, Wei Y, Wang F, Xie W, Chen Y, Liang H, Zhu X, Yang Y, Fang W, Huang Y, Zhao H, Zhang X, Liu S, Zhuang W, Huang M, Wang X, Zhang L
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396
METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation.
Han X, Li G, Yang H, Zhang C, Cao Y, Wang N, Ge L, Fan Z
Stem cells international 2023;2023:8992284
Stem cells international 2023;2023:8992284
N6-methyladenosine participates in mouse hippocampus neurodegeneration via PD-1/PD-L1 pathway.
Hu W, Xie H, Zeng Y, Pei P, Zhan X, Wang S, Wang Z
Frontiers in neuroscience 2023;17:1145092
Frontiers in neuroscience 2023;17:1145092
METTL3 promotes drug resistance to oxaliplatin in gastric cancer cells through DNA repair pathway.
Wang Y, Hong Z, Song J, Zhong P, Lin L
Frontiers in pharmacology 2023;14:1257410
Frontiers in pharmacology 2023;14:1257410
Mettl3 synergistically regulates TGF-β/SMAD2/3 to promote proliferation and metastasis of gastric cancer.
Yuan XN, Liu Q, Shao YC, Guan XQ, Yang ZL, Chu MF, Zhang JW, Tian YH, Wei L
American journal of cancer research 2023;13(7):3185-3202
American journal of cancer research 2023;13(7):3185-3202
Dissecting the effects of METTL3 on alternative splicing in prostate cancer.
Wang L, Shi L, Liang Y, Ng JK, Yin CH, Wang L, Hou J, Wang Y, Fung CS, Chiu PK, Ng CF, Tsui SK
Frontiers in oncology 2023;13:1227016
Frontiers in oncology 2023;13:1227016
METTL3-mediated m6A modification of has_circ_0007905 promotes age-related cataract progression through miR-6749-3p/EIF4EBP1.
Li R, Zhu H, Li Q, Tang J, Jin Y, Cui H
PeerJ 2023;11:e14863
PeerJ 2023;11:e14863
Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.
Li X, Fang J, Tao X, Xia J, Cheng B, Wang Y
PeerJ 2023;11:e14824
PeerJ 2023;11:e14824
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.
An X, Wu W, Yang L, Dong J, Liu B, Guo J, Chen J, Guo B, Cao W, Jiang Q
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71
m(6)A RNA methylation orchestrates transcriptional dormancy during paused pluripotency.
Collignon E, Cho B, Furlan G, Fothergill-Robinson J, Martin SB, McClymont SA, Ross RL, Limbach PA, Ramalho-Santos M
Nature cell biology 2023 Sep;25(9):1279-1289
Nature cell biology 2023 Sep;25(9):1279-1289
HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.
Huo FC, Zhu ZM, Du WQ, Pan YJ, Jiang X, Kang MJ, Liu BW, Mou J, Pei DS
Pharmacological research 2023 Sep;195:106863
Pharmacological research 2023 Sep;195:106863
METTL3-stabilized super enhancers-lncRNA SUCLG2-AS1 mediates the formation of a long-range chromatin loop between enhancers and promoters of SOX2 in metastasis and radiosensitivity of nasopharyngeal carcinoma.
Hu X, Wu J, Feng Y, Ma H, Zhang E, Zhang C, Sun Q, Wang T, Ge Y, Zong D, Chen W, He X
Clinical and translational medicine 2023 Sep;13(9):e1361
Clinical and translational medicine 2023 Sep;13(9):e1361
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.
Yu Z, Zheng L, Geng Y, Zhang Y, Wang Y, You G, Cai M, Li M, Cheng X, Zan J
Cellular signalling 2023 Sep;109:110751
Cellular signalling 2023 Sep;109:110751
Rna M(6) a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis.
Li Y, Zhang Y, Zhang T, Ping X, Wang D, Chen Y, Yu J, Liu C, Liu Z, Zheng Y, Yang Y, Ruan C, Li D, Du Z, Wang J, Xu L, Ma X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2300436
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2300436
PARP1 modulates METTL3 promoter chromatin accessibility and associated LPAR5 RNA m(6)A methylation to control cancer cell radiosensitivity.
Sun X, Bai C, Li H, Xie D, Chen S, Han Y, Luo J, Li Y, Ye Y, Jia J, Huang X, Guan H, Long D, Huang R, Gao S, Zhou PK
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Sep 6;31(9):2633-2650
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Sep 6;31(9):2633-2650
Site-specific Atg13 methylation-mediated autophagy regulates epithelial inflammation in PM2.5-induced pulmonary fibrosis.
Ning J, Pei Z, Wang M, Hu H, Chen M, Liu Q, Wu M, Yang P, Geng Z, Zheng J, Du Z, Hu W, Wang Q, Pang Y, Bao L, Niu Y, Leng S, Zhang R
Journal of hazardous materials 2023 Sep 5;457:131791
Journal of hazardous materials 2023 Sep 5;457:131791
Dynamic N6-methyladenosine RNA methylation landscapes reveal epi-transcriptomic modulation induced by ammonia nitrogen exposure in the Pacific whiteleg shrimp Litopenaeus vannamei.
Lei Y, Yuan Z, Zeng Q, Wan B, Liu J, Wang W
Journal of hazardous materials 2023 Sep 15;458:131996
Journal of hazardous materials 2023 Sep 15;458:131996
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181
Cell biology and toxicology 2023 Oct;39(5):2165-2181
Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane.
Wu Y, Yang Z, Su S, Xu X, Li Y, Li X, Gao Y, Sun D, Wan S, Pen M, Jin W, Ke C
Cell biology and toxicology 2023 Oct;39(5):2133-2148
Cell biology and toxicology 2023 Oct;39(5):2133-2148
m(6)A governs length-dependent enrichment of mRNAs in stress granules.
Ries RJ, Pickering BF, Poh HX, Namkoong S, Jaffrey SR
Nature structural & molecular biology 2023 Oct;30(10):1525-1535
Nature structural & molecular biology 2023 Oct;30(10):1525-1535
YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner.
Hwang HJ, Park TL, Kim HI, Park Y, Kim G, Song C, Cho WK, Kim YK
Nature communications 2023 Oct 6;14(1):6248
Nature communications 2023 Oct 6;14(1):6248
Enzymolysis-based RNA pull-down identifies YTHDC2 as an inhibitor of antiviral innate response.
Zhu J, Liu S, Fang J, Cui Z, Wang B, Wang Y, Liu L, Wang Q, Cao X
Cell reports 2023 Oct 31;42(10):113192
Cell reports 2023 Oct 31;42(10):113192
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Comprehensive Transcriptomic Profiling of m6A Modification in Age-Related Hearing Loss.
Feng M, Zhou X, Hu Y, Zhang J, Yang T, Chen Z, Yuan W
Biomolecules 2023 Oct 18;13(10)
Biomolecules 2023 Oct 18;13(10)
METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.
Yi J, Peng F, Zhao J, Gong X
Scientific reports 2023 Oct 12;13(1):17292
Scientific reports 2023 Oct 12;13(1):17292
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.
Zhuang A, Gu X, Ge T, Wang S, Ge S, Chai P, Jia R, Fan X
Cancer communications (London, England) 2023 Nov;43(11):1185-1206
Cancer communications (London, England) 2023 Nov;43(11):1185-1206
M2 macrophage exosomal LINC01001 promotes non-small cell lung cancer development by affecting METTL3 and glycolysis pathway.
Xu L, Li K, Li J, Xu F, Liang S, Kong Y, Chen B
Cancer gene therapy 2023 Nov;30(11):1569-1580
Cancer gene therapy 2023 Nov;30(11):1569-1580
DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer.
Li L, Wang F, Deng Z, Zhang G, Zhu L, Zhao Z, Liu R
BMC cancer 2023 Nov 7;23(1):1073
BMC cancer 2023 Nov 7;23(1):1073
circRNA-miRNA-mRNA network analysis to explore the pathogenesis of abnormal spermatogenesis due to aberrant m6A methylation.
Zhong D, Zhang L, Huang K, Chen M, Chen Y, Liu Q, Shi D, Li H
Cell and tissue research 2023 May;392(2):605-620
Cell and tissue research 2023 May;392(2):605-620
N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
Wang J, Yu H, Dong W, Zhang C, Hu M, Ma W, Jiang X, Li H, Yang P, Xiang D
Gastroenterology 2023 May;164(6):990-1005
Gastroenterology 2023 May;164(6):990-1005
RNA N6-methyladenosine reader IGF2BP3 interacts with MYCN and facilitates neuroblastoma cell proliferation.
Zhu K, Gao T, Wang Z, Zhang L, Tan K, Lv Z
Cell death discovery 2023 May 8;9(1):151
Cell death discovery 2023 May 8;9(1):151
Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification.
Lei C, Li N, Chen J, Wang Q
Molecules (Basel, Switzerland) 2023 May 3;28(9)
Molecules (Basel, Switzerland) 2023 May 3;28(9)
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.
Zheng J, Zhang Q, Zhao Z, Qiu Y, Zhou Y, Wu Z, Jiang C, Wang X, Jiang X
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127
MetBil as a novel molecular regulator in ischemia-induced cardiac fibrosis via METTL3-mediated m6A modification.
Zhuang Y, Li T, Hu X, Xie Y, Pei X, Wang C, Li Y, Liu J, Tian Z, Zhang X, Peng L, Meng B, Wu H, Yuan W, Pan Z, Lu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22797
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22797
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.
Gou Y, Wang H, Wang T, Wang H, Wang B, Jiao N, Yu Y, Cao Y, Wang H, Zhang Z
Immunology 2023 Mar;168(3):389-402
Immunology 2023 Mar;168(3):389-402
METTL3 protects METTL14 from STUB1-mediated degradation to maintain m(6) A homeostasis.
Zeng ZC, Pan Q, Sun YM, Huang HJ, Chen XT, Chen TQ, He B, Ye H, Zhu SX, Pu KJ, Fang K, Huang W, Chen YQ, Wang WT
EMBO reports 2023 Mar 6;24(3):e55762
EMBO reports 2023 Mar 6;24(3):e55762
YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.
Hesser CR, Walsh D
Journal of virology 2023 Mar 30;97(3):e0175822
Journal of virology 2023 Mar 30;97(3):e0175822
Rewired m(6)A epitranscriptomic networks link mutant p53 to neoplastic transformation.
Xu A, Liu M, Huang MF, Zhang Y, Hu R, Gingold JA, Liu Y, Zhu D, Chien CS, Wang WC, Liao Z, Yuan F, Hsu CW, Tu J, Yu Y, Rosen T, Xiong F, Jia P, Yang YP, Bazer DA, Chen YW, Li W, Huff CD, Zhu JJ, Aguilo F, Chiou SH, Boles NC, Lai CC, Hung MC, Zhao Z, Van Nostrand EL, Zhao R, Lee DF
Nature communications 2023 Mar 27;14(1):1694
Nature communications 2023 Mar 27;14(1):1694
RNA binding protein YTHDF1 mediates bisphenol S-induced Leydig cell damage by regulating the mitochondrial pathway of BCL2 and the expression of CDK2-CyclinE1.
Li JZ, Zhou SM, Yuan WB, Chen HQ, Zeng Y, Fan J, Zhang Z, Wang N, Cao J, Liu WB
Environmental pollution (Barking, Essex : 1987) 2023 Mar 15;321:121144
Environmental pollution (Barking, Essex : 1987) 2023 Mar 15;321:121144
USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m(6)A Modification of YAP1 mRNA.
Ge X, Ye W, Zhu Y, Cui M, Zhou J, Xiao C, Jiang D, Tang P, Wang J, Wang Z, Ji C, Zhou X, Cao X, Liu W, Cai W
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Mar 1;43(9):1456-1474
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Mar 1;43(9):1456-1474
ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH.
Wang T, Zhou LY, Li XM, Liu F, Liang L, Chen XZ, Ju J, Ponnusamy M, Wang K, Liu CY, Yan KW, Wang K
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Mar 1;31(3):847-865
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Mar 1;31(3):847-865
Role of N6-adenosine-methyltransferase subunits METTL3 and METTL14 in the biological properties of periodontal ligament cells.
Huang J, Guo C, Wang Y, Zhou Y
Tissue & cell 2023 Jun;82:102081
Tissue & cell 2023 Jun;82:102081
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
m(6)A epitranscriptomic regulation of tissue homeostasis during primate aging.
Wu Z, Lu M, Liu D, Shi Y, Ren J, Wang S, Jing Y, Zhang S, Zhao Q, Li H, Yu Z, Liu Z, Bi S, Wei T, Yang YG, Xiao J, Belmonte JCI, Qu J, Zhang W, Ci W, Liu GH
Nature aging 2023 Jun;3(6):705-721
Nature aging 2023 Jun;3(6):705-721
Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.
Yuan W, Hou Y, Wang Q, Lv T, Ren J, Fan L, Cai J, Xiang B, Lin Q, Liao M, Ding C, Chen L, Ren T
Veterinary microbiology 2023 Jun;281:109747
Veterinary microbiology 2023 Jun;281:109747
METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury.
Guo S, Lin T, Chen G, Shangguan Z, Zhou L, Chen Z, Shi T, Chen D, Wang Z, Liu W
Neurospine 2023 Jun;20(2):623-636
Neurospine 2023 Jun;20(2):623-636
Correlated with better prognosis, CSTA inhibits metastasis of nasopharyngeal carcinoma cells via suppressing AKT signaling through promoting METTL3 degradation.
Liu ZJ, Zheng LS, Li CZ, Peng LX, Mei Y, Lang YH, Xu L, Meng DF, Peng XS, Wang MD, Xie DH, Guo LL, Ding LY, Huang BJ, Qian CN
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166696
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166696
METTL3 promotes proliferation of goat endometrial epithelial cells by regulating CTGF in an m6A-dependent manner†.
Sun Y, Zhang XC, Li MD, Bu LG, Wang B, Li TY, Ding NZ, Ni H
Biology of reproduction 2023 Jun 9;108(6):902-911
Biology of reproduction 2023 Jun 9;108(6):902-911
Comprehensive analysis of long non-coding RNA expression profiles of GC-1spg cells with m6A methylation knockdown.
Zhong D, Yao C, Zhang L, Wang J, Liu Q, Shi D, Jiang M, Li H
Gene 2023 Jun 30;871:147430
Gene 2023 Jun 30;871:147430
High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m(6)A demethylation: a potential mechanism for diabetic cognitive dysfunction.
Qu M, Zuo L, Zhang M, Cheng P, Guo Z, Yang J, Li C, Wu J
Cell death & disease 2023 Jun 29;14(6):385
Cell death & disease 2023 Jun 29;14(6):385
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
Chen W, He Q, Liu J, Li N, Xiao K, Chen H
Carcinogenesis 2023 Jun 24;44(4):328-340
Carcinogenesis 2023 Jun 24;44(4):328-340
Targeting choroidal vasculopathy via up-regulation of tRNA-derived fragment tRF-22 expression for controlling progression of myopia.
Liu C, Li M, Shen Y, Han X, Wei R, Wang Y, Xu S, Zhou X
Journal of translational medicine 2023 Jun 24;21(1):412
Journal of translational medicine 2023 Jun 24;21(1):412
Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.
Jiang WJ, Sun MH, Li XH, Lee SH, Heo G, Zhou D, Cui XS
Journal of cellular physiology 2023 Jul;238(7):1592-1604
Journal of cellular physiology 2023 Jul;238(7):1592-1604
Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization.
Liu P, Chen Y, Zhang Z, Yuan Z, Sun JG, Xia S, Cao X, Chen J, Zhang CJ, Chen Y, Zhan H, Jin Y, Bao X, Gu Y, Zhang M, Xu Y
PLoS biology 2023 Jul;21(7):e3002199
PLoS biology 2023 Jul;21(7):e3002199
A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth.
Miyake K, Costa Cruz PH, Nagatomo I, Kato Y, Motooka D, Satoh S, Adachi Y, Takeda Y, Kawahara Y, Kumanogoh A
Cell reports 2023 Jul 25;42(7):112688
Cell reports 2023 Jul 25;42(7):112688
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.
Zhong J, Wu X, Gao Y, Chen J, Zhang M, Zhou H, Yang J, Xiao F, Yang X, Huang N, Qi H, Wang X, Bai F, Shi Y, Zhang N
Nature communications 2023 Jul 25;14(1):4467
Nature communications 2023 Jul 25;14(1):4467
Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer.
Gao Y, Zou T, Xu P, Wang Y, Jiang Y, Chen YX, Chen H, Hong J, Fang JY
Neoplasia (New York, N.Y.) 2023 Jan;35:100850
Neoplasia (New York, N.Y.) 2023 Jan;35:100850
FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.
Li B, Xi W, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J, Han B, Yao H
Nature communications 2023 Jan 30;14(1):489
Nature communications 2023 Jan 30;14(1):489
The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.
Du P, Meng L, Liao X, Liu Y, Mo X, Gong M, Liao Y
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116
METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.
Li D, He J, Fang C, Zhang Y, He M, Zhang Z, Hou J, Xu Q
International journal of molecular sciences 2023 Jan 11;24(2)
International journal of molecular sciences 2023 Jan 11;24(2)
Crosstalk between 5-methylcytosine and N(6)-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma.
Tian Y, Xiao H, Yang Y, Zhang P, Yuan J, Zhang W, Chen L, Fan Y, Zhang J, Cheng H, Deng T, Yang L, Wang W, Chen G, Wang P, Gong P, Niu X, Zhang X
Molecular cancer 2023 Jan 10;22(1):5
Molecular cancer 2023 Jan 10;22(1):5
Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.
Yang F, Zhang A
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway.
Li N, Luo R, Zhang W, Wu Y, Hu C, Liu M, Jiang D, Jiang Z, Zhao X, Wang Y, Li Q
Biogerontology 2023 Feb;24(1):99-110
Biogerontology 2023 Feb;24(1):99-110
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Chen Y, Liu X, Li L, He X, Zheng F, Zhang Y, Gao H, Jin Z, Wu D, Wang Q, Tao H, Zhao Y, Liu W, Zou L
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19
Heterogeneous Nuclear Protein U Degraded the m(6)A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.
Zhou H, Yan Y, Gao J, Ma M, Liu Y, Shi X, Zhang Q, Xu X
Journal of virology 2023 Feb 28;97(2):e0175122
Journal of virology 2023 Feb 28;97(2):e0175122
Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N(6)-Methyladenosine Modification of ATP13A3.
Li S, Xu S, Chen Y, Zhou J, Ben S, Guo M, Chu H, Gu D, Zhang Z, Wang M
Environmental science & technology 2023 Feb 21;57(7):2864-2876
Environmental science & technology 2023 Feb 21;57(7):2864-2876
F-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner.
Zhou H, Zeng C, Liu J, Luo H, Huang W
Cancers 2023 Feb 2;15(3)
Cancers 2023 Feb 2;15(3)
Novel RNA N6-methyladenosine regulator related signature for predicting clinical and immunological characteristics in breast cancer.
Zhang J, Liu G, Dai Z, Xie F, Zheng R, Yuan B, Guo L
Gene 2023 Feb 15;853:147095
Gene 2023 Feb 15;853:147095
The m(6)A methyltransferase METTL3 affects cell proliferation and migration by regulating YAP expression in Hirschsprung disease.
Huang Z, Luo C, Hou X, Yu D, Su Y, Li X, Luo Y, Liao G, Mu J, Wu K
Pediatric surgery international 2023 Feb 15;39(1):126
Pediatric surgery international 2023 Feb 15;39(1):126
RBM10 recruits METTL3 to induce N6-methyladenosine-MALAT1-dependent modification, inhibiting the invasion and migration of NSCLC.
Cao Y, Di X, Cong S, Tian C, Wang Y, Jin X, Zhao M, Zhou X, Li R, Wang K
Life sciences 2023 Feb 15;315:121359
Life sciences 2023 Feb 15;315:121359
m (6) A RNA methylation orchestrates transcriptional dormancy during developmental pausing.
Collignon E, Cho B, Fothergill-Robinson J, Furlan G, Ross RL, Limbach PA, Ramalho-Santos M
bioRxiv : the preprint server for biology 2023 Feb 1;
bioRxiv : the preprint server for biology 2023 Feb 1;
Increased m6A-RNA methylation and demethylase FTO suppression is associated with silica-induced pulmonary inflammation and fibrosis.
Xu Y, Wang L, Qian R, Zhao M, Chen X, Sun D, Wang Y, Cheng W, Chen Y, He Q, Dai Y, Yao Y
Toxicology 2023 Dec;500:153673
Toxicology 2023 Dec;500:153673
Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.
Gao X, Liang X, Liu B, Hong Y, He H, Shen Y, Chen J, Huang X, Hu B, Li W, Li X, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294
Mettl3/Ythdf2 regulate macrophage inflammation and ROS generation by controlling Pyk2 mRNA stability.
Cai Y, Yu R, Zhang Z, Li D, Yi B, Feng Z, Xu Q
Immunology letters 2023 Dec;264:64-73
Immunology letters 2023 Dec;264:64-73
Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging.
Huang J, Zhou F, Zhou H, Zheng X, Huo Z, Yang M, Xu Z, Liu R, Wang L, Wang X
PNAS nexus 2023 Dec;2(12):pgad390
PNAS nexus 2023 Dec;2(12):pgad390
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
SON is an essential m(6)A target for hematopoietic stem cell fate.
Luo H, Cortés-López M, Tam CL, Xiao M, Wakiro I, Chu KL, Pierson A, Chan M, Chang K, Yang X, Fecko D, Han G, Ahn EE, Morris QD, Landau DA, Kharas MG
Cell stem cell 2023 Dec 7;30(12):1658-1673.e10
Cell stem cell 2023 Dec 7;30(12):1658-1673.e10
METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis.
Song M, Yao H, Sun Z, Chen D, Xu X, Long G, Wu L, Hu W
Cellular & molecular biology letters 2023 Dec 7;28(1):101
Cellular & molecular biology letters 2023 Dec 7;28(1):101
Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.
Zhang Y, Wang R, Tan H, Wu K, Hu Y, Diao H, Wang D, Tang X, Leng M, Li X, Cai Z, Luo D, Shao X, Yan M, Chen Y, Rong X, Guo J
Journal of ethnopharmacology 2023 Dec 5;317:116766
Journal of ethnopharmacology 2023 Dec 5;317:116766
dTrmt10A impacts Hsp70 chaperone m(6)A levels and the stress response in the Drosophila brain.
Perlegos AE, Quan X, Donnelly KM, Shen H, Shields EJ, Elashal H, Fange Liu K, Bonini NM
Scientific reports 2023 Dec 28;13(1):22999
Scientific reports 2023 Dec 28;13(1):22999
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.
Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7
High Temperature-Induced m6A Epigenetic Changes Affect Early Porcine Embryonic Developmental Competence in Pigs.
Sun MH, Jiang WJ, Li XH, Lee SH, Heo G, Zhou D, Guo J, Cui XS
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2174-2183
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2174-2183
m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.
Zhang J, Song J, Liu S, Zhang Y, Qiu T, Jiang L, Bai J, Yao X, Wang N, Yang G, Sun X
The Science of the total environment 2023 Dec 20;905:167202
The Science of the total environment 2023 Dec 20;905:167202
A positive feedback circuit driven by m(6)A-modified circular RNA facilitates colorectal cancer liver metastasis.
Zeng K, Peng J, Xing Y, Zhang L, Zeng P, Li W, Zhang W, Pan Z, Zhou C, Lin J
Molecular cancer 2023 Dec 13;22(1):202
Molecular cancer 2023 Dec 13;22(1):202
Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma.
Cun Y, An S, Zheng H, Lan J, Chen W, Luo W, Yao C, Li X, Huang X, Sun X, Wu Z, Hu Y, Li Z, Zhang S, Wu G, Yang M, Tang M, Yu R, Liao X, Gao G, Zhao W, Wang J, Li J
Genomics, proteomics & bioinformatics 2023 Aug;21(4):707-728
Genomics, proteomics & bioinformatics 2023 Aug;21(4):707-728
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
Ai S, Li D, Gu X, Xu Y, Wang Y, Wang HL, Chen XT
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821
METTL14 is decreased and regulates m(6) A modification of α-synuclein in Parkinson's disease.
He H, Zhang Q, Liao J, Lei J, Luo M, Huang J, Chen M, Shen Y, Wang J, Xu P, Xiao Y
Journal of neurochemistry 2023 Aug;166(3):609-622
Journal of neurochemistry 2023 Aug;166(3):609-622
Maternal tamoxifen exposure leads to abnormal primordial follicle assembly.
Zhao J, Zhang J, Sun Y, Wang R, Shi D, Shen W, Sun X
Histochemistry and cell biology 2023 Aug;160(2):97-111
Histochemistry and cell biology 2023 Aug;160(2):97-111
WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata.
Gu Z, Liu J, Qin L, Zhang Y, Cui W, Huang H, Liu L, Cao Y, Zhang H
Journal of dermatological science 2023 Aug;111(2):43-51
Journal of dermatological science 2023 Aug;111(2):43-51
The roles of METTL3 on autophagy and proliferation of vascular smooth muscle cells are mediated by mTOR rather than by CDK1.
Luo H, Wu X, Huo B, Liu L, Jiang DS, Yi X
Cell division 2023 Aug 9;18(1):13
Cell division 2023 Aug 9;18(1):13
Characterization of m(6)A modifiers and RNA modifications in uterine fibroids.
George JW, Cancino RA, Miller JLG, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
bioRxiv : the preprint server for biology 2023 Aug 9;
bioRxiv : the preprint server for biology 2023 Aug 9;
A lncRNA from the FTO locus acts as a suppressor of the m(6)A writer complex and p53 tumor suppression signaling.
Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S, Cui XL, Zou Z, Yue Z, Emch MJ, Hawse JR, Wang L, He HH, Xia S, Han B, He C, Huang H
Molecular cell 2023 Aug 3;83(15):2692-2708.e7
Molecular cell 2023 Aug 3;83(15):2692-2708.e7
Reinvestigating the clinical relevance of the m(6)A writer METTL3 in urothelial carcinoma of the bladder.
Koch J, Neuberger M, Schmidt-Dengler M, Xu J, Carneiro VC, Ellinger J, Kriegmair MC, Nuhn P, Erben P, Michel MS, Helm M, Rodríguez-Paredes M, Nientiedt M, Lyko F
iScience 2023 Aug 18;26(8):107300
iScience 2023 Aug 18;26(8):107300
METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.
Hou X, Li Y, Song J, Peng L, Zhang W, Liu R, Yuan H, Feng T, Li J, Li W, Zhu C
Hepatology communications 2023 Aug 1;7(8)
Hepatology communications 2023 Aug 1;7(8)
Methyltransferase-like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation.
Fang ZM, Zhang SM, Luo H, Jiang DS, Huo B, Zhong X, Feng X, Cheng W, Chen Y, Feng G, Wu X, Zhao F, Yi X
Cell proliferation 2023 Apr;56(4):e13386
Cell proliferation 2023 Apr;56(4):e13386
N6-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication.
Zhu Y, Wang R, Zou J, Tian S, Yu L, Zhou Y, Ran Y, Jin M, Chen H, Zhou H
PLoS pathogens 2023 Apr;19(4):e1011305
PLoS pathogens 2023 Apr;19(4):e1011305
YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1-RPN2-PI3K/AKT/mTOR Axis.
Zhu J, Tong H, Sun Y, Li T, Yang G, He W
International journal of molecular sciences 2023 Apr 7;24(8)
International journal of molecular sciences 2023 Apr 7;24(8)
METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells.
Hou Y, Zhang X, Yao H, Hou L, Zhang Q, Tao E, Zhu X, Jiang S, Ren Y, Hong X, Lu S, Leng X, Xie Y, Gao Y, Liang Y, Zhong T, Long B, Fang JY, Meng X
EMBO reports 2023 Apr 5;24(4):e56325
EMBO reports 2023 Apr 5;24(4):e56325
FTO negatively regulates the cytotoxic activity of natural killer cells.
Kim SM, Oh SC, Lee SY, Kong LZ, Lee JH, Kim TD
EMBO reports 2023 Apr 5;24(4):e55681
EMBO reports 2023 Apr 5;24(4):e55681
N(6)-Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication.
Khan O, Tanuj GN, Choravada DR, Rajak KK, Chandra Sekar S, Lingaraju MC, Dhara SK, Gupta PK, Mishra BP, Dutt T, Gandham RK, Sajjanar B
Microbiology spectrum 2023 Apr 13;11(2):e0266622
Microbiology spectrum 2023 Apr 13;11(2):e0266622
METTL3 enhances dentinogenesis differentiation of dental pulp stem cells via increasing GDF6 and STC1 mRNA stability.
Pan Y, Liu Y, Cui D, Yu S, Zhou Y, Zhou X, Du W, Zheng L, Wan M
BMC oral health 2023 Apr 11;23(1):209
BMC oral health 2023 Apr 11;23(1):209
N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.
Ji D, Hu C, Ning J, Ying X, Zhang H, Zhang B, Liu B, Liu Q, Ji W, Zhang R
Ecotoxicology and environmental safety 2023 Apr 1;254:114755
Ecotoxicology and environmental safety 2023 Apr 1;254:114755
3D-Printed β-Tricalcium Phosphate Scaffolds Promote Osteogenic Differentiation of Bone Marrow-Deprived Mesenchymal Stem Cells in an N6-methyladenosine-Dependent Manner.
Jiao X, Sun X, Li W, Chu W, Zhang Y, Li Y, Wang Z, Zhou X, Ma J, Xu C, Dai K, Wang J, Gan Y
International journal of bioprinting 2022;8(2):544
International journal of bioprinting 2022;8(2):544
M(6)A Modifier-Mediated Methylation Characterized by Diverse Prognosis, Tumor Microenvironment, and Immunotherapy Response in Hepatocellular Carcinoma.
Liu F, Zhang X, Liu Z, Cai W, Song C, Jiang Y, Yin J, Liu Z, Huang C
Journal of oncology 2022;2022:2513813
Journal of oncology 2022;2022:2513813
RNA methylation-mediated LINC01559 suppresses colorectal cancer progression by regulating the miR-106b-5p/PTEN axis.
Shi K, Yang S, Chen C, Shao B, Guo Y, Wu X, Zhao L, Yang X, Zhang Q, Yuan W, Sun Z
International journal of biological sciences 2022;18(7):3048-3065
International journal of biological sciences 2022;18(7):3048-3065
The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
Wu Q, Zhang H, Yang D, Min Q, Wang Y, Zhang W, Zhan Q
International journal of biological sciences 2022;18(13):4824-4836
International journal of biological sciences 2022;18(13):4824-4836
Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.
Li N, Yi X, He Y, Huo B, Chen Y, Zhang Z, Wang Q, Li Y, Zhong X, Li R, Zhu XH, Fang Z, Wei X, Jiang DS
International journal of biological sciences 2022;18(10):4118-4134
International journal of biological sciences 2022;18(10):4118-4134
METTL3 Facilitates Tumor Progression by COL12A1/MAPK Signaling Pathway in Esophageal Squamous Cell Carcinoma.
Li J, Li Z, Xu Y, Huang C, Shan B
Journal of Cancer 2022;13(6):1972-1984
Journal of Cancer 2022;13(6):1972-1984
Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis.
Tian C, Chai J, Liu W, Zhang X, Li Y, Zuo H, Yuan G, Zhang H, Liu H, Chen Z
Frontiers in physiology 2022;13:923185
Frontiers in physiology 2022;13:923185
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
Li Z, Teng M, Jiang Y, Zhang L, Luo X, Liao Y, Yang B
Frontiers in immunology 2022;13:857727
Frontiers in immunology 2022;13:857727
m(6)A mRNA Methylation Was Associated With Gene Expression and Lipid Metabolism in Liver of Broilers Under Lipopolysaccharide Stimulation.
Guo F, Zhang Y, Ma J, Yu Y, Wang Q, Gao P, Wang L, Xu Z, Wei X, Jing M
Frontiers in genetics 2022;13:818357
Frontiers in genetics 2022;13:818357
METTL3/m(6)A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma.
Ge F, Li Z, Hu J, Pu Y, Zhao F, Kong L
Frontiers in pharmacology 2022;13:1002565
Frontiers in pharmacology 2022;13:1002565
Decreased RNA m(6)A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.
Tao M, Li X, He L, Rong X, Wang H, Pan J, Lu Z, Zhang X, Peng Y
American journal of cancer research 2022;12(2):893-906
American journal of cancer research 2022;12(2):893-906
Integrative proteomics and m6A microarray analyses of the signatures induced by METTL3 reveals prognostically significant in gastric cancer by affecting cellular metabolism.
Peng G, Chen S, Zheng N, Tang Y, Su X, Wang J, Dong R, Wu D, Hu M, Zhao Y, Liu M, Wu H
Frontiers in oncology 2022;12:996329
Frontiers in oncology 2022;12:996329
METTL3 antagonizes 5‑FU chemotherapy and confers drug resistance in colorectal carcinoma.
Li M, Xia M, Zhang Z, Tan Y, Li E, Guo Z, Fang M, Zhu Y, Hu Z
International journal of oncology 2022 Sep;61(3)
International journal of oncology 2022 Sep;61(3)
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.
Zeng X, Zhao F, Cui G, Zhang Y, Deshpande RA, Chen Y, Deng M, Kloeber JA, Shi Y, Zhou Q, Zhang C, Hou J, Kim W, Tu X, Yan Y, Xu Z, Chen L, Gao H, Guo G, Liu J, Zhu Q, Cao Y, Huang J, Wu Z, Zhu S, Yin P, Luo K, Mer G, Paull TT, Yuan J, Tao K, Lou Z
Nature cancer 2022 Sep;3(9):1088-1104
Nature cancer 2022 Sep;3(9):1088-1104
CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
Zhang M, Yang C, Ruan X, Liu X, Wang D, Liu L, Shao L, Wang P, Dong W, Xue Y
Communications biology 2022 Sep 5;5(1):908
Communications biology 2022 Sep 5;5(1):908
METTL3 suppresses anlotinib sensitivity by regulating m(6)A modification of FGFR3 in oral squamous cell carcinoma.
Chen J, Li S, Huang Z, Cao C, Wang A, He Q
Cancer cell international 2022 Sep 27;22(1):295
Cancer cell international 2022 Sep 27;22(1):295
m(6)A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated CCND1 mRNA Stabilization.
Bian Y, Wang Y, Xu S, Gao Z, Li C, Fan Z, Ding J, Wang K
Cells 2022 Sep 27;11(19)
Cells 2022 Sep 27;11(19)
Exploration of N6-Methyladenosine Profiles of mRNAs and the Function of METTL3 in Atherosclerosis.
Zhou Y, Jiang R, Jiang Y, Fu Y, Manafhan Y, Zhu J, Jia E
Cells 2022 Sep 24;11(19)
Cells 2022 Sep 24;11(19)
Mettl3-dependent m(6)A modification attenuates the brain stress response in Drosophila.
Perlegos AE, Shields EJ, Shen H, Liu KF, Bonini NM
Nature communications 2022 Sep 14;13(1):5387
Nature communications 2022 Sep 14;13(1):5387
FTO-dependent N(6)-Methyladenosine regulates the progression of endometriosis via the ATG5/PKM2 Axis.
Wang H, Liang Z, Gou Y, Li Z, Cao Y, Jiao N, Tan J, Yu Y, Zhang Z
Cellular signalling 2022 Oct;98:110406
Cellular signalling 2022 Oct;98:110406
The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.
Yoshinaga M, Han K, Morgens DW, Horii T, Kobayashi R, Tsuruyama T, Hia F, Yasukura S, Kajiya A, Cai T, Cruz PHC, Vandenbon A, Suzuki Y, Kawahara Y, Hatada I, Bassik MC, Takeuchi O
Nature communications 2022 Oct 28;13(1):6435
Nature communications 2022 Oct 28;13(1):6435
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350
Nature communications 2022 Oct 26;13(1):6350
N(6)-Methyladenine Modification of Hepatitis Delta Virus Regulates Its Virion Assembly by Recruiting YTHDF1.
Kim GW, Moon JS, Gudima SO, Siddiqui A
Journal of virology 2022 Oct 12;96(19):e0112422
Journal of virology 2022 Oct 12;96(19):e0112422
YTHDF3 modulates hematopoietic stem cells by recognizing RNA m(6)A modification on Ccnd1.
Zhang X, Cong T, Wei L, Zhong B, Wang X, Sun J, Wang S, Xu MM, Zhu P, Jiang H, Wang J
Haematologica 2022 Oct 1;107(10):2381-2394
Haematologica 2022 Oct 1;107(10):2381-2394
RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.
Jiang T, He X, Zhao Z, Zhang X, Wang T, Jia L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22618
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22618
Metformin combats obesity by targeting FTO in an m(6)A-YTHDF2-dependent manner.
Liao X, Liu J, Chen Y, Liu Y, Chen W, Zeng B, Liu Y, Luo Y, Huang C, Guo G, Wang Y, Wang X
Journal of drug targeting 2022 Nov;30(9):983-991
Journal of drug targeting 2022 Nov;30(9):983-991
Adenosine N(6)-methylation upregulates the expression of human CYP2B6 by altering the chromatin status.
Isono M, Nakano M, Fukami T, Nakajima M
Biochemical pharmacology 2022 Nov;205:115247
Biochemical pharmacology 2022 Nov;205:115247
A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells.
Porman AM, Roberts JT, Duncan ED, Chrupcala ML, Levine AA, Kennedy MA, Williams MM, Richer JK, Johnson AM
PLoS biology 2022 Nov;20(11):e3001885
PLoS biology 2022 Nov;20(11):e3001885
Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.
Yang Y, Qian Cai Q, Sheng Fu L, Wei Dong Y, Fan F, Zhong Wu X
Chemistry & biodiversity 2022 Nov;19(11):e202200333
Chemistry & biodiversity 2022 Nov;19(11):e202200333
Profiling RNA at chromatin targets in situ by antibody-targeted tagmentation.
Khyzha N, Henikoff S, Ahmad K
Nature methods 2022 Nov;19(11):1383-1392
Nature methods 2022 Nov;19(11):1383-1392
N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.
Shi HZ, Xiong JS, Gan L, Zhang Y, Zhang CC, Kong YQ, Miao QJ, Tian CC, Li R, Liu JQ, Zhang EJ, Bu WB, Wang Y, Cheng XF, Sun JF, Chen H
Clinical and translational medicine 2022 Nov;12(11):e1075
Clinical and translational medicine 2022 Nov;12(11):e1075
Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.
Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131
Discover oncology 2022 Nov 25;13(1):131
METTL3 upregulates COPS5 expression in osteosarcoma in an m(6)A-related manner to promote osteosarcoma progression.
Zhang C, Wan J, Liu Q, Long F, Wen Z, Liu Y
Experimental cell research 2022 Nov 15;420(2):113353
Experimental cell research 2022 Nov 15;420(2):113353
METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.
Cai Y, Yu R, Kong Y, Feng Z, Xu Q
Cellular signalling 2022 May;93:110283
Cellular signalling 2022 May;93:110283
N6-methyladenosine modification contributes to arecoline-mediated oral submucosal fibrosis.
Li X, Gao Y, Chen W, Gu Y, Song J, Zhang J, Ai Y
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2022 May;51(5):474-482
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2022 May;51(5):474-482
METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation.
Cai W, Ji Y, Han L, Zhang J, Ni Y, Cheng Y, Zhang Y
Journal of dental research 2022 May;101(5):580-589
Journal of dental research 2022 May;101(5):580-589
Lactylation-driven METTL3-mediated RNA m(6)A modification promotes immunosuppression of tumor-infiltrating myeloid cells.
Xiong J, He J, Zhu J, Pan J, Liao W, Ye H, Wang H, Song Y, Du Y, Cui B, Xue M, Zheng W, Kong X, Jiang K, Ding K, Lai L, Wang Q
Molecular cell 2022 May 5;82(9):1660-1677.e10
Molecular cell 2022 May 5;82(9):1660-1677.e10
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.
Yan R, Dai W, Wu R, Huang H, Shu M
Cancer letters 2022 May 28;534:215615
Cancer letters 2022 May 28;534:215615
lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus.
Liu HT, Zou YX, Zhu WJ, Sen-Liu, Zhang GH, Ma RR, Guo XY, Gao P
Cell death and differentiation 2022 Mar;29(3):627-641
Cell death and differentiation 2022 Mar;29(3):627-641
Detection of N6-methyladenosine in SARS-CoV-2 RNA by methylated RNA immunoprecipitation sequencing.
Li N, Rana TM
STAR protocols 2022 Mar 18;3(1):101067
STAR protocols 2022 Mar 18;3(1):101067
Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.
Qi Z, Wang S, Li J, Wen Y, Cui R, Zhang K, Liu Y, Yang X, Zhang L, Xu B, Liu W, Xu Z, Deng Y
Journal of hazardous materials 2022 Mar 15;426:128099
Journal of hazardous materials 2022 Mar 15;426:128099
Long noncoding RNA lnc-H2AFV-1 promotes cell growth by regulating aberrant m6A RNA modification in head and neck squamous cell carcinoma.
Chen X, Liu Y, Sun D, Sun R, Wang X, Li M, Song N, Ying J, Guo T, Jiang Y
Cancer science 2022 Jun;113(6):2071-2084
Cancer science 2022 Jun;113(6):2071-2084
DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.
Zhao L, Zhao Y, Liu Q, Huang J, Lu Y, Ping J
Microbiology spectrum 2022 Jun 29;10(3):e0109822
Microbiology spectrum 2022 Jun 29;10(3):e0109822
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.
Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6
Developmental cell 2022 Jun 20;57(12):1466-1481.e6
METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation.
Kong Y, Zhang Y, Cai Y, Li D, Yi B, Xu Q
Cellular signalling 2022 Jul;95:110335
Cellular signalling 2022 Jul;95:110335
Mettl3-mediated m(6) A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects.
Xu B, Li Q, Wu Y, Wang H, Xu J, Liu H, Xuan A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22392
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22392
METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression.
Chen HD, Li F, Chen S, Zhong ZH, Gao PF, Gao WZ
Cancer gene therapy 2022 Jul;29(7):1012-1020
Cancer gene therapy 2022 Jul;29(7):1012-1020
Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA.
Poh HX, Mirza AH, Pickering BF, Jaffrey SR
PLoS biology 2022 Jul;20(7):e3001683
PLoS biology 2022 Jul;20(7):e3001683
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.
Zhou H, Shen X, Yan C, Xiong W, Ma Z, Tan Z, Wang J, Li Y, Liu J, Duan A, Liu F
Stem cell research & therapy 2022 Jul 16;13(1):322
Stem cell research & therapy 2022 Jul 16;13(1):322
Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.
Liu Z, Cai Y, Deng M, Li D, Leng Q, Shi L, Tang Y, Wang F, Wan Y
Cell and tissue research 2022 Jan;387(1):131-142
Cell and tissue research 2022 Jan;387(1):131-142
Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma.
Wang Y, Zhao X, Li J, Wang X, Hu W, Zhang X
Technology in cancer research & treatment 2022 Jan-Dec;21:15330338221085373
Technology in cancer research & treatment 2022 Jan-Dec;21:15330338221085373
Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice.
Shi L, Jin X, Li Z, Gong R, Guo Y, Ma J, Zhang Y, Cai B, Yang B, Gong D, Pan Z
Acta biochimica et biophysica Sinica 2022 Jan 25;54(2):199-208
Acta biochimica et biophysica Sinica 2022 Jan 25;54(2):199-208
N6-Methyladenosine Modification of CDH1 mRNA Promotes PM2.5-Induced Pulmonary Fibrosis via Mediating Epithelial Mesenchymal Transition.
Ning J, Du H, Zhang Y, Liu Q, Jiang T, Pang Y, Tian X, Yan L, Niu Y, Zhang R
Toxicological sciences : an official journal of the Society of Toxicology 2022 Jan 24;185(2):143-157
Toxicological sciences : an official journal of the Society of Toxicology 2022 Jan 24;185(2):143-157
RNA N(6)-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice.
Li B, Zhang T, Liu M, Cui Z, Zhang Y, Liu M, Liu Y, Sun Y, Li M, Tian Y, Yang Y, Jiang H, Liang D
eLife 2022 Jan 10;11
eLife 2022 Jan 10;11
m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.
Gao M, Qi Z, Feng W, Huang H, Xu Z, Dong Z, Xu M, Han J, Kloeber JA, Huang J, Lou Z, Liu S
The Journal of biological chemistry 2022 Feb;298(2):101563
The Journal of biological chemistry 2022 Feb;298(2):101563
Hepatitis B Virus X Protein Expression Is Tightly Regulated by N6-Methyladenosine Modification of Its mRNA.
Kim GW, Siddiqui A
Journal of virology 2022 Feb 23;96(4):e0165521
Journal of virology 2022 Feb 23;96(4):e0165521
METTL3-m(6)A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.
Peng Z, Gong Y, Wang X, He W, Wu L, Zhang L, Xiong L, Huang Y, Su L, Shi P, Cao X, Liu R, Li Y, Xiao H
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Feb 2;30(2):932-946
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Feb 2;30(2):932-946
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749
European journal of pharmacology 2022 Feb 15;917:174749
TBK1-METTL3 axis facilitates antiviral immunity.
Chen J, Wei X, Wang X, Liu T, Zhao Y, Chen L, Luo Y, Du H, Li Y, Liu T, Cao L, Zhou Z, Zhang Z, Liang L, Li L, Yan X, Zhang X, Deng X, Yang G, Yin P, Hao J, Yin Z, You F
Cell reports 2022 Feb 15;38(7):110373
Cell reports 2022 Feb 15;38(7):110373
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.
Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766
Brain research 2022 Feb 15;1777:147766
N6-methyladenosine modification of the 5' epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein.
Kim GW, Moon JS, Siddiqui A
Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 15;119(7)
Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 15;119(7)
METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.
Yang L, Wu G, Wu Q, Peng L, Yuan L
Cell death discovery 2022 Feb 14;8(1):62
Cell death discovery 2022 Feb 14;8(1):62
The m(6)A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis.
Li Y, Kang X, Zhou Z, Pan L, Chen H, Liang X, Chu J, Dong S, Liu C, Yu S, Tu D, Zhang Y, Ge M, Chen W, Xu Y, Zhang Q
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Dec 7;30(12):3714-3728
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Dec 7;30(12):3714-3728
mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis.
Pan J, Xie Y, Li H, Li X, Chen J, Liu X, Zhou J, Tang X, He Z, Peng Z, Zhang H, Li Y, Xiang X, Yuan Y, Zhang D
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Dec 7;30(12):3694-3713
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Dec 7;30(12):3694-3713
METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10.
Cai J, Cui Z, Zhou J, Zhang B, Lu R, Ding Y, Hu H
Cancer cell international 2022 Dec 7;22(1):385
Cancer cell international 2022 Dec 7;22(1):385
The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.
Liu M, Ruan X, Liu X, Dong W, Wang D, Yang C, Liu L, Wang P, Zhang M, Xue Y
Cell death & disease 2022 Dec 3;13(12):1017
Cell death & disease 2022 Dec 3;13(12):1017
RNA-m6A modification of HDGF mediated by Mettl3 aggravates the progression of atherosclerosis by regulating macrophages polarization via energy metabolism reprogramming.
Zheng L, Chen X, Yin Q, Gu J, Chen J, Chen M, Zhang Y, Dong M, Jiang H, Yin N, Chen H, Li X
Biochemical and biophysical research communications 2022 Dec 20;635:120-127
Biochemical and biophysical research communications 2022 Dec 20;635:120-127
Stage-specific requirement for METTL3-dependent m(6)A modification during dental pulp stem cell differentiation.
Luo H, Liu W, Zhou Y, Zhang Y, Wu J, Wang R, Shao L
Journal of translational medicine 2022 Dec 16;20(1):605
Journal of translational medicine 2022 Dec 16;20(1):605
Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression.
Timcheva K, Dufour S, Touat-Todeschini L, Burnard C, Carpentier MC, Chuffart F, Merret R, Helsmoortel M, Ferré S, Grézy A, Couté Y, Rousseaux S, Khochbin S, Vourc'h C, Bousquet-Antonelli C, Kiernan R, Seigneurin-Berny D, Verdel A
Cell reports 2022 Dec 13;41(11):111784
Cell reports 2022 Dec 13;41(11):111784
Role of N6-methyladenosine RNA modification in the imbalanced inflammatory homeostasis of arsenic-induced skin lesions.
Yang F, Zhang A
Environmental toxicology 2022 Aug;37(8):1831-1839
Environmental toxicology 2022 Aug;37(8):1831-1839
Mettl3-mediated mRNA m(6)A modification controls postnatal liver development by modulating the transcription factor Hnf4a.
Xu Y, Zhou Z, Kang X, Pan L, Liu C, Liang X, Chu J, Dong S, Li Y, Liu Q, Sun Y, Yu S, Zhang Q
Nature communications 2022 Aug 5;13(1):4555
Nature communications 2022 Aug 5;13(1):4555
METTL14-dependent m(6)A modification controls iNKT cell development and function.
Cao L, Morgun E, Genardi S, Visvabharathy L, Cui Y, Huang H, Wang CR
Cell reports 2022 Aug 2;40(5):111156
Cell reports 2022 Aug 2;40(5):111156
METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner.
Li J, Yao H, Huang J, Li C, Zhang Y, Xu R, Wang Z, Long Z, Tang J, Wang L
Cell death & disease 2022 Aug 19;13(8):723
Cell death & disease 2022 Aug 19;13(8):723
PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y
The EMBO journal 2022 Aug 16;41(16):e110439
The EMBO journal 2022 Aug 16;41(16):e110439
Comprehensive analysis of RNA m6A methylation in pressure overload-induced cardiac hypertrophy.
Li W, Xing C, Bao L, Han S, Luo T, Wang Z, Fan H
BMC genomics 2022 Aug 11;23(1):576
BMC genomics 2022 Aug 11;23(1):576
m(6) A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels.
Liu Y, Zhai E, Chen J, Qian Y, Zhao R, Ma Y, Liu J, Huang Z, Cai S, Chen J
Cancer communications (London, England) 2022 Apr;42(4):327-344
Cancer communications (London, England) 2022 Apr;42(4):327-344
METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.
Zhu Y, Peng X, Zhou Q, Tan L, Zhang C, Lin S, Long M
Cell death & disease 2022 Apr 18;13(4):358
Cell death & disease 2022 Apr 18;13(4):358
METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification.
Zhou X, Yang Y, Li Y, Liang G, Kang D, Zhou B, Li Q
Frontiers in cell and developmental biology 2021;9:784719
Frontiers in cell and developmental biology 2021;9:784719
m6A Modification-Mediated DUXAP8 Regulation of Malignant Phenotype and Chemotherapy Resistance of Hepatocellular Carcinoma Through miR-584-5p/MAPK1/ERK Pathway Axis.
Liu Z, Lu J, Fang H, Sheng J, Cui M, Yang Y, Tang B, Zhang X
Frontiers in cell and developmental biology 2021;9:783385
Frontiers in cell and developmental biology 2021;9:783385
Characterization of Long Non-coding RNAs Modified by m(6)A RNA Methylation in Skeletal Myogenesis.
Xie SJ, Tao S, Diao LT, Li PL, Chen WC, Zhou ZG, Hu YX, Hou YR, Lei H, Xu WY, Chen WJ, Peng YW, Zhang Q, Xiao ZD
Frontiers in cell and developmental biology 2021;9:762669
Frontiers in cell and developmental biology 2021;9:762669
Dynamic m(6)A mRNA Methylation Reveals the Role of METTL3/14-m(6)A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration.
Xie SJ, Lei H, Yang B, Diao LT, Liao JY, He JH, Tao S, Hu YX, Hou YR, Sun YJ, Peng YW, Zhang Q, Xiao ZD
Frontiers in cell and developmental biology 2021;9:744171
Frontiers in cell and developmental biology 2021;9:744171
Validated Impacts of N6-Methyladenosine Methylated mRNAs on Apoptosis and Angiogenesis in Myocardial Infarction Based on MeRIP-Seq Analysis.
Zhang Y, Hua W, Dang Y, Cheng Y, Wang J, Zhang X, Teng M, Wang S, Zhang M, Kong Z, Lu X, Zheng Y
Frontiers in molecular biosciences 2021;8:789923
Frontiers in molecular biosciences 2021;8:789923
Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.
Li CM, Li M, Zhao WB, Ye ZC, Peng H
Frontiers in molecular biosciences 2021;8:654465
Frontiers in molecular biosciences 2021;8:654465
Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis.
Cheng Z, Gao S, Liang X, Lian C, Chen J, Fang C
BioMed research international 2021;2021:1015293
BioMed research international 2021;2021:1015293
N6-methyladenosine regulates ATM expression and downstream signaling.
Zhang X, Liu P, Zheng X, Wang J, Peng Q, Li Z, Wei L, Liu C, Wu Y, Wen Y, Yan Q, Ma J
Journal of Cancer 2021;12(23):7041-7051
Journal of Cancer 2021;12(23):7041-7051
Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice.
Su X, Shen Y, Jin Y, Kim IM, Weintraub NL, Tang Y
Frontiers in pharmacology 2021;12:654316
Frontiers in pharmacology 2021;12:654316
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.
Chen C, Yuan W, Zhou Q, Shao B, Guo Y, Wang W, Yang S, Guo Y, Zhao L, Dang Q, Yang X, Wang G, Kang Q, Ji Z, Liu J, Sun Z
Theranostics 2021;11(9):4298-4315
Theranostics 2021;11(9):4298-4315
Binding of RNA m6A by IGF2BP3 triggers chemoresistance of HCT8 cells via upregulation of ABCB1.
Yang Z, Zhao F, Gu X, Feng L, Xu M, Li T, Liu X, Zhang X
American journal of cancer research 2021;11(4):1428-1445
American journal of cancer research 2021;11(4):1428-1445
Identification and Validation of m6A-Related lncRNA Signature as Potential Predictive Biomarkers in Breast Cancer.
Lv W, Wang Y, Zhao C, Tan Y, Xiong M, Yi Y, He X, Ren Y, Wu Y, Zhang Q
Frontiers in oncology 2021;11:745719
Frontiers in oncology 2021;11:745719
Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.
Li K, Gao S, Ma L, Sun Y, Peng ZY, Wu J, Du N, Ren H, Tang SC, Sun X
Frontiers in oncology 2021;11:731561
Frontiers in oncology 2021;11:731561
N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway.
Tan L, Tang Y, Li H, Li P, Ye Y, Cen J, Gui C, Luo J, Cao J, Wei J
Frontiers in oncology 2021;11:641833
Frontiers in oncology 2021;11:641833
YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.
Fang C, He M, Li D, Xu Q
Cellular signalling 2021 Sep;85:110060
Cellular signalling 2021 Sep;85:110060
Vitamin B(12) Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.
Mosca P, Robert A, Alberto JM, Meyer M, Kundu U, Hergalant S, Umoret R, Coelho D, Guéant JL, Leheup B, Dreumont N
Molecular nutrition & food research 2021 Sep;65(17):e2100206
Molecular nutrition & food research 2021 Sep;65(17):e2100206
Multiomics analysis identifies key genes and pathways related to N6-methyladenosine RNA modification in ovarian cancer.
Xu H, Li X, Wang S, Li F, Gao J, Yan L, Zhu L
Epigenomics 2021 Sep;13(17):1359-1383
Epigenomics 2021 Sep;13(17):1359-1383
CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.
Liu X, Liu Y, Liu Z, Lin C, Meng F, Xu L, Zhang X, Zhang C, Zhang P, Gong S, Wu N, Ren Z, Song J, Zhang Y
Molecular cancer 2021 Sep 8;20(1):114
Molecular cancer 2021 Sep 8;20(1):114
METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W, O'Donnell JM, Tang B, Zhu X
Molecular neurodegeneration 2021 Sep 30;16(1):70
Molecular neurodegeneration 2021 Sep 30;16(1):70
Systematic calibration of epitranscriptomic maps using a synthetic modification-free RNA library.
Zhang Z, Chen T, Chen HX, Xie YY, Chen LQ, Zhao YL, Liu BD, Jin L, Zhang W, Liu C, Ma DZ, Chai GS, Zhang Y, Zhao WS, Ng WH, Chen J, Jia G, Yang J, Luo GZ
Nature methods 2021 Oct;18(10):1213-1222
Nature methods 2021 Oct;18(10):1213-1222
METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.
Zhao K, Yang C, Zhang J, Sun W, Zhou B, Kong X, Shi J
Cell death discovery 2021 Oct 13;7(1):291
Cell death discovery 2021 Oct 13;7(1):291
m(6)A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.
Takemoto S, Nakano M, Fukami T, Nakajima M
Biochemical pharmacology 2021 Nov;193:114766
Biochemical pharmacology 2021 Nov;193:114766
m(6)A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity.
Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA, Li HB, Ouyang X
Cell reports 2021 Nov 9;37(6):109968
Cell reports 2021 Nov 9;37(6):109968
Degradation of WTAP blocks antiviral responses by reducing the m(6) A levels of IRF3 and IFNAR1 mRNA.
Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A
EMBO reports 2021 Nov 4;22(11):e52101
EMBO reports 2021 Nov 4;22(11):e52101
Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis†.
Li X, Xiong W, Long X, Dai X, Peng Y, Xu Y, Zhang Z, Zhang L, Liu Y
Biology of reproduction 2021 Nov 15;105(5):1221-1233
Biology of reproduction 2021 Nov 15;105(5):1221-1233
Role of epigenetic m(6) A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.
Parial R, Li H, Li J, Archacki S, Yang Z, Wang IZ, Chen Q, Xu C, Wang QK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21465
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21465
Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.
Yang R, Lee EE, Kim J, Choi JH, Kolitz E, Chen Y, Crewe C, Salisbury NJH, Scherer PE, Cockerell C, Smith TR, Rosen L, Verlinden L, Galloway DA, Buck CB, Feltkamp MC, Sullivan CS, Wang RC
PLoS pathogens 2021 May;17(5):e1009582
PLoS pathogens 2021 May;17(5):e1009582
METTL3 regulates skeletal muscle specific miRNAs at both transcriptional and post-transcriptional levels.
Diao LT, Xie SJ, Lei H, Qiu XS, Huang MC, Tao S, Hou YR, Hu YX, Sun YJ, Zhang Q, Xiao ZD
Biochemical and biophysical research communications 2021 May 7;552:52-58
Biochemical and biophysical research communications 2021 May 7;552:52-58
mTORC1 promotes cell growth via m(6)A-dependent mRNA degradation.
Cho S, Lee G, Pickering BF, Jang C, Park JH, He L, Mathur L, Kim SS, Jung S, Tang HW, Monette S, Rabinowitz JD, Perrimon N, Jaffrey SR, Blenis J
Molecular cell 2021 May 20;81(10):2064-2075.e8
Molecular cell 2021 May 20;81(10):2064-2075.e8
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
Li N, Hui H, Bray B, Gonzalez GM, Zeller M, Anderson KG, Knight R, Smith D, Wang Y, Carlin AF, Rana TM
Cell reports 2021 May 11;35(6):109091
Cell reports 2021 May 11;35(6):109091
The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity.
Liu J, Gao M, He J, Wu K, Lin S, Jin L, Chen Y, Liu H, Shi J, Wang X, Chang L, Lin Y, Zhao YL, Zhang X, Zhang M, Luo GZ, Wu G, Pei D, Wang J, Bao X, Chen J
Nature 2021 Mar;591(7849):322-326
Nature 2021 Mar;591(7849):322-326
METTL3 regulates heterochromatin in mouse embryonic stem cells.
Xu W, Li J, He C, Wen J, Ma H, Rong B, Diao J, Wang L, Wang J, Wu F, Tan L, Shi YG, Shi Y, Shen H
Nature 2021 Mar;591(7849):317-321
Nature 2021 Mar;591(7849):317-321
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361
Cell research 2021 Mar;31(3):345-361
N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.
Chen S, Kumar S, Espada CE, Tirumuru N, Cahill MP, Hu L, He C, Wu L
PLoS pathogens 2021 Mar;17(3):e1009421
PLoS pathogens 2021 Mar;17(3):e1009421
RNA N(6)-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m(6)A-GLUT1-mTORC1 Axis and Is a Therapeutic Target.
Chen H, Gao S, Liu W, Wong CC, Wu J, Wu J, Liu D, Gou H, Kang W, Zhai J, Li C, Su H, Wang S, Soares F, Han J, He HH, Yu J
Gastroenterology 2021 Mar;160(4):1284-1300.e16
Gastroenterology 2021 Mar;160(4):1284-1300.e16
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W
Clinical and translational medicine 2021 Mar;11(3):e352
Clinical and translational medicine 2021 Mar;11(3):e352
mTORC1-chaperonin CCT signaling regulates m(6)A RNA methylation to suppress autophagy.
Tang HW, Weng JH, Lee WX, Hu Y, Gu L, Cho S, Lee G, Binari R, Li C, Cheng ME, Kim AR, Xu J, Shen Z, Xu C, Asara JM, Blenis J, Perrimon N
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 9;118(10)
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 9;118(10)
N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition.
Kim GW, Siddiqui A
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 9;118(10)
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 9;118(10)
N(6)-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles.
Wang X, Liu C, Zhang S, Yan H, Zhang L, Jiang A, Liu Y, Feng Y, Li D, Guo Y, Hu X, Lin Y, Bu P, Li D
Developmental cell 2021 Mar 8;56(5):702-715.e8
Developmental cell 2021 Mar 8;56(5):702-715.e8
MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.
Wu G, Suo C, Yang Y, Shen S, Sun L, Li ST, Zhou Y, Yang D, Wang Y, Cai Y, Wang N, Zhang H, Yang YG, Cao J, Gao P
EMBO reports 2021 Mar 3;22(3):e51519
EMBO reports 2021 Mar 3;22(3):e51519
A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.
Wu X, Sheng H, Wang L, Xia P, Wang Y, Yu L, Lv W, Hu J
Aging 2021 Mar 26;13(7):10034-10057
Aging 2021 Mar 26;13(7):10034-10057
RNA m(6) A methylation regulates virus-host interaction and EBNA2 expression during Epstein-Barr virus infection.
Zheng X, Wang J, Zhang X, Fu Y, Peng Q, Lu J, Wei L, Li Z, Liu C, Wu Y, Yan Q, Ma J
Immunity, inflammation and disease 2021 Jun;9(2):351-362
Immunity, inflammation and disease 2021 Jun;9(2):351-362
YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.
Jiang D, Hou J, Qian Y, Gao Y, Gao X, Wei S
Biochemical and biophysical research communications 2021 Jun 11;557:85-89
Biochemical and biophysical research communications 2021 Jun 11;557:85-89
Regulation of telomere homeostasis and genomic stability in cancer by N (6)-adenosine methylation (m(6)A).
Lee JH, Hong J, Zhang Z, de la Peña Avalos B, Proietti CJ, Deamicis AR, Guzmán G P, Lam HM, Garcia J, Roudier MP, Sisk AE, De La Rosa R, Vu K, Yang M, Liao Y, Scheirer J, Pechacek D, Yadav P, Rao MK, Zheng S, Johnson-Pais TL, Leach RJ, Elizalde PV, Dray E, Xu K
Science advances 2021 Jul;7(31)
Science advances 2021 Jul;7(31)
The N(6)-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.
Ondo K, Isono M, Nakano M, Hashiba S, Fukami T, Nakajima M
Biochemical pharmacology 2021 Jul;189:114402
Biochemical pharmacology 2021 Jul;189:114402
The m(6)A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.
Bechara R, Amatya N, Bailey RD, Li Y, Aggor FEY, Li DD, Jawale CV, Coleman BM, Dai N, Gokhale NS, Taylor TC, Horner SM, Poholek AC, Bansal A, Biswas PS, Gaffen SL
Science immunology 2021 Jul 2;6(61)
Science immunology 2021 Jul 2;6(61)
N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Cheng Y, Xie W, Pickering BF, Chu KL, Savino AM, Yang X, Luo H, Nguyen DT, Mo S, Barin E, Velleca A, Rohwetter TM, Patel DJ, Jaffrey SR, Kharas MG
Cancer cell 2021 Jul 12;39(7):958-972.e8
Cancer cell 2021 Jul 12;39(7):958-972.e8
Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Wang YJ, Yang B, Lai Q, Shi JF, Peng JY, Zhang Y, Hu KS, Li YQ, Peng JW, Yang ZZ, Li YT, Pan Y, Koeffler HP, Liao JY, Yin D
RNA biology 2021 Jan;18(1):131-143
RNA biology 2021 Jan;18(1):131-143
Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.
Dai DL, Li X, Wang L, Xie C, Jin Y, Zeng MS, Zuo Z, Xia TL
The Journal of biological chemistry 2021 Jan-Jun;296:100547
The Journal of biological chemistry 2021 Jan-Jun;296:100547
Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs.
Kim GW, Siddiqui A
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 19;118(3)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 19;118(3)
HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC.
Kim GW, Imam H, Khan M, Mir SA, Kim SJ, Yoon SK, Hur W, Siddiqui A
Hepatology (Baltimore, Md.) 2021 Feb;73(2):533-547
Hepatology (Baltimore, Md.) 2021 Feb;73(2):533-547
Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts.
Li T, Zhuang Y, Yang W, Xie Y, Shang W, Su S, Dong X, Wu J, Jiang W, Zhou Y, Li Y, Zhou X, Zhang M, Lu Y, Pan Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21162
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21162
Local translation in nuclear condensate amyloid bodies.
Theodoridis PR, Bokros M, Marijan D, Balukoff NC, Wang D, Kirk CC, Budine TD, Goldsmith HD, Wang M, Audas TE, Lee S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Loss of m(6)A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury.
Gong R, Wang X, Li H, Liu S, Jiang Z, Zhao Y, Yu Y, Han Z, Yu Y, Dong C, Li S, Xu B, Zhang W, Wang N, Li X, Gao X, Yang F, Bamba D, Ma W, Liu Y, Cai B
Pharmacological research 2021 Dec;174:105845
Pharmacological research 2021 Dec;174:105845
Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus.
Xue M, Zhang Y, Wang H, Kairis EL, Lu M, Ahmad S, Attia Z, Harder O, Zhang Z, Wei J, Chen P, Gao Y, Peeples ME, Sharma A, Boyaka P, He C, Hur S, Niewiesk S, Li J
PLoS pathogens 2021 Dec;17(12):e1010142
PLoS pathogens 2021 Dec;17(12):e1010142
YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.
Zhu X, Yang H, Zhang M, Wu X, Jiang L, Liu X, Lv K
Cancer cell international 2021 Dec 4;21(1):645
Cancer cell international 2021 Dec 4;21(1):645
Dynamic regulation of N(6),2'-O-dimethyladenosine (m(6)Am) in obesity.
Ben-Haim MS, Pinto Y, Moshitch-Moshkovitz S, Hershkovitz V, Kol N, Diamant-Levi T, Beeri MS, Amariglio N, Cohen HY, Rechavi G
Nature communications 2021 Dec 10;12(1):7185
Nature communications 2021 Dec 10;12(1):7185
Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice.
Xue A, Huang Y, Li M, Wei Q, Bu Q
Molecular neurobiology 2021 Aug;58(8):3759-3768
Molecular neurobiology 2021 Aug;58(8):3759-3768
KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy.
Qi Y, Yao R, Zhang W, Cui Q
Pharmacological research 2021 Aug;170:105713
Pharmacological research 2021 Aug;170:105713
Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.
Zhao S, Lu J, Chen Y, Wang Z, Cao J, Dong Y
Journal of reproductive immunology 2021 Aug;146:103341
Journal of reproductive immunology 2021 Aug;146:103341
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
Einstein JM, Perelis M, Chaim IA, Meena JK, Nussbacher JK, Tankka AT, Yee BA, Li H, Madrigal AA, Neill NJ, Shankar A, Tyagi S, Westbrook TF, Yeo GW
Molecular cell 2021 Aug 5;81(15):3048-3064.e9
Molecular cell 2021 Aug 5;81(15):3048-3064.e9
Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication.
Zhang X, Hao H, Ma L, Zhang Y, Hu X, Chen Z, Liu D, Yuan J, Hu Z, Guan W
mBio 2021 Aug 31;12(4):e0106721
mBio 2021 Aug 31;12(4):e0106721
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.
Ma S, Yan J, Barr T, Zhang J, Chen Z, Wang LS, Sun JC, Chen J, Caligiuri MA, Yu J
The Journal of experimental medicine 2021 Aug 2;218(8)
The Journal of experimental medicine 2021 Aug 2;218(8)
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
Sang W, Xue S, Jiang Y, Lu H, Zhu L, Wang C, Ma J
Life sciences 2021 Aug 1;278:119528
Life sciences 2021 Aug 1;278:119528
m(6)A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype.
Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, Kossenkov AV, Simon MC, Zhang R
Nature cell biology 2021 Apr;23(4):355-365
Nature cell biology 2021 Apr;23(4):355-365
Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m(6)A-GPR161 signalling axis.
Zong X, Wang H, Xiao X, Zhang Y, Hu Y, Wang F, Wang Y, Lu Z
RNA biology 2021 Apr;18(4):576-586
RNA biology 2021 Apr;18(4):576-586
Nonsegmented Negative-Sense RNA Viruses Utilize N(6)-Methyladenosine (m(6)A) as a Common Strategy To Evade Host Innate Immunity.
Lu M, Xue M, Wang HT, Kairis EL, Ahmad S, Wei J, Zhang Z, Liu Q, Zhang Y, Gao Y, Garcin D, Peeples ME, Sharma A, Hur S, He C, Li J
Journal of virology 2021 Apr 12;95(9)
Journal of virology 2021 Apr 12;95(9)
Autophagy of the m(6)A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, He YY
Nature communications 2021 Apr 12;12(1):2183
Nature communications 2021 Apr 12;12(1):2183
EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.
Qi B, Yang C, Zhu Z, Chen H
Frontiers in cell and developmental biology 2020;8:574940
Frontiers in cell and developmental biology 2020;8:574940
A defined N6-methyladenosine (m(6)A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions.
Gheller BJ, Blum JE, Fong EHH, Malysheva OV, Cosgrove BD, Thalacker-Mercer AE
Cell death discovery 2020;6(1):95
Cell death discovery 2020;6(1):95
Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke.
Si W, Li Y, Ye S, Li Z, Liu Y, Kuang W, Chen D, Zhu M
Frontiers in molecular neuroscience 2020;13:103
Frontiers in molecular neuroscience 2020;13:103
The M6A methyltransferase METTL3 promotes the development and progression of prostate carcinoma via mediating MYC methylation.
Yuan Y, Du Y, Wang L, Liu X
Journal of Cancer 2020;11(12):3588-3595
Journal of Cancer 2020;11(12):3588-3595
m(6)A RNA Methylation Regulators Contribute to Eutopic Endometrium and Myometrium Dysfunction in Adenomyosis.
Zhai J, Li S, Sen S, Opoku-Anane J, Du Y, Chen ZJ, Giudice LC
Frontiers in genetics 2020;11:716
Frontiers in genetics 2020;11:716
m(6)A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.
He JJ, Li Z, Rong ZX, Gao J, Mu Y, Guan YD, Ren XX, Zi YY, Liu LY, Fan Q, Zhou M, Duan YM, Zhou Q, Deng YZ, Sun LQ
Frontiers in oncology 2020;10:1166
Frontiers in oncology 2020;10:1166
m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation.
Xu J, Chen Q, Tian K, Liang R, Chen T, Gong A, Mathy NW, Yu T, Chen X
Oncology reports 2020 Sep;44(3):973-986
Oncology reports 2020 Sep;44(3):973-986
Knockdown of m6A methyltransferase METTL3 in gastric cancer cells results in suppression of cell proliferation.
Jiang L, Chen T, Xiong L, Xu JH, Gong AY, Dai B, Wu G, Zhu K, Lu E, Mathy NW, Chen XM
Oncology letters 2020 Sep;20(3):2191-2198
Oncology letters 2020 Sep;20(3):2191-2198
N(6)-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling.
Kim GW, Imam H, Khan M, Siddiqui A
The Journal of biological chemistry 2020 Sep 11;295(37):13123-13133
The Journal of biological chemistry 2020 Sep 11;295(37):13123-13133
Validation strategies for antibodies targeting modified ribonucleotides.
Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert FD, Angstman NB, Cardoso MC, König J, Hüttelmaier S, Dieterich C, Canzar S, Helm M, Heissmeyer V, Feederle R, Meister G
RNA (New York, N.Y.) 2020 Oct;26(10):1489-1506
RNA (New York, N.Y.) 2020 Oct;26(10):1489-1506
METTL3 potentiates resistance to cisplatin through m(6) A modification of TFAP2C in seminoma.
Wei J, Yin Y, Zhou J, Chen H, Peng J, Yang J, Tang Y
Journal of cellular and molecular medicine 2020 Oct;24(19):11366-11380
Journal of cellular and molecular medicine 2020 Oct;24(19):11366-11380
Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
Ho-Xuan H, Glažar P, Latini C, Heizler K, Haase J, Hett R, Anders M, Weichmann F, Bruckmann A, Van den Berg D, Hüttelmaier S, Rajewsky N, Hackl C, Meister G
Nucleic acids research 2020 Oct 9;48(18):10368-10382
Nucleic acids research 2020 Oct 9;48(18):10368-10382
Context-dependent functional compensation between Ythdf m(6)A reader proteins.
Lasman L, Krupalnik V, Viukov S, Mor N, Aguilera-Castrejon A, Schneir D, Bayerl J, Mizrahi O, Peles S, Tawil S, Sathe S, Nachshon A, Shani T, Zerbib M, Kilimnik I, Aigner S, Shankar A, Mueller JR, Schwartz S, Stern-Ginossar N, Yeo GW, Geula S, Novershtern N, Hanna JH
Genes & development 2020 Oct 1;34(19-20):1373-1391
Genes & development 2020 Oct 1;34(19-20):1373-1391
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA.
Gao XQ, Zhang YH, Liu F, Ponnusamy M, Zhao XM, Zhou LY, Zhai M, Liu CY, Li XM, Wang M, Shan C, Shan PP, Wang Y, Dong YH, Qian LL, Yu T, Ju J, Wang T, Wang K, Chen XZ, Wang YH, Zhang J, Li PF, Wang K
Nature cell biology 2020 Nov;22(11):1319-1331
Nature cell biology 2020 Nov;22(11):1319-1331
Analysis of METTL3 and METTL14 in hepatocellular carcinoma.
Liu X, Qin J, Gao T, Li C, Chen X, Zeng K, Xu M, He B, Pan B, Xu X, Pan Y, Sun H, Xu T, Wang S
Aging 2020 Nov 6;12(21):21638-21659
Aging 2020 Nov 6;12(21):21638-21659
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
Wu Z, Shi Y, Lu M, Song M, Yu Z, Wang J, Wang S, Ren J, Yang YG, Liu GH, Zhang W, Ci W, Qu J
Nucleic acids research 2020 Nov 4;48(19):11083-11096
Nucleic acids research 2020 Nov 4;48(19):11083-11096
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
bioRxiv : the preprint server for biology 2020 Nov 16;
bioRxiv : the preprint server for biology 2020 Nov 16;
Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
Zhou L, Yang C, Zhang N, Zhang X, Zhao T, Yu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109964
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109964
Dynamic landscape and evolution of m6A methylation in human.
Zhang H, Shi X, Huang T, Zhao X, Chen W, Gu N, Zhang R
Nucleic acids research 2020 Jun 19;48(11):6251-6264
Nucleic acids research 2020 Jun 19;48(11):6251-6264
ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.
Tian J, Ying P, Ke J, Zhu Y, Yang Y, Gong Y, Zou D, Peng X, Yang N, Wang X, Mei S, Zhang Y, Wang C, Zhong R, Chang J, Miao X
International journal of cancer 2020 Jun 15;146(12):3281-3293
International journal of cancer 2020 Jun 15;146(12):3281-3293
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550
Carcinogenesis 2020 Jul 10;41(5):541-550
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
Yu J, Shen L, Liu Y, Ming H, Zhu X, Chu M, Lin J
Molecular and cellular biochemistry 2020 Jan;463(1-2):203-210
Molecular and cellular biochemistry 2020 Jan;463(1-2):203-210
Direct RNA sequencing enables m(6)A detection in endogenous transcript isoforms at base-specific resolution.
Lorenz DA, Sathe S, Einstein JM, Yeo GW
RNA (New York, N.Y.) 2020 Jan;26(1):19-28
RNA (New York, N.Y.) 2020 Jan;26(1):19-28
Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts.
Imam H, Kim GW, Mir SA, Khan M, Siddiqui A
PLoS pathogens 2020 Feb;16(2):e1008338
PLoS pathogens 2020 Feb;16(2):e1008338
Integrative network analysis identifies cell-specific trans regulators of m6A.
An S, Huang W, Huang X, Cun Y, Cheng W, Sun X, Ren Z, Chen Y, Chen W, Wang J
Nucleic acids research 2020 Feb 28;48(4):1715-1729
Nucleic acids research 2020 Feb 28;48(4):1715-1729
METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export.
Li D, Cai L, Meng R, Feng Z, Xu Q
International journal of molecular sciences 2020 Feb 28;21(5)
International journal of molecular sciences 2020 Feb 28;21(5)
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
NADP modulates RNA m(6)A methylation and adipogenesis via enhancing FTO activity.
Wang L, Song C, Wang N, Li S, Liu Q, Sun Z, Wang K, Yu SC, Yang Q
Nature chemical biology 2020 Dec;16(12):1394-1402
Nature chemical biology 2020 Dec;16(12):1394-1402
Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism.
Liu X, Gonzalez G, Dai X, Miao W, Yuan J, Huang M, Bade D, Li L, Sun Y, Wang Y
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Dec 2;28(12):2593-2604
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Dec 2;28(12):2593-2604
m(6)A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.
Wang Y, Sun J, Lin Z, Zhang W, Wang S, Wang W, Wang Q, Ning G
Diabetes 2020 Aug;69(8):1708-1722
Diabetes 2020 Aug;69(8):1708-1722
Interplay of m(6)A and H3K27 trimethylation restrains inflammation during bacterial infection.
Wu C, Chen W, He J, Jin S, Liu Y, Yi Y, Gao Z, Yang J, Yang J, Cui J, Zhao W
Science advances 2020 Aug;6(34):eaba0647
Science advances 2020 Aug;6(34):eaba0647
Epitranscriptomic N(6)-Methyladenosine Modification Is Required for Direct Lineage Reprogramming into Neurons.
Choi H, Baek S, Cho B, Kim S, Kim J, Chang Y, Shin J, Kim J
ACS chemical biology 2020 Aug 21;15(8):2087-2097
ACS chemical biology 2020 Aug 21;15(8):2087-2097
N(6)-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
Lu M, Zhang Z, Xue M, Zhao BS, Harder O, Li A, Liang X, Gao TZ, Xu Y, Zhou J, Feng Z, Niewiesk S, Peeples ME, He C, Li J
Nature microbiology 2020 Apr;5(4):584-598
Nature microbiology 2020 Apr;5(4):584-598
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification.
Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R
The Journal of biological chemistry 2020 Apr 24;295(17):5626-5639
The Journal of biological chemistry 2020 Apr 24;295(17):5626-5639
Programmable RNA N(6)-methyladenosine editing by CRISPR-Cas9 conjugates.
Liu XM, Zhou J, Mao Y, Ji Q, Qian SB
Nature chemical biology 2019 Sep;15(9):865-871
Nature chemical biology 2019 Sep;15(9):865-871
Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.
Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C
Cell reports 2019 Sep 24;28(13):3435-3449.e5
Cell reports 2019 Sep 24;28(13):3435-3449.e5
Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.
Xue M, Zhao BS, Zhang Z, Lu M, Harder O, Chen P, Lu Z, Li A, Ma Y, Xu Y, Liang X, Zhou J, Niewiesk S, Peeples ME, He C, Li J
Nature communications 2019 Oct 9;10(1):4595
Nature communications 2019 Oct 9;10(1):4595
Regulation of Co-transcriptional Pre-mRNA Splicing by m(6)A through the Low-Complexity Protein hnRNPG.
Zhou KI, Shi H, Lyu R, Wylder AC, Matuszek Ż, Pan JN, He C, Parisien M, Pan T
Molecular cell 2019 Oct 3;76(1):70-81.e9
Molecular cell 2019 Oct 3;76(1):70-81.e9
Resveratrol and Curcumin Improve Intestinal Mucosal Integrity and Decrease m(6)A RNA Methylation in the Intestine of Weaning Piglets.
Gan Z, Wei W, Wu J, Zhao Y, Zhang L, Wang T, Zhong X
ACS omega 2019 Oct 22;4(17):17438-17446
ACS omega 2019 Oct 22;4(17):17438-17446
Endoribonucleolytic Cleavage of m(6)A-Containing RNAs by RNase P/MRP Complex.
Park OH, Ha H, Lee Y, Boo SH, Kwon DH, Song HK, Kim YK
Molecular cell 2019 May 2;74(3):494-507.e8
Molecular cell 2019 May 2;74(3):494-507.e8
HIV-1 envelope proteins up-regulate N(6)-methyladenosine levels of cellular RNA independently of viral replication.
Tirumuru N, Wu L
The Journal of biological chemistry 2019 Mar 1;294(9):3249-3260
The Journal of biological chemistry 2019 Mar 1;294(9):3249-3260
Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis.
Yang F, Jin H, Que B, Chao Y, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W, Lin S, Ji W
Oncogene 2019 Jun;38(24):4755-4772
Oncogene 2019 Jun;38(24):4755-4772
m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY
Nature communications 2019 Jun 25;10(1):2782
Nature communications 2019 Jun 25;10(1):2782
Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells.
Tian C, Huang Y, Li Q, Feng Z, Xu Q
International journal of molecular sciences 2019 Jan 28;20(3)
International journal of molecular sciences 2019 Jan 28;20(3)
Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response.
Zong X, Zhao J, Wang H, Lu Z, Wang F, Du H, Wang Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Jan 15;202(2):567-578
Journal of immunology (Baltimore, Md. : 1950) 2019 Jan 15;202(2):567-578
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Hao H, Hao S, Chen H, Chen Z, Zhang Y, Wang J, Wang H, Zhang B, Qiu J, Deng F, Guan W
Nucleic acids research 2019 Jan 10;47(1):362-374
Nucleic acids research 2019 Jan 10;47(1):362-374
m(6)A modification controls the innate immune response to infection by targeting type I interferons.
Winkler R, Gillis E, Lasman L, Safra M, Geula S, Soyris C, Nachshon A, Tai-Schmiedel J, Friedman N, Le-Trilling VTK, Trilling M, Mandelboim M, Hanna JH, Schwartz S, Stern-Ginossar N
Nature immunology 2019 Feb;20(2):173-182
Nature immunology 2019 Feb;20(2):173-182
m(6)A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Wang F, Wang Y, Wang X
Cell death & disease 2019 Feb 20;10(3):171
Cell death & disease 2019 Feb 20;10(3):171
METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling.
Zhang Y, Gu X, Li D, Cai L, Xu Q
International journal of molecular sciences 2019 Dec 27;21(1)
International journal of molecular sciences 2019 Dec 27;21(1)
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma.
Green NH, Galvan DL, Badal SS, Chang BH, LeBleu VS, Long J, Jonasch E, Danesh FR
Oncogene 2019 Aug;38(34):6211-6225
Oncogene 2019 Aug;38(34):6211-6225
METTL3 and ALKBH5 oppositely regulate m(6)A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M, Jin J, Ding X, Wu S, Huang H, Yu T, Zhang M, Hong H, Yao S, Zhao Y, Zhang Z
Autophagy 2019 Aug;15(8):1419-1437
Autophagy 2019 Aug;15(8):1419-1437
HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N(6)-methyladenosine.
Miao W, Li L, Zhao Y, Dai X, Chen X, Wang Y
Nature communications 2019 Aug 9;10(1):3613
Nature communications 2019 Aug 9;10(1):3613
m(6)A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.
Cheng Y, Luo H, Izzo F, Pickering BF, Nguyen D, Myers R, Schurer A, Gourkanti S, Brüning JC, Vu LP, Jaffrey SR, Landau DA, Kharas MG
Cell reports 2019 Aug 13;28(7):1703-1716.e6
Cell reports 2019 Aug 13;28(7):1703-1716.e6
m(6)A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.
Chen J, Zhang YC, Huang C, Shen H, Sun B, Cheng X, Zhang YJ, Yang YG, Shu Q, Yang Y, Li X
Genomics, proteomics & bioinformatics 2019 Apr;17(2):154-168
Genomics, proteomics & bioinformatics 2019 Apr;17(2):154-168
Mettl3-mediated mRNA m(6)A methylation promotes dendritic cell activation.
Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X
Nature communications 2019 Apr 23;10(1):1898
Nature communications 2019 Apr 23;10(1):1898
mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI
Nature 2018 Sep;561(7724):556-560
Nature 2018 Sep;561(7724):556-560
m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Liu J, Eckert MA, Harada BT, Liu SM, Lu Z, Yu K, Tienda SM, Chryplewicz A, Zhu AC, Yang Y, Huang JT, Chen SM, Xu ZG, Leng XH, Yu XC, Cao J, Zhang Z, Liu J, Lengyel E, He C
Nature cell biology 2018 Sep;20(9):1074-1083
Nature cell biology 2018 Sep;20(9):1074-1083
The m(6)A-methylase complex recruits TREX and regulates mRNA export.
Lesbirel S, Viphakone N, Parker M, Parker J, Heath C, Sudbery I, Wilson SA
Scientific reports 2018 Sep 14;8(1):13827
Scientific reports 2018 Sep 14;8(1):13827
mRNA m(6)A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
Wang X, Sun B, Jiang Q, Wu R, Cai M, Yao Y, Liu Q, Shi H, Feng J, Wang Y
International journal of obesity (2005) 2018 Nov;42(11):1912-1924
International journal of obesity (2005) 2018 Nov;42(11):1912-1924
A dynamic N(6)-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Yan F, Al-Kali A, Zhang Z, Liu J, Pang J, Zhao N, He C, Litzow MR, Liu S
Cell research 2018 Nov;28(11):1062-1076
Cell research 2018 Nov;28(11):1062-1076
METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.
Hua W, Zhao Y, Jin X, Yu D, He J, Xie D, Duan P
Gynecologic oncology 2018 Nov;151(2):356-365
Gynecologic oncology 2018 Nov;151(2):356-365
Mettl3-mediated m(6)A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y, Zheng R, Jiang Y, Ye L, Chen Q, Zhou X, Lin S, Yuan Q
Nature communications 2018 Nov 14;9(1):4772
Nature communications 2018 Nov 14;9(1):4772
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m(6)A mRNA Methylation.
Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham CM, Dolan K, Zhu X, Hubert N, Tao Y, Lin F, Martinez-Guryn K, Huang Y, Wang T, Liu J, He C, Chang EB, Leone V
Cell reports 2018 Nov 13;25(7):1816-1828.e4
Cell reports 2018 Nov 13;25(7):1816-1828.e4
METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells.
Feng Z, Li Q, Meng R, Yi B, Xu Q
Journal of cellular and molecular medicine 2018 May;22(5):2558-2568
Journal of cellular and molecular medicine 2018 May;22(5):2558-2568
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d.
Knuckles P, Lence T, Haussmann IU, Jacob D, Kreim N, Carl SH, Masiello I, Hares T, Villaseñor R, Hess D, Andrade-Navarro MA, Biggiogera M, Helm M, Soller M, Bühler M, Roignant JY
Genes & development 2018 Mar 1;32(5-6):415-429
Genes & development 2018 Mar 1;32(5-6):415-429
Transient N-6-Methyladenosine Transcriptome Sequencing Reveals a Regulatory Role of m6A in Splicing Efficiency.
Louloupi A, Ntini E, Conrad T, Ørom UAV
Cell reports 2018 Jun 19;23(12):3429-3437
Cell reports 2018 Jun 19;23(12):3429-3437
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, Jiang B, Xu M, Cheng J, Chen GQ, Zhao X, Yu J
Nucleic acids research 2018 Jun 1;46(10):5195-5208
Nucleic acids research 2018 Jun 1;46(10):5195-5208
The Role of m(6)A/m-RNA Methylation in Stress Response Regulation.
Engel M, Eggert C, Kaplick PM, Eder M, Röh S, Tietze L, Namendorf C, Arloth J, Weber P, Rex-Haffner M, Geula S, Jakovcevski M, Hanna JH, Leshkowitz D, Uhr M, Wotjak CT, Schmidt MV, Deussing JM, Binder EB, Chen A
Neuron 2018 Jul 25;99(2):389-403.e9
Neuron 2018 Jul 25;99(2):389-403.e9
The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.
Taketo K, Konno M, Asai A, Koseki J, Toratani M, Satoh T, Doki Y, Mori M, Ishii H, Ogawa K
International journal of oncology 2018 Feb;52(2):621-629
International journal of oncology 2018 Feb;52(2):621-629
Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.
Xia H, Zhong C, Wu X, Chen J, Tao B, Xia X, Shi M, Zhu Z, Trudeau VL, Hu W
Genetics 2018 Feb;208(2):729-743
Genetics 2018 Feb;208(2):729-743
Dynamic m6A modification regulates local translation of mRNA in axons.
Yu J, Chen M, Huang H, Zhu J, Song H, Zhu J, Park J, Ji SJ
Nucleic acids research 2018 Feb 16;46(3):1412-1423
Nucleic acids research 2018 Feb 16;46(3):1412-1423
N(6)-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB
Molecular cell 2018 Feb 15;69(4):636-647.e7
Molecular cell 2018 Feb 15;69(4):636-647.e7
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I
Genes & development 2018 Dec 1;32(23-24):1472-1484
Genes & development 2018 Dec 1;32(23-24):1472-1484
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
Kudou K, Komatsu T, Nogami J, Maehara K, Harada A, Saeki H, Oki E, Maehara Y, Ohkawa Y
Open biology 2017 Sep;7(9)
Open biology 2017 Sep;7(9)
Region-specific RNA m(6)A methylation represents a new layer of control in the gene regulatory network in the mouse brain.
Chang M, Lv H, Zhang W, Ma C, He X, Zhao S, Zhang ZW, Zeng YX, Song S, Niu Y, Tong WM
Open biology 2017 Sep;7(9)
Open biology 2017 Sep;7(9)
NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.
Li Q, Li X, Tang H, Jiang B, Dou Y, Gorospe M, Wang W
Journal of cellular biochemistry 2017 Sep;118(9):2587-2598
Journal of cellular biochemistry 2017 Sep;118(9):2587-2598
The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
Vu LP, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, Carroll M, Mason CE, Jaffrey SR, Kharas MG
Nature medicine 2017 Nov;23(11):1369-1376
Nature medicine 2017 Nov;23(11):1369-1376
m(6)A Facilitates eIF4F-Independent mRNA Translation.
Coots RA, Liu XM, Mao Y, Dong L, Zhou J, Wan J, Zhang X, Qian SB
Molecular cell 2017 Nov 2;68(3):504-514.e7
Molecular cell 2017 Nov 2;68(3):504-514.e7
m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.
Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, Riggs AD, He C, Shi Y
Cell reports 2017 Mar 14;18(11):2622-2634
Cell reports 2017 Mar 14;18(11):2622-2634
N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.
Liu N, Zhou KI, Parisien M, Dai Q, Diatchenko L, Pan T
Nucleic acids research 2017 Jun 2;45(10):6051-6063
Nucleic acids research 2017 Jun 2;45(10):6051-6063
RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.
Knuckles P, Carl SH, Musheev M, Niehrs C, Wenger A, Bühler M
Nature structural & molecular biology 2017 Jul;24(7):561-569
Nature structural & molecular biology 2017 Jul;24(7):561-569
AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N(6)-methyladenosine.
Wu W, Feng J, Jiang D, Zhou X, Jiang Q, Cai M, Wang X, Shan T, Wang Y
Scientific reports 2017 Feb 8;7:41606
Scientific reports 2017 Feb 8;7:41606
Thiol-linked alkylation of RNA to assess expression dynamics.
Herzog VA, Reichholf B, Neumann T, Rescheneder P, Bhat P, Burkard TR, Wlotzka W, von Haeseler A, Zuber J, Ameres SL
Nature methods 2017 Dec;14(12):1198-1204
Nature methods 2017 Dec;14(12):1198-1204
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.
Slobodin B, Han R, Calderone V, Vrielink JAFO, Loayza-Puch F, Elkon R, Agami R
Cell 2017 Apr 6;169(2):326-337.e12
Cell 2017 Apr 6;169(2):326-337.e12
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Lin S, Choe J, Du P, Triboulet R, Gregory RI
Molecular cell 2016 May 5;62(3):335-345
Molecular cell 2016 May 5;62(3):335-345
N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.
Tirumuru N, Zhao BS, Lu W, Lu Z, He C, Wu L
eLife 2016 Jul 2;5
eLife 2016 Jul 2;5
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Chen T, Hao YJ, Zhang Y, Li MM, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ, Yang YG, Zhou Q
Cell stem cell 2015 Mar 5;16(3):289-301
Cell stem cell 2015 Mar 5;16(3):289-301
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Manor YS, Ben-Haim MS, Eyal E, Yunger S, Pinto Y, Jaitin DA, Viukov S, Rais Y, Krupalnik V, Chomsky E, Zerbib M, Maza I, Rechavi Y, Massarwa R, Hanna S, Amit I, Levanon EY, Amariglio N, Stern-Ginossar N, Novershtern N, Rechavi G, Hanna JH
Science (New York, N.Y.) 2015 Feb 27;347(6225):1002-6
Science (New York, N.Y.) 2015 Feb 27;347(6225):1002-6
N6-methyladenosine-dependent regulation of messenger RNA stability.
Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C
Nature 2014 Jan 2;505(7481):117-20
Nature 2014 Jan 2;505(7481):117-20
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C
Nature chemical biology 2014 Feb;10(2):93-5
Nature chemical biology 2014 Feb;10(2):93-5
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
Zhao X, Yang Y, Sun BF, Shi Y, Yang X, Xiao W, Hao YJ, Ping XL, Chen YS, Wang WJ, Jin KX, Wang X, Huang CM, Fu Y, Ge XM, Song SH, Jeong HS, Yanagisawa H, Niu Y, Jia GF, Wu W, Tong WM, Okamoto A, He C, Rendtlew Danielsen JM, Wang XJ, Yang YG
Cell research 2014 Dec;24(12):1403-19
Cell research 2014 Dec;24(12):1403-19
m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.
Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, Bouley DM, Lujan E, Haddad B, Daneshvar K, Carter AC, Flynn RA, Zhou C, Lim KS, Dedon P, Wernig M, Mullen AC, Xing Y, Giallourakis CC, Chang HY
Cell stem cell 2014 Dec 4;15(6):707-19
Cell stem cell 2014 Dec 4;15(6):707-19
RNA-methylation-dependent RNA processing controls the speed of the circadian clock.
Fustin JM, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I, Okamura H
Cell 2013 Nov 7;155(4):793-806
Cell 2013 Nov 7;155(4):793-806
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 15073-1-AP(METTL3 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The METTL3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human METTL3. This antibody recognizes human,mouse,rat antigen. The METTL3 antibody has been validated for the following applications: ELISA, WB, IP analysis.
