67733-1-Ig

antibody from Proteintech Group

Targeting: METTL3 M6A, MT-A70, Spo8

Provider product page for 67733-1-Ig

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [33]
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Product number: 67733-1-Ig - Provider product page
Provider: Proteintech Group
Product name: METTL3 antibody
Antibody type: Monoclonal
Description: KD/KO validated METTL3 antibody (Cat. #67733-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2D8H1
Vial size: 20ul, 150ul

METTL3 protein structure - 67733-1-Ig shown in red.

Submitted references FUS is an N1- and N6-methyladenosine-binding protein.

Liang X, Zhao T, Dai X, Sun Y, Yuan J, Afzalpurkar S, Duong C, Yu A, Tang F, He X, Liu X, Chen X, Cao Z, Wang Y
Nucleic acids research 2026 Feb 24;54(5)

HIV-1 Vpr activates microglia by upregulating m6A modification through ubiquitin-proteasome pathway-mediated degradation of the demethylase ALKBH5.

Peng Q, Li W, Qian F, Zhu Y, Hu S, Shi Y, Xia Y, Liu W, Shu X, Wan P, Liu Y, Sun B
Virulence 2026 Dec;17(1):2645908

METTL3-mediated m(6)A methylation of lncRNA PVT1 promotes the progression of oral squamous cell carcinoma via the miR-185-5p/SERPINB4 axis.

Chen C, Li J, Yang B, Kong L, Zhang D, Guo J, Zhou L, Bai G, Zhao H, Meng Z
American journal of cancer research 2025;15(6):2872-2889

RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.

Yan Z, Cao H, Zhang X, Wang Y, Chang Q
International immunopharmacology 2025 Sep 23;162:115141

METTL3 facilitates colorectal cancer growth through altering the abundance of intestinal Akkermansia muciniphila.

Wu L, Lian W, Bai R, Chen H, Wu J, Li H, Zhao L
Cancer gene therapy 2025 Oct;32(10):1098-1106

METTL3-dependent m(6)A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation.

Yang N, Lai Y, Yu G, Zhang X, Shi J, Xiang L, Zhang J, Wu Y, Jiang X, Zhang X, Yang L, Gao W, Ding J, Wang X, Xiao J, Zhou K
Autophagy 2025 Oct;21(10):2168-2191

Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.

Wang J, Deng J, Sun B, Qiao G, Yang J, Gao Z, Zhang Q, Dong M, Qu P, Wang Z
Cellular signalling 2025 Nov;135:112024

Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway.

Wen L, Lin X, Hu D, Li J, Xie K, Li S, Su S, Duan X, Zhong G, Lin Y, Chen Y, Xu T, Zeng Q
Atherosclerosis 2025 Mar;402:119109

FOXD2-AS1 is modulated by METTL3 with the assistance of YTHDF1 to affect proliferation and apoptosis in esophageal cancer.

Wang Z, Liu XC, Gao ZG, Shi WD, Wang WC
Acta pharmaceutica (Zagreb, Croatia) 2025 Mar 1;75(1):69-86

METTL3 methylated KIF15 promotes nasopharyngeal carcinoma progression and radiation resistance by blocking ATG7-mediated autophagy through the activation of STAT3 pathway.

Li S, Wang S, Zhang L, Wu X, Tian L, Zou J, Pi G
Translational oncology 2025 Jan;51:102161

TRMU Confers Resistance of Melanoma Cells to Vemurafenib through Modulating Mitochondrial Activities.

Guo S, Qi T, Wang Y
Journal of proteome research 2025 Dec 5;24(12):5913-5920

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway.

Liang Z, Liu J, Gou Y, Wang H, Li Z, Cao Y, Zhang H, Bai R, Zhang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e08220

METTL3-Mediated m6A Modification Regulates the Osteogenic Differentiation through LncRNA CUTALP in Periodontal Mesenchymal Stem Cells of Periodontitis Patients.

Chen X, Qin Y, Wang X, Lei H, Zhang X, Luo H, Guo C, Sun W, Fang S, Qin W, Jin Z
Stem cells international 2024;2024:3361794

Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4.

Meng X, Wang Z, Yang Q, Liu Y, Gao Y, Chen H, Li A, Li R, Wang J, Sun G
Cell death & disease 2024 Oct 5;15(10):729

HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma.

Chen Y, Bian S, Zhang J, Luan Y, Yin B, Dai W, Wang H, Chen X, Dong Y, Cai Y, Dong R, Yu L, Shu M
Cell reports 2024 Oct 22;43(10):114756

Role of m6A Methylation Regulators in the Diagnosis and Subtype Classification of COPD Based on the GEO Database.

Zhang P, Gao N, Li X, Zheng X, Kong D, Wu J
Journal of cellular and molecular medicine 2024 Nov;28(22):e70226

RNA reading protein YTHDF2 mediates Benzo(k)fluoranthene induced male reproductive injury by regulating the stability of BCL2.

Li YW, Wang DD, Chen HQ, Zeng Y, Wang N, Shi Y, Li JY, Zhou NY, Wang DP, Chen Q, Han X, Cao J, Liu WB
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124889

Landscape of transcriptome-wide m(6)A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise.

Chen C, Jiang C, Lin T, Hu Y, Wu H, Xiang Q, Yang M, Wang S, Han X, Tao J
Acta physiologica (Oxford, England) 2024 Jun;240(6):e14154

Upregulation of eIF2α by m(6)A modification accelerates the proliferation of pulmonary artery smooth muscle cells in MCT-induced pulmonary arterial hypertension rats.

Zhang J, Huang WQ, Zhang YR, Liang N, Li NP, Tan GK, Gong SX, Wang AP
Journal of cardiovascular translational research 2024 Jun;17(3):598-608

DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.

Xu J, Liu LY, Zhi FJ, Song YJ, Zhang ZH, Li B, Zheng FY, Gao PC, Zhang SZ, Zhang YY, Zhang Y, Qiu Y, Jiang B, Li YQ, Peng C, Chu YF
EMBO reports 2024 Feb;25(2):770-795

Suppression of the METTL3-m(6)A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity.

Wang Z, Shang J, Qiu Y, Cheng H, Tao M, Xie E, Pei X, Li W, Zhang L, Wu A, Li G
Cell reports 2024 Feb 27;43(2):113796

The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability.

Zhang J, Chen F, Tang M, Xu W, Tian Y, Liu Z, Shu Y, Yang H, Zhu Q, Lu X, Peng B, Liu X, Xu X, Gullerova M, Zhu WG
Cell reports 2024 Feb 27;43(2):113779

N6-methyladenosine modification of B7-H3 mRNA promotes the development and progression of colorectal cancer.

Chen R, Su F, Zhang T, Wu D, Yang J, Guan Q, Chai C
iScience 2024 Feb 16;27(2):108956

SALL4 promotes cancer stem-like cell phenotype and radioresistance in oral squamous cell carcinomas via methyltransferase-like 3-mediated m6A modification.

Huang J, Li H, Yang Z, Liu R, Li Y, Hu Y, Zhao S, Gao X, Yang X, Wei J
Cell death & disease 2024 Feb 14;15(2):139

Endogenous RBM4 prevents Ang II-induced cardiomyocyte hypertrophy via downregulating the expression of PTBP1.

Sun W, Fang X, Zhang H, Lu Y, Wang P, Li J, Li M
Acta biochimica et biophysica Sinica 2024 Aug 7;57(3):365-377

The role of m6A RNA methylation regulator in meningioma.

Yang Y, Luo L, Zhou Z
Aging 2023 Oct 31;15(21):12068-12084

NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL.

Kang T, Zhang C, Lei H, Luo R, Liu M, Wang S, Zhang X, Duan Q, Xiao S, Zheng Y
The Journal of investigative dermatology 2023 Jun;143(6):977-988.e2

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246

m6A RNA Methylation Regulators Contribute to Predict and as a Therapy Target of Pulmonary Fibrosis.

Deng MS, Chen KJ, Zhang DD, Li GH, Weng CM, Wang JM
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2425065

Reduction of Methyltransferase-like 3-Mediated RNA N6-Methyladenosine Exacerbates the Development of Psoriasis Vulgaris in Imiquimod-Induced Psoriasis-like Mouse Model.

Wang Y, Huang J, Jin H
International journal of molecular sciences 2022 Oct 21;23(20)

The Combined Effects of Circular RNA Methylation Promote Pulmonary Fibrosis.

Wang S, Luo W, Huang J, Chen M, Ding J, Cheng Y, Zhang W, Fang S, Wang J, Chao J
American journal of respiratory cell and molecular biology 2022 May;66(5):510-523

Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.

Yan R, Dai W, Wu R, Huang H, Shu M
Cancer letters 2022 May 28;534:215615

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.

Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L, Zhao W
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176

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