67733-1-Ig

antibody from Proteintech Group

Targeting: METTL3 M6A, MT-A70, Spo8

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

67733-1-Ig

Provider

Proteintech Group

Product name

METTL3 antibody

Antibody type

Monoclonal

Description

KD/KO validated METTL3 antibody (Cat. #67733-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2D8H1

Vial size

20ul, 150ul

References

Submitted references

METTL3-Mediated m6A Modification Regulates the Osteogenic Differentiation through LncRNA CUTALP in Periodontal Mesenchymal Stem Cells of Periodontitis Patients.

Chen X, Qin Y, Wang X, Lei H, Zhang X, Luo H, Guo C, Sun W, Fang S, Qin W, Jin Z
Stem cells international 2024;2024:3361794

---

Landscape of transcriptome-wide m(6)A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise.

Chen C, Jiang C, Lin T, Hu Y, Wu H, Xiang Q, Yang M, Wang S, Han X, Tao J
Acta physiologica (Oxford, England) 2024 Jun;240(6):e14154

---

Upregulation of eIF2α by m(6)A modification accelerates the proliferation of pulmonary artery smooth muscle cells in MCT-induced pulmonary arterial hypertension rats.

Zhang J, Huang WQ, Zhang YR, Liang N, Li NP, Tan GK, Gong SX, Wang AP
Journal of cardiovascular translational research 2024 Jun;17(3):598-608

---

DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.

Xu J, Liu LY, Zhi FJ, Song YJ, Zhang ZH, Li B, Zheng FY, Gao PC, Zhang SZ, Zhang YY, Zhang Y, Qiu Y, Jiang B, Li YQ, Peng C, Chu YF
EMBO reports 2024 Feb;25(2):770-795

---

Suppression of the METTL3-m(6)A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity.

Wang Z, Shang J, Qiu Y, Cheng H, Tao M, Xie E, Pei X, Li W, Zhang L, Wu A, Li G
Cell reports 2024 Feb 27;43(2):113796

---

The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability.

Zhang J, Chen F, Tang M, Xu W, Tian Y, Liu Z, Shu Y, Yang H, Zhu Q, Lu X, Peng B, Liu X, Xu X, Gullerova M, Zhu WG
Cell reports 2024 Feb 27;43(2):113779

---

N6-methyladenosine modification of B7-H3 mRNA promotes the development and progression of colorectal cancer.

Chen R, Su F, Zhang T, Wu D, Yang J, Guan Q, Chai C
iScience 2024 Feb 16;27(2):108956

---

SALL4 promotes cancer stem-like cell phenotype and radioresistance in oral squamous cell carcinomas via methyltransferase-like 3-mediated m6A modification.

Huang J, Li H, Yang Z, Liu R, Li Y, Hu Y, Zhao S, Gao X, Yang X, Wei J
Cell death & disease 2024 Feb 14;15(2):139

---

The role of m6A RNA methylation regulator in meningioma.

Yang Y, Luo L, Zhou Z
Aging 2023 Oct 31;15(21):12068-12084

---

NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL.

Kang T, Zhang C, Lei H, Luo R, Liu M, Wang S, Zhang X, Duan Q, Xiao S, Zheng Y
The Journal of investigative dermatology 2023 Jun;143(6):977-988.e2

---

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246

---

m6A RNA Methylation Regulators Contribute to Predict and as a Therapy Target of Pulmonary Fibrosis.

Deng MS, Chen KJ, Zhang DD, Li GH, Weng CM, Wang JM
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2425065

---

Reduction of Methyltransferase-like 3-Mediated RNA N6-Methyladenosine Exacerbates the Development of Psoriasis Vulgaris in Imiquimod-Induced Psoriasis-like Mouse Model.

Wang Y, Huang J, Jin H
International journal of molecular sciences 2022 Oct 21;23(20)

---

The Combined Effects of Circular RNA Methylation Promote Pulmonary Fibrosis.

Wang S, Luo W, Huang J, Chen M, Ding J, Cheng Y, Zhang W, Fang S, Wang J, Chao J
American journal of respiratory cell and molecular biology 2022 May;66(5):510-523

---

Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.

Yan R, Dai W, Wu R, Huang H, Shu M
Cancer letters 2022 May 28;534:215615

---

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.

Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L, Zhao W
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176