Antibody data
- Antibody Data
- Antigen structure
- References [75]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
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- Product number
- 12916-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12916-1-AP, RRID:AB_2086699
- Product name
- CUL4B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CUL4B antibody (Cat. #12916-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeted protein degradation via intramolecular bivalent glues.
Proapoptotic effect of WS-299 induced by NOXA accumulation and NRF2-counterbalanced oxidative stress damage through targeting RBX1-UBE2M interaction in gastric cancers.
Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression.
Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition.
Cullin-RING E3 ubiquitin ligase 4 regulates neurite morphogenesis during neurodevelopment.
Histone ubiquitination-related gene CUL4B promotes lung adenocarcinoma progression and cisplatin resistance.
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.
c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8(+) T cell immunity.
Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway.
Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.
MOF negatively regulates estrogen receptor α signaling via CUL4B-mediated protein degradation in breast cancer.
Comparative maternal protein profiling of mouse biparental and uniparental embryos.
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer.
AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis.
Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3(SPOP) E3 ligase in cancer cells.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.
Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization.
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Early growth response-1 is a new substrate of the GSK3β-FBXW7 axis.
CUL4B increases platinum-based drug resistance in colorectal cancer through EMT: A study in its mechanism.
Aurora kinase a promotes the progression of papillary thyroid carcinoma by activating the mTORC2-AKT signalling pathway.
SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells.
Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.
The CRL4VPRBP(DCAF1) E3 ubiquitin ligase directs constitutive RAG1 degradation in a non-lymphoid cell line.
CUL4(high) Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.
Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1.
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Overexpressed NEDD8 as a potential therapeutic target in esophageal squamous cell carcinoma.
Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2(Prame) complex.
A functional motif of long noncoding RNA Nron against osteoporosis.
DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.
The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.
FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.
The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.
Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and proteasomal degradation of the transcription factor AHR.
Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus.
Rational discovery of molecular glue degraders via scalable chemical profiling.
Induction of NEDD8-conjugating enzyme E2 UBE2F by platinum protects lung cancer cells from apoptosis and confers to platinum-insensitivity.
CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy.
CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.
The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth.
Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment.
The PRDM14-CtBP1/2-PRC2 complex regulates transcriptional repression during the transition from primed to naïve pluripotency.
Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes.
The CRL3(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration.
Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism.
CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4.
Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction.
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2.
The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation.
High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.
UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F.
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.
Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.
Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.
Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.
Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis.
Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.
A transcriptional target of androgen receptor, miR-421 regulates proliferation and metabolism of prostate cancer cells.
The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels.
The neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer.
Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex.
AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.
CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Cul4B regulates neural progenitor cell growth.
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis.
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
Hsia O, Hinterndorfer M, Cowan AD, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE, Ciulli A
Nature 2024 Mar;627(8002):204-211
Nature 2024 Mar;627(8002):204-211
Proapoptotic effect of WS-299 induced by NOXA accumulation and NRF2-counterbalanced oxidative stress damage through targeting RBX1-UBE2M interaction in gastric cancers.
Ma T, Song Q, Cheng B, Guo E, Wang X, Li M, Dai M, Li S, Feng S, Yu B
Bioorganic chemistry 2024 Mar;144:107142
Bioorganic chemistry 2024 Mar;144:107142
Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression.
Chen Z, Wang X, Gao X, Arslanovic N, Chen K, Tyler J
bioRxiv : the preprint server for biology 2024 Jun 11;
bioRxiv : the preprint server for biology 2024 Jun 11;
Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition.
Li Y, Shen S, Guo H, Li H, Zhang L, Zhang B, Yu XF, Wei W
Cell reports 2024 Feb 27;43(2):113749
Cell reports 2024 Feb 27;43(2):113749
Cullin-RING E3 ubiquitin ligase 4 regulates neurite morphogenesis during neurodevelopment.
Shim T, Kim JY, Kim W, Lee YI, Cho B, Moon C
iScience 2024 Feb 16;27(2):108933
iScience 2024 Feb 16;27(2):108933
Histone ubiquitination-related gene CUL4B promotes lung adenocarcinoma progression and cisplatin resistance.
Yin Y, Zhang L, Zeng Y, Chen D, Guan H, Ran G, Du K
Frontiers in genetics 2023;14:1242137
Frontiers in genetics 2023;14:1242137
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.
Varland S, Silva RD, Kjosås I, Faustino A, Bogaert A, Billmann M, Boukhatmi H, Kellen B, Costanzo M, Drazic A, Osberg C, Chan K, Zhang X, Tong AHY, Andreazza S, Lee JJ, Nedyalkova L, Ušaj M, Whitworth AJ, Andrews BJ, Moffat J, Myers CL, Gevaert K, Boone C, Martinho RG, Arnesen T
Nature communications 2023 Oct 27;14(1):6774
Nature communications 2023 Oct 27;14(1):6774
c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8(+) T cell immunity.
Dar AA, Kim DD, Gordon SM, Klinzing K, Rosen S, Guha I, Porter N, Ortega Y, Forsyth KS, Roof J, Fazelinia H, Spruce LA, Eisenlohr LC, Behrens EM, Oliver PM
Nature communications 2023 Nov 4;14(1):7098
Nature communications 2023 Nov 4;14(1):7098
Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway.
Wang W, Zhang Z, Zhao M, Wang Y, Ge Y, Shan L
The Journal of biological chemistry 2023 Jan;299(1):102812
The Journal of biological chemistry 2023 Jan;299(1):102812
Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.
Qiu R, Zhao S, Lu C, Xu Z, Shu E, Weng Q, Chen W, Fang S, Chen W, Zheng L, Zhao Z, Yang Y, Ji J
Experimental cell research 2023 Apr 1;425(1):113525
Experimental cell research 2023 Apr 1;425(1):113525
MOF negatively regulates estrogen receptor α signaling via CUL4B-mediated protein degradation in breast cancer.
Zhang X, Yang Y, Li D, Wu Z, Liu H, Zhao Z, Zhu H, Xie F, Li X
Frontiers in oncology 2022;12:868866
Frontiers in oncology 2022;12:868866
Comparative maternal protein profiling of mouse biparental and uniparental embryos.
Chen F, Ma B, Lin Y, Luo X, Xu T, Zhang Y, Chen F, Li Y, Zhang Y, Luo B, Zhang Q, Xie X
GigaScience 2022 Sep 3;11
GigaScience 2022 Sep 3;11
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer.
Xu T, Ma Q, Li Y, Yu Q, Pan P, Zheng Y, Li Z, Xiong X, Hou T, Yu B, Liu H, Sun Y
Signal transduction and targeted therapy 2022 Oct 17;7(1):354
Signal transduction and targeted therapy 2022 Oct 17;7(1):354
AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis.
Wang Y, Luo M, Wang F, Tong Y, Li L, Shu Y, Qiao K, Zhang L, Yan G, Liu J, Ji H, Xie Y, Zhang Y, Gao WQ, Liu Y
Nature communications 2022 Nov 24;13(1):7215
Nature communications 2022 Nov 24;13(1):7215
Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3(SPOP) E3 ligase in cancer cells.
Zhou Q, Lin W, Wang C, Sun F, Ju S, Chen Q, Wang Y, Chen Y, Li H, Wang L, Hu Z, Jin H, Wang X, Sun Y
Nature communications 2022 May 31;13(1):3034
Nature communications 2022 May 31;13(1):3034
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP, Cicka D, Yang X, Fan D, Reyna MA, Cooper LAD, Moreno CS, Zhou W, Owonikoko TK, Lonial S, Khuri FR, Du Y, Ramalingam SS, Mills GB, Fu H
Cell 2022 May 26;185(11):1974-1985.e12
Cell 2022 May 26;185(11):1974-1985.e12
Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.
He ZX, An Q, Wei B, Zhou WJ, Wei BF, Gong YP, Zhang X, Gao G, Dong GJ, Huo JL, Zhang XH, Yang FF, Liu HM, Ma LY, Zhao W
Journal of medicinal chemistry 2022 Jan 13;65(1):163-190
Journal of medicinal chemistry 2022 Jan 13;65(1):163-190
Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization.
Chen C, Gu L, Matye DJ, Clayton YD, Hasan MN, Wang Y, Friedman JE, Li T
Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 8;119(6)
Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 8;119(6)
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Gourdomichali O, Zonke K, Kattan FG, Makridakis M, Kontostathi G, Vlahou A, Doxakis E
Biology 2022 Feb 11;11(2)
Biology 2022 Feb 11;11(2)
Early growth response-1 is a new substrate of the GSK3β-FBXW7 axis.
Yin L, Zhang J, Sun Y
Neoplasia (New York, N.Y.) 2022 Dec;34:100839
Neoplasia (New York, N.Y.) 2022 Dec;34:100839
CUL4B increases platinum-based drug resistance in colorectal cancer through EMT: A study in its mechanism.
Luo JW, Wang CM, Su JW, Yi TZ, Tang SH
Journal of cellular and molecular medicine 2022 Dec;26(23):5767-5778
Journal of cellular and molecular medicine 2022 Dec;26(23):5767-5778
Aurora kinase a promotes the progression of papillary thyroid carcinoma by activating the mTORC2-AKT signalling pathway.
Zhao Z, Wang H, Kang N, Wang Z, Hou X, Hu L, Qie S, Guo J, Wei S, Ruan X, Zheng X
Cell & bioscience 2022 Dec 5;12(1):195
Cell & bioscience 2022 Dec 5;12(1):195
SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells.
Yang Y, Qiu R, Zhao S, Shen L, Tang B, Weng Q, Xu Z, Zheng L, Chen W, Shu G, Wang Y, Zhao Z, Chen M, Ji J
BMC biology 2022 Dec 27;20(1):294
BMC biology 2022 Dec 27;20(1):294
Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.
Zhou W, Dong G, Gao G, He Z, Xu J, Aziz S, Ma L, Zhao W
Biochemistry and cell biology = Biochimie et biologie cellulaire 2022 Aug 1;100(4):309-324
Biochemistry and cell biology = Biochimie et biologie cellulaire 2022 Aug 1;100(4):309-324
The CRL4VPRBP(DCAF1) E3 ubiquitin ligase directs constitutive RAG1 degradation in a non-lymphoid cell line.
Schabla NM, Swanson PC
PloS one 2021;16(10):e0258683
PloS one 2021;16(10):e0258683
CUL4(high) Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.
Wang Y, Yan F, Nasar A, Chen ZS, Altorki NK, Stiles B, Narula N, Zhou P
The American journal of pathology 2021 Sep;191(9):1638-1650
The American journal of pathology 2021 Sep;191(9):1638-1650
Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1.
Zhang J, Cui J, Zhao F, Yang L, Xu X, Shi Y, Wei B
Redox biology 2021 Oct;46:102114
Redox biology 2021 Oct;46:102114
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
Zhou W, Xu C, Dong G, Qiao H, Yang J, Liu H, Ding L, Sun K, Zhao W
European journal of medicinal chemistry 2021 May 5;217:113326
European journal of medicinal chemistry 2021 May 5;217:113326
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, Lawatscheck J, Baek K, Garz AK, Rudelius M, Deuschle FC, Keller U, Lemeer S, Verbeek M, Götze KS, Skerra A, Weber WA, Buchner J, Schulman BA, Kuster B, Fernández-Sáiz V, Bassermann F
Molecular cell 2021 Mar 18;81(6):1170-1186.e10
Molecular cell 2021 Mar 18;81(6):1170-1186.e10
Overexpressed NEDD8 as a potential therapeutic target in esophageal squamous cell carcinoma.
Xian J, Wang S, Jiang Y, Li L, Cai L, Chen P, Liu Y, Zeng X, Chen G, Ding C, Hoffman RM, Jia L, Zhao H, Zhang Y
Cancer biology & medicine 2021 Mar 18;19(4):504-17
Cancer biology & medicine 2021 Mar 18;19(4):504-17
Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2(Prame) complex.
Zhang W, Li L, Cai L, Liang Y, Xu J, Liu Y, Zhou L, Ding C, Zhang Y, Zhao H, Qin J, Shao Z, Wei W, Jia L
Cell death and differentiation 2021 Jun;28(6):1926-1940
Cell death and differentiation 2021 Jun;28(6):1926-1940
A functional motif of long noncoding RNA Nron against osteoporosis.
Jin F, Li J, Zhang YB, Liu X, Cai M, Liu M, Li M, Ma C, Yue R, Zhu Y, Lai R, Wang Z, Ji X, Wei H, Dong J, Liu Z, Wang Y, Sun Y, Wang X
Nature communications 2021 Jun 3;12(1):3319
Nature communications 2021 Jun 3;12(1):3319
DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.
Wang X, Wang HY, Hu GS, Tang WS, Weng L, Zhang Y, Guo H, Yao SS, Liu SY, Zhang GL, Han Y, Liu M, Zhang XD, Cen X, Shen HF, Xiao N, Liu CQ, Wang HR, Huang J, Liu W, Li P, Zhao TJ
Cell reports 2021 Jun 22;35(12):109281
Cell reports 2021 Jun 22;35(12):109281
The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.
Tang WS, Weng L, Wang X, Liu CQ, Hu GS, Yin ST, Tao Y, Hong NN, Guo H, Liu W, Wang HR, Zhao TJ
Cell reports 2021 Jul 6;36(1):109314
Cell reports 2021 Jul 6;36(1):109314
FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.
Shen JZ, Qiu Z, Wu Q, Finlay D, Garcia G, Sun D, Rantala J, Barshop W, Hope JL, Gimple RC, Sangfelt O, Bradley LM, Wohlschlegel J, Rich JN, Spruck C
Cell 2021 Jan 21;184(2):352-369.e23
Cell 2021 Jan 21;184(2):352-369.e23
The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.
Dar AA, Sawada K, Dybas JM, Moser EK, Lewis EL, Park E, Fazelinia H, Spruce LA, Ding H, Seeholzer SH, Oliver PM
PLoS biology 2021 Feb;19(2):e3001041
PLoS biology 2021 Feb;19(2):e3001041
Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and proteasomal degradation of the transcription factor AHR.
Rijo MP, Diani-Moore S, Yang C, Zhou P, Rifkind AB
The Journal of biological chemistry 2021 Aug;297(2):100886
The Journal of biological chemistry 2021 Aug;297(2):100886
Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.
Dong X, Han Y, Zhang E, Wang Y, Zhang P, Wang C, Zhong L, Li Q
Aging 2021 Apr 4;13(7):10603-10618
Aging 2021 Apr 4;13(7):10603-10618
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus.
Bayraktar G, Yuanxiang P, Confettura AD, Gomes GM, Raza SA, Stork O, Tajima S, Suetake I, Karpova A, Yildirim F, Kreutz MR
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2020 Nov;45(12):2120-2130
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2020 Nov;45(12):2120-2130
Rational discovery of molecular glue degraders via scalable chemical profiling.
Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE
Nature chemical biology 2020 Nov;16(11):1199-1207
Nature chemical biology 2020 Nov;16(11):1199-1207
Induction of NEDD8-conjugating enzyme E2 UBE2F by platinum protects lung cancer cells from apoptosis and confers to platinum-insensitivity.
Zhou L, Zhu J, Chen W, Jiang Y, Hu T, Wang Y, Ye X, Zhan M, Ji C, Xu Z, Wang X, Gu Y, Jia L
Cell death & disease 2020 Nov 12;11(11):975
Cell death & disease 2020 Nov 12;11(11):975
CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy.
Fu SJ, Hu MC, Peng YJ, Fang HY, Hsiao CT, Chen TY, Jeng CJ, Tang CY
Cells 2020 May 26;9(6)
Cells 2020 May 26;9(6)
CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.
Li T, Wu S, Jia L, Cao W, Yao Y, Zhao G, Li H
Cancer biology & medicine 2020 May 15;17(2):357-370
Cancer biology & medicine 2020 May 15;17(2):357-370
The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth.
Cui D, Dai X, Shu J, Ma Y, Wei D, Xiong X, Zhao Y
Cell death and differentiation 2020 Mar;27(3):1119-1133
Cell death and differentiation 2020 Mar;27(3):1119-1133
Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment.
Jiang Y, Cheng W, Li L, Zhou L, Liang Y, Zhang W, Chen W, Wang S, Zhao H, Chen G, Zhou W, Ji G, Zhang Y, Hoffman RM, Wang M, Jia L
Cell biology and toxicology 2020 Aug;36(4):349-364
Cell biology and toxicology 2020 Aug;36(4):349-364
The PRDM14-CtBP1/2-PRC2 complex regulates transcriptional repression during the transition from primed to naïve pluripotency.
Yamamoto M, Suwa Y, Sugiyama K, Okashita N, Kawaguchi M, Tani N, Matsubara K, Nakamura A, Seki Y
Journal of cell science 2020 Aug 14;133(15)
Journal of cell science 2020 Aug 14;133(15)
Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes.
Yu Q, Hu Z, Shen Y, Jiang Y, Pan P, Hou T, Pan ZQ, Huang J, Sun Y
Neoplasia (New York, N.Y.) 2020 Apr;22(4):179-191
Neoplasia (New York, N.Y.) 2020 Apr;22(4):179-191
The CRL3(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration.
Li L, Zhang W, Liu Y, Liu X, Cai L, Kang J, Zhang Y, Chen W, Dong C, Zhang Y, Wang M, Wei W, Jia L
Signal transduction and targeted therapy 2020 Apr 24;5(1):42
Signal transduction and targeted therapy 2020 Apr 24;5(1):42
Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism.
Lai TC, Hu MC
Scientific reports 2019 Mar 28;9(1):5304
Scientific reports 2019 Mar 28;9(1):5304
CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4.
Qi M, Hu J, Cui Y, Jiao M, Feng T, Li X, Pang Y, Chen X, Qin R, Su P, Zhang H, Wang Y, Gong Y, Han B
Oncogenesis 2019 Mar 14;8(3):23
Oncogenesis 2019 Mar 14;8(3):23
Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction.
Wang S, Zhao L, Shi XJ, Ding L, Yang L, Wang ZZ, Shen D, Tang K, Li XJ, Mamun M, Li H, Yu B, Zheng YC, Wang S, Liu HM
Journal of medicinal chemistry 2019 Mar 14;62(5):2772-2797
Journal of medicinal chemistry 2019 Mar 14;62(5):2772-2797
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Zhou W, Ma L, Ding L, Guo Q, He Z, Yang J, Qiao H, Li L, Yang J, Yu S, Zhao L, Wang S, Liu HM, Suo Z, Zhao W
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2.
Sun H, Zhang J, Xin S, Jiang M, Zhang J, Li Z, Cao Q, Lou H
PLoS genetics 2019 Feb;15(2):e1007685
PLoS genetics 2019 Feb;15(2):e1007685
The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation.
Sun S, Kelekar S, Kliewer SA, Mangelsdorf DJ
Genes & development 2019 Aug 1;33(15-16):1083-1094
Genes & development 2019 Aug 1;33(15-16):1083-1094
High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.
Zhou H, Zhou W, Zhou B, Liu L, Chern TR, Chinnaswamy K, Lu J, Bernard D, Yang CY, Li S, Wang M, Stuckey J, Sun Y, Wang S
Journal of medicinal chemistry 2018 Mar 8;61(5):1934-1950
Journal of medicinal chemistry 2018 Mar 8;61(5):1934-1950
UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F.
Zhou W, Xu J, Tan M, Li H, Li H, Wei W, Sun Y
Molecular cell 2018 Jun 21;70(6):1008-1024.e6
Molecular cell 2018 Jun 21;70(6):1008-1024.e6
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.
Nagai T, Mukoyama S, Kagiwada H, Goshima N, Mizuno K
Journal of cell science 2018 Dec 12;131(24)
Journal of cell science 2018 Dec 12;131(24)
Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.
Jia L, Yan F, Cao W, Chen Z, Zheng H, Li H, Pan Y, Narula N, Ren X, Li H, Zhou P
The Journal of biological chemistry 2017 Feb 17;292(7):2966-2978
The Journal of biological chemistry 2017 Feb 17;292(7):2966-2978
Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K
Biochemical and biophysical research communications 2017 Aug 19;490(2):423-428
Biochemical and biophysical research communications 2017 Aug 19;490(2):423-428
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.
Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D
Science (New York, N.Y.) 2017 Apr 28;356(6336)
Science (New York, N.Y.) 2017 Apr 28;356(6336)
Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.
Peng YJ, Huang JJ, Wu HH, Hsieh HY, Wu CY, Chen SC, Chen TY, Tang CY
Scientific reports 2016 Sep 1;6:32444
Scientific reports 2016 Sep 1;6:32444
Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis.
Yin Y, Liu L, Yang C, Lin C, Veith GM, Wang C, Sutovsky P, Zhou P, Ma L
The Journal of biological chemistry 2016 Mar 25;291(13):6923-35
The Journal of biological chemistry 2016 Mar 25;291(13):6923-35
Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.
Eichner R, Heider M, Fernández-Sáiz V, van Bebber F, Garz AK, Lemeer S, Rudelius M, Targosz BS, Jacobs L, Knorn AM, Slawska J, Platzbecker U, Germing U, Langer C, Knop S, Einsele H, Peschel C, Haass C, Keller U, Schmid B, Götze KS, Kuster B, Bassermann F
Nature medicine 2016 Jul;22(7):735-43
Nature medicine 2016 Jul;22(7):735-43
A transcriptional target of androgen receptor, miR-421 regulates proliferation and metabolism of prostate cancer cells.
Meng D, Yang S, Wan X, Zhang Y, Huang W, Zhao P, Li T, Wang L, Huang Y, Li T, Li Y
The international journal of biochemistry & cell biology 2016 Apr;73:30-40
The international journal of biochemistry & cell biology 2016 Apr;73:30-40
The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels.
Chen YA, Peng YJ, Hu MC, Huang JJ, Chien YC, Wu JT, Chen TY, Tang CY
Scientific reports 2015 May 29;5:10667
Scientific reports 2015 May 29;5:10667
The neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer.
Xu J, Li L, Yu G, Ying W, Gao Q, Zhang W, Li X, Ding C, Jiang Y, Wei D, Duan S, Lei Q, Li P, Shi T, Qian X, Qin J, Jia L
Molecular & cellular proteomics : MCP 2015 Mar;14(3):499-509
Molecular & cellular proteomics : MCP 2015 Mar;14(3):499-509
Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex.
Yamashita K, Ide M, Furukawa KT, Suzuki A, Hirano H, Ohno S
Molecular biology of the cell 2015 Jul 1;26(13):2426-38
Molecular biology of the cell 2015 Jul 1;26(13):2426-38
AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.
Antonioli M, Albiero F, Nazio F, Vescovo T, Perdomo AB, Corazzari M, Marsella C, Piselli P, Gretzmeier C, Dengjel J, Cecconi F, Piacentini M, Fimia GM
Developmental cell 2014 Dec 22;31(6):734-46
Developmental cell 2014 Dec 22;31(6):734-46
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K
Cell metabolism 2014 Apr 1;19(4):712-21
Cell metabolism 2014 Apr 1;19(4):712-21
A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.
Zhang S, Zhao H, Darzynkiewicz Z, Zhou P, Zhang Z, Lee EY, Lee MY
The Journal of biological chemistry 2013 Oct 11;288(41):29550-61
The Journal of biological chemistry 2013 Oct 11;288(41):29550-61
CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY
Science (New York, N.Y.) 2013 Dec 20;342(6165):1518-21
Science (New York, N.Y.) 2013 Dec 20;342(6165):1518-21
Cul4B regulates neural progenitor cell growth.
Liu HC, Enikolopov G, Chen Y
BMC neuroscience 2012 Sep 19;13:112
BMC neuroscience 2012 Sep 19;13:112
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.
Liu L, Yin Y, Li Y, Prevedel L, Lacy EH, Ma L, Zhou P
Cell research 2012 Aug;22(8):1258-69
Cell research 2012 Aug;22(8):1258-69
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis.
Yin Y, Lin C, Kim ST, Roig I, Chen H, Liu L, Veith GM, Jin RU, Keeney S, Jasin M, Moley K, Zhou P, Ma L
Developmental biology 2011 Aug 1;356(1):51-62
Developmental biology 2011 Aug 1;356(1):51-62
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
Aggarwal P, Vaites LP, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi AK, McMahon SB, Diehl JA
Cancer cell 2010 Oct 19;18(4):329-40
Cancer cell 2010 Oct 19;18(4):329-40
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 12916-1-AP(CUL4B antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CUL4B antibody 12916-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CUL4B (IP:12916-1-AP, 3ug; Detection:12916-1-AP 1:1000) with HeLa cells lysate 4650ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 12916-1-AP(CUL4B antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue