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- Antibody Data
- Antigen structure
- References [9]
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- Validations
- Immunohistochemistry [1]
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- Product number
- HPA011880 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA011880, RRID:AB_1847340
- Product name
- Anti-CUL4B
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human CUL4B, Gene description: cullin 4B, Validated applications: WB, IHC, ICC, Uniprot ID: Q13620, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Cullin 4B Ubiquitin Ligase Is Important for Cell Survival and Regulates TGF-β1 Expression in Pleural Mesothelioma
Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase
Discovery and characterization of potent And‐1 inhibitors for cancer treatment
Importance of Cullin4 Ubiquitin Ligase in Malignant Pleural Mesothelioma
Aryl hydrocarbon receptor (AhR) regulates adipocyte differentiation by assembling CRL4B ubiquitin ligase to target PPARγ for proteasomal degradation
Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation
Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells
Prospective cohort study for identification of underlying genetic causes in neonatal encephalopathy using whole-exome sequencing
Kreienbühl J, Changkhong S, Orlowski V, Kirschner M, Opitz I, Meerang M
International Journal of Molecular Sciences 2023;24(17):13410
International Journal of Molecular Sciences 2023;24(17):13410
Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
Yi J, Tavana O, Li H, Wang D, Baer R, Gu W
Nature Communications 2023;14(1)
Nature Communications 2023;14(1)
The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase
Wittig K, Sansam C, Noble T, Goins D, Sansam C
Nucleic Acids Research 2021;49(18):10507-10523
Nucleic Acids Research 2021;49(18):10507-10523
Discovery and characterization of potent And‐1 inhibitors for cancer treatment
Li J, Zhang Y, Sun J, Chen L, Gou W, Chen C, Zhou Y, Li Z, Chan D, Huang R, Pei H, Zheng W, Li Y, Xia M, Zhu W
Clinical and Translational Medicine 2021;11(12)
Clinical and Translational Medicine 2021;11(12)
Importance of Cullin4 Ubiquitin Ligase in Malignant Pleural Mesothelioma
Meerang M, Kreienbühl J, Orlowski V, Müller S, Kirschner M, Opitz I
Cancers 2020;12(11):3460
Cancers 2020;12(11):3460
Aryl hydrocarbon receptor (AhR) regulates adipocyte differentiation by assembling CRL4B ubiquitin ligase to target PPARγ for proteasomal degradation
Dou H, Duan Y, Zhang X, Yu Q, Di Q, Song Y, Li P, Gong Y
Journal of Biological Chemistry 2019;294(48):18504-18515
Journal of Biological Chemistry 2019;294(48):18504-18515
Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation
Lu G, Yi J, Gubas A, Wang Y, Wu Y, Ren Y, Wu M, Shi Y, Ouyang C, Tan H, Wang T, Wang L, Yang N, Deng S, Xia D, Chen R, Tooze S, Shen H
Autophagy 2019;15(11):1917-1934
Autophagy 2019;15(11):1917-1934
Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells
Schubert M, Chen C, Yu I, Pai C, Lin C, Lin S, Chen Y, Lin S
PLOS ONE 2019;14(7):e0219221
PLOS ONE 2019;14(7):e0219221
Prospective cohort study for identification of underlying genetic causes in neonatal encephalopathy using whole-exome sequencing
Bruun T, DesRoches C, Wilson D, Chau V, Nakagawa T, Yamasaki M, Hasegawa S, Fukao T, Marshall C, Mercimek-Andrews S
Genetics in Medicine 2018;20(5):486-494
Genetics in Medicine 2018;20(5):486-494
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human epididymis and skeletal muscle tissues using Anti-CUL4B antibody. Corresponding CUL4B RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
