BS2189
antibody from Bioworld Technology, Inc
Targeting: CYP21A2
CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS2189 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CYP21A2 (F177) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 141-190 of Human CYP21A2.
- Description
- The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP21A2 localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Activity of CYP21A2 is required for the synthesis of steroid hormones, including cortisol and aldosterone. Mutations in this gene is the primary cause of congenital adrenal hyperplasia (CAH), an autosomal recessive disorder. Gene conversion events involving the functional CYP21A2 gene (C21B) and a related pseudogene (C21A) located near the C21B gene may account for the majority of cases of steroid 21-hydroxylase deficiency.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of CYP21A2 (F177) pAb at 1:500 dilutionLane1:Hela cell lysate Lane2:sp2/0 cell lysateLane3:H9C2 cell lysate