orb149793

antibody from Biorbyt
Targeting: ATP7A MNK
Provider product page for orb149793
Western blot
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
orb149793 - Provider product page
Provider
Biorbyt
Product name
Copper Transporting ATPase 1 antibody
Antibody type
Monoclonal
Description
Mouse monoclonal to Copper Transporting ATPase 1 (Biotin). The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-trans locating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood. Mutations in the ATP7B gene lead to the autosomal recessive disorder, Wilson disease, characterized by neurological symptoms and hepatic damage..
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Biotin
Isotype
IgG
Antibody clone number
S60-4
Vial size
100 ug
Concentration
1 mg/ml
Storage
Conjugated antibodies should be stored at 4°C
ATP7A protein structure - orb149793 shown in red.