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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 372703 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#372703, RRID:AB_2632729
- Product name
- PE anti-human TIGIT (VSTM3)
- Antibody type
- Monoclonal
- Description
- T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3 or WUCAM, is a 26 kD, type I transmembrane protein and is a member of the PVR (poliovirus receptor) family of immunoglobulin-like domain containing proteins. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. TIGIT is a negative regulator of NK and T cell activation. Expression of TIGIT is associated with decreased functionality of CD8 T cells in chronic viral infection and tumors. TIGIT also promotes the differentiation of tolerogenic phenotype in dendritic cells with an increased secretion of IL-10 and a diminished production of IL-12.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Antibody clone number
- A15153G
- Vial size
- 25 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood leukocytes were stained with CD3 APC and TIGIT (clone A15153G) APC (top) or mouse IgG2a, κ PE isotype control (bottom). Data shown was gated on a lymphocyte population.
- Conjugate
- Yellow dye
