CABT-B1469

antibody from Creative Diagnostics

Targeting: GNRH1 GNRH, GRH, LHRH

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Immunoelectron microscopy (Recommended by provider)

Antibody Data

Product number

CABT-B1469

Provider

Creative Diagnostics

Product name

Anti-GNRH1 monoclonal antibody, clone IV22C

Antibody type

Monoclonal

Description

Gonadotropin-releasing hormone I (also known as GnRH, GnRH-I, Gonadoliberin-1, Gonadoliberin I, LHRH, LH-RH I, Luteinizing hormone-releasing hormone I) is encoded by the Gnrh1 (also known as Gnrh, Lhrh1, Lnrh) gene (Gene ID 14714) in murine species. GnRH/LHRH is initially produced as a 90-amino acid progonadoliberin-1 precursor protein (UniProt P13562), removal of the signal peptide (a.a. 1-21) yields progonadoliberin-1 (a.a. 22-90), which is further processed by a proteolytic cleavage to release the GnRH/LHRH decapeptide (a.a. 22-31) and the 56-a.a. prolactin release-inhibiting factor 1 (a.a. 35-90). The LHRH decapeptide functions as the primary endocrine link between the brain and the reproductive system. It plays a primary neuroendocrine role in orchestrating the developmental processes associated with sexual development in immature mammals and also in maintaining normal reproductive function in adults. LHRH-producing neurons are located mainly in the lateral anterior hypothalamus, septum, and medial preoptic area, from where they extend axons towards the median eminence and relese the hormone into the hypothalamo-hypophyseal portal blood vessels in an episodic or pulsatile manner.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG