19924-1-AP

antibody from Proteintech Group

Targeting: METTL16 METT10D, MGC3329

Provider product page for 19924-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [36]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 19924-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19924-1-AP, RRID:AB_10639364
Product name: METTL16 antibody
Antibody type: Polyclonal
Description: METTL16 antibody (Cat. #19924-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

METTL16 protein structure - 19924-1-AP shown in red.

Submitted references METTL16 antagonizes astaxanthin-induced ferroptosis in colorectal cancer cells.

Zeng X, Wang X, Wang J, Zheng R, Zhang Y, Li T, Ma J, Pan X
Translational cancer research 2026 Jan 31;15(1):9

Novel N(6)-methyladenosine (m(6)A) writer METTL16 promotes the cervical cancer tumorigenesis by targeting FTH1-dependent ferroptosis.

Huang Z, Luo Y, Gao Q, Wang L, Li C
Discover oncology 2026 Jan 20;17(1):304

METTL16 promotes MASLD progression through the regulation of lipid synthesis and immune response.

Li G, Wang L, Zhang L, Guo J, Sun Q
Biology direct 2026 Apr 9;21(1)

METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression.

Li J, Luo Q, Lu M, Lu C, Xu C, Ding J, Zhan T, Zhu J, Qian M, Lin S, Chang L, Li J, Wang K
International journal of biological sciences 2025;21(11):4782-4797

Norcantharidin inhibits the METTL16/MAT2A pathway to induce apoptosis and suppress tumor progression in ovarian cancer.

Zhang YY, Zeng QX, Wang L, Li KX, Zhang S, Wan P, Zhou XM, Chen Q
Archives of biochemistry and biophysics 2025 Sep;771:110510

IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation.

Sharma G, Gutierrez M, Jones AE, Kapoor S, Jaiswal AK, Neeb ZT, Rios A, Dorairaj P, Thaxton ML, Lin TL, Tran TM, Kabbani LES, Ritter AJ, Scherer GM, Sorrentino JP, Stiles L, Hoeve JT, Damoiseaux RD, Garg NK, Divakaruni AS, Sanford JR, Rao DS
Cell reports 2025 Oct 28;44(10):116330

Targeting METTL16 attenuates mesangial cell viability and fibrosis in a high-glucose state by suppressing m6A modification and the expression of RAP1B.

Wang W, Luo Y
BMC molecular and cell biology 2025 Oct 28;26(1):32

Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.

Wang N, Dai J, Li R, Li W, Liu D, Liu X, Mei Z, Lu H, He Z, Gu S
Ecotoxicology and environmental safety 2025 Oct 15;305:119228

METTL16 promotes progression of clear cell renal cell carcinoma via up-regulating N6-methyladenosine modification of KLK4 mRNA.

Fan B, Niu Y, Li T, Chen H, Zeng K, Li S, Ma Y
Molecular and cellular biochemistry 2025 Nov;480(11):5741-5751

Multi-omics and experimental validation identify methylation-related genes and METTL16 as key regulators in diabetic foot ulcer pathogenesis.

Tong Y, Li S, Shen L, Yan L, Zhu Z, Hua Q
Scientific reports 2025 Nov 27;15(1):42334

Targeting METTL3 protein by proteolysis-targeting chimeras: A novel therapeutic approach for acute myeloid leukemia.

Nar R, Wu Z, Li Y, Smith A, Zhang Y, Wang J, Yu F, Gao S, Yu C, Huo Z, Zheng G, Qian Z
Genes & diseases 2025 Jul;12(4):101452

The promoting effect of the POU3F2/METTL16/PFKM cascade on glycolysis and tumorigenesis of hepatocellular carcinoma.

Chen M, Yang Y, Hu G, Peng Z, Wen W
Annals of hepatology 2025 Jul-Dec;30(2):101776

ALKBH5 regulates intrauterine adhesion progression through m6A dependent FABP4 mRNA stabilization and serum lipid metabolism.

Yang X, Feng Q
Communications biology 2025 Jul 1;8(1):973

Platycodin D-mediated METTL16 downregulation promotes docetaxel treatment of prostate cancer by regulating ferroptosis.

Sun C, Sun X, Chen Y, Wu Y, Xiang C, Wu S
BMC cancer 2025 Jul 1;25(1):1042

ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization.

Guan Z, Wang X, Xu C, Lu R
Heliyon 2025 Jan 15;11(1):e41495

The cancer-testis lncRNA LINC01940 promotes gastric cancer malignant progression and chemoresistance by enhancing ribosome biogenesis via TAF15-mediated NOL11 SUMOylation.

Zang W, Fan D, Lu Z, Gao X, Xing D, Zhang G, Liu L, Yi J, Chen J, Hu Y, Xue W
Cellular & molecular biology letters 2025 Dec 16;31(1):14

HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.

He X, Li Y, Li J, Li Y, Chen S, Yan X, Xie Z, Du J, Chen G, Song J, Mei Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413121

Changes of m(6)A Regulatory Proteins and Nrf2 Signaling Molecules in Liver Tissue of Type 2 Diabetes Mellitus Rats.

Wang N, Yang J, Liu X, Liu G, He Z, Gu S
Cell biochemistry and biophysics 2024 Sep;82(3):2217-2226

METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.

Wang P, Zhou W, Chen F, Zhang X, Zhang Q, Chen Y, Zhang N
Experimental gerontology 2024 Sep;194:112496

METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer.

Bai X, Liu J, Zhou S, Wu L, Feng X, Zhang P
Journal of experimental & clinical cancer research : CR 2024 Nov 20;43(1):307

Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.

Liu X, Wang N, Gu S, He Z
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289

LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53-driven tumour progression through miR-5683/FGF2.

Liu N, Jiang X, Zhang G, Long S, Li J, Jiang M, Jia G, Sun R, Zhang L, Zhang Y
Clinical and translational medicine 2024 Jul;14(7):e1777

BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.

Fan Y, Pan Y, Jia L, Gu S, Liu B, Mei Z, Lv C, Huang H, Zhu G, Deng Q
Cancer medicine 2024 Jan;13(1):e6811

METTL16 inhibits pancreatic cancer proliferation and metastasis by promoting MROH8 RNA stability and inhibiting CAPN2 expression - experimental studies.

Yi T, Wang C, Ye X, Lin J, Lin C, Qin F, Yang W, Ye Y, Ning D, Lan J, Li H, Luo C, Ma J, Wei Z
International journal of surgery (London, England) 2024 Dec 1;110(12):7701-7719

METTL16 Inhibits the Malignant Progression of Epithelial Ovarian Cancer through the lncRNA MALAT1/β-Catenin Axis.

Li C, Liu J, Lyu Y, Ling S, Luo Y
Analytical cellular pathology (Amsterdam) 2023;2023:9952234

RNA methylation pattern and immune microenvironment characteristics mediated by m6A regulator in ischemic stroke.

Jia K, Xia W, Su Q, Yang S, Zhang Y, Ni X, Su Z, Meng D
Frontiers in genetics 2023;14:1148510

LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.

Zhang N, Liu X, Huang L, Zeng J, Ma C, Han L, Li W, Yu J, Yang M
Cell reports 2023 Dec 26;42(12):113479

A lncRNA from the FTO locus acts as a suppressor of the m(6)A writer complex and p53 tumor suppression signaling.

Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S, Cui XL, Zou Z, Yue Z, Emch MJ, Hawse JR, Wang L, He HH, Xia S, Han B, He C, Huang H
Molecular cell 2023 Aug 3;83(15):2692-2708.e7

Methylation Pattern Mediated by m(6)A Regulator and Tumor Microenvironment Invasion in Lung Adenocarcinoma.

Jiang F, Hu Y, Liu X, Wang M, Wu C
Oxidative medicine and cellular longevity 2022;2022:2930310

Identification and experimental validation of key m6A modification regulators as potential biomarkers of osteoporosis.

Qiao Y, Li J, Liu D, Zhang C, Liu Y, Zheng S
Frontiers in genetics 2022;13:1072948

METTL16-mediated translation of CIDEA promotes non-alcoholic fatty liver disease progression via m6A-dependent manner.

Tang J, Zhao X, Wei W, Liu W, Fan H, Liu XP, Li Y, Wang L, Guo J
PeerJ 2022;10:e14379

Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.

Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6

m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.

Gao M, Qi Z, Feng W, Huang H, Xu Z, Dong Z, Xu M, Han J, Kloeber JA, Huang J, Lou Z, Liu S
The Journal of biological chemistry 2022 Feb;298(2):101563

Clinical Significance of Methyltransferase-like 16 Expression in Epithelial Ovarian Cancer.

Li C, Qiao C, Ding H, Luo Y
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2022 Dec;32(12):1576-1580

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.

Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 19924-1-AP(METT10D antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon using 19924-1-AP(METT10D antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The METT10D antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human METT10D. This antibody recognizes human, mouse, rat antigen. The METT10D antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 19924-1-AP.pdf

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