Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 21916-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ONECUT2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ONECUT2 antibody (Cat. #21916-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY.
ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
ONECUT2 is a driver of neuroendocrine prostate cancer.
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.
Liu D, Zhang T, Chen X, Zhang B, Wang Y, Xie M, Ji X, Sun M, Huang W, Xia L
Cell death & disease 2021 Nov 27;12(12):1113
Cell death & disease 2021 Nov 27;12(12):1113
ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.
Seo EH, Kim HJ, Kim JH, Lim B, Park JL, Kim SY, Lee SI, Jeong HY, Song KS, Kim YS
International journal of cancer 2020 Jun 15;146(12):3354-3368
International journal of cancer 2020 Jun 15;146(12):3354-3368
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
LaFave LM, Kartha VK, Ma S, Meli K, Del Priore I, Lareau C, Naranjo S, Westcott PMK, Duarte FM, Sankar V, Chiang Z, Brack A, Law T, Hauck H, Okimoto A, Regev A, Buenrostro JD, Jacks T
Cancer cell 2020 Aug 10;38(2):212-228.e13
Cancer cell 2020 Aug 10;38(2):212-228.e13
ONECUT2 is a driver of neuroendocrine prostate cancer.
Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A, Beltran H, Wang Y, He HH
Nature communications 2019 Jan 17;10(1):278
Nature communications 2019 Jan 17;10(1):278
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.
Rotinen M, You S, Yang J, Coetzee SG, Reis-Sobreiro M, Huang WC, Huang F, Pan X, Yáñez A, Hazelett DJ, Chu CY, Steadman K, Morrissey CM, Nelson PS, Corey E, Chung LWK, Freedland SJ, Di Vizio D, Garraway IP, Murali R, Knudsen BS, Freeman MR
Nature medicine 2018 Dec;24(12):1887-1898
Nature medicine 2018 Dec;24(12):1887-1898
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The ONECUT2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ONECUT2. This antibody recognizes human, mouse antigen. The ONECUT2 antibody has been validated for the following applications: ELISA, WB analysis.