Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 21916-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ONECUT2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ONECUT2 antibody (Cat. #21916-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Gene-body DNA methylation of ONECUT2 predicts its expression and prostate cancer aggressiveness in needle biopsies.
ONECUT2-driven activation of ADAMTS14 boosts colorectal cancer stemness via Wnt pathway.
Transcriptional landscape and chromatin accessibility reveal key regulators for liver regenerative initiation and organoid formation.
Spatiotemporal and single-cell atlases to dissect regional specific cell types of the developing ovary.
ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancer.
ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity.
Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2.
Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma.
Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes.
Targeting ONECUT2 inhibits tumor angiogenesis via down-regulating ZKSCAN3/VEGFA.
ONECUT2 acts as a lineage plasticity driver in adenocarcinoma as well as neuroendocrine variants of prostate cancer.
ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer.
ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study.
Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.
Activation of ONECUT2 by RB1 loss in castration-resistant prostate cancer.
LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.
Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.
ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY.
Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells.
ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
ONECUT2 is a driver of neuroendocrine prostate cancer.
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.
Sekino Y, Li HT, Kaneko M, Inoue Y, Ramacciotti LS, Lu R, Deng Z, Zhou X, Song MM, Desai A, Jin M, Guo W, Yang X, Bhasin J, Hinata N, Freeman MR, Gill I, Aron M, Cen SY, Abreu AL, Liang G
Biomarker research 2026 Jan 16;14(1):18
Biomarker research 2026 Jan 16;14(1):18
ONECUT2-driven activation of ADAMTS14 boosts colorectal cancer stemness via Wnt pathway.
Jiang Y, Tan X
Human cell 2025 Nov 12;39(1):7
Human cell 2025 Nov 12;39(1):7
Transcriptional landscape and chromatin accessibility reveal key regulators for liver regenerative initiation and organoid formation.
Lian J, An Y, Wei W, Lu Y, Zhang X, Sun G, Guo H, Xu L, Chen X, Hu H
Cell reports 2025 May 27;44(5):115633
Cell reports 2025 May 27;44(5):115633
Spatiotemporal and single-cell atlases to dissect regional specific cell types of the developing ovary.
Zhao ZH, Meng TG, Chen XY, Gao F, Schatten H, Ou XH, Sun QY
Communications biology 2025 Jun 3;8(1):849
Communications biology 2025 Jun 3;8(1):849
ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancer.
Gutiérrez M, Zamora I, Iriarte R, Pajares MJ, Yang Q, Qian C, Otegui N, Fernández-Irigoyen J, Santamaría E, Alcala N, Sexton-Oates A, Fernández-Cuesta L, Barajas M, Calvo A, Montuenga LM, Knudsen B, You S, Freeman MR, Encío I, Rotinen M
Molecular medicine (Cambridge, Mass.) 2025 Jun 11;31(1):232
Molecular medicine (Cambridge, Mass.) 2025 Jun 11;31(1):232
ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity.
Zamora I, Gutiérrez M, Pascual A, Pajares MJ, Barajas M, Perez LM, You S, Knudsen BS, Freeman MR, Encío IJ, Rotinen M
Cellular oncology (Dordrecht, Netherlands) 2025 Feb;48(1):83-99
Cellular oncology (Dordrecht, Netherlands) 2025 Feb;48(1):83-99
Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.
Diao S, Zou JY, Wang S, Ghaddar N, Chan JE, Kim H, Poulain N, Koumenis C, Hatzoglou M, Walter P, Sonenberg N, Le Quesne J, Tammela T, Koromilas AE
bioRxiv : the preprint server for biology 2025 Feb 13;
bioRxiv : the preprint server for biology 2025 Feb 13;
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2.
Ging K, Frick L, Schlachetzki J, Armani A, Zhu Y, Gilormini PA, Dhingra A, Böck D, Marques A, Deen M, Chen X, Serdiuk T, Trevisan C, Sellitto S, Pisano C, Glass CK, Heutink P, Yin JA, Vocadlo DJ, Aguzzi A
NPJ Parkinson's disease 2024 Oct 22;10(1):192
NPJ Parkinson's disease 2024 Oct 22;10(1):192
Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma.
Li C, Xiao Y, Zhou J, Liu S, Zhang L, Song X, Guo X, Song Q, Zhao J, Deng N
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):469
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):469
Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes.
Deng Y, Lin Y, Chen S, Xiang Y, Chen H, Qi S, Oh HS, Das B, Komazin-Meredith G, Pesola JM, Knipe DM, Coen DM, Pan D
Nature communications 2024 Mar 5;15(1):1991
Nature communications 2024 Mar 5;15(1):1991
Targeting ONECUT2 inhibits tumor angiogenesis via down-regulating ZKSCAN3/VEGFA.
Zhang L, Li C, Song X, Guo R, Zhao W, Liu C, Chen X, Song Q, Wu B, Deng N
Biochemical pharmacology 2024 Jul;225:116315
Biochemical pharmacology 2024 Jul;225:116315
ONECUT2 acts as a lineage plasticity driver in adenocarcinoma as well as neuroendocrine variants of prostate cancer.
Qian C, Yang Q, Rotinen M, Huang R, Kim H, Gallent B, Yan Y, Cadaneanu RM, Zhang B, Kaochar S, Freedland SJ, Posadas EM, Ellis L, Di Vizio D, Morrissey C, Nelson PS, Brady L, Murali R, Campbell MJ, Yang W, Knudsen BS, Mostaghel EA, Ye H, Garraway IP, You S, Freeman MR
Nucleic acids research 2024 Jul 22;52(13):7740-7760
Nucleic acids research 2024 Jul 22;52(13):7740-7760
ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer.
Qian C, Yang Q, Rotinen M, Huang R, Kim H, Gallent B, Yan Y, Cadaneanu RM, Zhang B, Kaochar S, Freedland SJ, Posadas EM, Ellis L, Vizio DD, Morrissey C, Nelson PS, Brady L, Murali R, Campbell MJ, Yang W, Knudsen BS, Mostaghel EA, Ye H, Garraway IP, You S, Freeman MR
bioRxiv : the preprint server for biology 2023 Oct 12;
bioRxiv : the preprint server for biology 2023 Oct 12;
ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study.
Luna Velez MV, Neikes HK, Snabel RR, Quint Y, Qian C, Martens A, Veenstra GJC, Freeman MR, van Heeringen SJ, Vermeulen M
Nucleic acids research 2023 Feb 22;51(3):1277-1296
Nucleic acids research 2023 Feb 22;51(3):1277-1296
Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.
Chen CC, Tran W, Song K, Sugimoto T, Obusan MB, Wang L, Sheu KM, Cheng D, Ta L, Varuzhanyan G, Huang A, Xu R, Zeng Y, Borujerdpur A, Bayley NA, Noguchi M, Mao Z, Morrissey C, Corey E, Nelson PS, Zhao Y, Huang J, Park JW, Witte ON, Graeber TG
Cancer cell 2023 Dec 11;41(12):2066-2082.e9
Cancer cell 2023 Dec 11;41(12):2066-2082.e9
Activation of ONECUT2 by RB1 loss in castration-resistant prostate cancer.
Qian C, Yang Q, Freedland SJ, Di Vizio D, Ellis L, You S, Freeman MR
American journal of clinical and experimental urology 2022;10(6):397-407
American journal of clinical and experimental urology 2022;10(6):397-407
LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.
Yi Y, Yang N, Yang Z, Tao X, Li Y
Orthopaedic surgery 2022 Nov;14(11):3078-3091
Orthopaedic surgery 2022 Nov;14(11):3078-3091
Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.
Abu El Maaty MA, Terzic J, Keime C, Rovito D, Lutzing R, Yanushko D, Parisotto M, Grelet E, Namer IJ, Lindner V, Laverny G, Metzger D
Science advances 2022 Jul 22;8(29):eabo2295
Science advances 2022 Jul 22;8(29):eabo2295
ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY.
Liu D, Zhang T, Chen X, Zhang B, Wang Y, Xie M, Ji X, Sun M, Huang W, Xia L
Cell death & disease 2021 Nov 27;12(12):1113
Cell death & disease 2021 Nov 27;12(12):1113
Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells.
Shi L, Tan X, Liu X, Yu J, Bota-Rabassedas N, Niu Y, Luo J, Xi Y, Zong C, Creighton CJ, Glenn JS, Wang J, Kurie JM
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 22;118(25)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 22;118(25)
ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.
Seo EH, Kim HJ, Kim JH, Lim B, Park JL, Kim SY, Lee SI, Jeong HY, Song KS, Kim YS
International journal of cancer 2020 Jun 15;146(12):3354-3368
International journal of cancer 2020 Jun 15;146(12):3354-3368
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
LaFave LM, Kartha VK, Ma S, Meli K, Del Priore I, Lareau C, Naranjo S, Westcott PMK, Duarte FM, Sankar V, Chiang Z, Brack A, Law T, Hauck H, Okimoto A, Regev A, Buenrostro JD, Jacks T
Cancer cell 2020 Aug 10;38(2):212-228.e13
Cancer cell 2020 Aug 10;38(2):212-228.e13
ONECUT2 is a driver of neuroendocrine prostate cancer.
Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A, Beltran H, Wang Y, He HH
Nature communications 2019 Jan 17;10(1):278
Nature communications 2019 Jan 17;10(1):278
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.
Rotinen M, You S, Yang J, Coetzee SG, Reis-Sobreiro M, Huang WC, Huang F, Pan X, Yáñez A, Hazelett DJ, Chu CY, Steadman K, Morrissey CM, Nelson PS, Corey E, Chung LWK, Freedland SJ, Di Vizio D, Garraway IP, Murali R, Knudsen BS, Freeman MR
Nature medicine 2018 Dec;24(12):1887-1898
Nature medicine 2018 Dec;24(12):1887-1898
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ONECUT2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ONECUT2. This antibody recognizes human, mouse antigen. The ONECUT2 antibody has been validated for the following applications: ELISA, WB analysis.
