BS61061

antibody from Bioworld Technology, Inc
Targeting: PINX1 FLJ20565, Gno1, LPTL, LPTS, MGC8850, Pxr1
Provider product page for BS61061

Antibody data

Product number
BS61061 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PINX1 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human PINX1.
Description
PINX1 (PIN2/TRF1-interacting protein X1), also known as LPTL or LPTS (liver-related putative tumor suppressor), is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains one G-patch domain and one telomeric inhibiting domain (TID) at its C-terminus. PINX1 interacts with the telomere protein TRF1 and the telomerase reverse transcriptase TERT. The TID domain of PINX1 specifically interacts with TERT and functions to inhibit its activity, thus participating in the regulation of telomerase activity. Overexpression of PINX1 leads to shortened telomeres, further supporting an inhibitory role of PINX1 on telomerase activity. The depletion of PINX1 significantly increases telomerase activity and may lead to tumorigenicity of cancer cells. This suggests that PINX1 acts as a tumor suppressor and can inhibit cell proliferation. In addition, PINX1 is involved in nucleolar RNA maturation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PINX1 protein structure - BS61061 shown in red.