66983-1-Ig

antibody from Proteintech Group

Targeting: TRPV1 VR1

Provider product page for 66983-1-Ig

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
References [65]
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Product number: 66983-1-Ig - Provider product page
Provider: Proteintech Group
Product name: TRPV1 antibody
Antibody type: Monoclonal
Description: TRPV1 antibody (Cat. #66983-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: WB, ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1A3C9
Vial size: 20ul, 150ul

TRPV1 protein structure - 66983-1-Ig shown in red.

Submitted references UVB Upregulates Inflammatory Cytokines in Rosacea Cell Model by Promoting the Expression of TRPVs and TLR2.

Xie Y, Hu Y, Huang J, Liu J, Zhang Q
ImmunoTargets and therapy 2026;15:571037

Thymic stromal lymphopoietin modification gates chronic pain via regulation of transient receptor potential vanilloid type 1-caspase1.

Lu YY, Lu CC, Tsai HP, Wu CH
The International journal of neuroscience 2026 Mar;136(3):309-317

Manganese oxide nanozyme-loaded CO-releasing halloysite nanotubes for remodeling colonic immune, microbiota, and intestinal barrier homeostasis with concurrent pain relief in ulcerative colitis.

Zhang H, Zhou L, Zhou Q, Wen H, Lu H, Li J, Yu L, Li H, Zhu Y, Xu M, Lu B, Shi C, Zhang Y, Hu X, Shubhra QTH, He X, Cai X
Bioactive materials 2026 Feb;56:136-159

Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models.

Chen H, Li G, Deng L, Xu N, Lee SM, Nie X, Bian JS
Frontiers in pharmacology 2025;16:1585181

Refinement of TSLP expression mediates chronic allodynia associated with IL22/STAT3 axis.

Lu CC, Lu YY, Tsai HP, Wu CH
Neurochemistry international 2025 Sep;188:106022

Cannabidiol attenuates methamphetamine-induced oxidative neurotoxicity via regulating transient receptor potential vanilloid type 1.

Shen B, Yang G, Lv M, Wu Z, Zhang Y, Cao Y, Shu J, Dong W, Hou Z, Jing D, Xu J, Hou Y, Zhang X, Hong S, Li L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157015

Rutaecarpine alleviates liver fibrosis by modulating the TRPV1/Connexin 43 axis: A study based on transcriptome data, single-cell sequencing data, and cell experiments.

Zhao Y, Wu XQ, Liao SL
Biochemical and biophysical research communications 2025 Sep 25;781:152506

Ultrasound-responsive piezoelectric analgesic microspheres alleviate osteoarthritis pain.

Li X, Wang F, Zhang X, Liao B, Tan J, He X, Han W, Ding X, Wang Z, Jiang A, Liu C, Chen L, Bai D, Han X
Journal of controlled release : official journal of the Controlled Release Society 2025 Sep 10;385:114049

Transient receptor potential channels TRPA1 and TRPV1 are involved in chronic pain relief via Pulsed Radiofrequency in Rheumatoid Arthritis rat.

Wang YD, Xu Y, Zhu CM, Liu K, Zhao G, Hua H, Wang M, Li X
Neuropharmacology 2025 Nov 1;278:110548

Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons.

Li J, Cui Z, Gong H, Zhang Y, Yuan Z, Zhang Z, Ma Z, Zhou N, Huang C, Zhao Y, Li X, Zhang Z, Sun Y
Proceedings of the National Academy of Sciences of the United States of America 2025 Jun 17;122(24):e2424169122

Cannabidiol ameliorates seizures and neuronal damage in ferric chloride-induced posttraumatic epilepsy by targeting TRPV1 channel.

Ma L, Gao Y, Chen J, Hai D, Yu J, Tang S, Liu N, Liu Y
Journal of ethnopharmacology 2025 Jul 24;351:120072

Silver Needle Thermal Therapy Improves Mitochondrial Injury in the Skeletal Muscle of MPS Rats by Inhibiting the TRPV1/CaMKII Pathway.

Huang Y, An S, Tang Y, Yang X, Shen C, Huang Y, Wang L, Wo C
Physiological research 2025 Jul 23;74(3):481-492

Epidural injection of varying doses of capsaicin alleviates inflammatory pain in rats via the TLR4/AKT/NF-κB pathway.

Sana SRGL, Lv C, Yu S, Deng X, Dong Y
Inflammopharmacology 2025 Jan;33(1):257-267

Yu-Xue-Bi capsule ameliorates aggressive synovitis and joint damage in rheumatoid arthritis via modulating the SUCNR1/HIF-1α/TRPV1 axis.

Chen W, Zhang C, Xu M, Li T, Li X, Li P, Gong X, Qu Y, Zhou C, Mao X, Lin N, Liu W, Jiang Q, Xu H, Zhang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156354

Metabolite Profiling and Anti-Inflammatory Activities of Fritillaria cirrhosa D. Don Bulbs Derived from Tissue Culture.

Wang Y, Liu J, Zhang E, Yang Y, Lu Q, Zhu Z, Li R
Molecules (Basel, Switzerland) 2025 Jan 31;30(3)

The extract from Quzhou Aurantii Fructus attenuates cough variant asthma through inhibiting the TRPV1/Ca(2+)/NFAT/TSLP pathway and ferroptosis via TRPV1 mediation in ovalbumin-induced mice.

Tian M, Huang W, Chen J, Liu X, Wang H, Pan X, Wang L, Li Q, Gao L, Ye Y
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119038

Dietary cannabidiol oil mitigates metabolic dysfunction in mice with high-fat diet-induced obesity.

Bravo Iniguez A, Sun Q, Tian Q, Du M, Zhu MJ
The Journal of nutritional biochemistry 2025 Dec;146:110040

An Enhanced Cancer Immunogenic Cell Death Strategy: Fibrate-Oxaliplatin(IV) Conjugates with Modulating Tumor Immune Microenvironment.

Liang XJ, Guo X, Zhu PH, Zhao ZH, You Z, Yang K, Song Y, Li L, Song XQ
Journal of medicinal chemistry 2025 Dec 25;68(24):26328-26347

Effects of transient receptor potential channel activation during myogenic progression and skeletal muscle function during voluntary exercise.

Yamamoto H, Kojima K, Kasai S, Takimoto Y, Kato A, Yamamoto K, Moriya Y, Koida A, Agata U
Bioscience, biotechnology, and biochemistry 2025 Dec 18;90(1):66-75

A TRPV1 agonist from the transcriptome profiling of Dipsastraea rotumana inhibits neuroinflammation in vivo through the NF-κB and MAPK pathways.

Chen H, Xu N, Kam H, Zhao C, Chen Q, Fan G, Siu SWI, Wong CTT, Qiu JW, Cheung AK, Teixeira A, Rádis-Baptista G, Wong PK, Li S, Gong G, Lee SM
Pharmacological research 2025 Aug;218:107837

Bifunctional TRPV1 Targeted Magnetothermal Switch to Attenuate Osteoarthritis Progression.

Lv Z, Wang P, Li W, Xie Y, Sun W, Jin X, Jiang R, Fei Y, Liu Y, Shi T, Guo H, Sun Z, Lin J, Wang X, Tan G, Wu Y, Bao N, Shi D
Research (Washington, D.C.) 2024;7:0316

Exploring the Analgesic Initiation Mechanism of Tuina in the Dorsal Root Ganglion of Minor CCI Rats via the TRPV1/TRPA1-cGMP Pathway.

Yang Z, Sa C, Yu T, Chen J, Zhang R, Zhang Y, Liu J, Zhang H, Sun J
Pain research & management 2024;2024:2437396

Sertraline Alleviates Chronic Prostatitis by Regulating the TRPV1 Channel.

Lao Y, Bai Y, Guan X, Wang J, Wang Y, Li R, Ding Y, Dong Z
Journal of inflammation research 2024;17:4257-4275

Capsaicin Attenuates LPS-Induced Acute Lung Injury by Inhibiting Inflammation and Autophagy Through Regulation of the TRPV1/AKT Pathway.

Hu Q, Liu H, Wang R, Yao L, Chen S, Wang Y, Lv C
Journal of inflammation research 2024;17:153-170

Schizonepeta tenuifolia Briq-Saposhnikovia divaricata decoction alleviates atopic dermatitis via downregulating macrophage TRPV1.

Li H, Liang J, Li P, Li X, Liu Q, Yang S, Zhang C, Liu S, He Y, Tan C
Frontiers in pharmacology 2024;15:1413513

Gabapentin alleviates peripheral nerve sensitization induced by inflammatory arthritis via ionotropic glutamate receptor NR2B subunit.

Meng Y, Tan M, Yan Jiang X, Wang T, Li Shen H
Neuroscience 2024 Sep 25;556:1-13

Dietary capsaicin attenuates cardiac injury after myocardial infarction in type 2 diabetic mice by inhibiting ferroptosis through activation of TRPV1 and Nrf2/HMOX1 pathway.

Yang C, Guo W, He R, Meng X, Fu J, Lu Y
International immunopharmacology 2024 Oct 25;140:112852

Bleomycin triggers chronic mechanical nociception by activating TRPV1 and glial reaction-mediated neuroinflammation via TSLP/TSLPR/pSTAT5 signals.

Lu YY, Lin CY, Lu CC, Tsai HP, Wang WT, Zhang ZH, Wu CH
Brain research bulletin 2024 Oct 15;217:111081

A proteomics-based study of the mechanism of oxymatrine to ameliorate hepatic fibrosis in mice.

Wu J, Jin X, Li W, Liu E
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2024 Oct 15;1247:124280

CDDO regulates central and peripheral sensitization to attenuate post-herpetic neuralgia by targeting TRPV1/PKC-δ/p-Akt signals.

Lu CC, Lin CY, Lu YY, Tsai HP, Lin CL, Wu CH
Journal of cellular and molecular medicine 2024 Mar;28(6):e18131

Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome.

Li ZY, Mao YQ, Hua Q, Sun YH, Wang HY, Ye XG, Hu JX, Wang YJ, Jiang M
World journal of gastroenterology 2024 Mar 14;30(10):1431-1449

TRPV1 inhibition suppresses non-small cell lung cancer progression by inhibiting tumour growth and enhancing the immune response.

Wang Y, Zhang Y, Ouyang J, Yi H, Wang S, Liu D, Dai Y, Song K, Pei W, Hong Z, Chen L, Zhang W, Liu Z, Mcleod HL, He Y
Cellular oncology (Dordrecht, Netherlands) 2024 Jun;47(3):779-791

Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro-Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia.

Wang Y, Zhou X, Yao L, Hu Q, Liu H, Zhao G, Wang K, Zeng J, Sun M, Lv C
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2306916

Kilohertz high-frequency electrical stimulation ameliorate hyperalgesia by modulating transient receptor potential vanilloid-1 and N-methyl-D-aspartate receptor-2B signaling pathways in chronic constriction injury of sciatic nerve mice.

Fang K, Lu P, Cheng W, Yu B
Molecular pain 2024 Jan-Dec;20:17448069231225810

Palmitic acid and trans-4-hydroxy-3-methoxycinnamate, the active ingredients of Yaobishu formula, reduce inflammation and pain by regulating gut microbiota and metabolic changes after lumbar disc herniation to activate autophagy and the Wnt/β-catenin pathway.

Li S, Chen T, Zhou Y, Li X
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166972

NIR Laser Irradiation Promotes Osteogenic Differentiation of PDLSCs Through the Activation of TRPV1 Channels and Subsequent Calcium Signaling.

Zeng JH, Ma B, Shen XQ, Geng YM
Photobiomodulation, photomedicine, and laser surgery 2024 Dec;42(12):747-753

MUC1‑ND interacts with TRPV1 to promote corneal epithelial cell proliferation in diabetic dry eye mice by partly activating the AKT signaling pathway.

Li H, Zhang Y, Chen Y, Zhu R, Zou W, Chen H, Hu J, Feng S, Zhong Y, Lu X
Molecular medicine reports 2024 Dec;30(6)

Berberine in combination with evodiamine ameliorates gastroesophageal reflux disease through TAS2R38/TRPV1-mediated regulation of MAPK/NF-κB signaling pathways and macrophage polarization.

Cui G, Wang M, Li X, Wang C, Shon K, Liu Z, Ren L, Yang X, Li X, Wu Y, Sun Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156251

Artesunate remarkably alleviates interstitial cystitis/bladder pain syndrome in a murine model: Novel molecular signature deciphered by bulk tissue and single-cell transcriptomic analysis.

Wu Y, Shi B, He Y, Wang S, Zhou J, Qi J, Ding J, Wang Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 15;38(23):e70225

Gut microbiota are involved in leptin-induced thermoregulation in the Mongolian gerbil (Meriones unguiculatus).

Tang L, Lv J, Zhang X, Wang CZ, Wang D
The Journal of experimental biology 2024 Dec 1;227(23)

PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1.

Chen H, Sun B, Gao W, Qiu Y, Wei W, Li Y, Ye W, Song H, Hua C, Lin X
iScience 2024 Aug 16;27(8):110467

Near Infrared Responsive Gold Nanorods Attenuate Osteoarthritis Progression by Targeting TRPV1.

Li W, Lv Z, Wang P, Xie Y, Sun W, Guo H, Jin X, Liu Y, Jiang R, Fei Y, Tan G, Jiang H, Wang X, Liu Z, Wang Z, Xu N, Gong W, Wu R, Shi D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(16):e2307683

Study on mechanism of transdermal administration of eugenol for pain treatment by network pharmacology and molecular docking technology.

Ye H, Lin Q, Mei Q, Liu Q, Cao S
Heliyon 2024 Apr 30;10(8):e29722

Zhisou powder suppresses airway inflammation in LPS and CS-induced post-infectious cough model mice via TRPA1/TRPV1 channels.

Xu Y, Cao S, Wang SF, Ma W, Gou XJ
Journal of ethnopharmacology 2024 Apr 24;324:117741

Role of TRPV1 and TRPA1 in TSLP production in nasal epithelial cells.

Li J, Wang F, Meng C, Zhu D
International immunopharmacology 2024 Apr 20;131:111916

Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro.

Han J, Wu J, Liu H, Huang Y, Ju W, Xing Y, Zhang X, Yang J
Open life sciences 2023;18(1):20220647

Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats.

Liu L, Zhao Y, An W, Zhao M, Ding N, Liu H, Ge N, Wen J, Zhang X, Zu S, Sun W
Molecular neurobiology 2023 Sep;60(9):5000-5012

Total alkaloids of Fritillaria unibracteata var. wabuensis bulbus ameliorate chronic asthma via the TRPV1/Ca(2+)/NFAT pathway.

Peng M, Li J, Zhou J, Zhang B, Liao J, Yang D, Wang Y, Yang Y, Li R, Tang X, Lu Q, Zhao Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154946

Thermo-TRP channels are involved in BAT thermoregulation in cold-acclimated Brandt's voles.

Lv J, Tang L, Zhang X, Wang D
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Jan;263:110794

Smart nanostructures for targeted oxygen-producing photodynamic therapy of skin photoaging and potential mechanism.

Wang Y, Lu Z, Huang Y, Jia W, Wang W, Zhang X, Chen C, Li Y, Yang C, Jiang G
Nanomedicine (London, England) 2023 Feb;18(3):217-231

Luteolin Alleviates Oxidative Stress in Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke via Modulation of the TRPV1 and CYP2A13/NRF2 Signaling Pathways.

Zhou L, Jian T, Wan Y, Huang R, Fang H, Wang Y, Liang C, Ding X, Chen J
International journal of molecular sciences 2023 Dec 27;25(1)

TRPV2, a novel player in the human ovary and human granulosa cells.

Eubler K, Caban KM, Dissen GA, Berg U, Berg D, Herrmann C, Kreitmair N, Tiefenbacher A, Fröhlich T, Mayerhofer A
Molecular human reproduction 2023 Aug 30;29(9)

Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation.

Li T, Jiang S, Zhang Y, Luo J, Li M, Ke H, Deng Y, Yang T, Sun X, Chen H
Nature communications 2023 Apr 29;14(1):2498

Role of TRPV1 ion channel in cervical squamous cell carcinoma genesis.

Wang Z, Dong J, Tian W, Qiao S, Wang H
Frontiers in molecular biosciences 2022;9:980262

Cannabidiol Inhibits Inflammation Induced by Cutibacterium acnes-Derived Extracellular Vesicles via Activation of CB2 Receptor in Keratinocytes.

Jiang Z, Jin S, Fan X, Cao K, Liu Y, Wang X, Ma Y, Xiang L
Journal of inflammation research 2022;15:4573-4583

Pinelliae rhizoma alleviated acute lung injury induced by lipopolysaccharide via suppressing endoplasmic reticulum stress-mediated NLRP3 inflammasome.

Wang NN, Zhang XX, Shen P, Huang CS, Deng HF, Zhou L, Yue LX, Shen BY, Zhou W, Gao Y
Frontiers in pharmacology 2022;13:883865

Effect of Xiongmatang Extract on Behavioral and TRPV1-CGRP/CGRP-R Pathway in Rats With Migraine.

Liu D, Chang L, Wang J, Zhu Q, Jiang N, Azhar M, Ahmed A, Zeng G
Frontiers in pharmacology 2022;13:835187

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis.

Lv Z, Han J, Li J, Guo H, Fei Y, Sun Z, Dong J, Wang M, Fan C, Li W, Xie Y, Sun W, Chen J, Liu Y, Chen F, Liu Z, Liu A, Wu R, Xu X, Yan W, Jiang Q, Ikegawa S, Chen X, Shi D
EBioMedicine 2022 Oct;84:104258

The Contribution of TSLP Activation to Hyperalgesia in Dorsal Root Ganglia Neurons of a Rat.

Lu CC, Lu YY, Tsai HP, Wu CH
International journal of molecular sciences 2022 Feb 11;23(4)

Noninvasive near-infrared light triggers the remote activation of thermo-responsive TRPV1 channels in neurons based on biodegradable/photothermal polymer micelles.

Chen WH, Onoe T, Kamimura M
Nanoscale 2022 Feb 10;14(6):2210-2220

Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats.

Liu Y, Zhang L, Xu ZH, Zhu J, Ma JL, Gao YP, Xu GY
Molecular pain 2022 Apr;18:17448069221143671

Functional Characterization of Ovine Dorsal Root Ganglion Neurons Reveal Peripheral Sensitization after Osteochondral Defect.

Chakrabarti S, Ai M, Wong K, Newell K, Henson FMD, Smith ESJ
eNeuro 2021 Sep-Oct;8(5)

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)/CaMKII/Nrf2 signaling pathway.

Lv Z, Xu X, Sun Z, Yang YX, Guo H, Li J, Sun K, Wu R, Xu J, Jiang Q, Ikegawa S, Shi D
Cell death & disease 2021 May 18;12(6):504

Effect of local ozone treatment on rats with anterior rectal resection and the possible mechanisms.

Zhang W, Wu M, Chen P, Zhang J, Ma J, Cheng Y, Li X, Hu J, Li W, Du Y, Ding K, Fan Z
Biomedical engineering online 2021 Aug 6;20(1):79

Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury.

Liu Z, Wang P, Lu S, Guo R, Gao W, Tong H, Yin Y, Han X, Liu T, Chen X, Zhu MX, Yang Z
Cell calcium 2020 Jun;88:102198

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