SYNC

This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Description

Syncoilin, intermediate filament protein

Tissue specificity

Group enriched (skeletal muscle, smooth muscle, tongue)

Subcell location

Golgi apparatus, Vesicles, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (32679906 - 32703596)

Ensembl ID

ENSG00000162520  (ver. 103.38)

Orthologs

Mouse Sync: ENSMUSG00000001333

UniProt

Q9H7C4

neXtProt

NX_Q9H7C4

Human splice variants
Mouse splice variants

Protein structure