23995-1-AP

antibody from Proteintech Group

Targeting: FNDC5 FRCP2

Provider product page for 23995-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [29]
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Validations
Immunohistochemistry [1]

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Product number: 23995-1-AP - Provider product page
Provider: Proteintech Group
Product name: FNDC5 antibody
Antibody type: Polyclonal
Description: FNDC5 antibody (Cat. #23995-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FNDC5 protein structure - 23995-1-AP shown in red.

Submitted references Maternal prednisone exposure during pregnancy elevates susceptibility to osteoporosis in female offspring: The role of mitophagy/FNDC5 alteration in skeletal muscle.

Du ZY, Zhu HL, Chang W, Zhang YF, Ling Q, Wang KW, Zhang J, Zhang QB, Kan XL, Wang QN, Wang H, Zhou Y
Journal of hazardous materials 2024 May 5;469:133997

FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis.

Dong Q, Han Z, Gao M, Tian L
Journal of orthopaedic surgery and research 2024 Mar 30;19(1):205

FNDC5/Irisin protects neurons through Caspase3 and Bax pathways.

Zhang QX, Zhang LJ, Zhao N, Chang SH, Yang L
Cell biochemistry and function 2024 Jan;42(1):e3912

Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.

Shang X, Hao X, Hou W, Liu J, Chi R, Deng X, Pan C, Xu T
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49

Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin†.

Chae SA, Du M, Zhu MJ, Son JS
Biology of reproduction 2024 Feb 10;110(2):355-364

Exerkine FNDC5/irisin-enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin-1.

Tao L, Wang J, Wang K, Liu Q, Li H, Xu S, Gu C, Zhu Y
Aging cell 2024 Aug;23(8):e14181

1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5'-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway.

Kikuchi K, Otsuka S, Takada S, Nakanishi K, Setoyama K, Sakakima H, Tanaka E, Maruyama I
Aging 2023 Nov 9;15(21):11740-11763

Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis.

Li T, Yang J, Tan A, Chen H
Diabetology & metabolic syndrome 2023 Nov 22;15(1):239

CRISPRa-based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning.

Zhu H, Liu D, Sui M, Zhou M, Wang B, Qi Q, Wang T, Zhang G, Wan F, Zhang B
Clinical and translational medicine 2023 Jul;13(7):e1326

Irisin protects against doxorubicin-induced cardiotoxicity by improving AMPK-Nrf2 dependent mitochondrial fusion and strengthening endogenous anti-oxidant defense mechanisms.

Zhuo C, Xin J, Huang W, Zhang D, Yan X, Li R, Li H, Lan J, Lin L, Li L, Wang X, Liu L, Wang Y, Li X, Mao Y, Chen H, Wu S, Yang X, Jiang W
Toxicology 2023 Aug 1;494:153597

Low FNDC5/Irisin expression is associated with aggressive phenotypes in gastric cancer.

Xu L, Ye Y, Sun Y, Zhong W, Chi L, Lin Y, Liu H, Li S, Chen H, Li C, Lin Y, Wang Q, Xue F, Lin Y
Frontiers in pharmacology 2022;13:981201

Exercise hormone irisin prevents physical inactivity-induced cognitive decline in mice.

Park J, Kim J, Mikami T
Behavioural brain research 2022 Sep 5;433:114008

Deng CY, Zhu TT, Lian S, Wang JF, Wu R, Zheng JS
Journal of veterinary research 2022 Mar;66(1):131-140

Effects of exercise and dietary intervention on muscle, adipose tissue, and blood IRISIN levels in obese male mice and their relationship with the beigeization of white adipose tissue.

Li J, Yi X, Li T, Yao T, Li D, Hu G, Ma Y, Chang B, Cao S
Endocrine connections 2022 Mar 14;11(3)

Expression analysis of irisin during different development stages of skeletal muscle in mice.

Yan Y, Yang D, Wen P, Li Y, Ge Y, Ma P, Yuan J, Zhang P, Zhu Z, Luo X, Yu X, Wang H
Gene expression patterns : GEP 2022 Dec;46:119287

Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway.

Wu Y, Sun F, Guo Y, Zhang Y, Li L, Dang R, Jiang P
Behavioural neurology 2021;2021:2630445

Vitellogenin 2 promotes muscle development and stimulates the browning of white fat.

Li Y, Sun X, Bai Y, Ji Y, Ren H, Yu X, Yan Y, He X, Dong Y, Zhang L, Luo X, Wang H
Aging 2021 Oct 5;13(19):22985-23003

Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice.

Bretland KA, Lin L, Bretland KM, Smith MA, Fleming SM, Dengler-Crish CM
Neuropathology and applied neurobiology 2021 Dec;47(7):967-978

Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway.

He W, Wang P, Chen Q, Li C
Skeletal muscle 2020 Sep 15;10(1):25

Hepatic FNDC5 is a potential local protective factor against Non-Alcoholic Fatty Liver.

Canivet CM, Bonnafous S, Rousseau D, Leclere PS, Lacas-Gervais S, Patouraux S, Sans A, Luci C, Bailly-Maitre B, Iannelli A, Tran A, Anty R, Gual P
Biochimica et biophysica acta. Molecular basis of disease 2020 May 1;1866(5):165705

Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis.

Ren Y, Zhang J, Wang M, Bi J, Wang T, Qiu M, Lv Y, Wu Z, Wu R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110101

Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53.

Liu Y, Fu Y, Liu Z, Shu S, Wang Y, Cai J, Tang C, Dong Z
Biochimica et biophysica acta. Molecular basis of disease 2020 Jul 1;1866(7):165792

Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM.

Lang X, Zhao N, He Q, Li X, Li X, Sun C, Zhang X
Brain research bulletin 2020 Dec;165:30-39

Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance.

Shen S, Liao Q, Zhang T, Pan R, Lin L
British journal of pharmacology 2019 Oct;176(20):3983-4001

The saturated fatty acid palmitate induces insulin resistance through Smad3-mediated down-regulation of FNDC5 in myotubes.

Guo Q, Wei X, Hu H, Yang D, Zhang B, Fan X, Liu J, He H, Oh Y, Wu Q, Zhang Y, Wang C, Liu C, Gu N
Biochemical and biophysical research communications 2019 Dec 10;520(3):619-626

Effects of myostatin deficiency on PGC-1α and FNDC5 expression in three different murine muscle types.

Bai Y, Bi H, Li L, Li J, Yu X, Ren H, Li Y, Ji Y, Li H, Wang H
Acta histochemica 2019 Apr;121(3):323-329

Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway.

Belviranlı M, Okudan N
Neuromolecular medicine 2018 Sep;20(3):386-400

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer's disease.

Noda Y, Kuzuya A, Tanigawa K, Araki M, Kawai R, Ma B, Sasakura Y, Maesako M, Tashiro Y, Miyamoto M, Uemura K, Okuno Y, Kinoshita A
Molecular brain 2018 Oct 24;11(1):61

Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK-Akt-eNOS-NO Pathway in the Spontaneously Hypertensive Rat.

Fu J, Han Y, Wang J, Liu Y, Zheng S, Zhou L, Jose PA, Zeng C
Journal of the American Heart Association 2016 Oct 26;5(11)

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FNDC5 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FNDC5. This antibody recognizes human, mouse antigen. The FNDC5 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 23995-1-AP.pdf

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