19962-1-AP

antibody from Proteintech Group

Targeting: ITPR1 ACV, Insp3r1, IP3R1, PPP1R94, SCA15, SCA16, SCA29

Provider product page for 19962-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [25]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 19962-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19962-1-AP, RRID:AB_10638786
Product name: ITPR1-specific antibody
Antibody type: Polyclonal
Description: ITPR1-specific antibody (Cat. #19962-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ITPR1 protein structure - 19962-1-AP shown in red.

Submitted references MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism.

Liu S, Han S, Wang C, Chen H, Xu Q, Feng S, Wang Y, Yao J, Zhou Q, Tang X, Lin L, Hu L, Davidson AJ, Yang B, Ye C, Yang F, Mao J, Tong C, Chen J, Jiang H
International journal of biological sciences 2024;20(2):569-584

Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.

Li Y, Wang HB, Cao JL, Zhang WJ, Wang HL, Xu CH, Li KP, Liu Y, Wang JR, Ha HL, Fu SJ, Yang L
Journal of translational medicine 2024 Mar 10;22(1):261

Role of PLC/IP(3) /IP(3) R axis in excess molybdenum exposure induced apoptosis in duck renal tubular epithelial cells.

Guo H, Zhang C, Pu W, Chu X, Huang G, Cui T, Huang B, Liu H, Dai X
Environmental toxicology 2024 Jan;39(1):172-183

OrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools.

Lee A, Sung G, Shin S, Lee SY, Sim J, Nhung TTM, Nghi TD, Park SK, Sathieshkumar PP, Kang I, Mun JY, Kim JS, Rhee HW, Park KM, Kim K
Nature communications 2024 Feb 29;15(1):1851

SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.

Wang Y, Wang M, Su H, Song J, Ren M, Hu P, Liu G, Tong X
Free radical biology & medicine 2024 Feb 20;212:284-294

Estrogen receptor subtype mediated anti-inflammation and vasorelaxation via genomic and nongenomic actions in septic mice.

Zhang L, Wan H, Zhang M, Lu W, Xu F, Dong H
Frontiers in endocrinology 2023;14:1152634

Mitochondrial dysfunction and calcium dyshomeostasis in the pectoralis major muscle of broiler chickens with wooden breast myopathy.

Zhang X, Xing T, Li J, Zhang L, Gao F
Poultry science 2023 Sep;102(9):102872

Intracellular Calcium Overload and Activation of CaMKK/AMPK Signaling Are Related to the Acceleration of Muscle Glycolysis of Broiler Chickens Subjected to Acute Stress.

Liao H, Zhang L, Li J, Xing T, Gao F
Journal of agricultural and food chemistry 2023 Mar 8;71(9):4091-4100

Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease.

Marinho D, Ferreira IL, Lorenzoni R, Cardoso SM, Santana I, Rego AC
Aging cell 2023 Aug;22(8):e13895

Crosstalk between Mfn2-mediated mitochondria associated membranes disorder and autophagy induced by molybdenum and cadmium in sheep heart.

Peng C, Yang S, Yang F, Xiong Z, Liu Q, Liao S, Huang K, Wan W, Cao H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113660

Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes.

Wang Y, Li X, Xu X, Qu X, Yang Y
Journal of cardiovascular pharmacology 2022 Sep 1;80(3):430-441

PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.

Li C, Li L, Yang M, Yang J, Zhao C, Han Y, Zhao H, Jiang N, Wei L, Xiao Y, Liu Y, Xiong X, Xi Y, Luo S, Deng F, Chen W, Yuan S, Zhu X, Xiao L, Sun L
Diabetes 2022 May 1;71(5):1034-1050

Systematic analysis of the expression and prognostic value of ITPR1 and correlation with tumor infiltrating immune cells in breast cancer.

Han B, Zhen F, Zheng XS, Hu J, Chen XS
BMC cancer 2022 Mar 21;22(1):297

A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.

Qin Y, Du Y, Chen L, Liu Y, Xu W, Liu Y, Li Y, Leng J, Wang Y, Zhang XY, Feng J, Zhang F, Jin L, Qiu Z, Gong X, Wang H
Molecular psychiatry 2022 Jul;27(7):2985-2998

MORTALIN-Ca(2+) axis drives innate rituximab resistance in diffuse large B-cell lymphoma.

Sun Q, Ye Y, Gui A, Sun X, Xie S, Zhan Y, Chen R, Yan Y, Gu J, Qiu S, Liu W, Zuo J, Zhang Q, Yang L
Cancer letters 2022 Jul 1;537:215678

Interleukin-6-Mediated-Ca(2+) Handling Abnormalities Contributes to Atrial Fibrillation in Sterile Pericarditis Rats.

Liao J, Zhang S, Yang S, Lu Y, Lu K, Wu Y, Wu Q, Zhao N, Dong Q, Chen L, Du Y
Frontiers in immunology 2021;12:758157

MAMs Protect Against Ectopic Fat Deposition and Lipid-Related Kidney Damage in DN Patients.

Yang M, Han Y, Luo S, Xiong X, Zhu X, Zhao H, Jiang N, Xiao Y, Wei L, Li C, Yang J, Sun L
Frontiers in endocrinology 2021;12:609580

Prenatal hypoxia induced ET(B)R activation and abnormal ROS signalling in pulmonary artery cells of rat offspring.

Zhang Y, Tang J, Li N, Tao J, Zhang Y, Zhang Y, Ye Y, Zheng Q, Xu T, Liu Y, Zhang P, Li L, Li H, He Y, Su H, He Q, Sun M, Xu Z
Reproductive toxicology (Elmsford, N.Y.) 2021 Oct;105:91-100

Sulforaphane Balances Ca(2+) Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).

Tian S, Lei P, Zhang J, Sun Y, Li B, Shan Y
Molecular nutrition & food research 2021 Jul;65(14):e2001076

ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.

Zhang M, Wang L, Yue Y, Zhang L, Liu T, Jing M, Liang X, Ma M, Xu S, Wang K, Wang X, Fan J
Journal of experimental & clinical cancer research : CR 2021 Feb 11;40(1):65

Label-Free Quantitative Proteomic Profiling of LAD2 Mast Cell Releasates Reveals the Mechanism of Tween-80-Induced Anaphylactoid Reaction.

Mi YN, Yan PP, Di J, Cao L, Xiao X, Liu DZ, Cao YX
Proteomics. Clinical applications 2020 Jul;14(4):e1900065

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.

Stoyas CA, Bushart DD, Switonski PM, Ward JM, Alaghatta A, Tang MB, Niu C, Wadhwa M, Huang H, Savchenko A, Gariani K, Xie F, Delaney JR, Gaasterland T, Auwerx J, Shakkottai VG, La Spada AR
Neuron 2020 Feb 19;105(4):630-644.e9

DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.

Yang M, Zhao L, Gao P, Zhu X, Han Y, Chen X, Li L, Xiao Y, Wei L, Li C, Xiao L, Yuan S, Liu F, Dong LQ, Kanwar YS, Sun L
EBioMedicine 2019 May;43:607-619

Memantine can improve chronic ethanol exposure-induced spatial memory impairment in male C57BL/6 mice by reducing hippocampal apoptosis.

Wang X, Yu H, You J, Wang C, Feng C, Liu Z, Li Y, Wei R, Xu S, Zhao R, Wu X, Zhang G
Toxicology 2018 Aug 1;406-407:21-32

Memantine Can Reduce Ethanol-Induced Caspase-3 Activity and Apoptosis in H4 Cells by Decreasing Intracellular Calcium.

Wang X, Chen J, Wang H, Yu H, Wang C, You J, Wang P, Feng C, Xu G, Wu X, Zhao R, Zhang G
Journal of molecular neuroscience : MN 2017 Aug;62(3-4):402-411

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 19962-1-AP(ITPR1-specific antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human testis using 19962-1-AP(ITPR1-specific antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ITPR1-specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ITPR1-specific. This antibody recognizes human,mouse,rat antigen. The ITPR1-specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 19962-1-AP.pdf

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