19962-1-AP

antibody from Proteintech Group

Targeting: ITPR1 ACV, Insp3r1, IP3R1, PPP1R94, SCA15, SCA16, SCA29

Provider product page for 19962-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [44]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 19962-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19962-1-AP, RRID:AB_10638786
Product name: ITPR1-specific antibody
Antibody type: Polyclonal
Description: ITPR1-specific antibody (Cat. #19962-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ITPR1 protein structure - 19962-1-AP shown in red.

Submitted references Ageing-Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1-Meditated Ca(2+) Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice.

Shi R, Zhang Y, Chen G, Zhang J, Liu J, Zhu H, Sun M, Duan Y
Cell proliferation 2026 May;59(5):e70120

Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction.

Zhao YY, Wang YH, Li ZH, Chang DY, Nie L, Zhao MH, Tang SCW, Chen M
Cell discovery 2026 Mar 31;12(1)

ITPR1 mediates the PI3K/AKT/mTOR pathway to regulate cellular autophagy, affecting lipopolysaccharide-induced pediatric inflammatory bowel disease.

Zhao X, Zhang X
BMC gastroenterology 2026 Mar 16;26(1)

NUSAP1 Drives Endometrial Carcinoma via IP3R Phosphorylation, Calcium Dyshomeostasis, and ER-Stress-Mediated Apoptosis.

Xiao H, Wang H, Yang H, Li F, Ma L, Ma H
ACS omega 2026 Jan 20;11(2):2499-2512

Membrane receptor TGR5 upregulates IP3R-induced calcium overload: Key mechanism of bile acid-induced acute pancreatitis.

Zhong Z, Cheng L, Jiang Z, Zhu Y, Zhao C, Deng C, Yang T, Chen M, Yu Q, Xie C, Dai X, Wang T
Cellular signalling 2026 Aug;144:112512

Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP(+)-induced neurological damage in the cellular model of Parkinson's disease.

Zhang C, Huang P, Cheng H, Yuan X, Zhou M, Liu Y, Liu T, Chen D, Xu Q, Cai J
Frontiers in pharmacology 2025;16:1509317

Mechanism of mitofusin 2, mitochondria-associated membrane, and the mitochondrial pathway in alleviating oxidative stress and cell senescence in bovine mammary epithelial cells.

Hu H, Liu J, Yin J, Hu G, Huang B, Tu L, Liu X, Xu B, Cao Y, Guo W, Fu S
Journal of dairy science 2025 Sep;108(9):10151-10172

Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.

Zhang F, Xie Y, Dang RN, Yu J, Tian XX, Li LJ, Zhou QM, An XM, Chen PL, Luo YQ, Wu YS, Liu J, Zou HM
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990

Inhibition of NPC Intracellular Cholesterol Transporter 1 Dually Regulates Aldosterone Secretion Via the Steroidogenic Acute Regulatory-Related Lipid Transfer Domain-3-Voltage-Dependent Anion Channel 1 Axis and Inositol 1,4,5-Trisphosphate Receptor Type 3-Calcium Signaling.

Chen J, Chen M, Hu J, Wu Z, Li H, Li W, He F, Peng C, Xu Y, Huang W, Gao R, Li Q, Ma L, Yang S
Journal of the American Heart Association 2025 Nov 4;14(21):e045554T

The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.

Guo Q, Li ZF, Hu DY, Li PJ, Wu KN, Fan HH, Deng J, Wu HM, Zhang X, Zhu JH
The EMBO journal 2025 May;44(10):2906-2927

Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.

Al-Maamari A, Sultan M, Wu S, Zhang T, Wang C, Han B, Duan Y, Ding SS, Chen N, Zhang H, Sun F, Chen X, Yu D, Su S
International journal of biological macromolecules 2025 May;310(Pt 4):143549

Reciprocal rescue of Wolfram syndrome by two causative genes.

Ham SJ, Yoon E, Lee DH, Kim S, Yoo H, Chung J
EMBO reports 2025 May;26(9):2459-2482

Ginsenoside Rh3-induced neurotoxicity involving the IP3R-Ca(2+)/NOX2/NF-κB signaling pathways.

Wang Y, Chen J, Li S, Cai Z
Journal of natural medicines 2025 Jul;79(4):791-806

Cadmium induces autophagy via IRE1 signaling pathway activated by Ca(2 +) in GC-2spd cells.

Han Y, Dai J, Cheng J, He Y, Zhao C, Li R, Zhang Y, Zhang L, Zhou T, Shi Y
Reproductive toxicology (Elmsford, N.Y.) 2025 Aug;135:108950

2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway.

Bao H, Chen X, Hu X, Cao Z, Zhou W, Chen B, Liao F, Wei F, Huang R, Li W, Chen Z
Scientific reports 2025 Aug 12;15(1):29469

The LncRNA RMST-miR-4295-ITPR1 axis: a key mechanism in regulating autophagy in triple-negative breast cancer cells.

Zhang L, Li S, Shi J, Guo H, Wang B, Geng C
BMC cancer 2025 Apr 26;25(1):782

MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism.

Liu S, Han S, Wang C, Chen H, Xu Q, Feng S, Wang Y, Yao J, Zhou Q, Tang X, Lin L, Hu L, Davidson AJ, Yang B, Ye C, Yang F, Mao J, Tong C, Chen J, Jiang H
International journal of biological sciences 2024;20(2):569-584

Comprehensively prognostic and immunological analyses of GLP-1 signaling-related genes in pan-cancer and validation in colorectal cancer.

Zhu C, Lai Y, Liu C, Teng L, Zhu Y, Lin X, Fu X, Lai Q, Liu S, Zhou X, Fang Y
Frontiers in pharmacology 2024;15:1387243

A new look at angiogenesis inhibition of geniposide in experimental arthritis by blocking angiopoietin-2 exocytosis.

Gan P, Wu H, Zhu Y, Shu Y, Wei Y
Phytotherapy research : PTR 2024 Mar;38(3):1245-1261

Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.

Li Y, Wang HB, Cao JL, Zhang WJ, Wang HL, Xu CH, Li KP, Liu Y, Wang JR, Ha HL, Fu SJ, Yang L
Journal of translational medicine 2024 Mar 10;22(1):261

ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome.

Liiv M, Vaarmann A, Safiulina D, Choubey V, Gupta R, Kuum M, Janickova L, Hodurova Z, Cagalinec M, Zeb A, Hickey MA, Huang YL, Gogichaishvili N, Mandel M, Plaas M, Vasar E, Loncke J, Vervliet T, Tsai TF, Bultynck G, Veksler V, Kaasik A
Nature communications 2024 Jul 21;15(1):6143

Role of PLC/IP(3) /IP(3) R axis in excess molybdenum exposure induced apoptosis in duck renal tubular epithelial cells.

Guo H, Zhang C, Pu W, Chu X, Huang G, Cui T, Huang B, Liu H, Dai X
Environmental toxicology 2024 Jan;39(1):172-183

OrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools.

Lee A, Sung G, Shin S, Lee SY, Sim J, Nhung TTM, Nghi TD, Park SK, Sathieshkumar PP, Kang I, Mun JY, Kim JS, Rhee HW, Park KM, Kim K
Nature communications 2024 Feb 29;15(1):1851

SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.

Wang Y, Wang M, Su H, Song J, Ren M, Hu P, Liu G, Tong X
Free radical biology & medicine 2024 Feb 20;212:284-294

Estrogen receptor subtype mediated anti-inflammation and vasorelaxation via genomic and nongenomic actions in septic mice.

Zhang L, Wan H, Zhang M, Lu W, Xu F, Dong H
Frontiers in endocrinology 2023;14:1152634

Mitochondrial dysfunction and calcium dyshomeostasis in the pectoralis major muscle of broiler chickens with wooden breast myopathy.

Zhang X, Xing T, Li J, Zhang L, Gao F
Poultry science 2023 Sep;102(9):102872

Intracellular Calcium Overload and Activation of CaMKK/AMPK Signaling Are Related to the Acceleration of Muscle Glycolysis of Broiler Chickens Subjected to Acute Stress.

Liao H, Zhang L, Li J, Xing T, Gao F
Journal of agricultural and food chemistry 2023 Mar 8;71(9):4091-4100

Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease.

Marinho D, Ferreira IL, Lorenzoni R, Cardoso SM, Santana I, Rego AC
Aging cell 2023 Aug;22(8):e13895

Crosstalk between Mfn2-mediated mitochondria associated membranes disorder and autophagy induced by molybdenum and cadmium in sheep heart.

Peng C, Yang S, Yang F, Xiong Z, Liu Q, Liao S, Huang K, Wan W, Cao H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113660

Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes.

Wang Y, Li X, Xu X, Qu X, Yang Y
Journal of cardiovascular pharmacology 2022 Sep 1;80(3):430-441

PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.

Li C, Li L, Yang M, Yang J, Zhao C, Han Y, Zhao H, Jiang N, Wei L, Xiao Y, Liu Y, Xiong X, Xi Y, Luo S, Deng F, Chen W, Yuan S, Zhu X, Xiao L, Sun L
Diabetes 2022 May 1;71(5):1034-1050

Systematic analysis of the expression and prognostic value of ITPR1 and correlation with tumor infiltrating immune cells in breast cancer.

Han B, Zhen F, Zheng XS, Hu J, Chen XS
BMC cancer 2022 Mar 21;22(1):297

A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.

Qin Y, Du Y, Chen L, Liu Y, Xu W, Liu Y, Li Y, Leng J, Wang Y, Zhang XY, Feng J, Zhang F, Jin L, Qiu Z, Gong X, Wang H
Molecular psychiatry 2022 Jul;27(7):2985-2998

MORTALIN-Ca(2+) axis drives innate rituximab resistance in diffuse large B-cell lymphoma.

Sun Q, Ye Y, Gui A, Sun X, Xie S, Zhan Y, Chen R, Yan Y, Gu J, Qiu S, Liu W, Zuo J, Zhang Q, Yang L
Cancer letters 2022 Jul 1;537:215678

Interleukin-6-Mediated-Ca(2+) Handling Abnormalities Contributes to Atrial Fibrillation in Sterile Pericarditis Rats.

Liao J, Zhang S, Yang S, Lu Y, Lu K, Wu Y, Wu Q, Zhao N, Dong Q, Chen L, Du Y
Frontiers in immunology 2021;12:758157

MAMs Protect Against Ectopic Fat Deposition and Lipid-Related Kidney Damage in DN Patients.

Yang M, Han Y, Luo S, Xiong X, Zhu X, Zhao H, Jiang N, Xiao Y, Wei L, Li C, Yang J, Sun L
Frontiers in endocrinology 2021;12:609580

Prenatal hypoxia induced ET(B)R activation and abnormal ROS signalling in pulmonary artery cells of rat offspring.

Zhang Y, Tang J, Li N, Tao J, Zhang Y, Zhang Y, Ye Y, Zheng Q, Xu T, Liu Y, Zhang P, Li L, Li H, He Y, Su H, He Q, Sun M, Xu Z
Reproductive toxicology (Elmsford, N.Y.) 2021 Oct;105:91-100

Sulforaphane Balances Ca(2+) Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).

Tian S, Lei P, Zhang J, Sun Y, Li B, Shan Y
Molecular nutrition & food research 2021 Jul;65(14):e2001076

ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.

Zhang M, Wang L, Yue Y, Zhang L, Liu T, Jing M, Liang X, Ma M, Xu S, Wang K, Wang X, Fan J
Journal of experimental & clinical cancer research : CR 2021 Feb 11;40(1):65

Label-Free Quantitative Proteomic Profiling of LAD2 Mast Cell Releasates Reveals the Mechanism of Tween-80-Induced Anaphylactoid Reaction.

Mi YN, Yan PP, Di J, Cao L, Xiao X, Liu DZ, Cao YX
Proteomics. Clinical applications 2020 Jul;14(4):e1900065

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.

Stoyas CA, Bushart DD, Switonski PM, Ward JM, Alaghatta A, Tang MB, Niu C, Wadhwa M, Huang H, Savchenko A, Gariani K, Xie F, Delaney JR, Gaasterland T, Auwerx J, Shakkottai VG, La Spada AR
Neuron 2020 Feb 19;105(4):630-644.e9

DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.

Yang M, Zhao L, Gao P, Zhu X, Han Y, Chen X, Li L, Xiao Y, Wei L, Li C, Xiao L, Yuan S, Liu F, Dong LQ, Kanwar YS, Sun L
EBioMedicine 2019 May;43:607-619

Memantine can improve chronic ethanol exposure-induced spatial memory impairment in male C57BL/6 mice by reducing hippocampal apoptosis.

Wang X, Yu H, You J, Wang C, Feng C, Liu Z, Li Y, Wei R, Xu S, Zhao R, Wu X, Zhang G
Toxicology 2018 Aug 1;406-407:21-32

Memantine Can Reduce Ethanol-Induced Caspase-3 Activity and Apoptosis in H4 Cells by Decreasing Intracellular Calcium.

Wang X, Chen J, Wang H, Yu H, Wang C, You J, Wang P, Feng C, Xu G, Wu X, Zhao R, Zhang G
Journal of molecular neuroscience : MN 2017 Aug;62(3-4):402-411

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 19962-1-AP(ITPR1-specific antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human testis using 19962-1-AP(ITPR1-specific antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ITPR1-specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ITPR1-specific. This antibody recognizes human,mouse,rat antigen. The ITPR1-specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 19962-1-AP.pdf

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