66948-1-Ig

antibody from Proteintech Group

Targeting: TMEM119 OBIF

Provider product page for 66948-1-Ig

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
References [39]
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Product number: 66948-1-Ig - Provider product page
Provider: Proteintech Group
Product name: TMEM119 antibody
Antibody type: Monoclonal
Description: TMEM119 antibody (Cat. #66948-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Pig, Mouse, Rat and has been validated for the following applications: WB, ELISA.
Reactivity: Human, Mouse, Rat, Porcine
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1E7A2
Vial size: 20ul, 150ul

TMEM119 protein structure - 66948-1-Ig shown in red.

Submitted references Analysis of immune-related alterations in blood and spinal cord of canine degenerative myelopathy, a spontaneous model of amyotrophic lateral sclerosis.

Yokota S, Kobatake Y, Yoshida K, Kamishina H, Yamato O, Maki S, Nakata K, Sasaki J, Sakai H, Hirashima J, Takashima S, Nishii N
Scientific reports 2026 Mar 14;16(1)

Red nucleus IL-15 facilitates the development of neuropathic pain in male rats by inducing inflammatory factors: implying the involvement of NF-κB and p38 MAPK.

Zhang MM, Wang WT, Li YJ, Tao XX, Li K, Chen JM, Yang QQ, Tian X, Yang J, Yu YL, Xu YL, Wu JB, Wang JY, Zeng XY
Brain, behavior, and immunity 2026 Jan;131:106137

Glial cell crosstalk in the local microenvironment following spinal cord injury.

Li E, Gao Y, Zhang J, Zou P, Qiao H, Zhang R, Huang Y
Brain research bulletin 2025 Sep;229:111436

Microglial Extracellular Vesicles Mediate C1q Deposition at the Pre-Synapse and Promote Synaptic Pruning.

D'Arrigo G, Cutugno G, Golia MT, Sironi F, Lombardi M, Colombo SF, Frigerio R, Cretich M, Gagni P, Battocchio E, Barone C, Azzoni E, Bellini S, Saraceno C, Ghidoni R, Bendotti C, Paolicelli RC, Gabrielli M, Verderio C
Journal of extracellular vesicles 2025 Dec;14(12):e70173

The DRP1 inhibitory peptide P110 provides neuroprotection after subarachnoid hemorrhage by suppressing neuronal apoptosis and stabilizing the blood-brain barrier.

Hao S, Luo J, Yuan S, Chen W, Zhang X, Zhao C, Xu H, Liu Z, Zhang D
Free radical biology & medicine 2025 Dec 1;240:1-14

Every-other-day fasting inhibits pyroptosis while regulating bile acid metabolism and activating TGR5 signaling in spinal cord injury.

Song H, Pang R, Chen Z, Wang L, Hu X, Feng J, Wang W, Liu J, Zhang A
Frontiers in molecular neuroscience 2024;17:1466125

Targeted Microglial Membrane-Coated MicroRNA Nanosponge Mediates Inhibition of Glioblastoma.

Yin Y, Tian N, Deng Z, Wang J, Kuang L, Tang Y, Zhu S, Dong Z, Wang Z, Wu X, Han M, Hu X, Deng Y, Yin T, Wang Y
ACS nano 2024 Oct 22;18(42):29089-29105

TREM1 promotes neuroinflammation after traumatic brain injury in rats: Possible involvement of ERK/cPLA2 signalling pathway.

Zhang C, Jiang F, Liu S, Ni H, Feng Z, Huang M, Lu Y, Qian Y, Shao J, Rui Q
Neuroscience 2024 Nov 22;561:74-86

Overcoming tyrosine kinase inhibitor resistance in lung cancer brain metastasis with CTLA4 blockade.

Fu M, Zhao J, Zhang L, Sheng Z, Li X, Qiu F, Feng Y, You M, Xu H, Zhang J, Zeng R, Huang Y, Li C, Chen W, Chen Z, Peng H, Li L, Wu Y, Ye D, Chi Y, Hua W, Mao Y
Cancer cell 2024 Nov 11;42(11):1882-1897.e7

Spi1 regulates the microglial/macrophage inflammatory response via the PI3K/AKT/mTOR signaling pathway after intracerebral hemorrhage.

Zhang G, Lu J, Zheng J, Mei S, Li H, Zhang X, Ping A, Gao S, Fang Y, Yu J
Neural regeneration research 2024 Jan;19(1):161-170

Panax quinquefolium saponins attenuates microglia activation following acute cerebral ischemia-reperfusion injury via Nrf2/miR-103-3p/TANK pathway.

Bai X, Qiu Y, Wang J, Dong Y, Zhang T, Jin H
Cell biology international 2024 Feb;48(2):201-215

TNF-α Levels Are Increased in Patients with Subjective Cognitive Impairment and Are Negatively Correlated with β Amyloid-42.

Serafini S, Ferretti G, Monterosso P, Angiolillo A, Di Costanzo A, Matrone C
Antioxidants (Basel, Switzerland) 2024 Feb 8;13(2)

TMEM119 (c.G143A, p.S48L) Mutation Is Involved in Primary Failure of Eruption by Attenuating Glycolysis-Mediated Osteogenesis.

Xu M, Wang D, Li K, Ma T, Wang Y, Xia B
International journal of molecular sciences 2024 Feb 29;25(5)

Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder.

Prince N, Peralta Marzal LN, Markidi A, Ahmed S, Adolfs Y, Pasterkamp RJ, Kumar H, Roeselers G, Garssen J, Kraneveld AD, Perez-Pardo P
Acta pharmacologica Sinica 2024 Aug;45(8):1591-1603

Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke.

Jiang X, Zhang R, Lu G, Zhou Y, Li J, Jiang X, Gu S, Liang H, Wang J
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2024 Apr 22;19(1):15

Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice.

Hu M, Bodnar B, Zhang Y, Xie F, Li F, Li S, Zhao J, Zhao R, Gedupoori N, Mo Y, Lin L, Li X, Meng W, Yang X, Wang H, Barbe MF, Srinivasan S, Bethea JR, Mo X, Xu H, Hu W
International journal of biological sciences 2023;19(10):3226-3248

Primary cilia-mediated regulation of microglial secretion in Alzheimer's disease.

Yeo S, Jang J, Jung HJ, Lee H, Choe Y
Frontiers in molecular biosciences 2023;10:1250335

HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.

Zhong X, Wang Y, Liu D, Liang Y, Liu W, Huang Y, Xie L, Cao W, Xu Y, Chen L
Neuroscience 2023 May 1;517:117-127

Microglial targeted therapy relieves cognitive impairment caused by Cntnap4 deficiency.

Zhang W, Chen H, Ding L, Huang J, Zhang M, Liu Y, Ma R, Zheng S, Gong J, Piña-Crespo JC, Zhang Y
Exploration (Beijing, China) 2023 Jun;3(3):20220160

Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke.

Li L, Cheng SQ, Sun YQ, Yu JB, Huang XX, Dong YF, Ji J, Zhang XY, Hu G, Sun XL
Cell reports 2023 Jun 27;42(6):112617

Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model.

Roseborough AD, Myers SJ, Khazaee R, Zhu Y, Zhao L, Iorio E, Elahi FM, Pasternak SH, Whitehead SN
Journal of neuroinflammation 2023 Jan 31;20(1):20

Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: Implications for blood-brain barrier dysfunction.

Roseborough AD, Zhu Y, Zhao L, Laviolette SR, Pasternak SH, Whitehead SN
Neurobiology of disease 2023 Feb;177:106001

FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.

Cai W, Hu M, Li C, Wu R, Lu D, Xie C, Zhang W, Li T, Shen S, Huang H, Qiu W, Liu Q, Lu Y, Lu Z
Autophagy 2023 Apr;19(4):1144-1163

Differential Effects of APOE Genotype on MicroRNA Cargo of Cerebrospinal Fluid Extracellular Vesicles in Females With Alzheimer's Disease Compared to Males.

Sandau US, McFarland TJ, Smith SJ, Galasko DR, Quinn JF, Saugstad JA
Frontiers in cell and developmental biology 2022;10:864022

Erxian decoction inhibits apoptosis by activating Akt1 and repairs spinal cord injury in rats.

Li E, Yan R, Yan K, Huang R, Zhang R, Wen Y, Li S, Li P, Ma Q, Liao B
Heliyon 2022 Nov;8(11):e11279

Tumor Microenvironment and Immune Escape in the Time Course of Glioblastoma.

Virtuoso A, De Luca C, Cirillo G, Riva M, Romano G, Bentivegna A, Lavitrano M, Papa M, Giovannoni R
Molecular neurobiology 2022 Nov;59(11):6857-6873

An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation.

Ferretti G, Romano A, Sirabella R, Serafini S, Maier TJ, Matrone C
Cell & bioscience 2022 Nov 8;12(1):182

Neutrophil Nanovesicle Protects against Experimental Autoimmune Encephalomyelitis through Enhancing Myelin Clearance by Microglia.

Shen S, Cheng X, Zhou L, Zhao Y, Wang H, Zhang J, Sun X, Wang Y, Shu Y, Xu Y, Tao Y, Li M, Lu Z, Cai W, Nie G, Qiu W
ACS nano 2022 Nov 22;16(11):18886-18897

Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats.

Liu Q, Zhou S, Wang X, Gu C, Guo Q, Li X, Zhang C, Zhang N, Zhang L, Huang F
Journal of neuroinflammation 2022 Jun 20;19(1):160

QKI deficiency in macrophages protects mice against JEV infection by regulating cell migration and antiviral response.

Deng L, Wang W, Bian P, Wu M, Wang L, Lei Y, Lu Z, Zhai D
Molecular immunology 2022 Aug;148:34-44

Microglia-Specific Expression of HEXA and HEXB Leads to Poor Prognosis in Glioblastoma Patients.

Jia M, Zhang W, Zhu J, Huang C, Zhou J, Lian J, Wang Y, Teng H, Huang Z
Frontiers in oncology 2021;11:685893

TMEM119 facilitates ovarian cancer cell proliferation, invasion, and migration via the PDGFRB/PI3K/AKT signaling pathway.

Sun T, Bi F, Liu Z, Yang Q
Journal of translational medicine 2021 Mar 17;19(1):111

Can quantifying morphology and TMEM119 expression distinguish between microglia and infiltrating macrophages after ischemic stroke and reperfusion in male and female mice?

Young KF, Gardner R, Sariana V, Whitman SA, Bartlett MJ, Falk T, Morrison HW
Journal of neuroinflammation 2021 Feb 22;18(1):58

Flow cytometry analysis of immune and glial cells in a trigeminal neuralgia rat model.

Lin J, Zhou L, Luo Z, Adam MI, Zhao L, Wang F, Luo D
Scientific reports 2021 Dec 7;11(1):23569

Age and sex differences in primary microglia culture: A comparative study.

Ngwa C, Qi S, Mamun AA, Xu Y, Sharmeen R, Liu F
Journal of neuroscience methods 2021 Dec 1;364:109359

Methane-Rich Saline Alleviates CA/CPR Brain Injury by Inhibiting Oxidative Stress, Microglial Activation-Induced Inflammatory Responses, and ER Stress-Mediated Apoptosis.

Cui R, Liu S, Wang C, Liu T, Ren J, Jia Y, Tong Y, Liu C, Zhang J
Oxidative medicine and cellular longevity 2020;2020:8829328

Electroacupuncture Treatment Attenuates Paclitaxel-Induced Neuropathic Pain in Rats via Inhibiting Spinal Glia and the TLR4/NF-κB Pathway.

Zhao YX, Yao MJ, Liu Q, Xin JJ, Gao JH, Yu XC
Journal of pain research 2020;13:239-250

Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression.

Li L, Zou Y, Liu B, Yang R, Yang J, Sun M, Li Z, Xu X, Li G, Liu S, Greffrath W, Treede RD, Li G, Liang S
ACS chemical neuroscience 2020 Dec 16;11(24):4387-4397

Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake.

Brenna S, Altmeppen HC, Mohammadi B, Rissiek B, Schlink F, Ludewig P, Krisp C, Schlüter H, Failla AV, Schneider C, Glatzel M, Puig B, Magnus T
Journal of extracellular vesicles 2020 Aug 27;9(1):1809065

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