Antibody data
- Antibody Data
- Antigen structure
- References [42]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 18309-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18309-1-AP, RRID:AB_2128759
- Product name
- Integrin Beta 3 antibody
- Antibody type
- Polyclonal
- Description
- Integrin Beta 3 antibody (Cat. #18309-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Human Seminal Extracellular Vesicles Enhance Endometrial Receptivity Through Leukemia Inhibitory Factor.
Decreased FoxO1 expression contributes to facet joint osteoarthritis pathogenesis by impairing chondrocyte migration and extracellular matrix synthesis.
Atp6v1h Deficiency Blocks Bone Loss in Simulated Microgravity Mice through the Fos-Jun-Src-Integrin Pathway.
hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model.
Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf.
Enhancer of zeste homolog 2 facilitates phenotypic transition of vascular smooth muscle cells leading to aortic aneurysm/dissection.
Enhancing endometrial receptivity: the roles of human chorionic gonadotropin in autophagy and apoptosis regulation in endometrial stromal cells.
Cleavage of periostin by MMP9 protects mice from kidney cystic disease.
Glycosylation-Engineered Platelet Membrane-Coated Interleukin 10 Nanoparticles for Targeted Inhibition of Vascular Restenosis.
Repurposing of rilpivirine for preventing platelet β3 integrin-dependent thrombosis by targeting c-Src active autophosphorylation.
ANNEXIN A2 FACILITATES NEOVASCULARIZATION TO PROTECT AGAINST MYOCARDIAL INFARCTION INJURY VIA INTERACTING WITH MACROPHAGE YAP AND ENDOTHELIAL INTEGRIN Β3.
Proteomic Characterization of Peritoneal Extracellular Vesicles in a Mouse Model of Peritoneal Fibrosis.
The Expression of αvβ3 and Osteopontin in Osteoarthritic Knee Cartilage and Their Correlations With Disease Severity and Chondrocyte Senescence.
Deposition of platelet-derived microparticles in podocytes contributes to diabetic nephropathy.
Integrin β(3) directly inhibits the Gα(13)-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosis.
JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice.
Platelet membrane-camouflaged nanoparticles carry microRNA inhibitor against myocardial ischaemia‒reperfusion injury.
Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer.
ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts.
A blood circulation-prolonging peptide anchored biomimetic phage-platelet hybrid nanoparticle system for prolonged blood circulation and optimized anti-bacterial performance.
Construction and evaluation of novel αvβ3 integrin ligand-conjugated ultrasmall star polymer micelles targeted glomerular podocytes through GFB permeation.
Biomimetic Platform Based on Mesoporous Platinum for Multisynergistic Cancer Therapy.
DMAG, a novel countermeasure for the treatment of thrombocytopenia.
Targeting Gα(13)-integrin interaction ameliorates systemic inflammation.
A comprehensive genome-wide analysis of long non-coding RNA and mRNA expression profiles of JAK2V617F-positive classical myeloproliferative neoplasms.
Unveiling the CHO surfaceome: Identification of cell surface proteins reveals cell aggregation-relevant mechanisms.
Blood group-related antigen Le(y) on human platelets and its involvement in platelet aggregation via a possible interaction with CD61.
Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf.
Platelet-derived porous nanomotor for thrombus therapy.
Quantitative proteomic profiling of tumor-associated vascular endothelial cells in colorectal cancer.
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Intratumoral platelet aggregate formation in a murine preclinical glioma model depends on podoplanin expression on tumor cells.
Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity.
Single-Cell Analysis of the Impact of Host Cell Heterogeneity on Infection with Foot-and-Mouth Disease Virus.
Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells.
Effects of Levonorgestrel and progesterone on Oviductal physiology in mammals.
Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway.
Adipocytes enhance expression of osteoclast adhesion-related molecules through the CXCL12/CXCR4 signalling pathway.
Increased expression of Talin1 in the eutopic and ectopic endometria of women with adenomyosis.
PET imaging of neovascularization with (68)Ga-3PRGD2 for assessing tumor early response to Endostar antiangiogenic therapy.
High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting.
Miao J, Tu Y, Jiang J, Ren R, Wu Q, Liang H, Wang T, Lin B, Wu J, Pan Y, Wang X, Jin H
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
Human Seminal Extracellular Vesicles Enhance Endometrial Receptivity Through Leukemia Inhibitory Factor.
Wang H, Lin Y, Chen R, Zhu Y, Wang H, Li S, Yu L, Zhang K, Liu Y, Jing T, Sun F
Endocrinology 2024 Mar 29;165(5)
Endocrinology 2024 Mar 29;165(5)
Decreased FoxO1 expression contributes to facet joint osteoarthritis pathogenesis by impairing chondrocyte migration and extracellular matrix synthesis.
Chen C, Xu G, Chen J, Wu C, Zhang J, Jiang J, Hong H, Cui Z
Cellular signalling 2024 Jan;113:110942
Cellular signalling 2024 Jan;113:110942
Atp6v1h Deficiency Blocks Bone Loss in Simulated Microgravity Mice through the Fos-Jun-Src-Integrin Pathway.
Zhao Z, Wang X, Ma Y, Duan X
International journal of molecular sciences 2024 Jan 4;25(1)
International journal of molecular sciences 2024 Jan 4;25(1)
hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model.
Xu H, Jiang W, Li X, Jiang J, Afridi SK, Deng L, Li R, Luo E, Zhang Z, Huang YA, Cui Y, So KF, Chen H, Qiu W, Tang C
NPJ Regenerative medicine 2024 Jan 20;9(1):4
NPJ Regenerative medicine 2024 Jan 20;9(1):4
Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf.
Li H, Zhu X, Sun Z, Wang Q, Song S, Xu Y, He G, Mao X
ACS pharmacology & translational science 2024 Jan 12;7(1):176-185
ACS pharmacology & translational science 2024 Jan 12;7(1):176-185
Enhancer of zeste homolog 2 facilitates phenotypic transition of vascular smooth muscle cells leading to aortic aneurysm/dissection.
Xue S, Leng S, Zhang F, Dang Z, Su G, Yu W
Experimental and therapeutic medicine 2024 Apr;27(4):145
Experimental and therapeutic medicine 2024 Apr;27(4):145
Enhancing endometrial receptivity: the roles of human chorionic gonadotropin in autophagy and apoptosis regulation in endometrial stromal cells.
Wang B, Gao M, Yao Y, Shen H, Li H, Sun J, Wang L, Zhang X
Reproductive biology and endocrinology : RB&E 2024 Apr 4;22(1):37
Reproductive biology and endocrinology : RB&E 2024 Apr 4;22(1):37
Cleavage of periostin by MMP9 protects mice from kidney cystic disease.
Djaziri N, Burel C, Abbad L, Bakey Z, Piedagnel R, Lelongt B
PloS one 2023;18(12):e0294922
PloS one 2023;18(12):e0294922
Glycosylation-Engineered Platelet Membrane-Coated Interleukin 10 Nanoparticles for Targeted Inhibition of Vascular Restenosis.
Li F, Rong Z, Chen T, Wang P, Di X, Ni L, Liu C
International journal of nanomedicine 2023;18:5011-5030
International journal of nanomedicine 2023;18:5011-5030
Repurposing of rilpivirine for preventing platelet β3 integrin-dependent thrombosis by targeting c-Src active autophosphorylation.
Liu K, Hao Z, Zheng H, Wang H, Zhang L, Yan M, Tuerhong R, Zhou Y, Wang Y, Pang T, Shi L
Thrombosis research 2023 Sep;229:53-68
Thrombosis research 2023 Sep;229:53-68
ANNEXIN A2 FACILITATES NEOVASCULARIZATION TO PROTECT AGAINST MYOCARDIAL INFARCTION INJURY VIA INTERACTING WITH MACROPHAGE YAP AND ENDOTHELIAL INTEGRIN Β3.
Zhang Y, Wang Y, Li J, Li C, Liu W, Long X, Wang Z, Zhao R, Ge J, Shi B
Shock (Augusta, Ga.) 2023 Oct 1;60(4):573-584
Shock (Augusta, Ga.) 2023 Oct 1;60(4):573-584
Proteomic Characterization of Peritoneal Extracellular Vesicles in a Mouse Model of Peritoneal Fibrosis.
Huang Q, Sun Y, Sun J, Peng L, Shang H, Wei D, Li C, Hu Z, Peng H
Journal of proteome research 2023 Mar 3;22(3):908-918
Journal of proteome research 2023 Mar 3;22(3):908-918
The Expression of αvβ3 and Osteopontin in Osteoarthritic Knee Cartilage and Their Correlations With Disease Severity and Chondrocyte Senescence.
Cheng C, Tian J, Gao SG, Zhou ZH, Yang RQ, Xiao K, Guo W, Liu L, Yang H, Zhang FJ
Applied immunohistochemistry & molecular morphology : AIMM 2023 Jan 1;31(1):57-63
Applied immunohistochemistry & molecular morphology : AIMM 2023 Jan 1;31(1):57-63
Deposition of platelet-derived microparticles in podocytes contributes to diabetic nephropathy.
Huang SJ, Zhang Y, Wang GH, Lu J, Chen PP, Zhang JX, Li XQ, Yuan BY, Liu XQ, Jiang TT, Wang MY, Liu WT, Ruan XZ, Liu BC, Ma KL
International urology and nephrology 2023 Feb;55(2):355-366
International urology and nephrology 2023 Feb;55(2):355-366
Integrin β(3) directly inhibits the Gα(13)-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosis.
Zhang Y, Zhao X, Shen B, Bai Y, Chang C, Stojanovic A, Wang C, Mack A, Deng G, Skidgel RA, Cheng N, Du X
Nature communications 2023 Aug 16;14(1):4966
Nature communications 2023 Aug 16;14(1):4966
JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice.
Xie Z, Wu XJ, Cheng RW, Cui JH, Yuan ST, Zhou JW, Liu QH
Acta pharmacologica Sinica 2023 Apr;44(4):897-912
Acta pharmacologica Sinica 2023 Apr;44(4):897-912
Platelet membrane-camouflaged nanoparticles carry microRNA inhibitor against myocardial ischaemia‒reperfusion injury.
Wang T, Zhou T, Xu M, Wang S, Wu A, Zhang M, Zhou YL, Shi J
Journal of nanobiotechnology 2022 Oct 4;20(1):434
Journal of nanobiotechnology 2022 Oct 4;20(1):434
Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer.
Zhang Y, Sun L, Li H, Ai L, Ma Q, Qiao X, Yang J, Zhang H, Ou X, Wang Y, Chen G, Xue J, Zhu X, Zhao Y, Yang Y, Liu C
eLife 2022 Mar 14;11
eLife 2022 Mar 14;11
ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts.
Liang X, Hou Y, Han L, Yu S, Zhang Y, Cao X, Yan J
Frontiers in cell and developmental biology 2021;9:702916
Frontiers in cell and developmental biology 2021;9:702916
A blood circulation-prolonging peptide anchored biomimetic phage-platelet hybrid nanoparticle system for prolonged blood circulation and optimized anti-bacterial performance.
Jin P, Wang L, Sha R, Liu L, Qian J, Ishimwe N, Zhang W, Qian J, Zhang Y, Wen L
Theranostics 2021;11(5):2278-2296
Theranostics 2021;11(5):2278-2296
Construction and evaluation of novel αvβ3 integrin ligand-conjugated ultrasmall star polymer micelles targeted glomerular podocytes through GFB permeation.
Huang C, Zhao X, Su M, Yin Z
Biomaterials 2021 Sep;276:121053
Biomaterials 2021 Sep;276:121053
Biomimetic Platform Based on Mesoporous Platinum for Multisynergistic Cancer Therapy.
Zhao G, Li J, Fangfang Lv, Wang X, Dong Q, Liu D, Zhang J, Li Z, Zhou X, Liu H
ACS biomaterials science & engineering 2021 Nov 8;7(11):5154-5164
ACS biomaterials science & engineering 2021 Nov 8;7(11):5154-5164
DMAG, a novel countermeasure for the treatment of thrombocytopenia.
Lin J, Zeng J, Liu S, Shen X, Jiang N, Wu YS, Li H, Wang L, Wu JM
Molecular medicine (Cambridge, Mass.) 2021 Nov 27;27(1):149
Molecular medicine (Cambridge, Mass.) 2021 Nov 27;27(1):149
Targeting Gα(13)-integrin interaction ameliorates systemic inflammation.
Cheng N, Zhang Y, Delaney MK, Wang C, Bai Y, Skidgel RA, Du X
Nature communications 2021 May 27;12(1):3185
Nature communications 2021 May 27;12(1):3185
A comprehensive genome-wide analysis of long non-coding RNA and mRNA expression profiles of JAK2V617F-positive classical myeloproliferative neoplasms.
Zhou J, Wu H, Guo C, Li B, Zhou LL, Liang AB, Fu JF
Bioengineered 2021 Dec;12(2):10564-10586
Bioengineered 2021 Dec;12(2):10564-10586
Unveiling the CHO surfaceome: Identification of cell surface proteins reveals cell aggregation-relevant mechanisms.
Klingler F, Mathias S, Schneider H, Buck T, Raab N, Zeh N, Shieh YW, Pfannstiel J, Otte K
Biotechnology and bioengineering 2021 Aug;118(8):3015-3028
Biotechnology and bioengineering 2021 Aug;118(8):3015-3028
Blood group-related antigen Le(y) on human platelets and its involvement in platelet aggregation via a possible interaction with CD61.
Zhu H, Ma Q, Li R, Fu M, Lu P
Transfusion 2020 Sep;60(9):2130-2138
Transfusion 2020 Sep;60(9):2130-2138
Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf.
Xu Y, Sun T, Zeng K, Xu M, Chen J, Xu X, Zhang Z, Cao B, Tang X, Wu D, Kong Y, Zeng Y, Mao X
Cell death & disease 2020 Sep 30;11(9):818
Cell death & disease 2020 Sep 30;11(9):818
Platelet-derived porous nanomotor for thrombus therapy.
Wan M, Wang Q, Wang R, Wu R, Li T, Fang D, Huang Y, Yu Y, Fang L, Wang X, Zhang Y, Miao Z, Zhao B, Wang F, Mao C, Jiang Q, Xu X, Shi D
Science advances 2020 May;6(22):eaaz9014
Science advances 2020 May;6(22):eaaz9014
Quantitative proteomic profiling of tumor-associated vascular endothelial cells in colorectal cancer.
Wang G, Yang Q, Li M, Zhang Y, Cai Y, Liang X, Fu Y, Xiao Z, Zhou M, Xie Z, Huang H, Huang Y, Chen Y, He Q, Peng F, Chen Z
Biology open 2019 May 13;8(5)
Biology open 2019 May 13;8(5)
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Li Y, Chen Y, Qiu C, Ma X, Lei K, Cai G, Liang X, Liu J
Journal of cellular biochemistry 2019 Feb;120(2):1560-1576
Journal of cellular biochemistry 2019 Feb;120(2):1560-1576
Intratumoral platelet aggregate formation in a murine preclinical glioma model depends on podoplanin expression on tumor cells.
Costa B, Eisemann T, Strelau J, Spaan I, Korshunov A, Liu HK, Bugert P, Angel P, Peterziel H
Blood advances 2019 Apr 9;3(7):1092-1102
Blood advances 2019 Apr 9;3(7):1092-1102
Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity.
Xu R, Shi G, Xu L, Gu Q, Fu Y, Zhang P, Cheng J, Jiang H
Journal of tissue engineering and regenerative medicine 2018 May;12(5):1209-1219
Journal of tissue engineering and regenerative medicine 2018 May;12(5):1209-1219
Single-Cell Analysis of the Impact of Host Cell Heterogeneity on Infection with Foot-and-Mouth Disease Virus.
Xin X, Wang H, Han L, Wang M, Fang H, Hao Y, Li J, Zhang H, Zheng C, Shen C
Journal of virology 2018 May 1;92(9)
Journal of virology 2018 May 1;92(9)
Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells.
Yan T, Zhang A, Shi F, Chang F, Mei J, Liu Y, Zhu Y
The Journal of biological chemistry 2018 Jun 29;293(26):10172-10185
The Journal of biological chemistry 2018 Jun 29;293(26):10172-10185
Effects of Levonorgestrel and progesterone on Oviductal physiology in mammals.
Li C, Zhang HY, Liang Y, Xia W, Zhu Q, Zhang D, Huang Z, Liang GL, Xue RH, Qi H, He XQ, Yuan JJ, Tan YJ, Huang HF, Zhang J
Reproductive biology and endocrinology : RB&E 2018 Jun 20;16(1):59
Reproductive biology and endocrinology : RB&E 2018 Jun 20;16(1):59
Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway.
Wang N, Zou C, Zhao S, Wang Y, Han C, Zheng Z
Investigative ophthalmology & visual science 2018 Aug 1;59(10):4210-4217
Investigative ophthalmology & visual science 2018 Aug 1;59(10):4210-4217
Adipocytes enhance expression of osteoclast adhesion-related molecules through the CXCL12/CXCR4 signalling pathway.
Luo T, Liu H, Feng W, Liu D, Du J, Sun J, Wang W, Han X, Guo J, Amizuka N, Li X, Li M
Cell proliferation 2017 Jun;50(3)
Cell proliferation 2017 Jun;50(3)
Increased expression of Talin1 in the eutopic and ectopic endometria of women with adenomyosis.
Jiang J, Sun A, Wang Y, Deng Y
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2016 Jun;32(6):469-72
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2016 Jun;32(6):469-72
PET imaging of neovascularization with (68)Ga-3PRGD2 for assessing tumor early response to Endostar antiangiogenic therapy.
Shi J, Jin Z, Liu X, Fan D, Sun Y, Zhao H, Zhu Z, Liu Z, Jia B, Wang F
Molecular pharmaceutics 2014 Nov 3;11(11):3915-22
Molecular pharmaceutics 2014 Nov 3;11(11):3915-22
High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting.
Zhang MZ, Li C, Fang BY, Yao MH, Ren QQ, Zhang L, Zhao YD
Nanotechnology 2014 Jun 27;25(25):255102
Nanotechnology 2014 Jun 27;25(25):255102
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human placenta tissue were subjected to SDS PAGE followed by western blot with 18309-1-AP(ITGB3 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 18309-1-AP(ITGB3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Integrin beta-3 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Integrin beta-3. This antibody recognizes human,mouse,rat antigen. The Integrin beta-3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.