Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations [0]
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- Product number
- 879 - Provider product page
- Provider
- YO Proteins AB
- Proper citation
- YO Proteins Cat#879, RRID:AB_2128756
- Product name
- Mouse anti-human CD61 (ß-integrin, Platelet GPIIIa, VNR ß-chain 3) monoclonal antibody, clone CRC54
- Antibody type
- Monoclonal
- Description
- Monoclonal antibody anti-human CD61 (ß-integrin, Platelet GPIIIa, VNR ß-chain 3) (IgG1 kappa, clone CRC54). Reacts with platelet glycoprotein gpIIIa/VNR ß chain. This glycoprotein is the common ß chain (ß3 Integrin) of the cytoadhesins, gpIIbIIIa and VNR. Reacts with platelets and megakaryocytes. The antibody reacts preferentially with the activated/occupied form of platelet GPIIb-IIIa (ligand-induced binding site or LIBS epitope) and dissociated form of GPIIIa. CRC54-epitope is located within the N-terminal region of GPIIIa (first 100 aminoacids). CRC54 does not react with platelets of patients with Glanzmann thrombastenia
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 1 ml
Submitted references The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.
Effects of platelet glycoprotein IIb-IIIa number and glycoprotein IIIa Leu33Pro polymorphism on platelet aggregation and sensitivity to glycoprotein IIb-IIIa antagonists.
Detection of an epitope specific for the dissociated form of glycoprotein IIIa of platelet membrane glycoprotein IIb-IIIa complex and its expression on the surface of adherent platelets.
Alghisi GC, Ponsonnet L, Rüegg C
PloS one 2009;4(2):e4449
PloS one 2009;4(2):e4449
Effects of platelet glycoprotein IIb-IIIa number and glycoprotein IIIa Leu33Pro polymorphism on platelet aggregation and sensitivity to glycoprotein IIb-IIIa antagonists.
Sirotkina OV, Khaspekova SG, Zabotina AM, Shimanova YV, Mazurov AV
Platelets 2007 Nov;18(7):506-14
Platelets 2007 Nov;18(7):506-14
Detection of an epitope specific for the dissociated form of glycoprotein IIIa of platelet membrane glycoprotein IIb-IIIa complex and its expression on the surface of adherent platelets.
Khaspekova SG, Vlasik TN, Byzova TV, Vinogradov DV, Berndt MC, Mazurov AV
British journal of haematology 1993 Oct;85(2):332-40
British journal of haematology 1993 Oct;85(2):332-40
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