Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 304413 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#304413, RRID:AB_2129617
- Product name
- LEAF™ Purified anti-human CD51/61 [23C6]
- Antibody type
- Monoclonal
- Antigen
- CD51/61
- Description
- CD51/CD61 is an integrin complex known as αVβ3. It is expressed at high levels on osteoclasts, endothelial cells, and melanoma cells and at low levels on platelets and macrophages. CD51 is a heterodimer composed of disulfide-linked 125 kD and 24 kD proteins. CD61 is also a member of the integrin family known as gpIIIa or β3 integrin. It is a 110 kD common β subunit of CD51/CD61 or CD41/CD61 complex. CD51/CD61, also known as the vitronectin receptor, mediates the binding of platelets to immobilized vitronectin without prior activation. Other ligands include RGD-containing proteins such as fibrinogen, fibronectin, von Willebrand factor (vWf), laminin, thrombospondin and the neural adhesion molecule L1. CD51/CD61 also mediates cell-cell adhesion via interaction with CD31. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components. The 23C6 antibody has been reported to be useful for blocking studies.
- Reactivity
- Human, Chicken/Avian, Rabbit
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 50 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
Submitted references Detection of tumor-associated neoangiogenesis by Doppler ultrasonography during early-stage ovarian cancer in laying hens: a preclinical model of human spontaneous ovarian cancer.
Barua A, Bitterman P, Bahr JM, Bradaric MJ, Hales DB, Luborsky JL, Abramowicz JS
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2010 Feb;29(2):173-82
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2010 Feb;29(2):173-82
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human melanoma cell line M21 stained with LEAF™ purified 23C6, followed by anti-mouse IgG FITC
- Conjugate
- Unconjugated