Ab110875

antibody from Aladdin Scientific
Targeting: ITGB3 CD61, GP3A, GPIIIa
Provider product page for Ab110875

Antibody data

Product number
Ab110875 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant Integrin beta 3 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human Integrin beta 3 Antibody, Recombinant, could be used for WB and so on.Application:WB: 1/500-1/1000Protein FunctionIntegrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 27-377
Vial size
100_l,10_l,1ml,50_l
Concentration
0,6 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
ITGB3 protein structure - Ab110875 shown in red.