FLRT2

This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Description

Fibronectin leucine rich transmembrane protein 2

Tissue specificity

Tissue enhanced (ovary, pancreas)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (85530144 - 85654428)

Ensembl ID

ENSG00000185070  (ver. 103.38)

Orthologs

Mouse Flrt2: ENSMUSG00000047414

UniProt

O43155

neXtProt

NX_O43155

Human splice variants
Mouse splice variants

Protein structure