Tissue expression
Cell line expression
Protein structure
CYP2A6
Cytochrome P450 family 2 subfamily A member 6CPA6, CYP2A, CYP2A3
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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OriGene | TA503827 | 1 references | Monoclonal |
WB
ICC
IHC
FC |
|
Invitrogen Antibodies | CF503805 | Monoclonal |
WB
ICC
IHC
FC |
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Proteintech Group | 21721-1-AP | 1 references | Polyclonal |
WB
EL
IHC
|
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antibodies-online | ABIN2718977 | Monoclonal |
WB
ICC
IHC
FC |
||
Abnova Corporation | MAB1858 | 3 references | Monoclonal |
WB
IHC |
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Supportive data in Antibodypedia
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Recommended by provider