FNab09756

antibody from FineTest Biotech

Targeting: ZRANB3 AH2, DKFZP434B1727

Western blot

ELISA

Immunocytochemistry

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Validation data

Product number: FNab09756 - Provider product page
Provider: FineTest Biotech
Product name: ZRANB3 antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: zinc finger, RAN-binding domain con taining 3
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

ZRANB3 protein structure - FNab09756 shown in red.