AGTO-L009D

antibody from Creative Biolabs

Targeting: IL3RA CD123

No application information provided.

Antibody Data

Product number

AGTO-L009D

Provider

Creative Biolabs

Product name

IL3-DT immunotoxin

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the IL3 to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to leukemia cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of leukemia.

Reactivity

Human

Host

Human