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- Antibody Data
- Antigen structure
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- Product number
- AGTO-L009E - Provider product page
- Provider
- Creative Biolabs
- Product name
- IL3-PE immunotoxin
- Antibody type
- Monoclonal
- Description
- This immunotoxin was achieved by conjugating/fusing the IL3 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to leukemia cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of leukemia.
- Reactivity
- Human
- Host
- Human
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