Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 306019 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#306019, RRID:AB_11218792
- Product name
- Brilliant Violet 650™ anti-human CD123 [6H6]
- Antibody type
- Monoclonal
- Antigen
- Human IL-3Rα transfected COS cells
- Description
- CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CDw131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development.
Charles N, Hardwick D, Daugas E, Illei GG, Rivera J
Nature medicine 2010 Jun;16(6):701-7
Nature medicine 2010 Jun;16(6):701-7
Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development.
Martín-Gayo E, Sierra-Filardi E, Corbí AL, Toribio ML
Blood 2010 Jul 1;115(26):5366-75
Blood 2010 Jul 1;115(26):5366-75
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood leukocytes were stained with HLA-DR FITC and CD123 (clone 6H6) Brilliant Violet 650™ (top) or mouse IgG1 Brilliant Violet 650™ isotype control (bottom).
- Conjugate
- Red dye