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- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [2]
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- Product number
- Ab177880 - Provider product page
- Provider
- Aladdin Scientific
- Product name
- Talacotuzumab (anti-IL-3Ra)
- Antibody type
- Recombinant
- Description
- Talacotuzumab (anti-IL-3Ra) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab (anti-IL-3Ra) has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab (anti-IL-3Ra) inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab (anti-IL-3Ra) has mutated the Fc region to increase affinity for CD16 (Fc_RIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab (anti-IL-3Ra) is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models.
- Reactivity
- Human
- Conjugate
- Unconjugated
- Vial size
- 100_g,10mg,1mg,5mg
- Concentration
- Lot by Lot
- Storage
- Store at -80_ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
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Supportive validation
- Submitted by
- Aladdin Scientific (provider)
- Main image
- Experimental details
- Talacotuzumab (anti-IL-3Ra) (Ab177880) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling IL-3Ra with Talacotuzumab (anti-IL-3Ra) (Ab177880) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156250).
- Submitted by
- Aladdin Scientific (provider)
- Main image
- Experimental details
- Talacotuzumab (anti-IL-3Ra) (Ab177880) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling IL-3Ra (red) with Talacotuzumab (anti-IL-3Ra) (Ab177880) conjugated with biotin and detected with SA-PE (rp156250). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
