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antibody from Invitrogen Antibodies
Targeting: CXCR3
CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 13-1839-82 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD183 (CXCR3) Monoclonal Antibody (CEW33D), Biotin, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The CEW33D monoclonal antibody reacts with human CD183. CD183, also known as CXCR3, is a G protein-coupled chemokine receptor that interacts with ligands CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC). Strongly associated with type 1 immunity, CD183 is induced in naive T cells upon activation and remains upregulated in T helper type (Th)1 cells, CD8 effector cells, NK cells and NKT cells. CD183-ligand interactions mediate infiltration of inflamed tissues in normal type 1 immune responses as well as in many inflammatory and autoimmune diseases. CD183 is also expressed on some B cells and plasmacytoid DC.
- Conjugate
- Biotin
- Antibody clone number
- CEW33D
- Concentration
- 0.5 mg/mL
Submitted references CCR3, CCR4, CCR5, and CXCR3 expression in peripheral blood CD4+ lymphocytes in gastric cancer patients.
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.
CXCR3 ligands: redundant, collaborative and antagonistic functions.
Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3.
The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig.
The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
Andalib A, Doulabi H, Maracy MR, Rezaei A, Hasheminia SJ
Advanced biomedical research 2013;2:31
Advanced biomedical research 2013;2:31
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.
Locci M, Havenar-Daughton C, Landais E, Wu J, Kroenke MA, Arlehamn CL, Su LF, Cubas R, Davis MM, Sette A, Haddad EK, International AIDS Vaccine Initiative Protocol C Principal Investigators., Poignard P, Crotty S
Immunity 2013 Oct 17;39(4):758-69
Immunity 2013 Oct 17;39(4):758-69
CXCR3 ligands: redundant, collaborative and antagonistic functions.
Groom JR, Luster AD
Immunology and cell biology 2011 Feb;89(2):207-15
Immunology and cell biology 2011 Feb;89(2):207-15
Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3.
Hoerning A, Koss K, Datta D, Boneschansker L, Jones CN, Wong IY, Irimia D, Calzadilla K, Benitez F, Hoyer PF, Harmon WE, Briscoe DM
European journal of immunology 2011 Aug;41(8):2291-302
European journal of immunology 2011 Aug;41(8):2291-302
The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig.
Piali L, Weber C, LaRosa G, Mackay CR, Springer TA, Clark-Lewis I, Moser B
European journal of immunology 1998 Mar;28(3):961-72
European journal of immunology 1998 Mar;28(3):961-72
The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
Qin S, Rottman JB, Myers P, Kassam N, Weinblatt M, Loetscher M, Koch AE, Moser B, Mackay CR
The Journal of clinical investigation 1998 Feb 15;101(4):746-54
The Journal of clinical investigation 1998 Feb 15;101(4):746-54
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD3 FITC (Product # 11-0036-42) and 0.25 µg of Mouse IgG1 K Isotype Control Biotin (Product # 13-4714-85) (left) or 0.25 µg of Anti-Human CD183 (CXCR3) Biotin (right) followed by Streptavidin PE (Product # 12-4317-87). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Biotin
