60088FI.1
antibody from STEMCELL Technologies Inc
Targeting: CXCR3
CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR
Antibody data
- Antibody Data
- Antigen structure
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- Validations [0]
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- Product number
- 60088FI.1 - Provider product page
- Provider
- STEMCELL Technologies Inc
- Product name
- Anti-Human CD183 (CXCR3) Antibody, Clone G025H7, FITC
- Antibody type
- Monoclonal
- Description
- The G025H7 antibody reacts with an extracellular epitope on human CD183 (CXCR3). CD183 is an ~40 kDa seven-pass G protein-coupled transmembrane chemokine receptor expressed predominantly on the surface of IL2-activated (Th1) T cells, as well as on natural killer (NK) cells, dendritic cells, mast cells, alveolar macrophages, eosinophils, and human airway epithelial cells. Binding of chemokines to CD183 induces cellular responses involved in leukocyte migration into inflamed tissue, including Ca2+ mobilization, integrin activation, cytoskeletal rearrangements and chemotaxis, and consequently CD183 plays roles in several inflammatory and autoimmune diseases. Three ligands for CD183 have been identified; Mig (CXCL9), IP-10 (CXCL10) and I-TAC (CXCL11), with the latter exhibiting the highest affinity for CD183 and the most potent induction of the chemotactic response. These chemokines are secreted by a variety of cells upon stimulation by IFN-gamma.
- Reactivity
- Human
- Isotype
- IgG
- Vial size
- 25 Tests
- Storage
- 2 - 8°C
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