353711

antibody from BioLegend

Targeting: CXCR3 CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

353711

Provider

BioLegend

Proper citation

BioLegend Cat#353711, RRID:AB_10962946

Product name

Alexa Fluor® 647 anti-human CD183 (CXCR3) [G025H7]

Antibody type

Monoclonal

Antigen

Human CXCR3 transfectants

Description

Human CXCR3, also known as GPR9, is a chemokine receptor that binds CXCL9, CXCL10, and CXCL11. It is a 38 kD seven-pass transmembrane receptor coupled to G-protein. CXCR3 is highly expressed by T lymphocytes (Th1), natural killer cells (NK cells), dendritic cells, mast cells, alveolar macrophages, eosinophils, and human airway epithelial cells. CXCR3 is important for effector lymphocyte recruitment into inflamed tissue in various inflammatory and autoimmune diseases, such as chronically inflamed human liver, Crohn's disease, rheumatoid arthritis, multiple sclerosis, and inflammatory skin diseases.

Reactivity

Human

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Vial size

25 tests

Storage

The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human peripheral blood lymphocytes were stained with CD3 PE and CXCR3 (G025H7) Alexa Fluor® 647 (top) or mouse IgG1 Alexa Fluor® 647 isotype control (bottom).

Conjugate

Red dye