Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 353719 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#353719, RRID:AB_11218804
- Product name
- PE/Cy7 anti-human CD183 (CXCR3)
- Antibody type
- Monoclonal
- Antigen
- Human CXCR3 transfectants
- Description
- Human CXCR3, also known as GPR9, is a chemokine receptor that binds CXCL9, CXCL10, and CXCL11. It is a 38 kD seven-pass transmembrane receptor coupled to G-protein. CXCR3 is highly expressed by T lymphocytes (Th1), natural killer cells (NK cells), dendritic cells, mast cells, alveolar macrophages, eosinophils, and human airway epithelial cells. CXCR3 is important for effector lymphocyte recruitment into inflamed tissue in various inflammatory and autoimmune diseases, such as chronically inflamed human liver, Crohn's disease, rheumatoid arthritis, multiple sclerosis, and inflammatory skin diseases.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Infrared dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral lymphocytes were stained with CD3 FITC and CXCR3 (clone G025H7) PE/Cy7 (top) or mouse IgG1, κ PE/Cy7 isotype control (bottom).
- Conjugate
- Near infrared dye